MX9801897A - Derivados de l-n6-(1-iminoetil)lisina, utiles como inhibidores de oxido nitrico sintetasa. - Google Patents
Derivados de l-n6-(1-iminoetil)lisina, utiles como inhibidores de oxido nitrico sintetasa.Info
- Publication number
- MX9801897A MX9801897A MX9801897A MX9801897A MX9801897A MX 9801897 A MX9801897 A MX 9801897A MX 9801897 A MX9801897 A MX 9801897A MX 9801897 A MX9801897 A MX 9801897A MX 9801897 A MX9801897 A MX 9801897A
- Authority
- MX
- Mexico
- Prior art keywords
- radical
- lower alkyl
- radicals
- hydrogen
- aromatic hydrocarbon
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se describen derivados de L-N6-(1-iminoetil)lisina de formula general (I), composiciones farmacéuticas que contienen estos compuestos, y su uso en terapia, en particular su uso como inhibidores de oxido nítrico sintetasa; Y es hidrogeno, radical alquilo inferior, radical alquenilo inferior, radical alquinilo inferior, radical hidrocarburo aromático, radical hidrocarburo alicíclico, amino, radical heterociclilo en el cual 1 a aproximadamente 4 heteroátomos se seleccionan independientemente de oxígeno, nitrogeno y azufre, en donde todos estos radicales mencionados pueden estar substituidos opcionalmente con hidrogeno, ciano, alquilo inferior, nitro, amino, radicales hidrocarburo alicíclicos, o radicales hidrocarburo aromáticos que pueden estar substituidos opcionalmente con alquilo inferior; X es radical alquilo inferior, radical alquenilo inferior, radical alquinilo inferior, radical hidrocarburo aromático, (CH2)mQ(CH2)n, en donde m=1-3, n=1-3, y Q es azufre, sulfinilo, sulfonilo u oxígeno, C=O, radical alquinilo inferior, radical hidrocarburo aromático, radical hidrocarburo alicíclico o radicales heterocíclicos en los cuales 1 a aproximadamente 4 heteroátomos se seleccionan independientemente de oxígeno, nitrogeno y azufre; en donde todos los radicales mencionados están sustituidos opcionalmente con hidrogeno, halogeno y alquilo inferior; R1, R2, R3 y R4 se seleccionan independientemente del grupo que consiste de hidrogeno y alquilo inferior; A es un radical alquilo inferior en el cual dicho radical está sustituido opcionalmente con hidrogeno, alquilo inferior, hidroxilo, alcoxi inferior, alcoxicarbonilo, alquilariloxi, tiol, tioalcoxi inferior, tioalquilariloxi, tioariloxi, sulfinilaquilo, sulfinilalquilarilo, sulfinilarilo, sulfonilalquilo, sulfonilalquilarilo, sulfonilarilo, halogeno, radicales hidrocarburo aromáticos, o radicales hidrocarburo alicíclicos; o A puede ser un enlace directo con el resto de la molécula; B es CH2R5 en donde R5 es amidina, guanidina, sulfonamida, amino, que pueden ser substituidos opcionalmente con radicales alquilo, alquilarilo o arilo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08526147 | 1995-09-11 | ||
| US08/526,147 US5830917A (en) | 1995-09-11 | 1995-09-11 | L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors |
| PCT/US1996/013819 WO1997010204A1 (en) | 1995-09-11 | 1996-09-09 | L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9801897A true MX9801897A (es) | 1998-05-31 |
| MXPA98001897A MXPA98001897A (es) | 1998-10-23 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| EP0861231A1 (en) | 1998-09-02 |
| CA2231768A1 (en) | 1997-03-20 |
| WO1997010204A1 (en) | 1997-03-20 |
| EP0861231B1 (en) | 2000-11-08 |
| PT861231E (pt) | 2001-02-28 |
| DE69610932T2 (de) | 2001-04-26 |
| DE69610932D1 (de) | 2000-12-14 |
| BR9610912A (pt) | 1999-03-30 |
| AU6903796A (en) | 1997-04-01 |
| JPH11512428A (ja) | 1999-10-26 |
| NZ316735A (en) | 1999-01-28 |
| DK0861231T3 (da) | 2001-01-08 |
| AU720070B2 (en) | 2000-05-25 |
| ATE197449T1 (de) | 2000-11-11 |
| GR3034944T3 (en) | 2001-02-28 |
| ES2152558T3 (es) | 2001-02-01 |
| US5830917A (en) | 1998-11-03 |
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