BR112018001726A2 - inibidores do vírus sincicial respiratório - Google Patents

inibidores do vírus sincicial respiratório

Info

Publication number
BR112018001726A2
BR112018001726A2 BR112018001726A BR112018001726A BR112018001726A2 BR 112018001726 A2 BR112018001726 A2 BR 112018001726A2 BR 112018001726 A BR112018001726 A BR 112018001726A BR 112018001726 A BR112018001726 A BR 112018001726A BR 112018001726 A2 BR112018001726 A2 BR 112018001726A2
Authority
BR
Brazil
Prior art keywords
respiratory syncytial
syncytial virus
virus inhibitors
inhibitors
cr1a
Prior art date
Application number
BR112018001726A
Other languages
English (en)
Inventor
Brochu Christian
Sturino Claudio
Kuhn Cyrille
Ghiro Elise
Sehgelmeble Fernando
Kalayanov Gennadiy
Westerlind Hans
Wähling Horst
Bylund Johan
Ersmark Karolina
Salvador Oden Lourdes
LEIJONMARCK Marie
Bertrand Megan
Ayesa Susana
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of BR112018001726A2 publication Critical patent/BR112018001726A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

compostos da formula (i), em que z1 é nr1a, chr1a ou cr1br1b; um dentre z2 e z3 é ch ou cr1a?, o outro é n, ch ou cr1a?; n é 0, 1 ou 2; q é 0, 1 ou 2; r1a, r1a?, r1b, r2 e r3 são conforme definido neste documento, seu uso como inibidores do vsr e aspectos relacionados.
BR112018001726A 2015-07-30 2016-07-28 inibidores do vírus sincicial respiratório BR112018001726A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1551051 2015-07-30
SE1650843 2016-06-15
PCT/SE2016/050733 WO2017018924A1 (en) 2015-07-30 2016-07-28 Respiratory syncytial virus inhibitors

Publications (1)

Publication Number Publication Date
BR112018001726A2 true BR112018001726A2 (pt) 2018-09-18

Family

ID=57884956

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018001726A BR112018001726A2 (pt) 2015-07-30 2016-07-28 inibidores do vírus sincicial respiratório

Country Status (10)

Country Link
US (1) US20190002436A1 (pt)
EP (1) EP3328859B1 (pt)
JP (1) JP6739516B2 (pt)
CN (1) CN107922407B (pt)
AU (1) AU2016298355A1 (pt)
BR (1) BR112018001726A2 (pt)
CA (1) CA2993144A1 (pt)
HK (1) HK1246781A1 (pt)
MX (1) MX2018001317A (pt)
WO (1) WO2017018924A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018038668A1 (en) * 2016-08-25 2018-03-01 Medivir Ab Respiratory syncytial virus inhibitors
WO2018038667A1 (en) * 2016-08-25 2018-03-01 Medivir Ab Respiratory syncytial virus inhibitors
CN108358832A (zh) * 2017-12-29 2018-08-03 上海艾康睿医药科技有限公司 一种合成4-[(2-氨基-4-氯)苯基]-氨基-n-哌啶甲酸乙酯的方法
WO2021098732A1 (zh) * 2019-11-18 2021-05-27 江苏恩华药业股份有限公司 一种1',2'-二氢-3'h-螺[环丁烷1,4'-异喹啉]-3'-酮衍生物及其应用
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016535043A (ja) * 2013-10-29 2016-11-10 メディヴィル・アクチエボラーグ キナゾリンベースの呼吸器合胞体ウイルス阻害剤
WO2015065336A1 (en) * 2013-10-29 2015-05-07 Medivir Ab Respiratory syncytial virus inhibitors
CN104693211A (zh) * 2013-12-10 2015-06-10 南京明德新药研发股份有限公司 作为抗病毒剂的咪唑衍生物及其制药用途

Also Published As

Publication number Publication date
JP2018525372A (ja) 2018-09-06
HK1246781A1 (zh) 2018-09-14
AU2016298355A1 (en) 2018-02-08
CN107922407B (zh) 2020-09-25
WO2017018924A1 (en) 2017-02-02
CA2993144A1 (en) 2017-02-02
MX2018001317A (es) 2018-04-30
CN107922407A (zh) 2018-04-17
US20190002436A1 (en) 2019-01-03
EP3328859A4 (en) 2019-03-13
JP6739516B2 (ja) 2020-08-12
EP3328859A1 (en) 2018-06-06
EP3328859B1 (en) 2020-06-03

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]