MX9708590A - Metodos para la produccion de ligandos a base de platino entre marcadores y moleculas bio-organicas, para marcar moleculas bio-organicas, para detectar substancias biologicas de interes y equipos de prueba de diagnostico. - Google Patents

Metodos para la produccion de ligandos a base de platino entre marcadores y moleculas bio-organicas, para marcar moleculas bio-organicas, para detectar substancias biologicas de interes y equipos de prueba de diagnostico.

Info

Publication number
MX9708590A
MX9708590A MX9708590A MX9708590A MX9708590A MX 9708590 A MX9708590 A MX 9708590A MX 9708590 A MX9708590 A MX 9708590A MX 9708590 A MX9708590 A MX 9708590A MX 9708590 A MX9708590 A MX 9708590A
Authority
MX
Mexico
Prior art keywords
bio
organic molecules
production
labelling
platinum
Prior art date
Application number
MX9708590A
Other languages
English (en)
Inventor
Hendrik Jan Houthoff
Jan Reedijk
Tinka Jelsma
Remco Maria Van Es
Franciscus Michiel Van De Berg
Edwin Leo Mario Lempers
Maireke Johanna Bloemink
Original Assignee
Kreatech Biotech Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kreatech Biotech Bv filed Critical Kreatech Biotech Bv
Publication of MX9708590A publication Critical patent/MX9708590A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invencion describe los métodos mejorados para producir compuestos de platino, los cuales, son muy adecuados para producir substancias marcadas, las cuales pueden ser utilizadas para detectar moléculas específicas de interés. Los compuestos de coordinacion de platino tienen dos grupos reactivos de los cuales uno es reemplazado por una marca y el otro puede ser reemplazado por una substancia para ser marcada. La produccion de substancias marcadas es muy mejorada por seleccion de los materiales iniciadores correctos produciendo los intermedios correctos. La eficiencia del marcado es muy mejorada, por lo cual permite la produccion de equipos los cuales son también parte de la presente invencion.
MX9708590A 1995-05-09 1997-11-07 Metodos para la produccion de ligandos a base de platino entre marcadores y moleculas bio-organicas, para marcar moleculas bio-organicas, para detectar substancias biologicas de interes y equipos de prueba de diagnostico. MX9708590A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95201197 1995-05-09

Publications (1)

Publication Number Publication Date
MX9708590A true MX9708590A (es) 1998-06-30

Family

ID=8220276

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708590A MX9708590A (es) 1995-05-09 1997-11-07 Metodos para la produccion de ligandos a base de platino entre marcadores y moleculas bio-organicas, para marcar moleculas bio-organicas, para detectar substancias biologicas de interes y equipos de prueba de diagnostico.

Country Status (12)

Country Link
EP (1) EP1019420B1 (es)
JP (1) JPH11505533A (es)
AT (1) ATE246696T1 (es)
AU (1) AU724320B2 (es)
CA (1) CA2218815C (es)
DE (1) DE69629403T2 (es)
DK (1) DK1019420T3 (es)
ES (1) ES2205030T3 (es)
MX (1) MX9708590A (es)
NZ (1) NZ307633A (es)
PT (1) PT1019420E (es)
WO (1) WO1996035696A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT937090E (pt) * 1996-10-08 2002-12-31 Kreatech Biotech Bv Metodos para a marcacao de nucleotidos, nucleotidos marcados e intermediarios uteis
CA2286282A1 (en) * 1997-04-07 1998-10-15 Institut National De La Sante Et De La Recherche Medicale Diagnostic means useful for predictive assessment of human hepatocellular carcinoma disease (hcc), as well as diagnostic methods using the same
WO1998045304A1 (en) * 1997-04-10 1998-10-15 Kreatech Biotechnology B.V. Trans-platinum compound, and diagnostic kit
EP0870770A1 (en) * 1997-04-10 1998-10-14 Kreatech Biotechnology B.V. A trans-platinum based compound, a diagnostic kit comprising said compound and a method for labeling a bio-organic molecule wherein use is made of said compound
EP1006199A1 (en) 1998-12-03 2000-06-07 Kreatech Biotechnology B.V. Applications with and methods for producing selected interstrand crosslinks in nucleic acid
GB0016836D0 (en) 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
EP1221465A1 (en) * 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
EP1373572B1 (en) 2001-03-02 2006-07-26 Stratagene California Compositions and methods using platinum compounds for nucleic acid labeling
DK1262778T3 (da) 2001-05-28 2008-02-18 Kreatech Biotech Bv Fremgangsmåde til differentieret mærkning ved anvendelse af platinkomplekser
US7138520B2 (en) 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
WO2005080331A1 (ja) * 2004-02-23 2005-09-01 Tetsuo Nagano 蛍光プローブ
EP1745802A1 (en) 2005-07-20 2007-01-24 Kreatech Biotechnology B.V. Method of conjugating therapeutic compounds to cell targeting moieties via metal complexes
EP2944647A1 (en) 2007-07-26 2015-11-18 Cellay, Inc. Highly visible chromosome-specific probes and related methods
WO2011153354A1 (en) 2010-06-03 2011-12-08 Cellay, Inc. Methods and kits for in situ detection of nucleotide sequences
WO2013048243A1 (en) 2011-09-29 2013-04-04 Apo-T B.V. Multi-specific binding molecules targeting aberrant cells
JP2015505241A (ja) 2011-12-12 2015-02-19 セレー，インコーポレイテッド 生物学的試料中の標的核酸の室温インサイチュ検出のための方法およびキット
US10668162B2 (en) 2012-01-06 2020-06-02 Linxis B.V. Method for preparing cell targeting conjugates, and the complexes obtained
JP2015504895A (ja) * 2012-01-13 2015-02-16 エーピーオー‐ティー ビー．ヴイ． 毒性部分を備える異常細胞拘束性免疫グロブリン
WO2014070460A1 (en) 2012-10-31 2014-05-08 Cellay, Inc. Methods and kits for performing in situ hybridization
AU2014346735A1 (en) 2013-11-07 2016-06-09 Cellay, Inc. Methods and kits for detecting a prostate carcinoma and predicting disease outcomes for prostate cancers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207416A (en) * 1974-09-05 1980-06-10 Engelhard Minerals & Chemicals Corporation Ethylenediamineplatinum(II) 2,4-dioxopyrimidine complexes
JPS56103192A (en) * 1980-01-18 1981-08-18 Yoshinori Kitani Novel platinum complex
JPS6087295A (ja) * 1983-10-19 1985-05-16 Nippon Kayaku Co Ltd 新規白金錯体
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
EP0386243A4 (en) * 1987-11-06 1990-10-10 Sagami Chemical Research Center Platinum (ii) complexes
US4946954A (en) * 1989-01-17 1990-08-07 Georgetown University Platinum pharmaceutical agents
NL9001639A (nl) * 1990-07-19 1992-02-17 Amc Amsterdam Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen.

Also Published As

Publication number Publication date
WO1996035696A1 (en) 1996-11-14
DE69629403D1 (de) 2003-09-11
CA2218815A1 (en) 1996-11-14
DK1019420T3 (da) 2003-11-24
CA2218815C (en) 2008-05-20
EP1019420B1 (en) 2003-08-06
AU724320B2 (en) 2000-09-14
ATE246696T1 (de) 2003-08-15
NZ307633A (en) 2000-01-28
PT1019420E (pt) 2003-12-31
AU5704096A (en) 1996-11-29
DE69629403T2 (de) 2004-06-24
ES2205030T3 (es) 2004-05-01
EP1019420A1 (en) 2000-07-19
JPH11505533A (ja) 1999-05-21

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