MX395589B - Método para preparar derivado de oxaespirociclo e intermediario del mismo. - Google Patents

Método para preparar derivado de oxaespirociclo e intermediario del mismo.

Info

Publication number
MX395589B
MX395589B MX2020003784A MX2020003784A MX395589B MX 395589 B MX395589 B MX 395589B MX 2020003784 A MX2020003784 A MX 2020003784A MX 2020003784 A MX2020003784 A MX 2020003784A MX 395589 B MX395589 B MX 395589B
Authority
MX
Mexico
Prior art keywords
derivative
preparing
oxaespirocycle
oxaspirocycle
favorable
Prior art date
Application number
MX2020003784A
Other languages
English (en)
Other versions
MX2020003784A (es
Inventor
Weixing Qi
Wenhai Li
Zhenjun Qiu
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2020003784A publication Critical patent/MX2020003784A/es
Publication of MX395589B publication Critical patent/MX395589B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a un metodo para preparar un derivado de oxaespirociclo y un intermediario del mismo; el metodo reduce los pasos de reaccion, mejora el rendimiento de la reaccion, es simple y facil de operar, y es favorable para produccion a gran escala industrial.
MX2020003784A 2017-09-28 2018-09-27 Método para preparar derivado de oxaespirociclo e intermediario del mismo. MX395589B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710896555 2017-09-28
PCT/CN2018/107901 WO2019062804A1 (zh) 2017-09-28 2018-09-27 一种氧杂螺环类衍生物的制备方法及其中间体

Publications (2)

Publication Number Publication Date
MX2020003784A MX2020003784A (es) 2020-08-03
MX395589B true MX395589B (es) 2025-03-25

Family

ID=65900832

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003784A MX395589B (es) 2017-09-28 2018-09-27 Método para preparar derivado de oxaespirociclo e intermediario del mismo.

Country Status (12)

Country Link
US (1) US11111236B2 (es)
EP (1) EP3689859A4 (es)
JP (1) JP2020535177A (es)
KR (1) KR20200060750A (es)
CN (1) CN110678453B (es)
AU (1) AU2018341782A1 (es)
BR (1) BR112020005858A2 (es)
CA (1) CA3076395A1 (es)
MX (1) MX395589B (es)
TW (1) TWI690524B (es)
WO (1) WO2019062804A1 (es)
ZA (1) ZA202002138B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111836807A (zh) * 2018-04-28 2020-10-27 四川科伦博泰生物医药股份有限公司 氧杂螺环类化合物及其制备方法和用途
JP7751645B2 (ja) * 2020-12-29 2025-10-08 上海海雁医薬科技有限公司 オキシスピロ環置換ピロロピラゾール誘導体及びその中間体並びにその調製方法
WO2023284788A1 (zh) * 2021-07-13 2023-01-19 上海海雁医药科技有限公司 Mor受体激动剂的药学上可接受的盐、其多晶型物及其用途
CN117624138A (zh) * 2022-08-29 2024-03-01 江苏恒瑞医药股份有限公司 一种氧杂螺环类衍生物的可药用盐、晶型及制备方法
CN120359196A (zh) 2023-01-18 2025-07-22 上海森辉医药有限公司 一种四氢-1-萘胺及其衍生物的制备方法
CN118638109B (zh) * 2024-04-30 2025-10-28 中山大学 一种阿片类药物-奥赛利定的制备方法
CN118994123B (zh) * 2024-10-23 2025-02-14 江苏恒瑞医药股份有限公司 制备9-(吡啶-2-基)-6-氧杂螺[4.5]癸烷衍生物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME02754B (me) * 2011-03-23 2018-01-20 Trevena Inc Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme
HUE048032T2 (hu) * 2015-10-15 2020-05-28 Jiangsu Hengrui Medicine Co Oxaspiro-származék, elõállítási eljárása és alkalmazásai gyógyszerekben
CN106588899B (zh) * 2015-10-15 2019-11-15 江苏恒瑞医药股份有限公司 吡啶基取代的6-氧杂螺[4.5]癸烷类衍生物、其制备方法及其在医药上的应用

Also Published As

Publication number Publication date
RU2020113709A3 (es) 2022-01-25
TWI690524B (zh) 2020-04-11
CA3076395A1 (en) 2019-04-04
CN110678453A (zh) 2020-01-10
US11111236B2 (en) 2021-09-07
KR20200060750A (ko) 2020-06-01
MX2020003784A (es) 2020-08-03
RU2020113709A (ru) 2021-10-18
AU2018341782A1 (en) 2020-04-16
US20200308151A1 (en) 2020-10-01
JP2020535177A (ja) 2020-12-03
CN110678453B (zh) 2023-03-10
ZA202002138B (en) 2021-05-26
EP3689859A4 (en) 2021-08-25
TW201914997A (zh) 2019-04-16
EP3689859A1 (en) 2020-08-05
WO2019062804A1 (zh) 2019-04-04
BR112020005858A2 (pt) 2020-09-29

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