MX9708678A - Proteasa activa, soluble del virus de la hepatitis c. - Google Patents
Proteasa activa, soluble del virus de la hepatitis c.Info
- Publication number
- MX9708678A MX9708678A MX9708678A MX9708678A MX9708678A MX 9708678 A MX9708678 A MX 9708678A MX 9708678 A MX9708678 A MX 9708678A MX 9708678 A MX9708678 A MX 9708678A MX 9708678 A MX9708678 A MX 9708678A
- Authority
- MX
- Mexico
- Prior art keywords
- protease
- soluble
- active hepatitis
- virus protease
- soluble hcv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
- C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se presenta una NS3 proteasa soluble del virus de la hepatitis C, que incluye la NS3 proteasa fusionada sobre un motivo de solubilizacion. Se presenta una fusion de las regiones NS3 y NS4 bajo condiciones en donde no están disociadas por la NS3 proteasa. Se presenta también la NS3 proteasa soluble del virus de la hepatitis C expresada de manera bacteriana. Se presentan células huéspedes donde al menos el 1% de la proteína total de la célula es NS3 proteasa soluble del virus de la hepatitis C.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08440409 | 1995-05-12 | ||
US08/440,409 US5843752A (en) | 1995-05-12 | 1995-05-12 | Soluble active hepatitis C virus protease |
PCT/US1996/006387 WO1996036702A2 (en) | 1995-05-12 | 1996-05-09 | Soluble, active hepatitis c virus protease |
Publications (2)
Publication Number | Publication Date |
---|---|
MXPA97008678A MXPA97008678A (es) | 1998-02-01 |
MX9708678A true MX9708678A (es) | 1998-02-28 |
Family
ID=23748650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9708678A MX9708678A (es) | 1995-05-12 | 1996-05-09 | Proteasa activa, soluble del virus de la hepatitis c. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5843752A (es) |
EP (1) | EP0826038A2 (es) |
JP (1) | JP3091231B2 (es) |
AU (1) | AU5729196A (es) |
CA (1) | CA2220575C (es) |
MX (1) | MX9708678A (es) |
WO (1) | WO1996036702A2 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2741077B1 (fr) * | 1995-11-14 | 1998-01-23 | Pasteur Institut | Vaccin polyvalent anti-dengue |
AU2933797A (en) * | 1996-05-10 | 1997-12-05 | Schering Corporation | Synthetic inhibitors of hepatitis c virus ns3 protease |
US5990276A (en) * | 1996-05-10 | 1999-11-23 | Schering Corporation | Synthetic inhibitors of hepatitis C virus NS3 protease |
IT1285158B1 (it) * | 1996-09-17 | 1998-06-03 | Angeletti P Ist Richerche Bio | Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il |
US6436666B1 (en) | 1996-10-17 | 2002-08-20 | Chiron Corporation | Protease regulator screening assay |
WO1998037180A2 (en) * | 1997-02-22 | 1998-08-27 | Abbott Laboratories | Hcv fusion protease and polynucleotide encoding same |
US6010848A (en) * | 1997-07-02 | 2000-01-04 | Smithkline Beecham Corporation | Screening methods using an atpase protein from hepatitis C virus |
GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
US6211338B1 (en) * | 1997-11-28 | 2001-04-03 | Schering Corporation | Single-chain recombinant complexes of hepatitis C virus NS3 protease and NS4A cofactor peptide |
WO2000001718A2 (en) * | 1998-07-02 | 2000-01-13 | University Of Florida | Ns4a-ns3 catalytic domain of hepatitis c |
JP2002534084A (ja) | 1999-01-08 | 2002-10-15 | ブリストル−マイヤーズ スクイブ カンパニー | C型肝炎ウイルスns3プロテアーゼの修飾形 |
US7074556B2 (en) * | 1999-03-02 | 2006-07-11 | Invitrogen Corporation | cDNA synthesis improvements |
US6562346B1 (en) * | 1999-10-27 | 2003-05-13 | Chiron Corporation | Activation of HCV-specific T cells |
US6986892B1 (en) * | 1999-11-24 | 2006-01-17 | Chiron Corporation | Immunogenic Hepatitis C virus non-structural polypeptides |
US20050074465A1 (en) * | 1999-11-24 | 2005-04-07 | Michael Houghton | HCV fusion proteins with modified NS3 domains |
EP1350105B1 (en) | 2000-06-15 | 2007-07-25 | Novartis Vaccines and Diagnostics, Inc. | Immunoassays for anti-hcv antibodies |
US7491808B2 (en) * | 2000-06-15 | 2009-02-17 | Novartis Vaccines And Diagnostics, Inc. | HCV non-structural protein mutants and uses thereof |
US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
AR029851A1 (es) * | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
PL206255B1 (pl) * | 2000-07-21 | 2010-07-30 | Dendreon Corporationdendreon Corporation | Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii |
BR0112666A (pt) | 2000-07-21 | 2003-06-10 | Schering Corp | Peptìdeos como inibidores de ns3-serina protease de vìrus da hepatite c |
US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
NZ538711A (en) * | 2002-09-09 | 2007-01-26 | Chiron Corp | Antigen/antibody/antigen sandwich assays for detecting hepatitis C virus infections |
CA2498653C (en) * | 2002-10-29 | 2010-12-14 | Boehringer Ingelheim International Gmbh | Inhibitor-resistant hcv ns3 protease |
WO2004048403A2 (en) * | 2002-11-26 | 2004-06-10 | Tripep Ab | Hepatisis c virus nonstructural protein 4a (ns4a) is an enhancer element |
US7827284B2 (en) * | 2002-12-20 | 2010-11-02 | Netsocket, Inc. | Method and arrangement in a communication system |
US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
JP4836281B2 (ja) * | 2004-08-27 | 2011-12-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | Hcv非構造タンパク質変異体およびその使用 |
EP2109748B1 (de) | 2007-01-18 | 2010-04-14 | Steyr Mannlicher Holding GmbH | Laufhalterung für eine kipplaufwaffe |
WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
US8815253B2 (en) | 2007-12-07 | 2014-08-26 | Novartis Ag | Compositions for inducing immune responses |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
EP0527788B1 (en) * | 1990-04-04 | 2004-06-30 | Chiron Corporation | Hepatitis c virus protease |
IT1272179B (it) * | 1994-02-23 | 1997-06-16 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv. |
US5714371A (en) * | 1995-05-12 | 1998-02-03 | Schering Corporation | Method for refolding insoluble aggregates of hepatitis C virus protease |
-
1995
- 1995-05-12 US US08/440,409 patent/US5843752A/en not_active Expired - Lifetime
-
1996
- 1996-05-09 CA CA002220575A patent/CA2220575C/en not_active Expired - Fee Related
- 1996-05-09 WO PCT/US1996/006387 patent/WO1996036702A2/en not_active Application Discontinuation
- 1996-05-09 EP EP96915539A patent/EP0826038A2/en not_active Withdrawn
- 1996-05-09 AU AU57291/96A patent/AU5729196A/en not_active Abandoned
- 1996-05-09 MX MX9708678A patent/MX9708678A/es not_active IP Right Cessation
- 1996-05-09 JP JP08534876A patent/JP3091231B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1996036702A3 (en) | 1997-01-16 |
WO1996036702A2 (en) | 1996-11-21 |
CA2220575C (en) | 2001-12-25 |
AU5729196A (en) | 1996-11-29 |
CA2220575A1 (en) | 1996-11-21 |
US5843752A (en) | 1998-12-01 |
JP3091231B2 (ja) | 2000-09-25 |
JPH10507933A (ja) | 1998-08-04 |
EP0826038A2 (en) | 1998-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |