MX392946B - Compuesto heterociclico. - Google Patents

Compuesto heterociclico.

Info

Publication number
MX392946B
MX392946B MX2019012810A MX2019012810A MX392946B MX 392946 B MX392946 B MX 392946B MX 2019012810 A MX2019012810 A MX 2019012810A MX 2019012810 A MX2019012810 A MX 2019012810A MX 392946 B MX392946 B MX 392946B
Authority
MX
Mexico
Prior art keywords
compound
heterocyclic compound
prevention
calcium
expected
Prior art date
Application number
MX2019012810A
Other languages
English (en)
Other versions
MX2019012810A (es
Inventor
Hideki Hirose
Koji Watanabe
Minoru Ikoma
Naoki Nishizawa
Sachie Morimoto
Shuji Kitamura
Taiji Asami
Takafumi Yukawa
Zenichi Ikeda
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of MX2019012810A publication Critical patent/MX2019012810A/es
Publication of MX392946B publication Critical patent/MX392946B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona un compuesto o una de sus sales que tiene una actividad antagonista del receptor sensible a calcio, y se espera que sea útil como agente para prevenir o tratar la insuficiencia cardíaca, la hipertensión pulmonar o similares. Los compuestos representados por la fórmula (I) o una de sus sales tiene una actividad antagonista del receptor sensible a calcio, y se espera que sea útil como agente para prevenir o tratar la insuficiencia cardíaca, la hipertensión pulmonar o similares, en donde cada símbolo se encuentra tal y como se describe en la memoria descriptiva.
MX2019012810A 2017-04-27 2018-04-26 Compuesto heterociclico. MX392946B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017087950 2017-04-27
PCT/JP2018/016996 WO2018199236A1 (ja) 2017-04-27 2018-04-26 複素環化合物

Publications (2)

Publication Number Publication Date
MX2019012810A MX2019012810A (es) 2022-06-03
MX392946B true MX392946B (es) 2025-03-24

Family

ID=63918548

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012810A MX392946B (es) 2017-04-27 2018-04-26 Compuesto heterociclico.

Country Status (13)

Country Link
US (1) US12202832B2 (es)
EP (1) EP3617208A4 (es)
JP (1) JP7177043B2 (es)
CN (1) CN110582499B (es)
AU (1) AU2018257332B2 (es)
CA (1) CA3061590A1 (es)
CO (1) CO2019012295A2 (es)
IL (1) IL270154B (es)
MX (1) MX392946B (es)
SA (1) SA519410385B1 (es)
SG (1) SG11201909811XA (es)
WO (1) WO2018199236A1 (es)
ZA (1) ZA201907793B (es)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA902280B (en) 1989-03-29 1990-12-28 Merrell Dow Pharma Selective adenosine receptor agents
PT1368355E (pt) 2001-03-14 2006-09-29 Gruenenthal Gmbh Pirazolopirimidinas e tiazolopirimidinas substituidas, como analgesicos
ZA200500782B (en) * 2002-08-26 2007-10-31 Takeda Pharmaceutical Calcium receptor modulating compound and use thereof
CA2494700C (en) * 2002-08-26 2011-06-28 Takeda Pharmaceutical Company Limited Calcium receptor modulating compound and use thereof
US7205322B2 (en) 2003-02-12 2007-04-17 Bristol-Myers Squibb Company Thiazolidine compounds as calcium sensing receptor modulators
US7501405B2 (en) 2003-04-11 2009-03-10 High Point Pharmaceuticals, Llc Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders
JP2005239611A (ja) * 2004-02-25 2005-09-08 Takeda Chem Ind Ltd ピラゾロピリミジン誘導体およびその用途
WO2007102531A1 (ja) 2006-03-08 2007-09-13 Takeda Pharmaceutical Company Limited 併用薬
JP5701608B2 (ja) 2007-12-06 2015-04-15 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
WO2009155448A1 (en) 2008-06-20 2009-12-23 Ligand Pharmaceuticals Inc. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
ES2623167T3 (es) 2012-02-03 2017-07-10 Sanofi Pirroldicarboxamidas condensadas y su uso como productos farmacéuticos
EP2927229B1 (en) * 2012-10-16 2018-09-05 Takeda Pharmaceutical Company Limited Benzene-fused 5-membered nitrogen-containing heteroaromatic compounds useful for prophylaxis or treatment of neurodegenerative diseases or epilepsy
EP2970307B1 (en) 2013-03-13 2020-03-11 Genentech, Inc. Pyrazolo compounds and uses thereof
CN104910118B (zh) 2014-03-13 2017-07-04 中国科学院上海药物研究所 一类双香豆素类化合物及其制备方法和用途
WO2017110881A1 (ja) 2015-12-25 2017-06-29 武田薬品工業株式会社 医薬
ES2882175T3 (es) 2016-03-28 2021-12-01 Takeda Pharmaceuticals Co Compuestos para su uso en el tratamiento de la hipertensión pulmonar

Also Published As

Publication number Publication date
WO2018199236A1 (ja) 2018-11-01
SA519410385B1 (ar) 2023-02-07
AU2018257332B2 (en) 2021-11-04
ZA201907793B (en) 2022-03-30
US12202832B2 (en) 2025-01-21
MX2019012810A (es) 2022-06-03
RU2019138176A3 (es) 2021-07-16
IL270154A (es) 2019-12-31
EP3617208A1 (en) 2020-03-04
CN110582499B (zh) 2022-04-29
US20210115048A1 (en) 2021-04-22
BR112019022457A2 (pt) 2020-05-12
CO2019012295A2 (es) 2020-02-28
JPWO2018199236A1 (ja) 2020-03-12
RU2019138176A (ru) 2021-05-27
SG11201909811XA (en) 2019-11-28
JP7177043B2 (ja) 2022-11-22
IL270154B (en) 2022-07-01
AU2018257332A1 (en) 2019-11-14
EP3617208A4 (en) 2020-08-26
CN110582499A (zh) 2019-12-17
CA3061590A1 (en) 2018-11-01

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