MX9301863A - Morfolin y tiomorfolin 4-ilamidas - Google Patents

Morfolin y tiomorfolin 4-ilamidas

Info

Publication number
MX9301863A
MX9301863A MX9301863A MX9301863A MX9301863A MX 9301863 A MX9301863 A MX 9301863A MX 9301863 A MX9301863 A MX 9301863A MX 9301863 A MX9301863 A MX 9301863A MX 9301863 A MX9301863 A MX 9301863A
Authority
MX
Mexico
Prior art keywords
ilamidas
tiomorfolin
morfolin
compounds
hiv
Prior art date
Application number
MX9301863A
Other languages
English (en)
Spanish (es)
Inventor
Peter Schneider
Guido Bold
Alexander Fassler
Marc Lang
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of MX9301863A publication Critical patent/MX9301863A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
MX9301863A 1992-04-01 1993-03-31 Morfolin y tiomorfolin 4-ilamidas MX9301863A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH105292 1992-04-01

Publications (1)

Publication Number Publication Date
MX9301863A true MX9301863A (es) 1994-02-28

Family

ID=4201332

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301863A MX9301863A (es) 1992-04-01 1993-03-31 Morfolin y tiomorfolin 4-ilamidas

Country Status (12)

Country Link
US (1) US5409927A (enExample)
EP (1) EP0565484A3 (enExample)
JP (1) JPH0649093A (enExample)
KR (1) KR930021655A (enExample)
AU (1) AU3562193A (enExample)
CA (1) CA2093109A1 (enExample)
FI (1) FI931415A7 (enExample)
IL (1) IL105228A0 (enExample)
MX (1) MX9301863A (enExample)
NO (1) NO931242L (enExample)
TW (1) TW217410B (enExample)
ZA (1) ZA932309B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753652A (en) * 1991-07-03 1998-05-19 Novartis Corporation Antiretroviral hydrazine derivatives
EP0633881B1 (en) 1992-03-11 2003-10-29 Narhex Limited Amine derivatives of oxo- and hydroxy-substitued hydrocarbons
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
KR20020042333A (ko) * 2000-11-30 2002-06-05 이계준 프로테아제 억제 활성을 갖는 약학적 조성물
ES2377118T3 (es) * 2004-09-21 2012-03-22 Trobio Ab Composición de proteasa estabilizada que comprende una serina proteasa, derivados de morfolino e inhibidores inversos de dicha serina proteasa
AU2005336535B2 (en) * 2005-09-22 2012-05-24 Trobio Ab Stabilized protease composition

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0316965A3 (en) * 1983-02-07 1989-08-09 Aktiebolaget Hässle Enzyme inhibitors
GB8322414D0 (en) * 1983-08-19 1983-09-21 Szelke M Renin inhibitors
FI88400C (fi) * 1984-08-06 1993-05-10 Upjohn Co Foerfarande foer framstaellning av renin inhiberande peptider
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
WO1987002986A1 (en) * 1985-11-15 1987-05-21 The Upjohn Company Novel renin inhibiting polypeptide analogs containing s-aryl-d- or l- or dl-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
JPH02500025A (ja) * 1986-09-30 1990-01-11 ジ・アップジョン・カンパニー 新規なｃ末端基を有するレニン抑制ペプチド
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
IL91307A0 (en) * 1988-08-24 1990-03-19 Merck & Co Inc Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them
EP0374097A3 (de) * 1988-12-15 1991-06-12 Ciba-Geigy Ag Verwendung von Peptidisosteren als retrovirale Proteasehemmer
EP0374098A3 (de) * 1988-12-15 1991-05-02 Ciba-Geigy Ag Retrovirale Proteasehemmer
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5126326A (en) * 1989-06-06 1992-06-30 Bio-Mega, Inc. Enzyme inhibiting peptide derivatives
US5242903A (en) * 1989-08-05 1993-09-07 Bayer Aktiengesellschaft Renin inhibitors
CA2066644A1 (en) * 1989-10-27 1991-04-28 Robert L. Heinrikson Method for treating hiv and other retroviruses and compounds useful therefor
IL98260A0 (en) * 1990-06-01 1992-06-21 Ciba Geigy Ag Hiv protease inhibiting oligopeptides,process for their preparation and pharmaceutical compositions containing them
CA2055685A1 (en) * 1990-11-19 1992-05-20 Samuel L. Graham Hiv protease inhibitors having polyether substituents
EP0532466A3 (en) * 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use

Also Published As

Publication number Publication date
CA2093109A1 (en) 1993-10-02
FI931415A7 (fi) 1993-10-02
TW217410B (enExample) 1993-12-11
US5409927A (en) 1995-04-25
JPH0649093A (ja) 1994-02-22
FI931415A0 (fi) 1993-03-29
NO931242L (no) 1993-10-04
IL105228A0 (en) 1993-07-08
AU3562193A (en) 1993-10-07
ZA932309B (en) 1993-10-18
EP0565484A3 (en) 1993-12-29
KR930021655A (ko) 1993-11-22
EP0565484A2 (de) 1993-10-13
NO931242D0 (no) 1993-03-31

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal