MX9301269A - Proteina de transferencia de triglicerido microsomal. - Google Patents
Proteina de transferencia de triglicerido microsomal.Info
- Publication number
- MX9301269A MX9301269A MX9301269A MX9301269A MX9301269A MX 9301269 A MX9301269 A MX 9301269A MX 9301269 A MX9301269 A MX 9301269A MX 9301269 A MX9301269 A MX 9301269A MX 9301269 A MX9301269 A MX 9301269A
- Authority
- MX
- Mexico
- Prior art keywords
- transfer protein
- microsomal triglyceride
- triglyceride transfer
- methods
- activity
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Vascular Medicine (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Child & Adolescent Psychology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
La presente invención se relaciona con las secuencias de ácido nucléico, particularmente las secuencias de ADN, que codifican para toda o parte de la subunidad de alto peso molecular de la proteína de transferencia de triglicérido microsomal, los vectores de expresión que contienen las secuencias de ADN, las células huésped que contienen los vectores de expresión, y los método para utilizar esos materiales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84750392A | 1992-03-06 | 1992-03-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9301269A true MX9301269A (es) | 1993-09-01 |
Family
ID=25300790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9301269A MX9301269A (es) | 1992-03-06 | 1993-03-08 | Proteina de transferencia de triglicerido microsomal. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0584446B2 (es) |
JP (1) | JP4298801B2 (es) |
AT (1) | ATE219514T1 (es) |
AU (1) | AU670930B2 (es) |
CA (1) | CA2091102C (es) |
DE (1) | DE69332041T3 (es) |
DK (1) | DK0584446T4 (es) |
ES (1) | ES2178640T5 (es) |
HU (1) | HU218419B (es) |
MX (1) | MX9301269A (es) |
PT (1) | PT584446E (es) |
ZA (1) | ZA931601B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
ZA961340B (en) | 1995-02-21 | 1997-09-11 | Bristol Myers Squibb Co | Inhibitors of microsomal triglyceride transfer protein and method. |
EP0902785B1 (en) * | 1996-04-30 | 2002-09-04 | Pfizer Inc. | Processes and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid 2-(2h- 1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide |
US5827875A (en) * | 1996-05-10 | 1998-10-27 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
US5885983A (en) * | 1996-05-10 | 1999-03-23 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
US5883109A (en) * | 1996-07-24 | 1999-03-16 | Bristol-Myers Squibb Company | Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug |
JP2002513379A (ja) * | 1996-07-24 | 2002-05-08 | ブリストル―マイヤーズ・スクイブ・カンパニー | Mtp抑制因子を用いる、高ldlの必要を持つ腫瘍の治療法 |
US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
WO1998031366A1 (en) * | 1997-01-17 | 1998-07-23 | Bristol-Myers Squibb Company | Method for treating atherosclerosis with an mpt inhibitor and cholesterol lowering drugs |
CA2286341A1 (en) * | 1997-05-01 | 1998-11-12 | John R. Ii Wetterau | Mtp inhibitors and fat soluble vitamin therapeutic combinations to lower serum lipid levels |
US5968950A (en) * | 1997-06-23 | 1999-10-19 | Pfizer Inc | Apo B-secretion/MTP inhibitor hydrochloride salt |
JP2959765B2 (ja) | 1997-12-12 | 1999-10-06 | 日本たばこ産業株式会社 | 3−ピペリジル−4−オキソキナゾリン誘導体及びそれを含有してなる医薬組成物 |
CA2324800A1 (en) * | 1999-11-10 | 2001-05-10 | Mary Anne Hickman | Use of apo b secretion/mtp inhibitors |
EP1294943A2 (en) * | 2000-01-20 | 2003-03-26 | Genome Therapeutics Corporation | RAPID DETERMINATION OF GENE STRUCTURE USING cDNA SEQUENCE |
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
JO2390B1 (en) | 2001-04-06 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Diphenylcarboxamides act as lipid-lowering agents |
ES2307799T3 (es) | 2001-06-28 | 2008-12-01 | Pfizer Products Inc. | Benzotiofenos, benzofuranos e indoles sustituidos con triamida como inhibidores de la proteina de transferencia de trigliceridos microsomal (mtp) y/o la secrecion de la apoliproteina b (apo b). |
ATE443156T1 (de) * | 2003-06-27 | 2009-10-15 | Univ New York State Res Found | Fluoreszenz-assay für mtp-aktivität |
AU2005214159A1 (en) | 2004-02-04 | 2005-09-01 | Pfizer Products Inc. | Substituted quinoline compounds |
AU2005221656B2 (en) | 2004-03-05 | 2011-06-23 | The Trustees Of The University Of Pennsylvania | Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects |
TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291205B1 (en) * | 1992-06-12 | 2001-09-18 | Merck & Co., Inc. | Method of increasing production of disulfide bonded recombinant proteins by saccharomyces cerevisiae |
-
1993
- 1993-03-05 CA CA002091102A patent/CA2091102C/en not_active Expired - Lifetime
- 1993-03-05 ZA ZA931601A patent/ZA931601B/xx unknown
- 1993-03-05 HU HU9300627A patent/HU218419B/hu unknown
- 1993-03-08 DE DE69332041T patent/DE69332041T3/de not_active Expired - Lifetime
- 1993-03-08 ES ES93103697T patent/ES2178640T5/es not_active Expired - Lifetime
- 1993-03-08 PT PT93103697T patent/PT584446E/pt unknown
- 1993-03-08 EP EP93103697A patent/EP0584446B2/en not_active Expired - Lifetime
- 1993-03-08 AT AT93103697T patent/ATE219514T1/de active
- 1993-03-08 MX MX9301269A patent/MX9301269A/es unknown
- 1993-03-08 JP JP04649993A patent/JP4298801B2/ja not_active Expired - Lifetime
- 1993-03-08 DK DK93103697.4T patent/DK0584446T4/da active
- 1993-03-09 AU AU34064/93A patent/AU670930B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AU670930B2 (en) | 1996-08-08 |
ES2178640T3 (es) | 2003-01-01 |
DK0584446T4 (da) | 2010-05-17 |
EP0584446B2 (en) | 2010-03-10 |
JPH0638761A (ja) | 1994-02-15 |
CA2091102C (en) | 2009-05-26 |
ES2178640T5 (es) | 2010-06-01 |
EP0584446A2 (en) | 1994-03-02 |
DK0584446T3 (da) | 2002-10-14 |
CA2091102A1 (en) | 1993-09-07 |
ATE219514T1 (de) | 2002-07-15 |
ZA931601B (en) | 1993-10-05 |
HUT67962A (en) | 1995-05-29 |
AU3406493A (en) | 1993-09-09 |
JP4298801B2 (ja) | 2009-07-22 |
HU9300627D0 (en) | 1993-05-28 |
HU218419B (hu) | 2000-08-28 |
PT584446E (pt) | 2002-09-30 |
DE69332041T3 (de) | 2011-05-05 |
DE69332041D1 (de) | 2002-07-25 |
EP0584446A3 (en) | 1995-04-26 |
EP0584446B1 (en) | 2002-06-19 |
DE69332041T2 (de) | 2004-04-29 |
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