MXPA00007165A - Polinucleotidos y polipeptidos de meth1 y meth2. - Google Patents

Info

Publication number

MXPA00007165A

MXPA00007165A MXPA00007165A MXPA00007165A MXPA00007165A MX PA00007165 A MXPA00007165 A MX PA00007165A MX PA00007165 A MXPA00007165 A MX PA00007165A MX PA00007165 A MXPA00007165 A MX PA00007165A MX PA00007165 A MXPA00007165 A MX PA00007165A

Authority

MX

Mexico

Prior art keywords

amino acids

polypeptide

meth2

meth1

seq

Prior art date

1998-01-23

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 399
• 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 380
• 229920001184 polypeptide Polymers 0.000 title claims abstract description 362
• 102000040430 polynucleotide Human genes 0.000 title claims description 160
• 108091033319 polynucleotide Proteins 0.000 title claims description 160
• 239000002157 polynucleotide Substances 0.000 title claims description 160
• 101000730038 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 8 Proteins 0.000 claims abstract description 376
• 102100032635 A disintegrin and metalloproteinase with thrombospondin motifs 8 Human genes 0.000 claims abstract description 366
• 102100027398 A disintegrin and metalloproteinase with thrombospondin motifs 1 Human genes 0.000 claims abstract description 357
• 101000936405 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 1 Proteins 0.000 claims abstract description 357
• 150000007523 nucleic acids Chemical class 0.000 claims abstract description 61
• 239000013598 vector Substances 0.000 claims abstract description 60
• 102000039446 nucleic acids Human genes 0.000 claims abstract description 50
• 108020004707 nucleic acids Proteins 0.000 claims abstract description 50
• 238000010188 recombinant method Methods 0.000 claims abstract description 6
• 150000001413 amino acids Chemical class 0.000 claims description 208
• 125000003729 nucleotide group Chemical group 0.000 claims description 118
• 239000002773 nucleotide Substances 0.000 claims description 116
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 110
• 239000002299 complementary DNA Substances 0.000 claims description 99
• 238000000034 method Methods 0.000 claims description 75
• 230000033115 angiogenesis Effects 0.000 claims description 27
• 238000012217 deletion Methods 0.000 claims description 24
• 230000037430 deletion Effects 0.000 claims description 24
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 21
• 238000006467 substitution reaction Methods 0.000 claims description 20
• 108091026890 Coding region Proteins 0.000 claims description 17
• 230000000295 complement effect Effects 0.000 claims description 13
• 230000002401 inhibitory effect Effects 0.000 claims description 10
• 230000008569 process Effects 0.000 claims description 9
• 238000000926 separation method Methods 0.000 claims description 9
• 238000004590 computer program Methods 0.000 claims description 8
• 230000004075 alteration Effects 0.000 claims description 7
• 238000003780 insertion Methods 0.000 claims description 6
• 230000037431 insertion Effects 0.000 claims description 6
• 239000011159 matrix material Substances 0.000 claims description 5
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims description 5
• 238000012258 culturing Methods 0.000 claims 1
• 238000001542 size-exclusion chromatography Methods 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 abstract description 176
• 102000004169 proteins and genes Human genes 0.000 abstract description 129
• 241000282414 Homo sapiens Species 0.000 abstract description 30
• 206010028980 Neoplasm Diseases 0.000 abstract description 26
• 201000011510 cancer Diseases 0.000 abstract description 15
• 230000001772 anti-angiogenic effect Effects 0.000 abstract description 13
• 238000002560 therapeutic procedure Methods 0.000 abstract description 9
• 238000002405 diagnostic procedure Methods 0.000 abstract description 5
• 238000004393 prognosis Methods 0.000 abstract description 4
• 102000002938 Thrombospondin Human genes 0.000 abstract 1
• 108060008245 Thrombospondin Proteins 0.000 abstract 1
• 235000001014 amino acid Nutrition 0.000 description 138
• 229940024606 amino acid Drugs 0.000 description 135
• 235000018102 proteins Nutrition 0.000 description 127
• 210000004027 cell Anatomy 0.000 description 107
• 239000012634 fragment Substances 0.000 description 88
• 102100036034 Thrombospondin-1 Human genes 0.000 description 64
• 108020004414 DNA Proteins 0.000 description 63
• 230000000694 effects Effects 0.000 description 48
• 230000014509 gene expression Effects 0.000 description 43
• 101710159964 Tail sheath protein Proteins 0.000 description 37
• 101710168563 Tail spike protein Proteins 0.000 description 37
• 235000019801 trisodium phosphate Nutrition 0.000 description 37
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 35
• 210000003056 antler Anatomy 0.000 description 35
• 241001328813 Methles Species 0.000 description 34
• 102000037865 fusion proteins Human genes 0.000 description 33
• 108020001507 fusion proteins Proteins 0.000 description 33
• 239000013615 primer Substances 0.000 description 29
• 210000001519 tissue Anatomy 0.000 description 28
• 101000659879 Homo sapiens Thrombospondin-1 Proteins 0.000 description 27
• 230000000890 antigenic effect Effects 0.000 description 26
• 238000003556 assay Methods 0.000 description 26
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 25
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 24
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 24
• 230000027455 binding Effects 0.000 description 24
• 108010006035 Metalloproteases Proteins 0.000 description 23
• 102000005741 Metalloproteases Human genes 0.000 description 23
• 108020004999 messenger RNA Proteins 0.000 description 23
• 238000000746 purification Methods 0.000 description 22
• 238000012360 testing method Methods 0.000 description 22
• 125000000539 amino acid group Chemical group 0.000 description 21
• 238000003752 polymerase chain reaction Methods 0.000 description 21
• 101800001224 Disintegrin Proteins 0.000 description 20
• 239000013612 plasmid Substances 0.000 description 20
• 238000004458 analytical method Methods 0.000 description 19
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 18
• 239000008188 pellet Substances 0.000 description 17
• 239000013604 expression vector Substances 0.000 description 16
• 230000028993 immune response Effects 0.000 description 16
• 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 15
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 15
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 15
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 15
• 210000003711 chorioallantoic membrane Anatomy 0.000 description 15
• 239000003550 marker Substances 0.000 description 15
• 239000000523 sample Substances 0.000 description 15
• 230000002491 angiogenic effect Effects 0.000 description 14
• 230000015572 biosynthetic process Effects 0.000 description 14
• 210000004899 c-terminal region Anatomy 0.000 description 14
• 238000010367 cloning Methods 0.000 description 14
• 239000000047 product Substances 0.000 description 14
• 230000035755 proliferation Effects 0.000 description 14
• 239000000243 solution Substances 0.000 description 14
• 238000003776 cleavage reaction Methods 0.000 description 13
• 230000007017 scission Effects 0.000 description 13
• 239000011780 sodium chloride Substances 0.000 description 13
• 241000124008 Mammalia Species 0.000 description 12
• 150000001875 compounds Chemical class 0.000 description 12
• 210000004087 cornea Anatomy 0.000 description 12
• 230000002163 immunogen Effects 0.000 description 12
• 208000015181 infectious disease Diseases 0.000 description 12
• 239000002609 medium Substances 0.000 description 12
• 239000000203 mixture Substances 0.000 description 12
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 11
• 230000001580 bacterial effect Effects 0.000 description 11
• 210000002889 endothelial cell Anatomy 0.000 description 11
• 108091008146 restriction endonucleases Proteins 0.000 description 11
• ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 10
• 108700026244 Open Reading Frames Proteins 0.000 description 10
• 108010076504 Protein Sorting Signals Proteins 0.000 description 10
• 238000007792 addition Methods 0.000 description 10
• 239000012472 biological sample Substances 0.000 description 10
• 210000004204 blood vessel Anatomy 0.000 description 10
• 235000018417 cysteine Nutrition 0.000 description 10
• 238000003745 diagnosis Methods 0.000 description 10
• 238000005755 formation reaction Methods 0.000 description 10
• 230000002068 genetic effect Effects 0.000 description 10
• 230000012010 growth Effects 0.000 description 10
• 238000004519 manufacturing process Methods 0.000 description 10
• 230000004048 modification Effects 0.000 description 10
• 238000012986 modification Methods 0.000 description 10
• 241000700605 Viruses Species 0.000 description 9
• 238000005119 centrifugation Methods 0.000 description 9
• 210000000349 chromosome Anatomy 0.000 description 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
• 238000009396 hybridization Methods 0.000 description 9
• 230000003463 hyperproliferative effect Effects 0.000 description 9
• 230000001404 mediated effect Effects 0.000 description 9
• 230000001105 regulatory effect Effects 0.000 description 9
• 208000024891 symptom Diseases 0.000 description 9
• 238000013518 transcription Methods 0.000 description 9
• 230000035897 transcription Effects 0.000 description 9
• 238000011282 treatment Methods 0.000 description 9
• 101000633605 Homo sapiens Thrombospondin-2 Proteins 0.000 description 8
• 108060003951 Immunoglobulin Proteins 0.000 description 8
• 241000699666 Mus <mouse, genus> Species 0.000 description 8
• 102100029529 Thrombospondin-2 Human genes 0.000 description 8
• 230000004071 biological effect Effects 0.000 description 8
• 230000006870 function Effects 0.000 description 8
• PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 8
• 102000018358 immunoglobulin Human genes 0.000 description 8
• 238000001727 in vivo Methods 0.000 description 8
• 102000006495 integrins Human genes 0.000 description 8
• 108010044426 integrins Proteins 0.000 description 8
• 210000004962 mammalian cell Anatomy 0.000 description 8
• 238000012163 sequencing technique Methods 0.000 description 8
• 239000006228 supernatant Substances 0.000 description 8
• 241000701447 unidentified baculovirus Species 0.000 description 8
• 241000894006 Bacteria Species 0.000 description 7
• -1 PDGF Proteins 0.000 description 7
• 108091034057 RNA (poly(A)) Proteins 0.000 description 7
• 108091081024 Start codon Proteins 0.000 description 7
• 210000001744 T-lymphocyte Anatomy 0.000 description 7
• 208000027418 Wounds and injury Diseases 0.000 description 7
• 210000001772 blood platelet Anatomy 0.000 description 7
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
• 239000003795 chemical substances by application Substances 0.000 description 7
• 230000000875 corresponding effect Effects 0.000 description 7
• 230000006378 damage Effects 0.000 description 7
• 230000004069 differentiation Effects 0.000 description 7
• 210000002950 fibroblast Anatomy 0.000 description 7
• 230000005764 inhibitory process Effects 0.000 description 7
• BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 7
• 230000008929 regeneration Effects 0.000 description 7
• 238000011069 regeneration method Methods 0.000 description 7
• 210000002966 serum Anatomy 0.000 description 7
• 210000003491 skin Anatomy 0.000 description 7
• 108020004635 Complementary DNA Proteins 0.000 description 6
• 102000053602 DNA Human genes 0.000 description 6
• 241000588724 Escherichia coli Species 0.000 description 6
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
• 108091060211 Expressed sequence tag Proteins 0.000 description 6
• 241000238631 Hexapoda Species 0.000 description 6
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 6
• 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 6
• 238000000636 Northern blotting Methods 0.000 description 6
• 108091034117 Oligonucleotide Proteins 0.000 description 6
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 6
• 206010052428 Wound Diseases 0.000 description 6
• 239000011543 agarose gel Substances 0.000 description 6
• 230000000903 blocking effect Effects 0.000 description 6
• 238000006243 chemical reaction Methods 0.000 description 6
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
• 208000035475 disorder Diseases 0.000 description 6
• 230000002500 effect on skin Effects 0.000 description 6
• 238000002474 experimental method Methods 0.000 description 6
• 230000004927 fusion Effects 0.000 description 6
• 239000000499 gel Substances 0.000 description 6
• 239000003112 inhibitor Substances 0.000 description 6
• 230000000977 initiatory effect Effects 0.000 description 6
• 210000004072 lung Anatomy 0.000 description 6
• 210000000056 organ Anatomy 0.000 description 6
• 239000002953 phosphate buffered saline Substances 0.000 description 6
• 230000008488 polyadenylation Effects 0.000 description 6
• 238000002360 preparation method Methods 0.000 description 6
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 6
• 102000005962 receptors Human genes 0.000 description 6
• 108020003175 receptors Proteins 0.000 description 6
• 230000004044 response Effects 0.000 description 6
• 239000001632 sodium acetate Substances 0.000 description 6
• 235000017281 sodium acetate Nutrition 0.000 description 6
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 6
• 239000000725 suspension Substances 0.000 description 6
• 238000001890 transfection Methods 0.000 description 6
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 5
• 206010061218 Inflammation Diseases 0.000 description 5
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 5
• 101710112987 Zinc metalloproteinase-disintegrin-like crotastatin Proteins 0.000 description 5
• 239000005557 antagonist Substances 0.000 description 5
• 230000001413 cellular effect Effects 0.000 description 5
• 230000035605 chemotaxis Effects 0.000 description 5
• 230000002759 chromosomal effect Effects 0.000 description 5
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 5
• 150000001945 cysteines Chemical class 0.000 description 5
• 230000007812 deficiency Effects 0.000 description 5
• 231100000673 dose–response relationship Toxicity 0.000 description 5
• 238000005516 engineering process Methods 0.000 description 5
• 210000002919 epithelial cell Anatomy 0.000 description 5
• 239000003102 growth factor Substances 0.000 description 5
• 229960004198 guanidine Drugs 0.000 description 5
• 229960000789 guanidine hydrochloride Drugs 0.000 description 5
• 210000002865 immune cell Anatomy 0.000 description 5
• 230000004054 inflammatory process Effects 0.000 description 5
• 208000014674 injury Diseases 0.000 description 5
• 239000003446 ligand Substances 0.000 description 5
• 108010082117 matrigel Proteins 0.000 description 5
• 230000035772 mutation Effects 0.000 description 5
• 230000010076 replication Effects 0.000 description 5
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
• 241000972773 Aulopiformes Species 0.000 description 4
• 208000023275 Autoimmune disease Diseases 0.000 description 4
• 101100230428 Caenorhabditis elegans hil-5 gene Proteins 0.000 description 4
• 108020004705 Codon Proteins 0.000 description 4
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
• 102000004190 Enzymes Human genes 0.000 description 4
• 108090000790 Enzymes Proteins 0.000 description 4
• 241000287828 Gallus gallus Species 0.000 description 4
• ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
• 108010093488 His-His-His-His-His-His Proteins 0.000 description 4
• 108090000144 Human Proteins Proteins 0.000 description 4
• 102000003839 Human Proteins Human genes 0.000 description 4
• 241001465754 Metazoa Species 0.000 description 4
• 206010029113 Neovascularisation Diseases 0.000 description 4
• 239000004677 Nylon Substances 0.000 description 4
• 241000714474 Rous sarcoma virus Species 0.000 description 4
• 239000004283 Sodium sorbate Substances 0.000 description 4
• 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 4
• 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 4
• 108010065451 T-340 Proteins 0.000 description 4
• 230000006427 angiogenic response Effects 0.000 description 4
• 230000033228 biological regulation Effects 0.000 description 4
• 210000001124 body fluid Anatomy 0.000 description 4
• 239000010839 body fluid Substances 0.000 description 4
• 239000000872 buffer Substances 0.000 description 4
• 239000011575 calcium Substances 0.000 description 4
• 238000004113 cell culture Methods 0.000 description 4
• 238000001516 cell proliferation assay Methods 0.000 description 4
• 230000003399 chemotactic effect Effects 0.000 description 4
• 235000013330 chicken meat Nutrition 0.000 description 4
• 238000012937 correction Methods 0.000 description 4
• 230000002596 correlated effect Effects 0.000 description 4
• 230000003247 decreasing effect Effects 0.000 description 4
• 230000008030 elimination Effects 0.000 description 4
• 238000003379 elimination reaction Methods 0.000 description 4
• 210000002257 embryonic structure Anatomy 0.000 description 4
• 229940088598 enzyme Drugs 0.000 description 4
• 210000001508 eye Anatomy 0.000 description 4
• 239000012894 fetal calf serum Substances 0.000 description 4
• 238000002873 global sequence alignment Methods 0.000 description 4
• 239000001963 growth medium Substances 0.000 description 4
• 210000002216 heart Anatomy 0.000 description 4
• 229960002897 heparin Drugs 0.000 description 4
• 229920000669 heparin Polymers 0.000 description 4
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 4
• 210000003917 human chromosome Anatomy 0.000 description 4
• 229940072221 immunoglobulins Drugs 0.000 description 4
• 238000011534 incubation Methods 0.000 description 4
• 239000000411 inducer Substances 0.000 description 4
• 230000003993 interaction Effects 0.000 description 4
• 238000002955 isolation Methods 0.000 description 4
• 150000002632 lipids Chemical class 0.000 description 4
• 210000004185 liver Anatomy 0.000 description 4
• 239000012528 membrane Substances 0.000 description 4
• 229960004452 methionine Drugs 0.000 description 4
• 229960000485 methotrexate Drugs 0.000 description 4
• 229920001778 nylon Polymers 0.000 description 4
• 239000008194 pharmaceutical composition Substances 0.000 description 4
• 229920000642 polymer Polymers 0.000 description 4
• 239000013641 positive control Substances 0.000 description 4
• 238000012545 processing Methods 0.000 description 4
• 230000002797 proteolythic effect Effects 0.000 description 4
• 235000019515 salmon Nutrition 0.000 description 4
• 230000003248 secreting effect Effects 0.000 description 4
• 239000000126 substance Substances 0.000 description 4
• 238000013519 translation Methods 0.000 description 4
• 230000008733 trauma Effects 0.000 description 4
• 230000002792 vascular Effects 0.000 description 4
• NKDFYOWSKOHCCO-YPVLXUMRSA-N 20-hydroxyecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@](C)(O)[C@H](O)CCC(C)(O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 NKDFYOWSKOHCCO-YPVLXUMRSA-N 0.000 description 3
• 208000030507 AIDS Diseases 0.000 description 3
• IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• 208000035473 Communicable disease Diseases 0.000 description 3
• 102000004127 Cytokines Human genes 0.000 description 3
• 108090000695 Cytokines Proteins 0.000 description 3
• 239000003155 DNA primer Substances 0.000 description 3
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 3
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
• 108010024636 Glutathione Proteins 0.000 description 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
• 241000699670 Mus sp. Species 0.000 description 3
• 206010035664 Pneumonia Diseases 0.000 description 3
• 241000700159 Rattus Species 0.000 description 3
• 238000012300 Sequence Analysis Methods 0.000 description 3
• 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 3
• 239000007983 Tris buffer Substances 0.000 description 3
• 108010006886 Vitrogen Proteins 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 239000000556 agonist Substances 0.000 description 3
• 235000011130 ammonium sulphate Nutrition 0.000 description 3
• 230000003321 amplification Effects 0.000 description 3
• 239000000427 antigen Substances 0.000 description 3
• 108091007433 antigens Proteins 0.000 description 3
• 102000036639 antigens Human genes 0.000 description 3
• 230000001363 autoimmune Effects 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 210000000988 bone and bone Anatomy 0.000 description 3
• 210000004556 brain Anatomy 0.000 description 3
• 238000004422 calculation algorithm Methods 0.000 description 3
• 239000003153 chemical reaction reagent Substances 0.000 description 3
• 238000002512 chemotherapy Methods 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 230000001684 chronic effect Effects 0.000 description 3
• 125000004122 cyclic group Chemical group 0.000 description 3
• 201000010099 disease Diseases 0.000 description 3
• 238000009826 distribution Methods 0.000 description 3
• 239000002158 endotoxin Substances 0.000 description 3
• 238000000605 extraction Methods 0.000 description 3
• 238000010353 genetic engineering Methods 0.000 description 3
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 3
• 208000024908 graft versus host disease Diseases 0.000 description 3
• 230000003394 haemopoietic effect Effects 0.000 description 3
• 230000035876 healing Effects 0.000 description 3
• 230000002439 hemostatic effect Effects 0.000 description 3
• 230000002209 hydrophobic effect Effects 0.000 description 3
• 208000026278 immune system disease Diseases 0.000 description 3
• 230000001976 improved effect Effects 0.000 description 3
• 239000012678 infectious agent Substances 0.000 description 3
• 206010022000 influenza Diseases 0.000 description 3
• 238000001802 infusion Methods 0.000 description 3
• 150000002500 ions Chemical class 0.000 description 3
• 210000003734 kidney Anatomy 0.000 description 3
• 239000008101 lactose Substances 0.000 description 3
• 239000000463 material Substances 0.000 description 3
• 230000007246 mechanism Effects 0.000 description 3
• 210000004379 membrane Anatomy 0.000 description 3
• 229930182817 methionine Natural products 0.000 description 3
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 3
• 238000002156 mixing Methods 0.000 description 3
• 210000002464 muscle smooth vascular Anatomy 0.000 description 3
• 230000014399 negative regulation of angiogenesis Effects 0.000 description 3
• 238000003199 nucleic acid amplification method Methods 0.000 description 3
• 210000001672 ovary Anatomy 0.000 description 3
• 210000000496 pancreas Anatomy 0.000 description 3
• 230000001575 pathological effect Effects 0.000 description 3
• 210000002826 placenta Anatomy 0.000 description 3
• 239000002987 primer (paints) Substances 0.000 description 3
• 206010039073 rheumatoid arthritis Diseases 0.000 description 3
• 230000028327 secretion Effects 0.000 description 3
• 238000002864 sequence alignment Methods 0.000 description 3
• 210000000329 smooth muscle myocyte Anatomy 0.000 description 3
• 239000011734 sodium Substances 0.000 description 3
• 239000001509 sodium citrate Substances 0.000 description 3
• 239000007787 solid Substances 0.000 description 3
• 125000006850 spacer group Chemical group 0.000 description 3
• 241000894007 species Species 0.000 description 3
• 238000003860 storage Methods 0.000 description 3
• 230000001629 suppression Effects 0.000 description 3
• 238000003786 synthesis reaction Methods 0.000 description 3
• 210000002435 tendon Anatomy 0.000 description 3
• 230000002537 thrombolytic effect Effects 0.000 description 3
• 210000001685 thyroid gland Anatomy 0.000 description 3
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
• 230000003612 virological effect Effects 0.000 description 3
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
• 229920001817 Agar Polymers 0.000 description 2
• 108010088751 Albumins Proteins 0.000 description 2
• 102000009027 Albumins Human genes 0.000 description 2
• 241000201370 Autographa californica nucleopolyhedrovirus Species 0.000 description 2
• 101100208237 Bos taurus THBS2 gene Proteins 0.000 description 2
• 102000049320 CD36 Human genes 0.000 description 2
• 108010045374 CD36 Antigens Proteins 0.000 description 2
• 108010078791 Carrier Proteins Proteins 0.000 description 2
• 108091033380 Coding strand Proteins 0.000 description 2
• 102100038385 Coiled-coil domain-containing protein R3HCC1L Human genes 0.000 description 2
• 206010010741 Conjunctivitis Diseases 0.000 description 2
• 239000004128 Copper(II) sulphate Substances 0.000 description 2
• 241000701022 Cytomegalovirus Species 0.000 description 2
• 102000012410 DNA Ligases Human genes 0.000 description 2
• 108010061982 DNA Ligases Proteins 0.000 description 2
• 238000001712 DNA sequencing Methods 0.000 description 2
• 229920002307 Dextran Polymers 0.000 description 2
• 206010012689 Diabetic retinopathy Diseases 0.000 description 2
• 102100024746 Dihydrofolate reductase Human genes 0.000 description 2
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
• 241000196324 Embryophyta Species 0.000 description 2
• 208000001860 Eye Infections Diseases 0.000 description 2
• 241000233866 Fungi Species 0.000 description 2
• 206010018612 Gonorrhoea Diseases 0.000 description 2
• 239000001922 Gum ghatti Substances 0.000 description 2
• 101710154606 Hemagglutinin Proteins 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101100005713 Homo sapiens CD4 gene Proteins 0.000 description 2
• 206010020751 Hypersensitivity Diseases 0.000 description 2
• 108010002352 Interleukin-1 Proteins 0.000 description 2
• 108091092195 Intron Proteins 0.000 description 2
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
• 208000019693 Lung disease Diseases 0.000 description 2
• 208000016604 Lyme disease Diseases 0.000 description 2
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
• 201000009906 Meningitis Diseases 0.000 description 2
• 206010027476 Metastases Diseases 0.000 description 2
• CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 2
• 229930193140 Neomycin Natural products 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 2
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 2
• 101710182846 Polyhedrin Proteins 0.000 description 2
• 239000004237 Ponceau 6R Substances 0.000 description 2
• 102100038567 Properdin Human genes 0.000 description 2
• 108010005642 Properdin Proteins 0.000 description 2
• 101710176177 Protein A56 Proteins 0.000 description 2
• 201000004681 Psoriasis Diseases 0.000 description 2
• 206010037549 Purpura Diseases 0.000 description 2
• 241001672981 Purpura Species 0.000 description 2
• 101710086015 RNA ligase Proteins 0.000 description 2
• 108020004511 Recombinant DNA Proteins 0.000 description 2
• 208000033464 Reiter syndrome Diseases 0.000 description 2
• 206010063837 Reperfusion injury Diseases 0.000 description 2
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
• 241000607142 Salmonella Species 0.000 description 2
• 208000019802 Sexually transmitted disease Diseases 0.000 description 2
• 108020004682 Single-Stranded DNA Proteins 0.000 description 2
• 238000002105 Southern blotting Methods 0.000 description 2
• 239000004138 Stearyl citrate Substances 0.000 description 2
• 108010022394 Threonine synthase Proteins 0.000 description 2
• 208000007536 Thrombosis Diseases 0.000 description 2
• 201000005485 Toxoplasmosis Diseases 0.000 description 2
• 239000013504 Triton X-100 Substances 0.000 description 2
• 229920004890 Triton X-100 Polymers 0.000 description 2
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
• 208000025865 Ulcer Diseases 0.000 description 2
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
• HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 2
• 230000005856 abnormality Effects 0.000 description 2
• 230000003213 activating effect Effects 0.000 description 2
• 230000001919 adrenal effect Effects 0.000 description 2
• 239000008272 agar Substances 0.000 description 2
• 230000004520 agglutination Effects 0.000 description 2
• 230000002776 aggregation Effects 0.000 description 2
• 238000004220 aggregation Methods 0.000 description 2
• 150000001371 alpha-amino acids Chemical class 0.000 description 2
• 235000008206 alpha-amino acids Nutrition 0.000 description 2
• 239000001164 aluminium sulphate Substances 0.000 description 2
• 239000001166 ammonium sulphate Substances 0.000 description 2
• 229960000723 ampicillin Drugs 0.000 description 2
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
• 239000004037 angiogenesis inhibitor Substances 0.000 description 2
• 230000000844 anti-bacterial effect Effects 0.000 description 2
• 230000005875 antibody response Effects 0.000 description 2
• 208000006673 asthma Diseases 0.000 description 2
• 210000003719 b-lymphocyte Anatomy 0.000 description 2
• 239000011324 bead Substances 0.000 description 2
• 238000004166 bioassay Methods 0.000 description 2
• 210000005013 brain tissue Anatomy 0.000 description 2
• 210000000481 breast Anatomy 0.000 description 2
• 239000001201 calcium disodium ethylene diamine tetra-acetate Substances 0.000 description 2
• 239000001527 calcium lactate Substances 0.000 description 2
• 239000001362 calcium malate Substances 0.000 description 2
• 239000001506 calcium phosphate Substances 0.000 description 2
• 229910000389 calcium phosphate Inorganic materials 0.000 description 2
• 235000011010 calcium phosphates Nutrition 0.000 description 2
• 239000004330 calcium propionate Substances 0.000 description 2
• 239000001175 calcium sulphate Substances 0.000 description 2
• 239000001427 calcium tartrate Substances 0.000 description 2
• 210000000170 cell membrane Anatomy 0.000 description 2
• 230000004663 cell proliferation Effects 0.000 description 2
• 208000026106 cerebrovascular disease Diseases 0.000 description 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
• 210000001072 colon Anatomy 0.000 description 2
• 238000002316 cosmetic surgery Methods 0.000 description 2
• 239000004148 curcumin Substances 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 238000011161 development Methods 0.000 description 2
• 230000018109 developmental process Effects 0.000 description 2
• 229960002086 dextran Drugs 0.000 description 2
• 206010012601 diabetes mellitus Diseases 0.000 description 2
• 238000000502 dialysis Methods 0.000 description 2
• 230000029087 digestion Effects 0.000 description 2
• 102000004419 dihydrofolate reductase Human genes 0.000 description 2
• 108020001096 dihydrofolate reductase Proteins 0.000 description 2
• SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
• 239000004193 disodium 5'-ribonucleotide Substances 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 238000007876 drug discovery Methods 0.000 description 2
• 208000001848 dysentery Diseases 0.000 description 2
• 230000003511 endothelial effect Effects 0.000 description 2
• 210000003038 endothelium Anatomy 0.000 description 2
• 239000003623 enhancer Substances 0.000 description 2
• 239000013613 expression plasmid Substances 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 208000011323 eye infectious disease Diseases 0.000 description 2
• 239000004222 ferrous gluconate Substances 0.000 description 2
• 235000013924 ferrous gluconate Nutrition 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
• 238000009472 formulation Methods 0.000 description 2
• 230000002538 fungal effect Effects 0.000 description 2
• ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 2
• 238000007429 general method Methods 0.000 description 2
• 201000006592 giardiasis Diseases 0.000 description 2
• 239000004247 glycine and its sodium salt Substances 0.000 description 2
• 208000001786 gonorrhea Diseases 0.000 description 2
• 150000003278 haem Chemical class 0.000 description 2
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 2
• 230000023597 hemostasis Effects 0.000 description 2
• 208000006454 hepatitis Diseases 0.000 description 2
• 231100000283 hepatitis Toxicity 0.000 description 2
• 238000004128 high performance liquid chromatography Methods 0.000 description 2
• 238000012188 high-throughput screening assay Methods 0.000 description 2
• GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 2
• 238000005805 hydroxylation reaction Methods 0.000 description 2
• 210000000987 immune system Anatomy 0.000 description 2
• 230000003053 immunization Effects 0.000 description 2
• 238000002649 immunization Methods 0.000 description 2
• 238000007901 in situ hybridization Methods 0.000 description 2
• 239000004179 indigotine Substances 0.000 description 2
• 230000006698 induction Effects 0.000 description 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• 230000000968 intestinal effect Effects 0.000 description 2
• 238000001990 intravenous administration Methods 0.000 description 2
• 229910052740 iodine Inorganic materials 0.000 description 2
• 229960000318 kanamycin Drugs 0.000 description 2
• 229930027917 kanamycin Natural products 0.000 description 2
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 2
• 229930182823 kanamycin A Natural products 0.000 description 2
• 239000000231 karaya gum Substances 0.000 description 2
• 210000003041 ligament Anatomy 0.000 description 2
• 230000004807 localization Effects 0.000 description 2
• 239000001755 magnesium gluconate Substances 0.000 description 2
• 201000001441 melanoma Diseases 0.000 description 2
• 230000031864 metaphase Effects 0.000 description 2
• 230000009401 metastasis Effects 0.000 description 2
• 238000013508 migration Methods 0.000 description 2
• 230000005012 migration Effects 0.000 description 2
• 230000001617 migratory effect Effects 0.000 description 2
• 230000003278 mimic effect Effects 0.000 description 2
• 210000003205 muscle Anatomy 0.000 description 2
• 239000013642 negative control Substances 0.000 description 2
• 229960004927 neomycin Drugs 0.000 description 2
• 201000001119 neuropathy Diseases 0.000 description 2
• 230000007823 neuropathy Effects 0.000 description 2
• 230000003472 neutralizing effect Effects 0.000 description 2
• 210000000440 neutrophil Anatomy 0.000 description 2
• 231100000252 nontoxic Toxicity 0.000 description 2
• 230000003000 nontoxic effect Effects 0.000 description 2
• 230000002688 persistence Effects 0.000 description 2
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
• 210000002381 plasma Anatomy 0.000 description 2
• 239000013600 plasmid vector Substances 0.000 description 2
• 210000001778 pluripotent stem cell Anatomy 0.000 description 2
• 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 2
• 238000006116 polymerization reaction Methods 0.000 description 2
• 239000011148 porous material Substances 0.000 description 2
• 239000002244 precipitate Substances 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• 230000002062 proliferating effect Effects 0.000 description 2
• 239000000473 propyl gallate Substances 0.000 description 2
• 210000002307 prostate Anatomy 0.000 description 2
• 238000011002 quantification Methods 0.000 description 2
• 208000002574 reactive arthritis Diseases 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 239000011347 resin Substances 0.000 description 2
• 229920005989 resin Polymers 0.000 description 2
• 230000001177 retroviral effect Effects 0.000 description 2
• 238000010839 reverse transcription Methods 0.000 description 2
• 238000010186 staining Methods 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• 230000000638 stimulation Effects 0.000 description 2
• 210000002784 stomach Anatomy 0.000 description 2
• 239000000758 substrate Substances 0.000 description 2
• 239000001797 sucrose acetate isobutyrate Substances 0.000 description 2
• 239000004173 sunset yellow FCF Substances 0.000 description 2
• 238000001356 surgical procedure Methods 0.000 description 2
• 208000011580 syndromic disease Diseases 0.000 description 2
• 208000006379 syphilis Diseases 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 210000001550 testis Anatomy 0.000 description 2
• 206010043554 thrombocytopenia Diseases 0.000 description 2
• 239000004408 titanium dioxide Substances 0.000 description 2
• 238000010361 transduction Methods 0.000 description 2
• 230000026683 transduction Effects 0.000 description 2
• 238000012546 transfer Methods 0.000 description 2
• 230000000472 traumatic effect Effects 0.000 description 2
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
• 229960004799 tryptophan Drugs 0.000 description 2
• 201000008827 tuberculosis Diseases 0.000 description 2
• 231100000397 ulcer Toxicity 0.000 description 2
• 210000002700 urine Anatomy 0.000 description 2
• 239000003981 vehicle Substances 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• 238000001262 western blot Methods 0.000 description 2
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
• 108091064702 1 family Proteins 0.000 description 1
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
• 208000010543 22q11.2 deletion syndrome Diseases 0.000 description 1
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
• 108091022885 ADAM Proteins 0.000 description 1
• 102000029791 ADAM Human genes 0.000 description 1
• 108091022879 ADAMTS Proteins 0.000 description 1
• 102000029750 ADAMTS Human genes 0.000 description 1
• 108091005660 ADAMTS1 Proteins 0.000 description 1
• 101150108397 Abcd2 gene Proteins 0.000 description 1
• 206010063409 Acarodermatitis Diseases 0.000 description 1
• 241000589291 Acinetobacter Species 0.000 description 1
• HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
• 241000606750 Actinobacillus Species 0.000 description 1
• 102000007469 Actins Human genes 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 108010059616 Activins Proteins 0.000 description 1
• 102000005606 Activins Human genes 0.000 description 1
• 208000026872 Addison Disease Diseases 0.000 description 1
• 108700028369 Alleles Proteins 0.000 description 1
• 206010027654 Allergic conditions Diseases 0.000 description 1
• 208000024827 Alzheimer disease Diseases 0.000 description 1
• 208000004881 Amebiasis Diseases 0.000 description 1
• 206010001980 Amoebiasis Diseases 0.000 description 1
• 206010002198 Anaphylactic reaction Diseases 0.000 description 1
• 206010003591 Ataxia Diseases 0.000 description 1
• 241001112741 Bacillaceae Species 0.000 description 1
• 241000193738 Bacillus anthracis Species 0.000 description 1
• 208000031729 Bacteremia Diseases 0.000 description 1
• 206010004053 Bacterial toxaemia Diseases 0.000 description 1
• 208000023328 Basedow disease Diseases 0.000 description 1
• HNNIWKQLJSNAEQ-UHFFFAOYSA-N Benzydamine hydrochloride Chemical compound Cl.C12=CC=CC=C2C(OCCCN(C)C)=NN1CC1=CC=CC=C1 HNNIWKQLJSNAEQ-UHFFFAOYSA-N 0.000 description 1
• 241000702628 Birnaviridae Species 0.000 description 1
• 206010005098 Blastomycosis Diseases 0.000 description 1
• 241000588807 Bordetella Species 0.000 description 1
• 241000589968 Borrelia Species 0.000 description 1
• 208000003508 Botulism Diseases 0.000 description 1
• 206010006500 Brucellosis Diseases 0.000 description 1
• 208000011691 Burkitt lymphomas Diseases 0.000 description 1
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
• 241000589876 Campylobacter Species 0.000 description 1
• 241000222122 Candida albicans Species 0.000 description 1
• 206010007134 Candida infections Diseases 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 208000003732 Cat-scratch disease Diseases 0.000 description 1
• 206010007882 Cellulitis Diseases 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 102000019034 Chemokines Human genes 0.000 description 1
• 108010012236 Chemokines Proteins 0.000 description 1
• 201000006082 Chickenpox Diseases 0.000 description 1
• 241001227713 Chiron Species 0.000 description 1
• 241000606161 Chlamydia Species 0.000 description 1
• 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 1
• 208000032544 Cicatrix Diseases 0.000 description 1
• 241000193403 Clostridium Species 0.000 description 1
• 241000223205 Coccidioides immitis Species 0.000 description 1
• 208000003495 Coccidiosis Diseases 0.000 description 1
• 108010035532 Collagen Proteins 0.000 description 1
• 102000008186 Collagen Human genes 0.000 description 1
• 108010022452 Collagen Type I Proteins 0.000 description 1
• 102000012422 Collagen Type I Human genes 0.000 description 1
• 102100036213 Collagen alpha-2(I) chain Human genes 0.000 description 1
• 206010009944 Colon cancer Diseases 0.000 description 1
• 201000003874 Common Variable Immunodeficiency Diseases 0.000 description 1
• 208000032170 Congenital Abnormalities Diseases 0.000 description 1
• 108091035707 Consensus sequence Proteins 0.000 description 1
• 238000011537 Coomassie blue staining Methods 0.000 description 1
• 241001354243 Corona Species 0.000 description 1
• 241000186216 Corynebacterium Species 0.000 description 1
• 241000699802 Cricetulus griseus Species 0.000 description 1
• 208000011231 Crohn disease Diseases 0.000 description 1
• 201000007336 Cryptococcosis Diseases 0.000 description 1
• 241000221204 Cryptococcus neoformans Species 0.000 description 1
• 208000008953 Cryptosporidiosis Diseases 0.000 description 1
• 206010011502 Cryptosporidiosis infection Diseases 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• 101150074155 DHFR gene Proteins 0.000 description 1
• 108010017826 DNA Polymerase I Proteins 0.000 description 1
• 208000020401 Depressive disease Diseases 0.000 description 1
• 201000004624 Dermatitis Diseases 0.000 description 1
• 208000000398 DiGeorge Syndrome Diseases 0.000 description 1
• 238000012286 ELISA Assay Methods 0.000 description 1
• 206010014561 Emphysema Diseases 0.000 description 1
• 101000904460 Encephalitozoon cuniculi (strain GB-M1) Probable glycerol-3-phosphate dehydrogenase Proteins 0.000 description 1
• 241000588921 Enterobacteriaceae Species 0.000 description 1
• YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 241001596967 Escherichia coli M15 Species 0.000 description 1
• 241000701988 Escherichia virus T5 Species 0.000 description 1
• 108700024394 Exon Proteins 0.000 description 1
• 101710089384 Extracellular protease Proteins 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 206010016654 Fibrosis Diseases 0.000 description 1
• 206010016952 Food poisoning Diseases 0.000 description 1
• 208000019331 Foodborne disease Diseases 0.000 description 1
• 206010017711 Gangrene Diseases 0.000 description 1
• 208000015872 Gaucher disease Diseases 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 206010018364 Glomerulonephritis Diseases 0.000 description 1
• 239000004366 Glucose oxidase Substances 0.000 description 1
• 108010015776 Glucose oxidase Proteins 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 208000015023 Graves' disease Diseases 0.000 description 1
• 208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
• HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 1
• 208000031886 HIV Infections Diseases 0.000 description 1
• 208000037357 HIV infectious disease Diseases 0.000 description 1
• 241000606790 Haemophilus Species 0.000 description 1
• 206010061192 Haemorrhagic fever Diseases 0.000 description 1
• 208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
• 206010019196 Head injury Diseases 0.000 description 1
• 241000589989 Helicobacter Species 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• 206010019663 Hepatic failure Diseases 0.000 description 1
• 208000009889 Herpes Simplex Diseases 0.000 description 1
• 208000007514 Herpes zoster Diseases 0.000 description 1
• 108091006054 His-tagged proteins Proteins 0.000 description 1
• 241001272567 Hominoidea Species 0.000 description 1
• 101000743767 Homo sapiens Coiled-coil domain-containing protein R3HCC1L Proteins 0.000 description 1
• 101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 description 1
• 101000829419 Homo sapiens Spermatogenic leucine zipper protein 1 Proteins 0.000 description 1
• 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 1
• 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
• 241000714259 Human T-lymphotropic virus 2 Species 0.000 description 1
• 208000023105 Huntington disease Diseases 0.000 description 1
• 208000019758 Hypergammaglobulinemia Diseases 0.000 description 1
• 108091009325 IgG binding proteins Proteins 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 206010021531 Impetigo Diseases 0.000 description 1
• 206010061216 Infarction Diseases 0.000 description 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
• 229930010555 Inosine Natural products 0.000 description 1
• UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• 102000004877 Insulin Human genes 0.000 description 1
• 206010023076 Isosporiasis Diseases 0.000 description 1
• 241000588748 Klebsiella Species 0.000 description 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
• 238000011050 LAL assay Methods 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 208000004554 Leishmaniasis Diseases 0.000 description 1
• 241000713666 Lentivirus Species 0.000 description 1
• 206010024229 Leprosy Diseases 0.000 description 1
• 206010024238 Leptospirosis Diseases 0.000 description 1
• 208000000706 Leukocyte-Adhesion Deficiency Syndrome Diseases 0.000 description 1
• 241000186781 Listeria Species 0.000 description 1
• 206010025327 Lymphopenia Diseases 0.000 description 1
• 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 description 1
• 201000005505 Measles Diseases 0.000 description 1
• PKVZBNCYEICAQP-UHFFFAOYSA-N Mecamylamine hydrochloride Chemical compound Cl.C1CC2C(C)(C)C(NC)(C)C1C2 PKVZBNCYEICAQP-UHFFFAOYSA-N 0.000 description 1
• 102000003792 Metallothionein Human genes 0.000 description 1
• 108090000157 Metallothionein Proteins 0.000 description 1
• 206010049567 Miller Fisher syndrome Diseases 0.000 description 1
• 208000001089 Multiple system atrophy Diseases 0.000 description 1
• 208000005647 Mumps Diseases 0.000 description 1
• 101100278853 Mus musculus Dhfr gene Proteins 0.000 description 1
• 206010028372 Muscular weakness Diseases 0.000 description 1
• 241000186359 Mycobacterium Species 0.000 description 1
• 230000004988 N-glycosylation Effects 0.000 description 1
• 238000005481 NMR spectroscopy Methods 0.000 description 1
• 229910002651 NO3 Inorganic materials 0.000 description 1
• 241000588653 Neisseria Species 0.000 description 1
• 208000028389 Nerve injury Diseases 0.000 description 1
• 208000009869 Neu-Laxova syndrome Diseases 0.000 description 1
• 206010029240 Neuritis Diseases 0.000 description 1
• 101100202932 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) tsp-4 gene Proteins 0.000 description 1
• 244000061176 Nicotiana tabacum Species 0.000 description 1
• 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
• 108010077850 Nuclear Localization Signals Proteins 0.000 description 1
• 101710163270 Nuclease Proteins 0.000 description 1
• 241000765083 Ondina Species 0.000 description 1
• 208000001388 Opportunistic Infections Diseases 0.000 description 1
• 208000001132 Osteoporosis Diseases 0.000 description 1
• 101000666901 Oxyuranus scutellatus scutellatus Kunitz-type serine protease inhibitor taicotoxin Proteins 0.000 description 1
• 238000012408 PCR amplification Methods 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
• 208000018737 Parkinson disease Diseases 0.000 description 1
• 206010034016 Paronychia Diseases 0.000 description 1
• 241000029132 Paronychia Species 0.000 description 1
• 241000606860 Pasteurella Species 0.000 description 1
• 241000721454 Pemphigus Species 0.000 description 1
• 102000035195 Peptidases Human genes 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 201000005702 Pertussis Diseases 0.000 description 1
• 241000286209 Phasianidae Species 0.000 description 1
• BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
• 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
• 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
• 208000000474 Poliomyelitis Diseases 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 239000004793 Polystyrene Substances 0.000 description 1
• 241000700625 Poxviridae Species 0.000 description 1
• 208000004210 Pressure Ulcer Diseases 0.000 description 1
• 108010050808 Procollagen Proteins 0.000 description 1
• 108010064622 Procollagen N-Endopeptidase Proteins 0.000 description 1
• 102000015339 Procollagen N-endopeptidase Human genes 0.000 description 1
• 206010036774 Proctitis Diseases 0.000 description 1
• 208000031482 Prosthesis-Related Infections Diseases 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 241000589516 Pseudomonas Species 0.000 description 1
• 206010037660 Pyrexia Diseases 0.000 description 1
• 206010037742 Rabies Diseases 0.000 description 1
• 101100208249 Rattus norvegicus Thbs4 gene Proteins 0.000 description 1
• 241000702247 Reoviridae Species 0.000 description 1
• 102000009661 Repressor Proteins Human genes 0.000 description 1
• 108010034634 Repressor Proteins Proteins 0.000 description 1
• 206010057190 Respiratory tract infections Diseases 0.000 description 1
• 241000712907 Retroviridae Species 0.000 description 1
• 241000711931 Rhabdoviridae Species 0.000 description 1
• AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
• 241000702670 Rotavirus Species 0.000 description 1
• 241000710801 Rubivirus Species 0.000 description 1
• 241000447727 Scabies Species 0.000 description 1
• 206010039587 Scarlet Fever Diseases 0.000 description 1
• 108091058545 Secretory proteins Proteins 0.000 description 1
• 102000040739 Secretory proteins Human genes 0.000 description 1
• 108091081021 Sense strand Proteins 0.000 description 1
• 206010040047 Sepsis Diseases 0.000 description 1
• 206010053879 Sepsis syndrome Diseases 0.000 description 1
• 206010040070 Septic Shock Diseases 0.000 description 1
• 241000607720 Serratia Species 0.000 description 1
• 208000009106 Shy-Drager Syndrome Diseases 0.000 description 1
• 239000001744 Sodium fumarate Substances 0.000 description 1
• 208000029033 Spinal Cord disease Diseases 0.000 description 1
• 241000256248 Spodoptera Species 0.000 description 1
• 102100036428 Spondin-1 Human genes 0.000 description 1
• 101710092167 Spondin-1 Proteins 0.000 description 1
• 241000295644 Staphylococcaceae Species 0.000 description 1
• 206010072148 Stiff-Person syndrome Diseases 0.000 description 1
• 241000187747 Streptomyces Species 0.000 description 1
• 108090000787 Subtilisin Proteins 0.000 description 1
• 108010056079 Subtilisins Proteins 0.000 description 1
• 102000005158 Subtilisins Human genes 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
• 101150050863 T gene Proteins 0.000 description 1
• 206010043189 Telangiectasia Diseases 0.000 description 1
• 208000000491 Tendinopathy Diseases 0.000 description 1
• 206010043255 Tendonitis Diseases 0.000 description 1
• 206010043376 Tetanus Diseases 0.000 description 1
• 239000004098 Tetracycline Substances 0.000 description 1
• 208000001117 Theileriasis Diseases 0.000 description 1
• 108091036066 Three prime untranslated region Proteins 0.000 description 1
• 102000006601 Thymidine Kinase Human genes 0.000 description 1
• 108020004440 Thymidine kinase Proteins 0.000 description 1
• 241000710924 Togaviridae Species 0.000 description 1
• 208000013222 Toxemia Diseases 0.000 description 1
• 108700009124 Transcription Initiation Site Proteins 0.000 description 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
• 241000224526 Trichomonas Species 0.000 description 1
• YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
• 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 1
• 208000037386 Typhoid Diseases 0.000 description 1
• 206010046788 Uterine haemorrhage Diseases 0.000 description 1
• 206010046851 Uveitis Diseases 0.000 description 1
• 206010046865 Vaccinia virus infection Diseases 0.000 description 1
• 206010046980 Varicella Diseases 0.000 description 1
• 241000700647 Variola virus Species 0.000 description 1
• 206010054880 Vascular insufficiency Diseases 0.000 description 1
• 206010058874 Viraemia Diseases 0.000 description 1
• 108020005202 Viral DNA Proteins 0.000 description 1
• 208000033559 Waldenström macroglobulinemia Diseases 0.000 description 1
• 206010048038 Wound infection Diseases 0.000 description 1
• 241000607734 Yersinia <bacteria> Species 0.000 description 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
• 101710204001 Zinc metalloprotease Proteins 0.000 description 1
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
• 210000001015 abdomen Anatomy 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 239000000011 acetone peroxide Substances 0.000 description 1
• 230000021736 acetylation Effects 0.000 description 1
• 238000006640 acetylation reaction Methods 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000000488 activin Substances 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 230000010933 acylation Effects 0.000 description 1
• 238000005917 acylation reaction Methods 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 208000009956 adenocarcinoma Diseases 0.000 description 1
• 239000000853 adhesive Substances 0.000 description 1
• 230000001070 adhesive effect Effects 0.000 description 1
• 210000000577 adipose tissue Anatomy 0.000 description 1
• 238000009098 adjuvant therapy Methods 0.000 description 1
• 210000004100 adrenal gland Anatomy 0.000 description 1
• 238000001042 affinity chromatography Methods 0.000 description 1
• 238000000246 agarose gel electrophoresis Methods 0.000 description 1
• 238000013019 agitation Methods 0.000 description 1
• 229960003767 alanine Drugs 0.000 description 1
• 235000004279 alanine Nutrition 0.000 description 1
• 238000012867 alanine scanning Methods 0.000 description 1
• 125000001931 aliphatic group Chemical group 0.000 description 1
• 201000009961 allergic asthma Diseases 0.000 description 1
• 208000026935 allergic disease Diseases 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• 230000009435 amidation Effects 0.000 description 1
• 238000007112 amidation reaction Methods 0.000 description 1
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
• 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
• 230000036783 anaphylactic response Effects 0.000 description 1
• 208000003455 anaphylaxis Diseases 0.000 description 1
• 208000007502 anemia Diseases 0.000 description 1
• 239000002870 angiogenesis inducing agent Substances 0.000 description 1
• 229940121369 angiogenesis inhibitor Drugs 0.000 description 1
• 210000004102 animal cell Anatomy 0.000 description 1
• 125000000129 anionic group Chemical group 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000003110 anti-inflammatory effect Effects 0.000 description 1
• 230000000692 anti-sense effect Effects 0.000 description 1
• 230000000840 anti-viral effect Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 239000002246 antineoplastic agent Substances 0.000 description 1
• 230000036528 appetite Effects 0.000 description 1
• 235000019789 appetite Nutrition 0.000 description 1
• 206010003246 arthritis Diseases 0.000 description 1
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 1
• 229960005261 aspartic acid Drugs 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 201000008680 babesiosis Diseases 0.000 description 1
• 239000003899 bactericide agent Substances 0.000 description 1
• 230000006399 behavior Effects 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• 239000000440 bentonite Substances 0.000 description 1
• CNBGNNVCVSKAQZ-UHFFFAOYSA-N benzidamine Natural products C12=CC=CC=C2C(OCCCN(C)C)=NN1CC1=CC=CC=C1 CNBGNNVCVSKAQZ-UHFFFAOYSA-N 0.000 description 1
• 108010005774 beta-Galactosidase Proteins 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 229960002685 biotin Drugs 0.000 description 1
• 235000020958 biotin Nutrition 0.000 description 1
• 239000011616 biotin Substances 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 230000023555 blood coagulation Effects 0.000 description 1
• 208000014759 blood platelet disease Diseases 0.000 description 1
• 208000016363 blood protein disease Diseases 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 239000004161 brilliant blue FCF Substances 0.000 description 1
• 206010006451 bronchitis Diseases 0.000 description 1
• 239000007853 buffer solution Substances 0.000 description 1
• 239000000279 calcium ferrocyanide Substances 0.000 description 1
• 244000309466 calf Species 0.000 description 1
• 201000003984 candidiasis Diseases 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
• 230000000747 cardiac effect Effects 0.000 description 1
• 208000003295 carpal tunnel syndrome Diseases 0.000 description 1
• 239000000969 carrier Substances 0.000 description 1
• 210000000845 cartilage Anatomy 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 230000003197 catalytic effect Effects 0.000 description 1
• 238000005277 cation exchange chromatography Methods 0.000 description 1
• 239000003729 cation exchange resin Substances 0.000 description 1
• 230000024245 cell differentiation Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 108091092328 cellular RNA Proteins 0.000 description 1
• 230000030570 cellular localization Effects 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 208000015114 central nervous system disease Diseases 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 230000003196 chaotropic effect Effects 0.000 description 1
• 238000001311 chemical methods and process Methods 0.000 description 1
• 238000007385 chemical modification Methods 0.000 description 1
• 208000025302 chronic primary adrenal insufficiency Diseases 0.000 description 1
• 230000027288 circadian rhythm Effects 0.000 description 1
• 230000035602 clotting Effects 0.000 description 1
• 238000012761 co-transfection Methods 0.000 description 1
• 230000015271 coagulation Effects 0.000 description 1
• 238000005345 coagulation Methods 0.000 description 1
• 201000003486 coccidioidomycosis Diseases 0.000 description 1
• 230000001149 cognitive effect Effects 0.000 description 1
• 229920001436 collagen Polymers 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 239000000356 contaminant Substances 0.000 description 1
• 238000011109 contamination Methods 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 238000010411 cooking Methods 0.000 description 1
• 238000001816 cooling Methods 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 238000002425 crystallisation Methods 0.000 description 1
• 230000008025 crystallization Effects 0.000 description 1
• 208000031513 cyst Diseases 0.000 description 1
• 229940127089 cytotoxic agent Drugs 0.000 description 1
• SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 1
• SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 1
• RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
• HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 1
• NHVNXKFIZYSCEB-XLPZGREQSA-N dTTP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C1 NHVNXKFIZYSCEB-XLPZGREQSA-N 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 238000004925 denaturation Methods 0.000 description 1
• 230000036425 denaturation Effects 0.000 description 1
• 210000004207 dermis Anatomy 0.000 description 1
• 229960000633 dextran sulfate Drugs 0.000 description 1
• 201000004587 dientamoebiasis Diseases 0.000 description 1
• 210000002249 digestive system Anatomy 0.000 description 1
• 239000012470 diluted sample Substances 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 230000003292 diminished effect Effects 0.000 description 1
• 206010013023 diphtheria Diseases 0.000 description 1
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
• 231100000676 disease causative agent Toxicity 0.000 description 1
• 239000004198 disodium guanylate Substances 0.000 description 1
• 238000010494 dissociation reaction Methods 0.000 description 1
• 230000005593 dissociations Effects 0.000 description 1
• 239000006196 drop Substances 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 230000000437 effect on angiogenesis Effects 0.000 description 1
• 238000004520 electroporation Methods 0.000 description 1
• 238000010828 elution Methods 0.000 description 1
• 230000013020 embryo development Effects 0.000 description 1
• 210000001671 embryonic stem cell Anatomy 0.000 description 1
• 206010014599 encephalitis Diseases 0.000 description 1
• 201000002491 encephalomyelitis Diseases 0.000 description 1
• 206010014665 endocarditis Diseases 0.000 description 1
• 230000002124 endocrine Effects 0.000 description 1
• 210000003372 endocrine gland Anatomy 0.000 description 1
• 230000002357 endometrial effect Effects 0.000 description 1
• 108010002082 endometriosis protein-1 Proteins 0.000 description 1
• 206010014801 endophthalmitis Diseases 0.000 description 1
• 210000003989 endothelium vascular Anatomy 0.000 description 1
• 238000004146 energy storage Methods 0.000 description 1
• 230000002255 enzymatic effect Effects 0.000 description 1
• 238000009585 enzyme analysis Methods 0.000 description 1
• 210000003979 eosinophil Anatomy 0.000 description 1
• 230000008556 epithelial cell proliferation Effects 0.000 description 1
• 230000008472 epithelial growth Effects 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 230000029142 excretion Effects 0.000 description 1
• 230000001747 exhibiting effect Effects 0.000 description 1
• 210000003414 extremity Anatomy 0.000 description 1
• 208000030533 eye disease Diseases 0.000 description 1
• 239000004744 fabric Substances 0.000 description 1
• 235000019197 fats Nutrition 0.000 description 1
• 238000000855 fermentation Methods 0.000 description 1
• 230000004151 fermentation Effects 0.000 description 1
• 239000012091 fetal bovine serum Substances 0.000 description 1
• 239000000835 fiber Substances 0.000 description 1
• 230000004761 fibrosis Effects 0.000 description 1
• 239000000945 filler Substances 0.000 description 1
• 238000011049 filling Methods 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 235000019688 fish Nutrition 0.000 description 1
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
• 235000012041 food component Nutrition 0.000 description 1
• 235000019249 food preservative Nutrition 0.000 description 1
• 239000005452 food preservative Substances 0.000 description 1
• 230000002431 foraging effect Effects 0.000 description 1
• 210000001061 forehead Anatomy 0.000 description 1
• 230000022244 formylation Effects 0.000 description 1
• 238000006170 formylation reaction Methods 0.000 description 1
• 238000010230 functional analysis Methods 0.000 description 1
• 238000002825 functional assay Methods 0.000 description 1
• 230000006251 gamma-carboxylation Effects 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 208000007565 gingivitis Diseases 0.000 description 1
• 229940116332 glucose oxidase Drugs 0.000 description 1
• 235000019420 glucose oxidase Nutrition 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 239000006451 grace's insect medium Substances 0.000 description 1
• 230000037308 hair color Effects 0.000 description 1
• 238000003306 harvesting Methods 0.000 description 1
• 210000003128 head Anatomy 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 201000011066 hemangioma Diseases 0.000 description 1
• 208000007475 hemolytic anemia Diseases 0.000 description 1
• 210000001624 hip Anatomy 0.000 description 1
• 210000003630 histaminocyte Anatomy 0.000 description 1
• 238000002744 homologous recombination Methods 0.000 description 1
• 230000006801 homologous recombination Effects 0.000 description 1
• 230000003054 hormonal effect Effects 0.000 description 1
• 102000049483 human SPZ1 Human genes 0.000 description 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
• 210000004754 hybrid cell Anatomy 0.000 description 1
• 210000004408 hybridoma Anatomy 0.000 description 1
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 1
• 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
• 230000033444 hydroxylation Effects 0.000 description 1
• 230000009610 hypersensitivity Effects 0.000 description 1
• 230000003100 immobilizing effect Effects 0.000 description 1
• 238000012151 immunohistochemical method Methods 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 210000003000 inclusion body Anatomy 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 229910052738 indium Inorganic materials 0.000 description 1
• APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
• 230000007574 infarction Effects 0.000 description 1
• 230000002458 infectious effect Effects 0.000 description 1
• 230000008595 infiltration Effects 0.000 description 1
• 238000001764 infiltration Methods 0.000 description 1
• 230000004968 inflammatory condition Effects 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 239000000893 inhibin Substances 0.000 description 1
• ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 229910052500 inorganic mineral Inorganic materials 0.000 description 1
• 229960003786 inosine Drugs 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 230000026045 iodination Effects 0.000 description 1
• 238000006192 iodination reaction Methods 0.000 description 1
• 239000011630 iodine Substances 0.000 description 1
• XMBWDFGMSWQBCA-RNFDNDRNSA-M iodine-131(1-) Chemical compound [131I-] XMBWDFGMSWQBCA-RNFDNDRNSA-M 0.000 description 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 206010023332 keratitis Diseases 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 101150066555 lacZ gene Proteins 0.000 description 1
• 150000002597 lactoses Chemical class 0.000 description 1
• 238000002386 leaching Methods 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• 231100000225 lethality Toxicity 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 238000007834 ligase chain reaction Methods 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 238000001638 lipofection Methods 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 238000009630 liquid culture Methods 0.000 description 1
• 208000019423 liver disease Diseases 0.000 description 1
• 208000007903 liver failure Diseases 0.000 description 1
• 231100000835 liver failure Toxicity 0.000 description 1
• 231100000516 lung damage Toxicity 0.000 description 1
• 206010025135 lupus erythematosus Diseases 0.000 description 1
• 210000004324 lymphatic system Anatomy 0.000 description 1
• 231100001023 lymphopenia Toxicity 0.000 description 1
• 201000000564 macroglobulinemia Diseases 0.000 description 1
• 210000002540 macrophage Anatomy 0.000 description 1
• 208000002780 macular degeneration Diseases 0.000 description 1
• 229910001629 magnesium chloride Inorganic materials 0.000 description 1
• CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
• 201000004792 malaria Diseases 0.000 description 1
• 230000010534 mechanism of action Effects 0.000 description 1
• 238000013160 medical therapy Methods 0.000 description 1
• 230000006996 mental state Effects 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
• 230000011987 methylation Effects 0.000 description 1
• 238000007069 methylation reaction Methods 0.000 description 1
• 235000010755 mineral Nutrition 0.000 description 1
• 239000011707 mineral Substances 0.000 description 1
• 238000010369 molecular cloning Methods 0.000 description 1
• 239000002808 molecular sieve Substances 0.000 description 1
• 238000012544 monitoring process Methods 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 201000006417 multiple sclerosis Diseases 0.000 description 1
• 208000010805 mumps infectious disease Diseases 0.000 description 1
• 238000002703 mutagenesis Methods 0.000 description 1
• 231100000350 mutagenesis Toxicity 0.000 description 1
• 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 1
• 230000036473 myasthenia Effects 0.000 description 1
• 201000005962 mycosis fungoides Diseases 0.000 description 1
• 208000010125 myocardial infarction Diseases 0.000 description 1
• 239000007922 nasal spray Substances 0.000 description 1
• 229940097496 nasal spray Drugs 0.000 description 1
• 201000009240 nasopharyngitis Diseases 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 239000006225 natural substrate Substances 0.000 description 1
• 210000003739 neck Anatomy 0.000 description 1
• 230000009826 neoplastic cell growth Effects 0.000 description 1
• 201000008383 nephritis Diseases 0.000 description 1
• 230000008764 nerve damage Effects 0.000 description 1
• 210000000944 nerve tissue Anatomy 0.000 description 1
• 210000000653 nervous system Anatomy 0.000 description 1
• 210000002569 neuron Anatomy 0.000 description 1
• 230000009871 nonspecific binding Effects 0.000 description 1
• 229940099990 ogen Drugs 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 238000010915 one-step procedure Methods 0.000 description 1
• 238000001543 one-way ANOVA Methods 0.000 description 1
• 229940127240 opiate Drugs 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 239000000668 oral spray Substances 0.000 description 1
• 229940041678 oral spray Drugs 0.000 description 1
• 201000008482 osteoarthritis Diseases 0.000 description 1
• 230000002611 ovarian Effects 0.000 description 1
• 238000012261 overproduction Methods 0.000 description 1
• 230000003647 oxidation Effects 0.000 description 1
• 238000007254 oxidation reaction Methods 0.000 description 1
• 239000001301 oxygen Substances 0.000 description 1
• 238000004806 packaging method and process Methods 0.000 description 1
• 230000000242 pagocytic effect Effects 0.000 description 1
• 244000045947 parasite Species 0.000 description 1
• 230000003071 parasitic effect Effects 0.000 description 1
• 230000000849 parathyroid Effects 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• 230000006320 pegylation Effects 0.000 description 1
• 210000004197 pelvis Anatomy 0.000 description 1
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
• 238000010647 peptide synthesis reaction Methods 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 210000000578 peripheral nerve Anatomy 0.000 description 1
• 210000001428 peripheral nervous system Anatomy 0.000 description 1
• 208000033808 peripheral neuropathy Diseases 0.000 description 1
• 210000004303 peritoneum Anatomy 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 239000012071 phase Substances 0.000 description 1
• 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 238000005222 photoaffinity labeling Methods 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 230000019612 pigmentation Effects 0.000 description 1
• 230000001817 pituitary effect Effects 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 230000004481 post-translational protein modification Effects 0.000 description 1
• 230000001323 posttranslational effect Effects 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 230000035935 pregnancy Effects 0.000 description 1
• 230000013823 prenylation Effects 0.000 description 1
• 238000004321 preservation Methods 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 239000004018 propan-1,2-diol esters of fatty acids Substances 0.000 description 1
• 208000011354 prosthesis-related infectious disease Diseases 0.000 description 1
• 230000004853 protein function Effects 0.000 description 1
• 230000012743 protein tagging Effects 0.000 description 1
• 239000012264 purified product Substances 0.000 description 1
• 238000004445 quantitative analysis Methods 0.000 description 1
• 230000006340 racemization Effects 0.000 description 1
• 239000011541 reaction mixture Substances 0.000 description 1
• 230000006884 regulation of angiogenesis Effects 0.000 description 1
• 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
• 238000004153 renaturation Methods 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 230000001850 reproductive effect Effects 0.000 description 1
• 230000000241 respiratory effect Effects 0.000 description 1
• 208000020029 respiratory tract infectious disease Diseases 0.000 description 1
• 210000003660 reticulum Anatomy 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 238000012552 review Methods 0.000 description 1
• 201000003068 rheumatic fever Diseases 0.000 description 1
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
• 210000003705 ribosome Anatomy 0.000 description 1
• 238000007363 ring formation reaction Methods 0.000 description 1
• 238000005096 rolling process Methods 0.000 description 1
• 201000005404 rubella Diseases 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 201000000306 sarcoidosis Diseases 0.000 description 1
• 208000005687 scabies Diseases 0.000 description 1
• 231100000241 scar Toxicity 0.000 description 1
• 230000037387 scars Effects 0.000 description 1
• 238000003345 scintillation counting Methods 0.000 description 1
• 239000006152 selective media Substances 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 230000036303 septic shock Effects 0.000 description 1
• 208000002491 severe combined immunodeficiency Diseases 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 239000004332 silver Substances 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 210000002027 skeletal muscle Anatomy 0.000 description 1
• 210000000813 small intestine Anatomy 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000007974 sodium acetate buffer Substances 0.000 description 1
• URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• 239000004296 sodium metabisulphite Substances 0.000 description 1
• 239000001488 sodium phosphate Substances 0.000 description 1
• 229910000162 sodium phosphate Inorganic materials 0.000 description 1
• 235000011008 sodium phosphates Nutrition 0.000 description 1
• 210000004872 soft tissue Anatomy 0.000 description 1
• 238000010532 solid phase synthesis reaction Methods 0.000 description 1
• 230000003381 solubilizing effect Effects 0.000 description 1
• 230000000392 somatic effect Effects 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 238000007619 statistical method Methods 0.000 description 1
• 210000002536 stromal cell Anatomy 0.000 description 1
• 239000012609 strong anion exchange resin Substances 0.000 description 1
• 238000012916 structural analysis Methods 0.000 description 1
• 230000004960 subcellular localization Effects 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 238000010254 subcutaneous injection Methods 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• 125000001424 substituent group Chemical group 0.000 description 1
• MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 description 1
• 229960004291 sucralfate Drugs 0.000 description 1
• 230000019635 sulfation Effects 0.000 description 1
• 238000005670 sulfation reaction Methods 0.000 description 1
• 239000011593 sulfur Substances 0.000 description 1
• 229910052717 sulfur Inorganic materials 0.000 description 1
• 210000001179 synovial fluid Anatomy 0.000 description 1
• 238000010189 synthetic method Methods 0.000 description 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
• 229910052713 technetium Inorganic materials 0.000 description 1
• GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
• 208000009056 telangiectasis Diseases 0.000 description 1
• 201000004415 tendinitis Diseases 0.000 description 1
• 230000002381 testicular Effects 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 235000019364 tetracycline Nutrition 0.000 description 1
• 150000003522 tetracyclines Chemical class 0.000 description 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
• 229940126585 therapeutic drug Drugs 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1
• 210000000115 thoracic cavity Anatomy 0.000 description 1
• 210000001541 thymus gland Anatomy 0.000 description 1
• 230000017423 tissue regeneration Effects 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 108700012359 toxins Proteins 0.000 description 1
• 238000012301 transgenic model Methods 0.000 description 1
• 230000014616 translation Effects 0.000 description 1
• YFDSDPIBEUFTMI-UHFFFAOYSA-N tribromoethanol Chemical compound OCC(Br)(Br)Br YFDSDPIBEUFTMI-UHFFFAOYSA-N 0.000 description 1
• 229950004616 tribromoethanol Drugs 0.000 description 1
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
• 229910052722 tritium Inorganic materials 0.000 description 1
• 201000002311 trypanosomiasis Diseases 0.000 description 1
• 201000008297 typhoid fever Diseases 0.000 description 1
• 241001430294 unidentified retrovirus Species 0.000 description 1
• 208000019206 urinary tract infection Diseases 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1
• 208000007089 vaccinia Diseases 0.000 description 1
• 230000006496 vascular abnormality Effects 0.000 description 1
• 208000023577 vascular insufficiency disease Diseases 0.000 description 1
• 230000004865 vascular response Effects 0.000 description 1
• 210000005166 vasculature Anatomy 0.000 description 1
• 201000009371 venous hemangioma Diseases 0.000 description 1
• 238000011179 visual inspection Methods 0.000 description 1
• 238000012800 visualization Methods 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 230000029663 wound healing Effects 0.000 description 1
• 210000005253 yeast cell Anatomy 0.000 description 1
• 229910052725 zinc Inorganic materials 0.000 description 1
• 239000011701 zinc Substances 0.000 description 1