MX9102647A - Nueva proteina capaz de inducir una respuesta inmunoprotectora contra la infeccion causada por toxoplasma gondii y para clonar y expresar un gen que codifica a la proteina. - Google Patents

Nueva proteina capaz de inducir una respuesta inmunoprotectora contra la infeccion causada por toxoplasma gondii y para clonar y expresar un gen que codifica a la proteina.

Info

Publication number
MX9102647A
MX9102647A MX9102647A MX9102647A MX9102647A MX 9102647 A MX9102647 A MX 9102647A MX 9102647 A MX9102647 A MX 9102647A MX 9102647 A MX9102647 A MX 9102647A MX 9102647 A MX9102647 A MX 9102647A
Authority
MX
Mexico
Prior art keywords
clone
inducing
express
gene
response against
Prior art date
Application number
MX9102647A
Other languages
English (en)
Inventor
Rafael Saavedra-Duran
Pascal Herion
Original Assignee
Smithkline Beecham Biolog
Innogenetics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Biolog, Innogenetics Sa filed Critical Smithkline Beecham Biolog
Publication of MX9102647A publication Critical patent/MX9102647A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/45—Toxoplasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se describe un antígeno purificado de T.gondii que tiene un peso molecular de 54kDa (como se determina mediante la prueba de manchado de Western), el cual es reactivo con los anticuerpos inducidos contra una proteína recombinante, obtenida mediante la expresión de una cADN de T.gondii definida (secuencia 1) en una célula del huésped; también se describen fragmentos inmunogénicos del antígeno de 54kDa.
MX9102647A 1990-12-20 1991-12-18 Nueva proteina capaz de inducir una respuesta inmunoprotectora contra la infeccion causada por toxoplasma gondii y para clonar y expresar un gen que codifica a la proteina. MX9102647A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909027728A GB9027728D0 (en) 1990-12-20 1990-12-20 Novel protein

Publications (1)

Publication Number Publication Date
MX9102647A true MX9102647A (es) 1994-03-31

Family

ID=10687389

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9102647A MX9102647A (es) 1990-12-20 1991-12-18 Nueva proteina capaz de inducir una respuesta inmunoprotectora contra la infeccion causada por toxoplasma gondii y para clonar y expresar un gen que codifica a la proteina.

Country Status (14)

Country Link
US (1) US6077690A (es)
EP (1) EP0652956A1 (es)
JP (1) JPH06505865A (es)
KR (2) KR100250944B1 (es)
AU (1) AU661982B2 (es)
CA (1) CA2098845A1 (es)
GB (1) GB9027728D0 (es)
IE (1) IE914422A1 (es)
MX (1) MX9102647A (es)
NZ (1) NZ241043A (es)
PT (1) PT99842A (es)
SG (1) SG48325A1 (es)
WO (1) WO1992011366A1 (es)
ZA (1) ZA919982B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6172194A (en) * 1993-02-08 1994-08-29 Paravax, Inc. Defective sindbis virus vectors that express (toxoplasma gondii) p30 antigens
EP0695356A1 (en) * 1993-04-30 1996-02-07 SMITHKLINE BEECHAM BIOLOGICALS s.a. Cloning, expression and vaccine composition corresponding to a peptide antigen of toxoplasma gondii
ZA958366B (en) * 1994-10-06 1996-04-24 Akzo Nobel Nv New toxoplasma gondii antigens
GB9929434D0 (en) * 1999-12-13 2000-02-09 Smithkline Beecham Biolog Novel vaccine composition
JPWO2002017960A1 (ja) * 2000-08-31 2004-12-09 中外製薬株式会社 トキソプラズマ・ゴンディに対するワクチン
CN101137674A (zh) 2005-03-08 2008-03-05 肯顿有限公司 刚地弓形虫的嵌合重组抗原

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3940598A1 (de) * 1989-12-08 1991-06-13 Behringwerke Ag Toxoplasma gondii-antigene, ihre herstellung und ihre verwendung
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
FR2618680B1 (fr) * 1987-07-31 1990-05-11 Pasteur Institut Antigenes d'excretion-secretion specifiques de toxoplasma gondii, leurs produits d'expression, leur procede d'obtention et leurs applications diagnostiques et prophylactiques
US4877726A (en) * 1988-03-02 1989-10-31 Research Institute Of Palo Alto Medical Foundation Method for the detection of acute-phase toxoplasma infection
IL93883A (en) * 1989-04-12 1993-02-21 Iscar Ltd Cutting insert for a milling cutting tool

Also Published As

Publication number Publication date
IE914422A1 (en) 1992-07-01
CA2098845A1 (en) 1992-06-21
KR100260998B1 (en) 2000-06-15
NZ241043A (en) 1993-09-27
KR930703445A (ko) 1993-11-30
GB9027728D0 (en) 1991-02-13
SG48325A1 (en) 1998-04-17
AU661982B2 (en) 1995-08-17
EP0652956A1 (en) 1995-05-17
AU9071491A (en) 1992-07-22
PT99842A (pt) 1992-12-31
ZA919982B (en) 1992-12-30
US6077690A (en) 2000-06-20
JPH06505865A (ja) 1994-07-07
WO1992011366A1 (en) 1992-07-09
KR100250944B1 (ko) 2000-04-15

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