MX9306730A - Carbamatos de alcoxicarbonil y arilcarbonil de rapamicina y composicion farmaceutica que los contiene. - Google Patents

Carbamatos de alcoxicarbonil y arilcarbonil de rapamicina y composicion farmaceutica que los contiene.

Info

Publication number
MX9306730A
MX9306730A MX9306730A MX9306730A MX9306730A MX 9306730 A MX9306730 A MX 9306730A MX 9306730 A MX9306730 A MX 9306730A MX 9306730 A MX9306730 A MX 9306730A MX 9306730 A MX9306730 A MX 9306730A
Authority
MX
Mexico
Prior art keywords
carbamates
image
arycarbonyl
rapamicine
alcoxycarbonyl
Prior art date
Application number
MX9306730A
Other languages
English (en)
Inventor
Wenling Kao
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of MX9306730A publication Critical patent/MX9306730A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención proporciona carbamatos de N-arilcarbonilo y N-alcoxicarbonilo de rapamicina de la fórmula mostrada en lo siguiente, en la que (Ver Fórmula); R1 es C-N-C-A Y R2 es H o CCH2(R4)2 o (Ver Fórmula); R1 y R2 son ambos -C-N-C-A y en donde A es alcoxi inferior o arilo o heteroarilo, R3 es H o metilo y R4 es alquilo de C1-C6, alquenilo C2-C6 o alquinilo C2-C6 que poseen actividad inmunosupresora y/o antifúngica y/o antitumoral y/o antiinflamatoria in vitro y/o inhibir la proliferación de timocito in vivo. Estos compuestos se espera que sean útiles en el tratamiento de rechazo a transplantes, enfermedades autoinmunes, infecciones por hongos, cáncer y enfermedades de inflamación.
MX9306730A 1992-10-29 1993-10-28 Carbamatos de alcoxicarbonil y arilcarbonil de rapamicina y composicion farmaceutica que los contiene. MX9306730A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/968,115 US5262423A (en) 1992-10-29 1992-10-29 Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents

Publications (1)

Publication Number Publication Date
MX9306730A true MX9306730A (es) 1994-06-30

Family

ID=25513757

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9306730A MX9306730A (es) 1992-10-29 1993-10-28 Carbamatos de alcoxicarbonil y arilcarbonil de rapamicina y composicion farmaceutica que los contiene.

Country Status (12)

Country Link
US (1) US5262423A (es)
EP (1) EP0666861B1 (es)
JP (1) JPH08502748A (es)
AT (1) ATE166653T1 (es)
AU (1) AU5322294A (es)
CA (1) CA2148247A1 (es)
DE (1) DE69318846T2 (es)
DK (1) DK0666861T3 (es)
ES (1) ES2116471T3 (es)
MX (1) MX9306730A (es)
TW (1) TW239136B (es)
WO (1) WO1994010176A1 (es)

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Also Published As

Publication number Publication date
DK0666861T3 (da) 1998-11-09
DE69318846T2 (de) 1999-01-28
US5262423A (en) 1993-11-16
CA2148247A1 (en) 1994-05-11
DE69318846D1 (en) 1998-07-02
ES2116471T3 (es) 1998-07-16
ATE166653T1 (de) 1998-06-15
JPH08502748A (ja) 1996-03-26
AU5322294A (en) 1994-05-24
EP0666861A1 (en) 1995-08-16
WO1994010176A1 (en) 1994-05-11
TW239136B (es) 1995-01-21
EP0666861B1 (en) 1998-05-27

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