MX9703957A - Antagonistas de taquicinina. - Google Patents

Antagonistas de taquicinina.

Info

Publication number
MX9703957A
MX9703957A MX9703957A MX9703957A MX9703957A MX 9703957 A MX9703957 A MX 9703957A MX 9703957 A MX9703957 A MX 9703957A MX 9703957 A MX9703957 A MX 9703957A MX 9703957 A MX9703957 A MX 9703957A
Authority
MX
Mexico
Prior art keywords
phenyl
sulfur
indol
pyridyl
trifluoromethyl
Prior art date
Application number
MX9703957A
Other languages
English (en)
Other versions
MXPA97003957A (es
Inventor
Soo Young Ko
Christopher Walpole
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9425085.9A external-priority patent/GB9425085D0/en
Priority claimed from GBGB9426016.3A external-priority patent/GB9426016D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX9703957A publication Critical patent/MX9703957A/es
Publication of MXPA97003957A publication Critical patent/MXPA97003957A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Proporcionan compuestos de formula I: en donde R1 es fenilo mono o disustituido, n es cero o 1, X1 es oxígeno, azufre o =NCN, X2 y X3 son cada uno independientemente oxígeno o azufre, R2 es hidrogeno o 5 metilo, R3 es fenilo, fenilosustituido con halo, 2-naftilo, IH indol-3-ilo o 1-metil-indol-3-ilo, Z es -N(CH3)- o -CH2-, R4 es fenilo, 3, 5-bis(trifluorometil)fenilo o piridilo, y R5 es hidrogeno, fenilo, 3,5-bis(trifluorometil)fenilo o piridilo, por lo que, cuando X3 es azufre, Z es -N(CH3)- y una sal de adicion de ácido del mismo que tiene actividad antagonista para taquicina, y son utiles como sustancias farmacéuticas, por ejemplo, para el tratamiento del dolor.
MXPA/A/1997/003957A 1994-12-13 1997-05-29 Antagonistas de taquicinina MXPA97003957A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9425085.9A GB9425085D0 (en) 1994-12-13 1994-12-13 Organic compounds
GB9425085.9 1994-12-13
GB9426016.3 1994-12-22
GBGB9426016.3A GB9426016D0 (en) 1994-12-22 1994-12-22 Organic compounds
PCT/EP1995/004910 WO1996018643A1 (en) 1994-12-13 1995-12-12 Tachykinin antagonists

Publications (2)

Publication Number Publication Date
MX9703957A true MX9703957A (es) 1997-09-30
MXPA97003957A MXPA97003957A (es) 1998-07-03

Family

ID=

Also Published As

Publication number Publication date
CA2204130A1 (en) 1996-06-20
JPH10511935A (ja) 1998-11-17
AR001332A1 (es) 1997-10-22
FI971685A0 (fi) 1997-04-18
PE38997A1 (es) 1997-10-02
EP0797583A1 (en) 1997-10-01
IL116323A0 (en) 1996-03-31
NO972526L (no) 1997-06-03
NO972526D0 (no) 1997-06-03
FI971685A (fi) 1997-08-13
CZ179097A3 (en) 1997-10-15
AU4343796A (en) 1996-07-03
CO4700289A1 (es) 1998-12-29
HUT77002A (hu) 1998-03-02
SK74697A3 (en) 1997-11-05
WO1996018643A1 (en) 1996-06-20
BR9509997A (pt) 1997-12-30
PL320217A1 (en) 1997-09-15
TR199501568A2 (tr) 1996-07-21

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