MX9206702A - Novedosos acidos aminoalcanfosfinicos. - Google Patents
Novedosos acidos aminoalcanfosfinicos.Info
- Publication number
- MX9206702A MX9206702A MX9206702A MX9206702A MX9206702A MX 9206702 A MX9206702 A MX 9206702A MX 9206702 A MX9206702 A MX 9206702A MX 9206702 A MX9206702 A MX 9206702A MX 9206702 A MX9206702 A MX 9206702A
- Authority
- MX
- Mexico
- Prior art keywords
- ethyl
- dichlorophenyl
- dimethoxyphenyl
- hydrogen
- phenyl
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- -1 1- (4-chlorophenyl) ethyl Chemical group 0.000 abstract 48
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000006512 3,4-dichlorobenzyl group Chemical group [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C([H])([H])* 0.000 abstract 2
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000005806 3,4,5-trimethoxybenzyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])* 0.000 abstract 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 abstract 1
- 125000006185 3,4-dimethyl benzyl group Chemical group [H]C1=C(C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- RRXSYZFVDIRTFB-UHFFFAOYSA-N C[CH]C1=CC=C(OC)C=C1 Chemical group C[CH]C1=CC=C(OC)C=C1 RRXSYZFVDIRTFB-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Air Bags (AREA)
Abstract
Compuestos de la fórmula I: donde R es butilo, R1 es hidrógeno, R2 3,4-diclorobencilo, 1-(4-clorofenil)etilo, o 1-(3,4-dicloro)fenetilo, y R3 es hidrógeno, o R es dietoximetilo, R1 es hidrógeno y R2 es 2,6- ó 3,5-diclorobencilo, pirid-3-imetilo, 1-(4-metoxifenil)etilo, 1-(4-cloro-yodo-fenil)etilo, ó 1-(3-cloro-4-yodo-fenil)etilo, ó R1 es hidroxi y R2 es 3,4-diclorobencilo, 1-(3-cloro-4-yodo-fenil)etilo, 1-(4-cloro-3-yodo-fenil)-etilo, o 1-(3,4-diclorofenil)etilo, y R3 es hidrógeno, o R es ciclohexilmetilo, R1 es hidrógeno y R2 es 3,5-diclorobencilo, quinolin-4-ilmetilo, 1-(3-clorofenil)etilo, o 1,(3,4,5-trimetoxifenil)etilo, o R1 es hidroxi y R2 es 3,4-dimetilbencilo, 3,4-metilendioxibencilo, 1-(3,4-clorofenil)etilo, 1-(3,4-diclorofenil)etilo, 1-(3-cloro-4-yodo-fenil)etilo, 1-(4-cloro-3-yodo-fenil)etilo, 1-(2,4-dimetoxifenil)etilo, 1-(2,5-dimetoxifenil)etilo, 1-(2,6-dimetoxifenil)etilo, 1-(3,4-dimetoxifenil)etilo, 1-(3,4-metilendioxifenil)etilo,1-(3,5-dimetoxifeni l)etilo,1-(3,4,5-trimetoxi)fenetilo, 3-fenilprop-2-ilo, 2-(3,4-diclorofenil)propilo,2-(3,4-diclorofenil)pr opilo, 3-(3,4-diclorofenil)prop-2-ilo, o 3-fenil-3-hidroxi-prop-2-ilo, y R3 es hidrógeno, o R es ciclohexilmetilo, R1 es hidrógeno, R2 es 4-clorobencilo, y R3 es metilo, o R ciclohex-3-enilmetilo, R1 (S)-hidroxi, R2 es 1(S)-(3,4-diclorofenil)etilo, y R3 hidrógeno, o R es bencilo, R1 es hidroxi, R2 es alfaciclopropil-3,4-diclorobencilo, 3,4,5-trimetoxibencilo, 1-(3,5-dimetoxifenil)etilo, 1-(3,4-diclorofenil)etilo, 2-(3,4-diclorofenil)etilo, 1-(3-cloro-4-yodo-fenil)etilo, 1-(3,4-diclorofenil)-2 hidroxi-etilo, 2-(3,4-diclorofenil-2-hidroxietilo, 1-(2,4-dimetoxifenil)etilo, 1-(2,5-dimetoxifenil)etilo, 1-(2,6-dimetoxifenil)etilo, 1-(3,4-dimetoxifenil)etilo, 1-(3,4-metilendioxifeniletilo,1-(3,4,5-trimetoxife nil)etilo,3-fenilprop-2-ilo, 3-fenil-3-hidroxi-prop-2-ilo, 1-,2-, ó 3-(3,4-diclorofenil)propilo, 3-(3,4-diclorofenil)prop-2-ilo, 3-(3,4-diclorofenil)3-hidroxi-prop-2-ilo ó 4-(3,4-diclorofenil)butilo, y R3 es hidrógeno, ó R es 4-clorobencilo, 4-metilbencilo, 4-metoxibencilo, o ciclohex-3-enilmetilo, y R1 , R2, y R3 son hidrógeno, y sales de los mismos, que tienen propiedades antagonistas de GABAß, y se pueden utilizar para el tratamiento de enfermedades que responden a los antagonistas de GABAß.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH340491 | 1991-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9206702A true MX9206702A (es) | 1994-06-30 |
Family
ID=4255259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9206702A MX9206702A (es) | 1991-11-21 | 1992-11-19 | Novedosos acidos aminoalcanfosfinicos. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5376684A (es) |
| EP (2) | EP0543780A3 (es) |
| JP (1) | JPH05247069A (es) |
| KR (1) | KR930010047A (es) |
| AU (2) | AU662938B2 (es) |
| CA (1) | CA2083307A1 (es) |
| FI (1) | FI925243A (es) |
| IL (1) | IL103808A0 (es) |
| MX (1) | MX9206702A (es) |
| NO (4) | NO924479L (es) |
| NZ (1) | NZ245185A (es) |
| PH (1) | PH30097A (es) |
| TW (1) | TW213466B (es) |
| ZA (1) | ZA928979B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL98502A (en) * | 1990-06-22 | 1998-04-05 | Ciba Geigy Ag | History of Aminoalkene Phosphine Acid, Process for Their Preparation and Pharmaceutical Preparations Containing Them |
| EP0543780A3 (en) * | 1991-11-21 | 1993-09-01 | Ciba-Geigy Ag | Novel aminoalkanephosphinic acids and their salts |
| AU662404B2 (en) * | 1992-05-08 | 1995-08-31 | Novartis Ag | Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids |
| AU7130196A (en) * | 1995-09-28 | 1997-04-17 | Novartis Ag | Novel hydroxylated and alkoxylated N- and/or P-aralkylphosphinic acid derivatives |
| EP1000071B1 (en) * | 1997-06-23 | 2004-11-17 | Polychip Pharmaceuticals Pty. Ltd. | Gaba-c receptor antagonists for stimulating memory capacity |
| DE10014127A1 (de) * | 2000-03-22 | 2001-10-18 | Hassan Jomaa | Verwendung von phosphororganischen Verbindungen zur Behandlung von Infektionen |
| US6462084B1 (en) | 2001-05-14 | 2002-10-08 | Brookhaven Science Associates, Llc | Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG |
| AR045794A1 (es) * | 2003-09-23 | 2005-11-16 | Aventis Pharma Inc | Procedimiento para preparar derivados de acido 3- amino-2- hidroxipropilfosfinico |
| GB0327186D0 (en) * | 2003-11-21 | 2003-12-24 | Novartis Ag | Organic compounds |
| US7494985B2 (en) * | 2004-11-03 | 2009-02-24 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| WO2006050471A2 (en) * | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
| JP2008530125A (ja) * | 2005-02-11 | 2008-08-07 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | 置換されたプロパンホスフィン酸エステル |
| US7585996B2 (en) * | 2006-09-15 | 2009-09-08 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2440239A1 (de) * | 1974-08-22 | 1976-03-04 | Hoechst Ag | Innere ammoniumsalze von phosphinsaeuren |
| EP0093081B1 (de) * | 1982-04-23 | 1986-03-19 | Ciba-Geigy Ag | Herbizide und pflanzenwuchsregulierende Mittel |
| US4536355A (en) * | 1982-10-08 | 1985-08-20 | Zoecon Corporation | Phenoxyphenylaminoalkylphosphinates useful in weed control |
| GB8425872D0 (en) * | 1984-10-12 | 1984-11-21 | Ciba Geigy Ag | Chemical compounds |
| US5243062A (en) * | 1984-10-12 | 1993-09-07 | Ciba-Geigy Corporation | Substituted propane-phosphonous acid compounds |
| DK704488D0 (da) * | 1988-12-19 | 1988-12-19 | Novo Industri As | Nye n-substituerede azaheterocykliske carboxylsyrer |
| GB8728483D0 (en) * | 1987-12-04 | 1988-01-13 | Ciba Geigy Ag | Chemical compounds |
| US5300679A (en) * | 1987-12-04 | 1994-04-05 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
| US5190933A (en) * | 1987-12-04 | 1993-03-02 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
| DK270488D0 (da) * | 1988-05-18 | 1988-05-18 | Novo Industri As | Hidtil ukendte o-substituerede ketoximer |
| GB8820266D0 (en) * | 1988-08-26 | 1988-09-28 | Smith Kline French Lab | Compounds |
| US5281747A (en) * | 1989-05-13 | 1994-01-25 | Ciba-Geigy Corporation | Substituted aminoalkylphosphinic acids |
| GB8911017D0 (en) * | 1989-05-13 | 1989-06-28 | Ciba Geigy Ag | Substituted aminoalkylphosphinic acids |
| US5190934A (en) * | 1989-06-03 | 1993-03-02 | Ciba-Geigy Corporation | P-subsituted propane-phosphinic acid compounds |
| GB8912814D0 (en) * | 1989-06-03 | 1989-07-19 | Ciba Geigy Ag | P-substituted propane-phospinic acid compounds |
| IL98502A (en) * | 1990-06-22 | 1998-04-05 | Ciba Geigy Ag | History of Aminoalkene Phosphine Acid, Process for Their Preparation and Pharmaceutical Preparations Containing Them |
| EP0543780A3 (en) * | 1991-11-21 | 1993-09-01 | Ciba-Geigy Ag | Novel aminoalkanephosphinic acids and their salts |
| AU662404B2 (en) * | 1992-05-08 | 1995-08-31 | Novartis Ag | Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids |
-
1992
- 1992-11-12 EP EP19920810879 patent/EP0543780A3/de not_active Ceased
- 1992-11-12 EP EP96118735A patent/EP0767174A1/de not_active Withdrawn
- 1992-11-18 FI FI925243A patent/FI925243A/fi not_active Application Discontinuation
- 1992-11-19 JP JP4310082A patent/JPH05247069A/ja active Pending
- 1992-11-19 IL IL103808A patent/IL103808A0/xx unknown
- 1992-11-19 MX MX9206702A patent/MX9206702A/es not_active Application Discontinuation
- 1992-11-19 NZ NZ245185A patent/NZ245185A/en unknown
- 1992-11-19 CA CA002083307A patent/CA2083307A1/en not_active Abandoned
- 1992-11-19 TW TW081109255A patent/TW213466B/zh active
- 1992-11-19 AU AU28504/92A patent/AU662938B2/en not_active Ceased
- 1992-11-19 US US07/979,513 patent/US5376684A/en not_active Expired - Fee Related
- 1992-11-20 ZA ZA928979A patent/ZA928979B/xx unknown
- 1992-11-20 NO NO92924479A patent/NO924479L/no unknown
- 1992-11-20 PH PH45301A patent/PH30097A/en unknown
- 1992-11-21 KR KR1019920021950A patent/KR930010047A/ko not_active Application Discontinuation
-
1994
- 1994-09-16 US US08/308,040 patent/US5500418A/en not_active Expired - Fee Related
-
1995
- 1995-12-14 AU AU40456/95A patent/AU4045695A/en not_active Abandoned
-
1997
- 1997-09-08 NO NO974115A patent/NO974115D0/no unknown
- 1997-09-08 NO NO974116A patent/NO974116D0/no unknown
- 1997-09-08 NO NO974117A patent/NO974117D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO974117L (no) | 1993-05-24 |
| JPH05247069A (ja) | 1993-09-24 |
| EP0543780A3 (en) | 1993-09-01 |
| CA2083307A1 (en) | 1993-05-22 |
| NO974115L (no) | 1993-05-24 |
| IL103808A0 (en) | 1993-04-04 |
| NO974117D0 (no) | 1997-09-08 |
| TW213466B (es) | 1993-09-21 |
| FI925243A0 (fi) | 1992-11-18 |
| KR930010047A (ko) | 1993-06-21 |
| US5376684A (en) | 1994-12-27 |
| NO974115D0 (no) | 1997-09-08 |
| EP0543780A2 (de) | 1993-05-26 |
| NO924479L (no) | 1993-05-24 |
| ZA928979B (en) | 1994-04-15 |
| EP0767174A1 (de) | 1997-04-09 |
| NO974116L (no) | 1993-05-24 |
| NO974116D0 (no) | 1997-09-08 |
| AU4045695A (en) | 1996-04-26 |
| AU2850492A (en) | 1993-05-27 |
| PH30097A (en) | 1996-12-27 |
| AU662938B2 (en) | 1995-09-21 |
| FI925243A (fi) | 1993-05-22 |
| NZ245185A (en) | 1995-04-27 |
| US5500418A (en) | 1996-03-19 |
| NO924479D0 (no) | 1992-11-20 |
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