MX9601175A - Carotenoides, retinoides y polienos conjugados relacionados, en estado oxidado, y sus fracciones y compuestos derivados, utiles como inductores de la diferenciacion de celulas, agentes citostaticos y agentes anti-tumorales. - Google Patents
Carotenoides, retinoides y polienos conjugados relacionados, en estado oxidado, y sus fracciones y compuestos derivados, utiles como inductores de la diferenciacion de celulas, agentes citostaticos y agentes anti-tumorales.Info
- Publication number
- MX9601175A MX9601175A MX9601175A MX9601175A MX9601175A MX 9601175 A MX9601175 A MX 9601175A MX 9601175 A MX9601175 A MX 9601175A MX 9601175 A MX9601175 A MX 9601175A MX 9601175 A MX9601175 A MX 9601175A
- Authority
- MX
- Mexico
- Prior art keywords
- oxidized
- beta
- carotene
- vitamin
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
El beta-caroteno, licopeno y cantaxantina, como carotenoides representativos, y, en una extension menor, el ácido retinoico, un retinoide representativo, se someten a una oxidacion extensa para suministrar substancias, de las cuales el beta-caroteno oxidado es un modelo, las cuales tienen propiedades utiles como agentes no toxicos contra la proliferacion de células, tumores y virus tumorigénicos, y son utiles como promotores de la diferenciacion celular. Es evidente, del análisis químico de la mezcla altamente oxidada de productos de beta-caroteno, que ninguna de las varias formas de la vitamina A está presente o solo en cantidades menores. Asimismo, las actividades biologicas de la cantaxantina y licopeno oxidados, que forman la vitamina A, indican la presencia de substancias activas, diferentes de la vitamina A. Aunque las actividades citostáticas y de promocion de la diferienciacion del beta-caroteno oxidado se asemejan a las de la propia vitamina A, en general, sus efectos son más potentes, en una amplia variedad de circunstancias. Diferentemente de la vitamina A, el beta-caroteno oxidado, segun la invencion, no es toxico. El carotenoide oxidado es una mezcla de compuestos que se pueden dividir en un numero de fracciones, de acuerdo con el peso molecular y la polaridad. Las fracciones exhiben una actividad contra el cáncer comparable a, o mayor que, la actividad contra el cáncer comparable a, o mayor que, la actividad del carotenoide oxidado no fraccionado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/288,315 US5475006A (en) | 1994-08-10 | 1994-08-10 | Extensively oxidized derivatives of carotenoids, retinoids and related conjugated polyenes useful as non-toxic cell-differentiation inducers, anti-proliferative agents, and anti-tumor agents |
PCT/CA1995/000484 WO1996005160A1 (en) | 1994-08-10 | 1995-08-10 | Oxidized carotenoids, retinoids and related conjugated polyenes, and derived fractions and compounds useful as cell-differentiation inducers, cytostatic agents, and anti-tumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9601175A true MX9601175A (es) | 1997-06-28 |
Family
ID=23106590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9601175A MX9601175A (es) | 1994-08-10 | 1995-08-10 | Carotenoides, retinoides y polienos conjugados relacionados, en estado oxidado, y sus fracciones y compuestos derivados, utiles como inductores de la diferenciacion de celulas, agentes citostaticos y agentes anti-tumorales. |
Country Status (19)
Country | Link |
---|---|
US (1) | US5475006A (es) |
EP (1) | EP0722431B1 (es) |
JP (1) | JP3983800B2 (es) |
KR (1) | KR100404724B1 (es) |
CN (1) | CN1131939A (es) |
AT (1) | ATE201394T1 (es) |
AU (1) | AU704640B2 (es) |
CA (1) | CA2171625C (es) |
CZ (1) | CZ103896A3 (es) |
DE (1) | DE69521020T2 (es) |
ES (1) | ES2160172T3 (es) |
FI (1) | FI961544A0 (es) |
GB (1) | GB2297325B (es) |
HK (1) | HK1013814A1 (es) |
MX (1) | MX9601175A (es) |
NZ (1) | NZ290769A (es) |
PL (1) | PL184296B1 (es) |
PT (1) | PT722431E (es) |
WO (1) | WO1996005160A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6432711B1 (en) * | 1993-11-03 | 2002-08-13 | Diacrin, Inc. | Embryonic stem cells capable of differentiating into desired cell lines |
US7132458B2 (en) * | 1994-08-10 | 2006-11-07 | Chemaphor Inc. | Oxidized carotenoid fractions and ketoaldehyde useful as cell-differentiation inducers, cytostatic agents, and anti-tumor agents |
US20040228871A1 (en) * | 1999-06-03 | 2004-11-18 | Tayyaba Hasan | Treatment and analysis of proliferative disorders |
IL135335A (en) * | 2000-03-29 | 2013-12-31 | Lycored Natural Prod Ind Ltd | Use of Carotenoids in Preparing Pharmaceuticals to Prevent Adverse Effects from Hormones and Pharmaceuticals Containing Carotenoids |
US20020031539A1 (en) * | 2000-08-30 | 2002-03-14 | The Brigham And Women's Hospital, Inc. | Oxidized forms of retinoic acid as ligands for peroxisome proliferator activated receptor gamma |
US20050037048A1 (en) * | 2003-08-11 | 2005-02-17 | Young-Ho Song | Medical devices containing antioxidant and therapeutic agent |
US20050064011A1 (en) * | 2003-08-11 | 2005-03-24 | Young-Ho Song | Implantable or insertable medical devices containing phenolic compound for inhibition of restenosis |
AU2005213895A1 (en) * | 2004-02-19 | 2005-09-01 | Chemaphor Inc. | Topical formulations for the treatment of skin conditions |
MX2007003773A (es) | 2004-09-28 | 2009-01-19 | Chemaphor Inc | Composiciones y metodos para promover ganancia de peso y conversion de alimentacion. |
US20090069417A1 (en) * | 2005-10-11 | 2009-03-12 | Yoav Sharoni | Carotenoid oxidation products as chemopreventive and chemotherapeutic agents |
US20090306222A1 (en) * | 2006-04-05 | 2009-12-10 | Chemaphor Inc. | Food supplements and uses thereof |
CA2698812A1 (en) | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
AU2008316225B2 (en) * | 2007-10-26 | 2014-06-19 | Avivagen Inc. | Compositions and methods for enhancing immune response |
EP2424512B1 (en) * | 2009-04-30 | 2020-06-03 | Avivagen Inc. | Methods and compositions for improving the health of animals |
MX2017013890A (es) | 2015-04-28 | 2018-03-15 | Avivagen Inc | Carotenoides oxidados y componentes de los mismos para prevenir enteritis necrotica. |
EP3337565A4 (en) * | 2015-08-20 | 2019-04-10 | IBR - Israeli Biotechnology Research Ltd. | CAROTINOID COMPOSITIONS WITH ANTIVIRAL EFFECT AND USE THEREOF |
CA3015322C (en) * | 2016-02-25 | 2023-01-03 | Avivagen Inc. | Plant or microorganism-derived carotenoid-oxygen copolymer compositions, methods of identifying, quantifying and producing same and uses thereof |
CN106614301A (zh) * | 2016-11-14 | 2017-05-10 | 鄂尔多斯市绿食保山羊食品有限公司 | 山羊的有机养殖方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2505869C3 (de) * | 1975-02-12 | 1978-05-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von symmetrischen Carotinoiden |
DE2635802C2 (de) * | 1976-08-09 | 1984-03-01 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von symmetrischen Carotinoiden |
DK595489D0 (da) * | 1989-11-27 | 1989-11-27 | Neurosearch As | Hydroxycarbonylderivater og fremgangsmaade til fremstilling af samme |
US5225604A (en) * | 1989-11-27 | 1993-07-06 | Neurosearch A/S | Hydroxycarbonyl derivatives and process for making the same |
US5310554A (en) * | 1992-10-27 | 1994-05-10 | Natural Carotene Corporation | High purity beta-carotene |
US5358915A (en) * | 1993-02-12 | 1994-10-25 | American Colloid Company | Process for regenerating spent acid-activated bentonite clays and smectite catalysts |
-
1994
- 1994-08-10 US US08/288,315 patent/US5475006A/en not_active Expired - Lifetime
-
1995
- 1995-08-10 JP JP50688496A patent/JP3983800B2/ja not_active Expired - Fee Related
- 1995-08-10 NZ NZ290769A patent/NZ290769A/en not_active IP Right Cessation
- 1995-08-10 MX MX9601175A patent/MX9601175A/es unknown
- 1995-08-10 CN CN95190750A patent/CN1131939A/zh active Pending
- 1995-08-10 KR KR1019960701872A patent/KR100404724B1/ko not_active IP Right Cessation
- 1995-08-10 ES ES95927612T patent/ES2160172T3/es not_active Expired - Lifetime
- 1995-08-10 AU AU31600/95A patent/AU704640B2/en not_active Ceased
- 1995-08-10 WO PCT/CA1995/000484 patent/WO1996005160A1/en not_active Application Discontinuation
- 1995-08-10 EP EP95927612A patent/EP0722431B1/en not_active Expired - Lifetime
- 1995-08-10 AT AT95927612T patent/ATE201394T1/de active
- 1995-08-10 PL PL95313907A patent/PL184296B1/pl not_active IP Right Cessation
- 1995-08-10 PT PT95927612T patent/PT722431E/pt unknown
- 1995-08-10 GB GB9604444A patent/GB2297325B/en not_active Expired - Fee Related
- 1995-08-10 CZ CZ961038A patent/CZ103896A3/cs unknown
- 1995-08-10 DE DE69521020T patent/DE69521020T2/de not_active Expired - Lifetime
- 1995-08-10 CA CA002171625A patent/CA2171625C/en not_active Expired - Fee Related
-
1996
- 1996-04-09 FI FI961544A patent/FI961544A0/fi unknown
-
1998
- 1998-12-24 HK HK98115319A patent/HK1013814A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GB2297325B (en) | 1999-01-13 |
KR960704828A (ko) | 1996-10-09 |
FI961544A (fi) | 1996-04-09 |
WO1996005160A1 (en) | 1996-02-22 |
JP3983800B2 (ja) | 2007-09-26 |
US5475006A (en) | 1995-12-12 |
FI961544A0 (fi) | 1996-04-09 |
ATE201394T1 (de) | 2001-06-15 |
PT722431E (pt) | 2001-11-30 |
GB2297325A (en) | 1996-07-31 |
EP0722431A1 (en) | 1996-07-24 |
JPH09504038A (ja) | 1997-04-22 |
EP0722431B1 (en) | 2001-05-23 |
ES2160172T3 (es) | 2001-11-01 |
DE69521020T2 (de) | 2001-11-15 |
PL184296B1 (pl) | 2002-09-30 |
CA2171625A1 (en) | 1996-02-22 |
CA2171625C (en) | 2008-10-14 |
DE69521020D1 (de) | 2001-06-28 |
AU704640B2 (en) | 1999-04-29 |
PL313907A1 (en) | 1996-08-05 |
KR100404724B1 (ko) | 2004-04-03 |
HK1013814A1 (en) | 1999-09-10 |
CZ103896A3 (en) | 1996-11-13 |
GB9604444D0 (en) | 1996-05-01 |
NZ290769A (en) | 1998-08-26 |
AU3160095A (en) | 1996-03-07 |
CN1131939A (zh) | 1996-09-25 |
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