MXPA00012586A - Glicosulfopeptidos y metodos de sintesis y uso de los mismos. - Google Patents
Glicosulfopeptidos y metodos de sintesis y uso de los mismos.Info
- Publication number
- MXPA00012586A MXPA00012586A MXPA00012586A MXPA00012586A MXPA00012586A MX PA00012586 A MXPA00012586 A MX PA00012586A MX PA00012586 A MXPA00012586 A MX PA00012586A MX PA00012586 A MXPA00012586 A MX PA00012586A MX PA00012586 A MXPA00012586 A MX PA00012586A
- Authority
- MX
- Mexico
- Prior art keywords
- glycan
- gsps
- methods
- synthesis
- group
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 3
- LAQPKDLYOBZWBT-NYLDSJSYSA-N (2s,4s,5r,6r)-5-acetamido-2-{[(2s,3r,4s,5s,6r)-2-{[(2r,3r,4r,5r)-5-acetamido-1,2-dihydroxy-6-oxo-4-{[(2s,3s,4r,5s,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-[(1r,2r)-1,2,3-trihydrox Chemical group O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]([C@@H](NC(C)=O)C=O)[C@@H]([C@H](O)CO)O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 LAQPKDLYOBZWBT-NYLDSJSYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000002001 anti-metastasis Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229920001542 oligosaccharide Polymers 0.000 abstract 1
- 150000002482 oligosaccharides Chemical class 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 125000005630 sialyl group Chemical group 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8947298P | 1998-06-16 | 1998-06-16 | |
| PCT/US1999/013455 WO1999065712A2 (en) | 1998-06-16 | 1999-06-15 | Glycosulfopeptides and methods of synthesis and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA00012586A true MXPA00012586A (es) | 2004-05-21 |
Family
ID=22217840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA00012586A MXPA00012586A (es) | 1998-06-16 | 1999-06-15 | Glicosulfopeptidos y metodos de sintesis y uso de los mismos. |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US6593459B1 (enExample) |
| EP (1) | EP1087996B1 (enExample) |
| JP (1) | JP2002518354A (enExample) |
| AU (1) | AU773542B2 (enExample) |
| CA (1) | CA2332563A1 (enExample) |
| DE (1) | DE69934890D1 (enExample) |
| MX (1) | MXPA00012586A (enExample) |
| WO (1) | WO1999065712A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223845B2 (en) | 1998-06-16 | 2007-05-29 | The Board Of Regents Of The University Of Oklahoma | Synthetic glycosulfopeptides and methods of synthesis thereof |
| US20030143662A1 (en) | 1998-06-16 | 2003-07-31 | Cummings Richard D. | Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof |
| MXPA00012586A (es) * | 1998-06-16 | 2004-05-21 | Univ Oklahoma | Glicosulfopeptidos y metodos de sintesis y uso de los mismos. |
| US6492152B1 (en) | 1999-06-15 | 2002-12-10 | The Board Of Regents Of The University Of Oklahoma | Core 1 β3-galactosyl transferases and methods of use thereof |
| HK1048140A1 (zh) * | 1999-12-15 | 2003-03-21 | The Board Of Regents Of The University Of Oklahoma | 核心1β3-半乳糖基轉移酶及其方法和用途 |
| EP1325123A4 (en) * | 2000-09-12 | 2004-07-21 | Inst Genetics Llc | INHIBITION OF STENOSIS OR RESTENOSIS USING P-SELECTINE ANTAGONISTS |
| SE0004828D0 (sv) * | 2000-12-22 | 2000-12-22 | Pharmacia Ab | Protein cluster II |
| JP2005503756A (ja) * | 2000-12-29 | 2005-02-10 | サビエント ファーマシューティカルズ，インコーポレイティド | 硫酸化部分を含むエピトープを含む単離分子、当該エピトープに対する抗体、及びその使用 |
| US7132510B2 (en) * | 2000-12-29 | 2006-11-07 | Bio-Technology General (Israel) Ltd. | Specific human antibodies for selective cancer therapy |
| US20040001822A1 (en) * | 2000-12-29 | 2004-01-01 | Avigdor Levanon | Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
| US20040001839A1 (en) * | 2000-12-29 | 2004-01-01 | Avigdor Levanon | Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
| US20040002450A1 (en) * | 2000-12-29 | 2004-01-01 | Janette Lazarovits | Y17 - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
| US6537780B2 (en) * | 2001-03-28 | 2003-03-25 | Applera Corporation | Isolated nucleic acid molecules encoding transferase enzymes |
| WO2003032925A2 (en) * | 2001-10-19 | 2003-04-24 | Cummings Richard D | Glycosulfopeptide inhibitors and methods of use thereof |
| EP1534725A2 (en) | 2002-05-16 | 2005-06-01 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| US20040202665A1 (en) * | 2002-07-01 | 2004-10-14 | Janette Lazarovits | Compositions and methods for therapeutic treatment |
| WO2004004636A2 (en) * | 2002-07-03 | 2004-01-15 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
| US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
| US20050069955A1 (en) * | 2003-06-30 | 2005-03-31 | Daniel Plaksin | Antibodies and uses thereof |
| US20050266009A1 (en) * | 2003-06-30 | 2005-12-01 | Savient Pharmaceuticals, Inc. | Antibodies and uses thereof |
| US20050152906A1 (en) * | 2003-06-30 | 2005-07-14 | Avigdor Levanon | Specific human antibodies |
| WO2005054264A2 (en) * | 2003-11-19 | 2005-06-16 | Glycomimetics, Inc. | Glycomimetic antagonists for both e- and p-selectins |
| EP1763533B1 (en) * | 2003-11-19 | 2008-01-09 | GlycoMimetics, Inc. | Specific antagonist for both e- and p-selectins |
| JP2007524693A (ja) * | 2004-02-20 | 2007-08-30 | ザ バーナム インスティチュート | 抗菌性の糖質及びそれを用いた方法 |
| US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
| TWI264608B (en) * | 2005-04-08 | 2006-10-21 | Delta Electronics Inc | Light tunnel module |
| WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
| CA2618638C (en) * | 2005-08-09 | 2014-03-11 | Glycomimetics, Inc. | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
| LT2264043T (lt) | 2005-09-02 | 2017-12-11 | Glycomimetics, Inc. | Heterobifunkciniai pan-selektino inhibitoriai |
| US20090176717A1 (en) * | 2006-06-01 | 2009-07-09 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
| EP2074132B1 (en) | 2006-10-12 | 2013-05-15 | GlycoMimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| CA2677747A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| US9486497B2 (en) | 2007-12-10 | 2016-11-08 | The University Of Queensland | Treatment of immunocompromised conditions |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| EP2318015B1 (en) * | 2008-06-13 | 2013-08-07 | GlycoMimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
| EP2424544A1 (en) | 2009-05-01 | 2012-03-07 | GlycoMimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| EP2654781B1 (en) | 2010-12-21 | 2018-01-24 | Selexys Pharmaceuticals Corporation | Anti-p-selectin antibodies and methods of their use and identification |
| EP3296310A1 (en) | 2011-12-22 | 2018-03-21 | GlycoMimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
| US9867841B2 (en) | 2012-12-07 | 2018-01-16 | Glycomimetics, Inc. | Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells |
| US10253071B2 (en) | 2013-06-03 | 2019-04-09 | Beth Israel Deaconess Medical Center, Inc. | Selectin inhibitors, composition, and uses related thereto |
| ES2754549T3 (es) | 2014-12-03 | 2020-04-20 | Glycomimetics Inc | Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4 |
| JP2019502727A (ja) | 2016-01-22 | 2019-01-31 | グリコミメティクス， インコーポレイテッド | Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤 |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| WO2018031445A1 (en) | 2016-08-08 | 2018-02-15 | Glycomimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4 |
| CA3037850A1 (en) | 2016-10-07 | 2018-04-12 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| EP3717013A1 (en) | 2017-11-30 | 2020-10-07 | GlycoMimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| CA3085356A1 (en) | 2017-12-29 | 2019-07-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| KR20200128025A (ko) | 2018-03-05 | 2020-11-11 | 글리코미메틱스, 인크. | 급성 골수성 백혈병 및 관련 병태의 치료 방법 |
| US20210244795A1 (en) * | 2018-06-11 | 2021-08-12 | The Wistar Institute Of Anatomy And Biology | Compositions and methods for in vivo post translational modification |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| KR20210126019A (ko) | 2019-01-15 | 2021-10-19 | 옵팀비아, 엘엘씨 | 엔지니어링된 아릴 설페이트-의존 효소 |
| JP2022540849A (ja) | 2019-07-09 | 2022-09-20 | オプティムヴィア、エルエルシー | 抗凝固性多糖類の合成方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS60197699A (ja) * | 1984-03-19 | 1985-10-07 | Fuji Yakuhin Kogyo Kk | コレシストキニンパンクレオザイミンｃ端ペプチドおよびその類縁体の製造方法 |
| US5874261A (en) | 1988-09-02 | 1999-02-23 | The Trustees Of The University Of Pennsylvania | Method for the purification of glycosyltransferases |
| US5047335A (en) | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
| US5929036A (en) | 1989-03-08 | 1999-07-27 | The Board Of Regents Of The University Of Oklahoma | Ligand or GMP-140 selectin and methods of use thereof |
| EP0481038B1 (en) | 1990-04-16 | 2002-10-02 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| JPH07501828A (ja) * | 1991-12-18 | 1995-02-23 | セントコー，インコーポレイテッド | セレクチン類で仲介される炎症のペプチド阻害剤 |
| JPH0686684A (ja) | 1992-05-26 | 1994-03-29 | Monsanto Co | シアロ抱合体の合成 |
| US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| WO1994005314A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of leukocyte adhesion |
| US5843707A (en) | 1992-10-23 | 1998-12-01 | Genetics Institute, Inc. | Nucleic acid encoding a novel P-selectin ligand protein |
| WO1994011498A1 (en) | 1992-11-16 | 1994-05-26 | Board Of Regents Of The University Of Oklahoma | Glycoprotein ligand for p-selectin and methods of use thereof |
| SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| US5730990A (en) * | 1994-06-24 | 1998-03-24 | Enzon, Inc. | Non-antigenic amine derived polymers and polymer conjugates |
| FR2723962B1 (fr) * | 1994-08-25 | 1996-10-31 | Univ Paris Curie | Hsv1-tk modifiee fonctionnelle |
| US5821329A (en) | 1996-06-06 | 1998-10-13 | Tanabe Seiyaku Co., Ltd. | Cyclic peptide inhibitors of β1 and β2 integrin-mediated adhesion |
| WO1997006176A2 (en) * | 1995-08-03 | 1997-02-20 | Board Of Regents Of The University Of Oklahoma | Peptide and o-glycan inhibitors of selectin mediated inflammation |
| KR100593466B1 (ko) * | 1997-01-21 | 2007-04-25 | 파스퇴르 메리오 세룸 에 박신 | 다당류-펩타이드접합체 |
| US6180096B1 (en) * | 1998-03-26 | 2001-01-30 | Schering Corporation | Formulations for protection of peg-interferon alpha conjugates |
| MXPA00012586A (es) * | 1998-06-16 | 2004-05-21 | Univ Oklahoma | Glicosulfopeptidos y metodos de sintesis y uso de los mismos. |
| US6165509A (en) * | 1998-09-01 | 2000-12-26 | University Of Washington | Pegylated drug complexed with bioadhesive polymer suitable for drug delivery and methods relating thereto |
| US6432409B1 (en) * | 1999-09-14 | 2002-08-13 | Antigen Express, Inc. | Hybrid peptides modulate the immune response |
-
1999
- 1999-06-15 MX MXPA00012586A patent/MXPA00012586A/es not_active IP Right Cessation
- 1999-06-15 DE DE69934890T patent/DE69934890D1/de not_active Expired - Lifetime
- 1999-06-15 AU AU45673/99A patent/AU773542B2/en not_active Ceased
- 1999-06-15 CA CA002332563A patent/CA2332563A1/en not_active Abandoned
- 1999-06-15 WO PCT/US1999/013455 patent/WO1999065712A2/en not_active Ceased
- 1999-06-15 JP JP2000554568A patent/JP2002518354A/ja not_active Withdrawn
- 1999-06-15 EP EP99928662A patent/EP1087996B1/en not_active Expired - Lifetime
- 1999-06-15 US US09/334,013 patent/US6593459B1/en not_active Expired - Fee Related
-
2001
- 2001-05-04 US US09/849,562 patent/US6545123B2/en not_active Expired - Fee Related
- 2001-05-04 US US09/849,031 patent/US6569998B2/en not_active Expired - Fee Related
-
2002
- 2002-12-20 US US10/329,068 patent/US20030144183A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20020026033A1 (en) | 2002-02-28 |
| EP1087996B1 (en) | 2007-01-17 |
| US6593459B1 (en) | 2003-07-15 |
| CA2332563A1 (en) | 1999-12-23 |
| US6569998B2 (en) | 2003-05-27 |
| AU773542B2 (en) | 2004-05-27 |
| JP2002518354A (ja) | 2002-06-25 |
| AU4567399A (en) | 2000-01-05 |
| US20030144183A1 (en) | 2003-07-31 |
| WO1999065712A3 (en) | 2000-04-20 |
| US20020042102A1 (en) | 2002-04-11 |
| DE69934890D1 (de) | 2007-03-08 |
| EP1087996A2 (en) | 2001-04-04 |
| US6545123B2 (en) | 2003-04-08 |
| WO1999065712A2 (en) | 1999-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |