MX9204817A - Benzo(f)quinolinonas, procedimiento para su obtencion y formulacion farmaceutica que las contiene. - Google Patents
Benzo(f)quinolinonas, procedimiento para su obtencion y formulacion farmaceutica que las contiene.Info
- Publication number
- MX9204817A MX9204817A MX9204817A MX9204817A MX9204817A MX 9204817 A MX9204817 A MX 9204817A MX 9204817 A MX9204817 A MX 9204817A MX 9204817 A MX9204817 A MX 9204817A MX 9204817 A MX9204817 A MX 9204817A
- Authority
- MX
- Mexico
- Prior art keywords
- quinolinones
- benzo
- procedure
- obtaining
- pharmaceutical formulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
- C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74811691A | 1991-08-21 | 1991-08-21 | |
| US78103991A | 1991-10-21 | 1991-10-21 | |
| US07/927,710 US5239075A (en) | 1991-08-21 | 1992-08-10 | Process for the preparation of benzo (f) quinolinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9204817A true MX9204817A (es) | 1993-04-01 |
Family
ID=27419359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9204817A MX9204817A (es) | 1991-08-21 | 1992-08-20 | Benzo(f)quinolinonas, procedimiento para su obtencion y formulacion farmaceutica que las contiene. |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US5239075A (es) |
| EP (1) | EP0532190B1 (es) |
| JP (1) | JP3504678B2 (es) |
| KR (1) | KR100235562B1 (es) |
| CN (1) | CN1039320C (es) |
| CA (1) | CA2076479A1 (es) |
| CZ (1) | CZ290369B6 (es) |
| DE (1) | DE69231610T2 (es) |
| FI (1) | FI102475B1 (es) |
| HU (2) | HUT68034A (es) |
| IL (1) | IL102881A (es) |
| MX (1) | MX9204817A (es) |
| NO (1) | NO178542C (es) |
| NZ (1) | NZ244038A (es) |
| RU (1) | RU2126386C1 (es) |
| SG (1) | SG67312A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5239075A (en) * | 1991-08-21 | 1993-08-24 | Eli Lilly And Company | Process for the preparation of benzo (f) quinolinones |
| GB9317314D0 (en) * | 1993-08-20 | 1993-10-06 | Smithkline Beecham Corp | Compounds |
| US5574160A (en) * | 1994-05-26 | 1996-11-12 | Eli Lilly And Company | Syntheis of benzoquinolinones |
| US5578724A (en) * | 1994-09-20 | 1996-11-26 | Eli Lilly And Company | Process for preparation of benzo[f]quinolinones |
| US5543417A (en) * | 1994-10-21 | 1996-08-06 | Merck & Co., Inc. | Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents |
| GB2294712B (en) * | 1994-11-01 | 1998-06-24 | Camco Drilling Group Ltd | Improvements in or relating to rotary drill bits |
| US5635197A (en) * | 1995-03-21 | 1997-06-03 | Eli Lilly And Company | Treatment and prevention of prostatic cancer metastasis |
| TW450809B (en) * | 1995-03-21 | 2001-08-21 | Lilly Co Eli | Pharmaceutical compositions for preventing or treating prostatic cancer comprising benzoquinolin-3-one derivatives |
| US5629007A (en) * | 1995-03-21 | 1997-05-13 | Eli Lilly And Company | Method of preventing prostatic cancer development |
| US5550134A (en) * | 1995-05-10 | 1996-08-27 | Eli Lilly And Company | Methods for inhibiting bone loss |
| BR9712711A (pt) * | 1996-10-30 | 1999-10-26 | Lilly Co Eli | Sìntese de benzo[f]quinolinonas |
| US6111110A (en) * | 1996-10-30 | 2000-08-29 | Eli Lilly And Company | Synthesis of benzo[f]quinolinones |
| EP0926148A1 (en) * | 1997-12-23 | 1999-06-30 | Applied Research Systems Ars Holding N.V. | Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors |
| CA2338298A1 (en) * | 1998-07-29 | 2000-02-10 | Merck & Co., Inc. | Tricyclic compounds |
| CA2354021A1 (en) * | 1998-12-07 | 2000-06-15 | Paul James Sirois | Crystalline form of an octahydro-benzo(f)quinolin-3-one derivative |
| JP2002531550A (ja) * | 1998-12-07 | 2002-09-24 | イーライ・リリー・アンド・カンパニー | ５α−還元酵素の阻害剤としてのベンゾキノリン−３−オン誘導体の結晶形 |
| GB0222516D0 (en) * | 2002-09-27 | 2002-11-06 | Karobio Ab | Novel compounds |
| US9073920B2 (en) | 2010-08-17 | 2015-07-07 | Purdue Research Foundation | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor |
| US11242341B2 (en) | 2016-10-06 | 2022-02-08 | Assia Chemical Industries Ltd. | Solid state forms of valbenazine |
| CN115504933A (zh) * | 2022-10-13 | 2022-12-23 | 广东工业大学 | 一种多取代喹啉酮化合物的制备方法及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4511569A (en) * | 1982-08-26 | 1985-04-16 | Schering Corporation | Tricyclic lactams and derivatives useful in increasing cardiac contractility |
| SE8302361D0 (sv) * | 1983-04-27 | 1983-04-27 | Astra Laekemedel Ab | New tricyclic amines |
| PH22879A (en) * | 1986-01-23 | 1989-01-19 | Hoffmann La Roche | Benzazecine derivatives |
| ZA883034B (en) * | 1987-04-29 | 1989-03-29 | Smithkline Beckman Corp | Steroid 5-alpha-reductase inhibitors |
| IN167395B (es) * | 1987-07-21 | 1990-10-20 | Hoffmann La Roche | |
| CA2011640A1 (en) * | 1989-03-20 | 1990-09-20 | Rene Imhof | Quinoline derivatives |
| US5300294A (en) * | 1990-06-27 | 1994-04-05 | Smithkline Beecham Corporation | Method of treating prostatic adenocarcinoma |
| US5239075A (en) * | 1991-08-21 | 1993-08-24 | Eli Lilly And Company | Process for the preparation of benzo (f) quinolinones |
| US5250539A (en) * | 1991-08-21 | 1993-10-05 | Eli Lilly And Company | Hexahydrobenzo[f]quinolinones |
-
1992
- 1992-08-10 US US07/927,710 patent/US5239075A/en not_active Expired - Fee Related
- 1992-08-19 HU HU9202711A patent/HUT68034A/hu unknown
- 1992-08-20 IL IL10288192A patent/IL102881A/en not_active IP Right Cessation
- 1992-08-20 CN CN92111068A patent/CN1039320C/zh not_active Expired - Fee Related
- 1992-08-20 SG SG1996003899A patent/SG67312A1/en unknown
- 1992-08-20 CZ CS19922566A patent/CZ290369B6/cs not_active IP Right Cessation
- 1992-08-20 EP EP92307637A patent/EP0532190B1/en not_active Expired - Lifetime
- 1992-08-20 NZ NZ244038A patent/NZ244038A/en unknown
- 1992-08-20 CA CA002076479A patent/CA2076479A1/en not_active Abandoned
- 1992-08-20 FI FI923752A patent/FI102475B1/fi active
- 1992-08-20 NO NO923265A patent/NO178542C/no unknown
- 1992-08-20 RU SU5052860/04A patent/RU2126386C1/ru not_active IP Right Cessation
- 1992-08-20 MX MX9204817A patent/MX9204817A/es not_active IP Right Cessation
- 1992-08-20 KR KR1019920014992A patent/KR100235562B1/ko not_active IP Right Cessation
- 1992-08-20 JP JP22136592A patent/JP3504678B2/ja not_active Expired - Fee Related
- 1992-08-20 DE DE69231610T patent/DE69231610T2/de not_active Expired - Fee Related
-
1993
- 1993-04-23 US US08/052,960 patent/US5334767A/en not_active Expired - Fee Related
-
1994
- 1994-04-06 US US08/223,884 patent/US5495021A/en not_active Expired - Fee Related
-
1995
- 1995-05-22 US US08/445,806 patent/US5541190A/en not_active Expired - Fee Related
- 1995-06-16 HU HU95P/P00235P patent/HU211338A9/hu unknown
-
1996
- 1996-04-17 US US08/633,990 patent/US5670512A/en not_active Expired - Fee Related
- 1996-07-17 US US08/683,750 patent/US5710163A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2076479A1 (en) | 1993-02-22 |
| DE69231610D1 (de) | 2001-02-01 |
| CZ290369B6 (cs) | 2002-07-17 |
| US5710163A (en) | 1998-01-20 |
| US5239075A (en) | 1993-08-24 |
| HUT68034A (en) | 1995-05-29 |
| EP0532190B1 (en) | 2000-12-27 |
| NO923265D0 (no) | 1992-08-20 |
| NZ244038A (en) | 1994-11-25 |
| SG67312A1 (en) | 1999-09-21 |
| CN1039320C (zh) | 1998-07-29 |
| IL102881A0 (en) | 1993-01-31 |
| KR100235562B1 (ko) | 1999-12-15 |
| NO178542B (no) | 1996-01-08 |
| NO923265L (no) | 1993-02-22 |
| CZ256692A3 (en) | 1993-04-14 |
| DE69231610T2 (de) | 2001-06-13 |
| FI923752A (fi) | 1993-02-22 |
| FI923752A0 (fi) | 1992-08-20 |
| EP0532190A3 (en) | 1993-07-14 |
| FI102475B (fi) | 1998-12-15 |
| HU211338A9 (en) | 1995-11-28 |
| EP0532190A2 (en) | 1993-03-17 |
| JPH05239032A (ja) | 1993-09-17 |
| KR930004268A (ko) | 1993-03-22 |
| US5670512A (en) | 1997-09-23 |
| US5334767A (en) | 1994-08-02 |
| JP3504678B2 (ja) | 2004-03-08 |
| RU2126386C1 (ru) | 1999-02-20 |
| CN1071418A (zh) | 1993-04-28 |
| IL102881A (en) | 1999-12-31 |
| NO178542C (no) | 1996-04-17 |
| FI102475B1 (fi) | 1998-12-15 |
| US5541190A (en) | 1996-07-30 |
| US5495021A (en) | 1996-02-27 |
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