US5362718A
(en)
*
|
1994-04-18 |
1994-11-08 |
American Home Products Corporation |
Rapamycin hydroxyesters
|
US5491231A
(en)
*
|
1994-11-28 |
1996-02-13 |
American Home Products Corporation |
Hindered N-oxide esters of rapamycin
|
US5563145A
(en)
*
|
1994-12-07 |
1996-10-08 |
American Home Products Corporation |
Rapamycin 42-oximes and hydroxylamines
|
US7056935B2
(en)
*
|
1995-06-07 |
2006-06-06 |
Gpi Nil Holdings, Inc. |
Rotamase enzyme activity inhibitors
|
US5780462A
(en)
*
|
1995-12-27 |
1998-07-14 |
American Home Products Corporation |
Water soluble rapamycin esters
|
US5922730A
(en)
*
|
1996-09-09 |
1999-07-13 |
American Home Products Corporation |
Alkylated rapamycin derivatives
|
US20010049381A1
(en)
*
|
1997-06-04 |
2001-12-06 |
Gpl Nil Holdings, Inc., |
Pyrrolidine derivative hair growth compositions and uses
|
US6274602B1
(en)
*
|
1998-06-03 |
2001-08-14 |
Gpi Nil Holdings, Inc. |
Heterocyclic thioester and ketone hair growth compositions and uses
|
US6187784B1
(en)
|
1998-06-03 |
2001-02-13 |
Gpi Nil Holdings, Inc. |
Pipecolic acid derivative hair growth compositions and uses
|
US6271244B1
(en)
|
1998-06-03 |
2001-08-07 |
Gpi Nil Holdings, Inc. |
N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
|
US5945441A
(en)
*
|
1997-06-04 |
1999-08-31 |
Gpi Nil Holdings, Inc. |
Pyrrolidine carboxylate hair revitalizing agents
|
US6187796B1
(en)
|
1998-06-03 |
2001-02-13 |
Gpi Nil Holdings, Inc. |
Sulfone hair growth compositions and uses
|
US6172087B1
(en)
|
1998-06-03 |
2001-01-09 |
Gpi Nil Holding, Inc. |
N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
|
EP1083872A1
(de)
*
|
1998-06-03 |
2001-03-21 |
GPI NIL Holdings, Inc. |
Haarwuchszusammensetzungen basierend auf pipekolinsäurederivaten
|
US6274617B1
(en)
|
1998-06-03 |
2001-08-14 |
Gpi Nil Holdings, Inc. |
Heterocyclic ester and amide hair growth compositions and uses
|
US6429215B1
(en)
|
1998-06-03 |
2002-08-06 |
Gpi Nil Holdings, Inc. |
N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
|
US6015809A
(en)
*
|
1998-08-17 |
2000-01-18 |
American Home Products Corporation |
Photocyclized rapamycin
|
US6331547B1
(en)
|
1999-08-18 |
2001-12-18 |
American Home Products Corporation |
Water soluble SDZ RAD esters
|
US6277983B1
(en)
|
2000-09-27 |
2001-08-21 |
American Home Products Corporation |
Regioselective synthesis of rapamycin derivatives
|
US20050002986A1
(en)
*
|
2000-05-12 |
2005-01-06 |
Robert Falotico |
Drug/drug delivery systems for the prevention and treatment of vascular disease
|
US8236048B2
(en)
|
2000-05-12 |
2012-08-07 |
Cordis Corporation |
Drug/drug delivery systems for the prevention and treatment of vascular disease
|
US6670355B2
(en)
*
|
2000-06-16 |
2003-12-30 |
Wyeth |
Method of treating cardiovascular disease
|
US6511986B2
(en)
|
2000-08-11 |
2003-01-28 |
Wyeth |
Method of treating estrogen receptor positive carcinoma
|
AU2001290841A1
(en)
|
2000-09-19 |
2002-04-02 |
American Home Products Corporation |
Water soluble rapamycin esters
|
US6399625B1
(en)
|
2000-09-27 |
2002-06-04 |
Wyeth |
1-oxorapamycins
|
AU9486901A
(en)
*
|
2000-09-29 |
2002-04-08 |
Cordis Corp |
Coated medical devices
|
US6399626B1
(en)
|
2000-10-02 |
2002-06-04 |
Wyeth |
Hydroxyesters of 7-desmethylrapamycin
|
US6440991B1
(en)
|
2000-10-02 |
2002-08-27 |
Wyeth |
Ethers of 7-desmethlrapamycin
|
US7829084B2
(en)
*
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
PT1553940E
(pt)
|
2002-07-30 |
2008-05-09 |
Wyeth Corp |
Formulações parentéricas contendo um hidroxi-éster de rapamicina
|
WO2004060283A2
(en)
|
2002-12-16 |
2004-07-22 |
Nitromed, Inc. |
Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
|
TWI492750B
(zh)
*
|
2003-01-27 |
2015-07-21 |
安德賽特公司 |
維生素-受體結合性藥物輸送共軛物、醫藥組合物、用途及製備方法
|
US7349971B2
(en)
*
|
2004-02-05 |
2008-03-25 |
Scenera Technologies, Llc |
System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information
|
DK1735321T3
(da)
*
|
2004-04-14 |
2009-01-12 |
Wyeth Corp |
Fremgangsmåde til fremstilling af rapamycin 42-estere og FK-506 32-estere med dicarboxylsyre, precursors for rapamycinkonjugater og antistoffer
|
MXPA06012404A
(es)
*
|
2004-04-27 |
2007-01-17 |
Wyeth Corp |
Marcado de rapamicina usando metilasas especificas de rapamicina.
|
EP1768662A2
(de)
|
2004-06-24 |
2007-04-04 |
Novartis Vaccines and Diagnostics, Inc. |
Immunstimulatoren kleiner moleküle und assays für deren nachweis
|
JP5149620B2
(ja)
|
2004-07-23 |
2013-02-20 |
エンドサイト,インコーポレイテッド |
2価リンカーおよびその結合体
|
RU2007112787A
(ru)
*
|
2004-10-28 |
2008-12-10 |
Вайет (Us) |
ПРИМЕНЕНИЕ ИНГИБИТОРА mTOR ПРИ ЛЕЧЕНИИ ЛЕЙОМИОМЫ МАТКИ
|
GB0503936D0
(en)
|
2005-02-25 |
2005-04-06 |
San Raffaele Centro Fond |
Method
|
JP5289935B2
(ja)
*
|
2005-03-16 |
2013-09-11 |
エンドサイト,インコーポレイテッド |
プテロイン酸およびその結合体の合成と精製
|
DK1912675T3
(en)
|
2005-07-25 |
2014-03-24 |
Emergent Product Dev Seattle |
B-cell reduction using specific and cd37-cd20-specific binding molecules
|
WO2007022494A2
(en)
*
|
2005-08-19 |
2007-02-22 |
Endocyte, Inc. |
Multi-drug ligand conjugates
|
TW200803892A
(en)
|
2005-11-04 |
2008-01-16 |
Wyeth Corp |
Antineoplastic combinations with MTOR inhibitor, herceptin, and/or HKI-272
|
BRPI0619493A2
(pt)
|
2005-12-07 |
2016-09-06 |
Wyeth Corp |
forma cristalina purificada de cci-779, processo para a purificação de cc-779, produto, método para monitorar a cristalização de cci-779, kit, composição farmacêutica, método para o tratamento de câncer, e, uso de um cci-779 purificado
|
CA2630786A1
(en)
*
|
2005-12-07 |
2007-06-14 |
Wyeth |
Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
|
JP2009518412A
(ja)
|
2005-12-07 |
2009-05-07 |
ワイス |
ラパマイシン42−エステルボロネートからラパマイシン42−エステルを調製するためのスケーラブルな方法
|
US7678901B2
(en)
*
|
2006-02-28 |
2010-03-16 |
Wyeth |
Rapamycin analogs containing an antioxidant moiety
|
US20080051691A1
(en)
*
|
2006-08-28 |
2008-02-28 |
Wyeth |
Implantable shunt or catheter enabling gradual delivery of therapeutic agents
|
US20080175887A1
(en)
*
|
2006-11-20 |
2008-07-24 |
Lixiao Wang |
Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
|
US8414525B2
(en)
|
2006-11-20 |
2013-04-09 |
Lutonix, Inc. |
Drug releasing coatings for medical devices
|
US8430055B2
(en)
|
2008-08-29 |
2013-04-30 |
Lutonix, Inc. |
Methods and apparatuses for coating balloon catheters
|
US9737640B2
(en)
|
2006-11-20 |
2017-08-22 |
Lutonix, Inc. |
Drug releasing coatings for medical devices
|
US8414526B2
(en)
|
2006-11-20 |
2013-04-09 |
Lutonix, Inc. |
Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
|
US8414910B2
(en)
|
2006-11-20 |
2013-04-09 |
Lutonix, Inc. |
Drug releasing coatings for medical devices
|
US20080276935A1
(en)
|
2006-11-20 |
2008-11-13 |
Lixiao Wang |
Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
|
US8998846B2
(en)
|
2006-11-20 |
2015-04-07 |
Lutonix, Inc. |
Drug releasing coatings for balloon catheters
|
US8425459B2
(en)
|
2006-11-20 |
2013-04-23 |
Lutonix, Inc. |
Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
|
US9700704B2
(en)
|
2006-11-20 |
2017-07-11 |
Lutonix, Inc. |
Drug releasing coatings for balloon catheters
|
WO2008083169A2
(en)
*
|
2006-12-26 |
2008-07-10 |
The Johns Hopkins University |
Compositions and methods for the treatment of immunologic disorders
|
US20090142342A1
(en)
*
|
2006-12-27 |
2009-06-04 |
Johns Hopkins University |
B7-h4 receptor agonist compositions and methods for treating inflammation and auto-immune diseases
|
US7989173B2
(en)
*
|
2006-12-27 |
2011-08-02 |
The Johns Hopkins University |
Detection and diagnosis of inflammatory disorders
|
CA2673752A1
(en)
*
|
2006-12-27 |
2008-07-10 |
The Johns Hopkins University |
Compositions and methods for stimulating an immune response
|
US20100104626A1
(en)
|
2007-02-16 |
2010-04-29 |
Endocyte, Inc. |
Methods and compositions for treating and diagnosing kidney disease
|
US9555139B2
(en)
|
2007-03-14 |
2017-01-31 |
Endocyte, Inc. |
Binding ligand linked drug delivery conjugates of tubulysins
|
TW200901989A
(en)
|
2007-04-10 |
2009-01-16 |
Wyeth Corp |
Anti-tumor activity of CCI-779 in papillary renal cell cancer
|
US9877965B2
(en)
|
2007-06-25 |
2018-01-30 |
Endocyte, Inc. |
Vitamin receptor drug delivery conjugates for treating inflammation
|
ES2732879T3
(es)
|
2007-06-25 |
2019-11-26 |
Endocyte Inc |
Conjugados que contienen enlazantes espaciadores hidrófilos
|
BRPI0814060A2
(pt)
*
|
2007-07-06 |
2015-01-06 |
Trubion Pharmaceuticals Inc |
Peptídeos ligantes tendo um domínio de ligação específico disposto em c-terminal
|
US20100048913A1
(en)
|
2008-03-14 |
2010-02-25 |
Angela Brodie |
Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
|
JP5647098B2
(ja)
|
2008-03-21 |
2014-12-24 |
ザ ユニヴァーシティー オヴ シカゴ |
オピオイド拮抗薬とmTOR阻害薬を用いた治療
|
JP6013733B2
(ja)
*
|
2008-04-11 |
2016-10-25 |
エマージェント プロダクト デベロップメント シアトル, エルエルシー |
Cd37免疫治療薬および二機能性化学療法薬とのその組合せ
|
CN104042612A
(zh)
|
2008-11-11 |
2014-09-17 |
得克萨斯大学体系董事会 |
哺乳动物雷帕霉素靶蛋白的抑制
|
CN102686600A
(zh)
|
2009-02-05 |
2012-09-19 |
托凯药业股份有限公司 |
甾体cyp17抑制剂/抗雄激素物质的新型药物前体
|
EP2473521A2
(de)
|
2009-08-31 |
2012-07-11 |
Amplimmune, Inc. |
B7-h4-fusionsproteine und ihre verwendung
|
US20120316137A1
(en)
|
2009-10-30 |
2012-12-13 |
Ariad Pharmaceuticals, Inc. |
Methods and Compositions for Treating Cancer
|
US9283211B1
(en)
|
2009-11-11 |
2016-03-15 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
WO2015103447A1
(en)
|
2013-12-31 |
2015-07-09 |
Rapamycin Holdings, Llc |
Oral rapamycin nanoparticle preparations and use
|
CA2792258A1
(en)
|
2010-03-05 |
2011-09-09 |
President And Fellows Of Harvard College |
Induced dendritic cell compositions and uses thereof
|
CN102844049B
(zh)
|
2010-04-27 |
2016-06-01 |
罗切格利卡特公司 |
无岩藻糖基化CD20抗体与mTOR抑制剂的联合疗法
|
US9896730B2
(en)
|
2011-04-25 |
2018-02-20 |
OSI Pharmaceuticals, LLC |
Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
|
EP2532740A1
(de)
|
2011-06-11 |
2012-12-12 |
Michael Schmück |
Antigenspezifische CD4+ und CD8+ zentrale Gedächtnis-T-Zellpräparate für adoptive T-Zelltherapie
|
WO2013126797A1
(en)
|
2012-02-24 |
2013-08-29 |
Purdue Research Foundation |
Cholecystokinin b receptor targeting for imaging and therapy
|
US20140080175A1
(en)
|
2012-03-29 |
2014-03-20 |
Endocyte, Inc. |
Processes for preparing tubulysin derivatives and conjugates thereof
|
WO2013155487A1
(en)
|
2012-04-12 |
2013-10-17 |
Yale University |
Vehicles for controlled delivery of different pharmaceutical agents
|
US20150290176A1
(en)
|
2012-10-12 |
2015-10-15 |
The Board Of Regents Of The University Of Texas System |
Use of mtor inhibitors to treat vascular cognitive impairment
|
WO2014062697A2
(en)
|
2012-10-16 |
2014-04-24 |
Endocyte, Inc. |
Drug delivery conjugates containing unnatural amino acids and methods for using
|
EP2914260A1
(de)
|
2012-10-31 |
2015-09-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Verfahren zur vorbeugung des antiphospholipid-syndroms (aps)
|
WO2014100439A2
(en)
|
2012-12-19 |
2014-06-26 |
Amplimmune, Inc. |
B7-h4 specific antibodies, and compositions and methods of use thereof
|
DK2968281T3
(da)
|
2013-03-13 |
2020-11-02 |
Univ Texas |
Mtor-hæmmere til forebyggelse af vækst af tarmpolyp
|
CA2904170A1
(en)
|
2013-03-14 |
2014-09-25 |
University Of Maryland, Baltimore |
Androgen receptor down-regulating agents and uses thereof
|
EP2997373A1
(de)
|
2013-05-17 |
2016-03-23 |
MedImmune, LLC |
Rezeptoren für b7-h4
|
CA2920317A1
(en)
|
2013-08-12 |
2015-02-19 |
Tokai Pharmaceuticals, Inc. |
Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
|
US9700544B2
(en)
|
2013-12-31 |
2017-07-11 |
Neal K Vail |
Oral rapamycin nanoparticle preparations
|
WO2015149001A1
(en)
|
2014-03-27 |
2015-10-01 |
The Brigham And Women's Hospital, Inc. |
Metabolically-activated drug conjugates to overcome resistance in cancer therapy
|
CA2968049A1
(en)
|
2014-04-16 |
2015-10-22 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
JP2017518307A
(ja)
|
2014-06-02 |
2017-07-06 |
チルドレンズ メディカル センター コーポレーション |
免疫調節のための方法および組成物
|
CN105461738B
(zh)
*
|
2014-06-03 |
2019-03-08 |
中国人民解放军军事医学科学院毒物药物研究所 |
一种雷帕霉素衍生物、其制备方法、其药物组合物及用途
|
MX2017001981A
(es)
|
2014-09-11 |
2017-12-12 |
Univ California |
Inhibidores de diana de rapamicina en celulas de mamifero de complejo 1 (mtorc1).
|
WO2017029391A1
(en)
|
2015-08-20 |
2017-02-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New method for treating cancer
|
AU2016316119A1
(en)
|
2015-09-04 |
2018-04-19 |
Yale University |
Polymeric bile acid nanocompositions targeting the pancreas and colon
|
US20190117799A1
(en)
|
2016-04-01 |
2019-04-25 |
The Brigham And Women's Hospital, Inc. |
Stimuli-responsive nanoparticles for biomedical applications
|
CA3032826A1
(en)
|
2016-08-03 |
2018-02-08 |
Nextcure, Inc. |
Compositions and methods for modulating lair signal transduction
|
KR20240035625A
(ko)
|
2016-09-21 |
2024-03-15 |
넥스트큐어 인코포레이티드 |
Siglec-15를 위한 항체 및 이의 사용 방법
|
EP4360714A3
(de)
|
2016-09-21 |
2024-07-24 |
Nextcure, Inc. |
Antikörper für siglec-15 und verfahren zur verwendung davon
|
ES2871499T3
(es)
|
2017-05-15 |
2021-10-29 |
Bard Inc C R |
Dispositivo médico con recubrimiento de elución de fármaco y capa intermedia
|
WO2019002168A1
(en)
|
2017-06-26 |
2019-01-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING OLMSTED SYNDROME
|
JP2020527044A
(ja)
|
2017-07-13 |
2020-09-03 |
アンセルム(アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル) |
CD8+CD45RCLOW/−Treg集団の拡大増殖および免疫抑制能力を高めるための方法
|
TW202014208A
(zh)
|
2018-05-01 |
2020-04-16 |
美商銳新醫藥公司 |
作為mTOR抑制劑之C40-、C28-及C-32連接之雷帕黴素類似物
|
EP3788050B1
(de)
|
2018-05-01 |
2024-08-28 |
Revolution Medicines, Inc. |
C26-verknüpfte rapamycinanaloga als mtor-inhibitoren
|
US11517628B2
(en)
|
2018-05-09 |
2022-12-06 |
Yale University |
Particles for spatiotemporal release of agents
|
US20210115378A1
(en)
|
2018-05-09 |
2021-04-22 |
Yale University |
Compositions and systems for ex vivo cell modulation and methods of use thereof
|
CN113164557A
(zh)
|
2018-07-23 |
2021-07-23 |
因柯利尔疗法公司 |
治疗神经性病症的方法
|
WO2020023417A1
(en)
|
2018-07-23 |
2020-01-30 |
Enclear Therapies, Inc. |
Methods of treating neurological disorders
|
EP3849545A1
(de)
|
2018-09-10 |
2021-07-21 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Verfahren zur behandlung von neurofibromatose
|
CN113226389B
(zh)
|
2018-11-14 |
2022-11-08 |
乐通公司 |
在经改性设备表面上具有药物洗脱涂层的医疗设备
|
CA3123886A1
(en)
|
2019-01-17 |
2020-07-23 |
James DAHLMAN |
Drug delivery systems containing oxidized cholesterols
|
CN113939324A
(zh)
|
2019-04-08 |
2022-01-14 |
巴德外周血管股份有限公司 |
在经改性装置表面上具有药物洗脱涂层的医疗装置
|
AU2020271894A1
(en)
|
2019-04-11 |
2021-12-02 |
Enclear Therapies, Inc. |
Methods of amelioration of cerebrospinal fluid and devices and systems therefor
|
CN116600789A
(zh)
|
2020-06-19 |
2023-08-15 |
耶鲁大学 |
用于诱导耐受性的聚合胆汁酸酯纳米颗粒
|
JP2024529341A
(ja)
|
2021-07-15 |
2024-08-06 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
粒子が付着している細胞に関連する組成物および方法
|
WO2024008799A1
(en)
|
2022-07-06 |
2024-01-11 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the treatment of proliferative glomerulonephritis
|
WO2024028433A1
(en)
|
2022-08-04 |
2024-02-08 |
Institut National de la Santé et de la Recherche Médicale |
Methods for the treatment of lymphoproliferative disorders
|