MX9703375A - Diaminociclobuteno-3,4-dionas. - Google Patents

Diaminociclobuteno-3,4-dionas.

Info

Publication number
MX9703375A
MX9703375A MX9703375A MX9703375A MX9703375A MX 9703375 A MX9703375 A MX 9703375A MX 9703375 A MX9703375 A MX 9703375A MX 9703375 A MX9703375 A MX 9703375A MX 9703375 A MX9703375 A MX 9703375A
Authority
MX
Mexico
Prior art keywords
carbon atoms
alkyl
hydrogen
group
alkylsulfonamido
Prior art date
Application number
MX9703375A
Other languages
English (en)
Other versions
MXPA97003375A (es
Inventor
Madelene Miyoko Antane
John Anthony Butera
Bradford Hammond Hirth
Schuyler Adam Antane
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/340,697 external-priority patent/US5464867A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of MXPA97003375A publication Critical patent/MXPA97003375A/es
Publication of MX9703375A publication Critical patent/MX9703375A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)

Abstract

El compuesto de la formula (I), en donde R1 y R2 son, independientemente de cada uno, el hidrogeno, el alquilo de cadena recta C1-10, alquilo ramificado C1-10, o alquilo cíclico o bicíclico C3-10; R3 es un acilo substituyente seleccionado del grupo que consiste del formilo, alcanoilo de 2 a 7 átomos de carbono, alquenoilo de 3 a 7 átomos de carbono, alquilsulfonilo de 1 a 7 átomos de carbono, aroilo de 7 a 12 átomos de carbono, arilalquenoilo de 9 a 20 átomos de carbono, arilsulfonilo de 6 a 12 átomos de carbono, arilalcanoilo de 8 a 12 átomos de carbono o arilalquilsulfonilo de 7 a 12 átomos de carbono; A se selecciona del grupo que consiste de (a), en donde R4 es hidrogeno, alquilo C1-6, perfluoroalquilo C1-6, alcoxi C1-6, perfluoroalcoxi C1-6, amino, alquilamino C1-6, dialquilamino C2-12, alquilsulfonamido C1-6, alquilcarboxamido que contiene de 2 a 7 átomos de carbono, nitro, ciano, carboxilo; o A es un grupo fenilo de la formula (b), en donde R5 y R6, son independientes de cada uno, seleccionados de los siguientes: ciano, nitro, amino, alquilo C1-6, perfluoroalquilo C1-6, alcoxi C1-6, perfluoroalcoxi C1-6, alquilamino C1-6, dialquilamino C2-12, sulfamilo, alquilsulfonamido C1-6, arilsulfonamido C6-12, alquilcarboxamido que contiene de 2 a 7 átomos de carbono, arilcarboxamido que contiene de 7 a 13 átomos de carbono, alcanoilo de C2 a C6, alquilsulfonilo C1-6, perfluoroalquilsulfonilo C1-6, arilsulfonilo C6-12, cloro, bromo, fluoro, yodo, 1-imidazolilo, carboxilo o hidrogeno; o una sal de éstos farmacéuticamente aceptable, son relajantes del musculo liso.
MX9703375A 1994-11-16 1995-10-03 Diaminociclobuteno-3,4-dionas. MX9703375A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08340697 1994-11-16
US08/340,697 US5464867A (en) 1994-11-16 1994-11-16 Diaminocyclobutene-3,4-diones
US08/459,598 US5512585A (en) 1994-11-16 1995-06-02 Diaminocyclobutene-3,4-diones
US08459598 1995-06-02
US08/460,170 US5530025A (en) 1994-11-16 1995-06-02 Diaminocyclobutene-3,4-diones
US08460170 1995-06-02
PCT/US1995/013125 WO1996015103A1 (en) 1994-11-16 1995-10-03 Diaminocyclobutene-3,4-diones

Publications (2)

Publication Number Publication Date
MXPA97003375A MXPA97003375A (es) 1997-08-01
MX9703375A true MX9703375A (es) 1997-08-30

Family

ID=27407419

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9703375A MX9703375A (es) 1994-11-16 1995-10-03 Diaminociclobuteno-3,4-dionas.

Country Status (16)

Country Link
EP (1) EP0796243B1 (es)
JP (1) JPH10509145A (es)
AT (1) ATE176223T1 (es)
AU (1) AU686896B2 (es)
BR (1) BR9509699A (es)
DE (1) DE69507639T2 (es)
DK (1) DK0796243T3 (es)
ES (1) ES2128774T3 (es)
FI (1) FI972089A (es)
GR (1) GR3029876T3 (es)
HK (1) HK1002276A1 (es)
HU (1) HU218794B (es)
IL (1) IL115547A (es)
MX (1) MX9703375A (es)
NZ (1) NZ294762A (es)
WO (1) WO1996015103A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0028844D0 (en) * 2000-11-27 2001-01-10 Celltech Chiroscience Ltd Chemical compounds
US6495576B2 (en) 2001-02-07 2002-12-17 Abbott Laboratories Aminal diones as potassium channel openers
PT1818325E (pt) * 2001-04-16 2010-05-12 Schering Corp Ciclobuteno-1,2-dionas 3,4-di-substituídas como ligandos de receptor de quimoquina cxc
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US6903131B2 (en) 2001-10-12 2005-06-07 Schering Corporation 3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
NZ535314A (en) 2002-03-18 2007-08-31 Schering Corp Combination treatments for chemokine-mediated diseases
EP1551818B1 (en) 2002-10-09 2009-02-04 Schering Corporation Thiadiazoledioxides and thiadiazoleoxides as cxc- and cc-chemokine receptor ligands
ATE406356T1 (de) 2003-12-19 2008-09-15 Schering Corp Thiadiazole als cxc- und cc- chemokinrezeptorliganden
US7671212B2 (en) 2003-12-22 2010-03-02 Schering Corporation Isothiazole dioxides as CXC- and CC-chemokine receptor ligands
EP2096107A1 (en) 2004-12-23 2009-09-02 GPC Biotech AG Derivatives of squaric acid with anti-proliferative activity
JP2009500334A (ja) 2005-06-29 2009-01-08 シェーリング コーポレイション Ｃｘｃ−ケモカインレセプターリガンドとしてのジ置換オキサジアゾール
ES2353401T3 (es) 2005-06-29 2011-03-01 Schering Corporation Oxidiazolopirazinas y tiadiazolopirazinas 5,6-di-sustituidas como ligandos del receptor de cxc-quimiocina.
CA2647592C (en) * 2006-05-26 2014-01-28 Abbott Laboratories Inhibitors of polo-like kinases
US8450348B2 (en) 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
JP5816082B2 (ja) 2008-06-24 2015-11-17 トポターゲット・アクティーゼルスカブＴｏｐｏＴａｒｇｅｔ Ａ／Ｓ ニコチンアミドの阻害剤としてのスクアリン酸誘導体
MX359259B (es) 2011-09-02 2018-09-20 Novartis Ag Sal de colina de un compuesto anti - inflamatorio de ciclobutenodiona sustituida.
KR102615234B1 (ko) 2018-09-21 2023-12-19 화이자 인코포레이티드 Ccr6 억제제로서 유용한 n-치환된-디옥소시클로부테닐아미노-3-히드록시-피콜린아미드
CN115000402B (zh) * 2022-07-08 2024-06-18 燕山大学 一种有机正极材料及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
US5354763A (en) * 1993-11-17 1994-10-11 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones

Also Published As

Publication number Publication date
FI972089A0 (fi) 1997-05-15
AU3764695A (en) 1996-06-06
JPH10509145A (ja) 1998-09-08
FI972089A (fi) 1997-07-15
HU218794B (hu) 2000-12-28
DK0796243T3 (da) 1999-09-13
DE69507639T2 (de) 1999-09-02
IL115547A (en) 1999-11-30
WO1996015103A1 (en) 1996-05-23
ATE176223T1 (de) 1999-02-15
GR3029876T3 (en) 1999-07-30
HK1002276A1 (en) 1998-08-14
ES2128774T3 (es) 1999-05-16
NZ294762A (en) 1998-11-25
HUT77286A (hu) 1998-03-30
AU686896B2 (en) 1998-02-12
EP0796243A1 (en) 1997-09-24
IL115547A0 (en) 1996-01-19
DE69507639D1 (de) 1999-03-11
BR9509699A (pt) 1998-06-30
EP0796243B1 (en) 1999-01-27

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