ES2152558T3 - Derivados de l-n6-(1-iminoetil)lisina utiles como inhibidores de oxido nitrico sintasa. - Google Patents

Derivados de l-n6-(1-iminoetil)lisina utiles como inhibidores de oxido nitrico sintasa.

Info

Publication number
ES2152558T3
ES2152558T3 ES96929765T ES96929765T ES2152558T3 ES 2152558 T3 ES2152558 T3 ES 2152558T3 ES 96929765 T ES96929765 T ES 96929765T ES 96929765 T ES96929765 T ES 96929765T ES 2152558 T3 ES2152558 T3 ES 2152558T3
Authority
ES
Spain
Prior art keywords
inhibitors
derivatives
nitrico
iminoetil
sintasa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96929765T
Other languages
English (en)
Inventor
William M Moore
E Ann Hallinan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2152558T3 publication Critical patent/ES2152558T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE PRESENTAN DERIVADOS DE L - N 6 - (1 - IMINOETIL)LISINA DE FORMULA GENERAL (I), COMPOSICIONES FARMACEUTICAS QUE CONTIENE ESTOS COMPUESTOS Y SU USO TERAPEUTICO, EN PARTICULAR SU USO COMO INHIBIDORES DE LA OXIDO NITRICO SINTASA. Y ES UN ATOMO DE HIDROGENO, UN RADICAL ALQUILO MENOR, UN RADICAL ALQUENILO MENOR, UN RADICAL ALQUINILO MENOR, UN RADICAL HIDROCARBURO AROMATICO, UN RADICAL HIDROCARBURO ALICICLICO, UN RADICAL AMINO, UN RADICAL HETEROCICLILO EN EL QUE SE SELECCIONAN INDEPENDIENTEMENTE DE 1 A 4 HETEROATOMOS ENTRE OXIGENO, NITROGENO Y AZUFRE, DONDE TODOS ESTOS RADICALES PUEDEN SER SUSTITUIDOS OPCIONALMENTE CON HIDROGENO, UN RADICAL CIANO, ALQUILO MENOR, NITRO, AMINO O HIDROCARBURO ALICICLICO, O HIDROCARBUROS ALICICLICOS AROMATICOS QUE PUEDEN SUSTITUIRSE OPCIONALMENTE CON UN RADICAL ALQUILO MENOR; X ES UN RADICAL ALQUILO MENOR, UN RADICAL ALQUENILO MENOR, UN RADICAL ALQUINILO MENOR, UN RADICAL HIDROCARBURO AROMATICO, UN RADICAL (CH 2 ) M Q(CH 2 ) N , DONDE M=1-3, N=1-3, Y Q ES AZUFRE, UN GRUPO SULFINILO, SULFONILO U OXIGENO, C=O, UN RADICAL ALQUINILO MENOR, UN RADICAL HIDROCARBURO AROMATICO, UN RADICAL HIDROCARBURO ALICICLICO O RADICALES HETEROCICLILOS EN LOS QUE SE SELECCIONAN INDEPENDIENTEMENTE DE 1 A 4 HETEROATOMOS ENTRE OXIGENO, NITROGENO Y AZUFRE, DONDE TODOS ESTOS RADICALES PUEDEN SER SUSTITUIDOS OPCIONALMENTE CON HIDROGENO, UN HALOGENO O UN RADICAL ALQUILO MENOR; R 1, R 2 , R 3 Y R 4 SE SELECCIONAN INDEPENDIENTEM ENTE DEL GRUPO FORMADO POR HIDROGENO Y UN RADICAL ALQUILO MENOR; A ES UN RADICAL ALQUILO MENOR QUE PUEDE SUSTITUIRSE OPCIONALMENTE CON HIDROGENO, UN RADICAL ALQUILO MENOR, HIDROXILO, ALQUIOXILO MENOR, ALQUIOXICARBONILO, ALQUILARILOXILO, TIOL, TIOALQUIOXILO MENOR, TIOALQUILARILOXILO, TIOARILOXILO, SULFINILALQUILO, SULFINILALQUILARILO, SULFINILARILO, SULFONILALQUILO, SULFONILALQUILARILO, SULFONILARILO, HALOGENO, HIDROCARBUROS AROMATICOS O HIDROCARBUROS ALICICLICOS; O A PUEDE SER UN ENLACE DIRECTO CON EL RESTO DE LA MOLECULA; B ES CH 2 R 5 DONDE R 5 ES UNA AMIDINA, GUANIDINA, SULFONAMIDA, UN GRUPO AMINO QUE PUEDE SUSTITUIRSE OPCIONALMENTE CON RADICALES ALQUILO, ALQUILARILO O ARILO.
ES96929765T 1995-09-11 1996-09-09 Derivados de l-n6-(1-iminoetil)lisina utiles como inhibidores de oxido nitrico sintasa. Expired - Lifetime ES2152558T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/526,147 US5830917A (en) 1995-09-11 1995-09-11 L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
ES2152558T3 true ES2152558T3 (es) 2001-02-01

Family

ID=24096116

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96929765T Expired - Lifetime ES2152558T3 (es) 1995-09-11 1996-09-09 Derivados de l-n6-(1-iminoetil)lisina utiles como inhibidores de oxido nitrico sintasa.

Country Status (14)

Country Link
US (1) US5830917A (es)
EP (1) EP0861231B1 (es)
JP (1) JPH11512428A (es)
AT (1) ATE197449T1 (es)
AU (1) AU720070B2 (es)
BR (1) BR9610912A (es)
CA (1) CA2231768A1 (es)
DE (1) DE69610932T2 (es)
DK (1) DK0861231T3 (es)
ES (1) ES2152558T3 (es)
GR (1) GR3034944T3 (es)
NZ (1) NZ316735A (es)
PT (1) PT861231E (es)
WO (1) WO1997010204A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE313525T1 (de) 2000-03-24 2006-01-15 Pharmacia Corp Amidino-verbindungen als hemmstoffe der stickstoffmonoxid-synthase
US6545170B2 (en) 2000-04-13 2003-04-08 Pharmacia Corporation 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR030416A1 (es) 2000-04-13 2003-08-20 Pharmacia Corp COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
US6956131B2 (en) 2000-04-13 2005-10-18 Pharmacia Corporation 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
AR034120A1 (es) 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
US6787668B2 (en) 2000-04-13 2004-09-07 Pharmacia Corporation 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR032318A1 (es) 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US7470815B1 (en) * 2001-06-22 2008-12-30 Northwestern University Selective neuronal nitric oxide synthase inhibitors
US20030109522A1 (en) * 2001-09-24 2003-06-12 Manning Pamela T. Ophthalmologic treatment methods using selective iNOS inhibitors
PL375375A1 (en) * 2002-08-02 2005-11-28 Pharmacia Corporation Methods for treatment and prevention of gastrointestinal conditions
DE102008061247A1 (de) * 2008-12-10 2010-06-24 Christian-Albrechts-Universität Zu Kiel Inhibitoren der Dimethylarginin Dimethylaminohydrolase

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1114155A (en) * 1964-08-24 1968-05-15 Evans Medical Ltd Guanidino derivatives
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
ZA852512B (en) * 1985-04-03 1985-11-27 Toray Industries Guanidine derivatives
US5196450A (en) * 1985-12-19 1993-03-23 Merrell Dow Pharmaceuticals Inc. Method of inhibiting protozoal growth
US5242947A (en) * 1988-02-10 1993-09-07 New York University Use of polyamines as ionic-channel regulating agents
ZA898440B (en) * 1988-11-10 1990-07-25 Merrell Dow Pharma Lactamimides in the treatment of drug-resistant protozoal infections
US5380945A (en) * 1989-06-21 1995-01-10 Abbott Laboratories Guanidino compounds as regulators of nitric oxide synthase
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
GB8929076D0 (en) * 1989-12-22 1990-02-28 Scras Treatment of shock by blocking agents of edrf effect or formation
CA2036770C (en) * 1990-02-26 2003-09-09 Jeffrey P. Whitten Inhibitors of nitric oxide biosynthesis
US5132453A (en) * 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
US5273875A (en) * 1991-03-22 1993-12-28 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
US5296466A (en) * 1992-02-19 1994-03-22 Board Of Regents, The University Of Texas System Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
JPH08504798A (ja) * 1992-12-18 1996-05-21 ザ ウエルカム ファウンデーション リミテッド 酵素阻害薬としての，ピリミジン，ピリジン，プテリジノンおよびインダゾール誘導体
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
DE69431194T2 (de) * 1993-10-21 2002-12-12 G.D. Searle & Co., Chicago Amidino-derivate nützlich als no synthase-hemmer
US5362744A (en) * 1993-11-22 1994-11-08 Warner-Lambert Company Tetrazole-substituted urea acat inhibitors
DE19536219C1 (de) * 1995-09-28 1996-11-07 Siemens Ag Hydraulikleitung mit integriertem, drucklosem Rücklauf

Also Published As

Publication number Publication date
ATE197449T1 (de) 2000-11-11
JPH11512428A (ja) 1999-10-26
NZ316735A (en) 1999-01-28
DE69610932T2 (de) 2001-04-26
WO1997010204A1 (en) 1997-03-20
DE69610932D1 (de) 2000-12-14
AU720070B2 (en) 2000-05-25
AU6903796A (en) 1997-04-01
EP0861231B1 (en) 2000-11-08
BR9610912A (pt) 1999-03-30
EP0861231A1 (en) 1998-09-02
GR3034944T3 (en) 2001-02-28
DK0861231T3 (da) 2001-01-08
US5830917A (en) 1998-11-03
MX9801897A (es) 1998-05-31
CA2231768A1 (en) 1997-03-20
PT861231E (pt) 2001-02-28

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