MX9707784A - beta-CARBOLINAS ANELADAS. - Google Patents

beta-CARBOLINAS ANELADAS.

Info

Publication number
MX9707784A
MX9707784A MX9707784A MX9707784A MX9707784A MX 9707784 A MX9707784 A MX 9707784A MX 9707784 A MX9707784 A MX 9707784A MX 9707784 A MX9707784 A MX 9707784A MX 9707784 A MX9707784 A MX 9707784A
Authority
MX
Mexico
Prior art keywords
anellated
carbolines
beta
substituted
compounds
Prior art date
Application number
MX9707784A
Other languages
English (en)
Inventor
Dieter Seidelmann
Andreas Huth
Preben H Olesen
Eckhard Ottow
Jonathan Turner
Margrit Hillmann
Belinda Cole
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MX9707784A publication Critical patent/MX9707784A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen compuestos de la formula (I), en el que A es un anillo insaturado de 5-6 miembros en el cual 1-2 C átomos pueden ser sustituidos por N, O y/o S y el cual puede ser sustituido con R5 y R6, el método para preparalos. Debido con su afinidad con los receptores de benzodiazepina, los compuestos de la formula (I), así como también sus sales pueden ser utilizadas como fármacos. Tienen diferente eficacia intrínseca (es decir, eficacia agonista, antagonista y/o inversamente agonista) con diferentes isoformas del receptor de benzodiazepina GABA.
MX9707784A 1995-04-12 1996-04-03 beta-CARBOLINAS ANELADAS. MX9707784A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19514524A DE19514524A1 (de) 1995-04-12 1995-04-12 Anellierte beta-Carboline
PCT/DE1996/000632 WO1996032392A1 (de) 1995-04-12 1996-04-03 ANELLIERTE β-CARBOLINE

Publications (1)

Publication Number Publication Date
MX9707784A true MX9707784A (es) 1997-12-31

Family

ID=7759938

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9707784A MX9707784A (es) 1995-04-12 1996-04-03 beta-CARBOLINAS ANELADAS.

Country Status (23)

Country Link
US (1) US6127368A (es)
EP (1) EP0820454B1 (es)
JP (1) JPH11503432A (es)
KR (1) KR100379585B1 (es)
CN (1) CN1072224C (es)
AT (1) ATE221068T1 (es)
AU (1) AU703635B2 (es)
CA (1) CA2217719A1 (es)
CZ (1) CZ319997A3 (es)
DE (2) DE19514524A1 (es)
HU (1) HUP9801771A3 (es)
IL (1) IL117734A (es)
MX (1) MX9707784A (es)
MY (1) MY113450A (es)
NO (1) NO309568B1 (es)
NZ (1) NZ304823A (es)
PL (1) PL185554B1 (es)
RU (1) RU2169148C2 (es)
SK (1) SK137097A3 (es)
TR (1) TR199701156T1 (es)
TW (1) TW412535B (es)
WO (1) WO1996032392A1 (es)
ZA (1) ZA962946B (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4130933A1 (de) * 1991-09-13 1993-03-18 Schering Ag Neue (beta)-carbolinderivate, deren herstellung und verwendung in arzneimitteln

Also Published As

Publication number Publication date
EP0820454A1 (de) 1998-01-28
NZ304823A (en) 1999-06-29
KR19980703825A (ko) 1998-12-05
TW412535B (en) 2000-11-21
TR199701156T1 (xx) 1998-02-21
AU5269696A (en) 1996-10-30
EP0820454B1 (de) 2002-07-24
HUP9801771A2 (hu) 1998-11-30
KR100379585B1 (ko) 2004-09-04
DE59609482D1 (de) 2002-08-29
NO309568B1 (no) 2001-02-19
SK137097A3 (en) 1998-08-05
ZA962946B (en) 1996-09-06
PL185554B1 (pl) 2003-05-30
NO974687D0 (no) 1997-10-10
JPH11503432A (ja) 1999-03-26
CZ319997A3 (cs) 1998-06-17
PL322847A1 (en) 1998-02-16
MY113450A (en) 2002-02-28
US6127368A (en) 2000-10-03
CN1181081A (zh) 1998-05-06
AU703635B2 (en) 1999-03-25
IL117734A (en) 1999-08-17
CN1072224C (zh) 2001-10-03
WO1996032392A1 (de) 1996-10-17
RU2169148C2 (ru) 2001-06-20
CA2217719A1 (en) 1996-10-17
NO974687L (no) 1997-12-11
IL117734A0 (en) 1996-07-23
ATE221068T1 (de) 2002-08-15
DE19514524A1 (de) 1996-10-17
HUP9801771A3 (en) 1999-01-28

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