MX9605674A - Diguanididas de acidos bencenodicarboxilicos sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents

Diguanididas de acidos bencenodicarboxilicos sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Info

Publication number
MX9605674A
MX9605674A MX9605674A MX9605674A MX9605674A MX 9605674 A MX9605674 A MX 9605674A MX 9605674 A MX9605674 A MX 9605674A MX 9605674 A MX9605674 A MX 9605674A MX 9605674 A MX9605674 A MX 9605674A
Authority
MX
Mexico
Prior art keywords
medicament
diguanidides
ischemia
preparation
well
Prior art date
Application number
MX9605674A
Other languages
English (en)
Inventor
Heinz-Werner Kleemann
Joachim Brendel
Jan-Robert Schwark
Andreas Weichert
Hans Jochen Lang
Udo Albus
Wolfang Scholz
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19543194A external-priority patent/DE19543194A1/de
Priority claimed from DE1996124064 external-priority patent/DE19624064A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MX9605674A publication Critical patent/MX9605674A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Diguanididas de ácidos bencenodicarboxilícos de la formula I (Ver Formula I) en donde R(1) a R(5) tienen los significados indicados en las reivindicaciones, son valiosos medicamentos antiarrítmicos con un componente cardiprotector, también para la prevencion de lesiones inducidas por isquemia, en particular en el desencadenamiento de arritmias del corazon inducidas por isquemia, como consecuencia de la inhibicion del mecanismo celular de intercambio de Na+/H+, se utilizan para el tratamiento de lesiones agudas o cronicas desencadenadas por isquemia. Además de ello, se distinguen por un fuerte efecto inhibidor sobre las proliferaciones de células. Son adecuados para evitar la génesis de la hipertension sanguínea.
MX9605674A 1995-11-20 1996-11-19 Diguanididas de acidos bencenodicarboxilicos sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene. MX9605674A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19543194A DE19543194A1 (de) 1995-11-20 1995-11-20 Substituierte Benzoldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE1996124064 DE19624064A1 (de) 1996-06-17 1996-06-17 Substituierte Benzoldicarbonsäure-diguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
MX9605674A true MX9605674A (es) 1997-05-31

Family

ID=26020502

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605674A MX9605674A (es) 1995-11-20 1996-11-19 Diguanididas de acidos bencenodicarboxilicos sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.

Country Status (18)

Country Link
EP (1) EP0774458A1 (es)
JP (1) JPH09169719A (es)
KR (1) KR980002018A (es)
AR (1) AR004331A1 (es)
AU (1) AU703352B2 (es)
BR (1) BR9605617A (es)
CA (1) CA2190693A1 (es)
CZ (1) CZ338296A3 (es)
HR (1) HRP960547A2 (es)
HU (1) HUP9603201A3 (es)
IL (1) IL119637A0 (es)
MX (1) MX9605674A (es)
NO (2) NO964903D0 (es)
NZ (1) NZ299772A (es)
PL (1) PL316438A1 (es)
SK (1) SK148796A3 (es)
TR (1) TR199600916A2 (es)
TW (1) TW353657B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819548A1 (de) 1998-04-30 1999-11-04 Merck Patent Gmbh Biphenylderivate
DE10044732A1 (de) * 2000-09-09 2002-03-21 Mahle Ventiltrieb Gmbh Rollenstößel für einen Verbrennungsmotor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE139526T1 (de) * 1992-02-15 1996-07-15 Hoechst Ag 3,5-substituierte benzoylguanidine, mit antiarrythmischer wirkung und inhibierender wirkung auf die proliferationen von zellen
IL109570A0 (en) 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
IL114670A0 (en) * 1994-08-05 1995-11-27 Fujisawa Pharmaceutical Co Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof

Also Published As

Publication number Publication date
SK148796A3 (en) 1997-10-08
NO964905L (no) 1997-05-21
NO964903D0 (no) 1996-11-19
HUP9603201A2 (en) 1997-05-28
JPH09169719A (ja) 1997-06-30
AU7180496A (en) 1997-05-29
IL119637A0 (en) 1997-02-18
CZ338296A3 (cs) 1998-05-13
HUP9603201A3 (en) 1997-11-28
HRP960547A2 (en) 1998-02-28
BR9605617A (pt) 1998-08-18
NZ299772A (en) 1998-12-23
CA2190693A1 (en) 1997-05-21
EP0774458A1 (de) 1997-05-21
TR199600916A2 (tr) 1997-06-21
PL316438A1 (en) 1997-05-26
AR004331A1 (es) 1998-11-04
TW353657B (en) 1999-03-01
KR980002018A (ko) 1998-03-30
HU9603201D0 (en) 1997-01-28
NO964905D0 (no) 1996-11-19
AU703352B2 (en) 1999-03-25

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