MX391083B - Uso de alfavirus en preparaciones de fármacos antitumorales. - Google Patents

Uso de alfavirus en preparaciones de fármacos antitumorales.

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Publication number
MX391083B
MX391083B MX2016010058A MX2016010058A MX391083B MX 391083 B MX391083 B MX 391083B MX 2016010058 A MX2016010058 A MX 2016010058A MX 2016010058 A MX2016010058 A MX 2016010058A MX 391083 B MX391083 B MX 391083B
Authority
MX
Mexico
Prior art keywords
alfavirus
drug preparations
alphavirus
antitumor drug
virus
Prior art date
Application number
MX2016010058A
Other languages
English (en)
Other versions
MX2016010058A (es
Inventor
Guangmei Yan
Haipeng Zhang
Jiankai Liang
Jun Hu
Kai Li
Suizhen Lin
Xiao Xiao
Yuan Lin
Original Assignee
Guangzhou Virotech Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Virotech Pharmaceutical Co Ltd filed Critical Guangzhou Virotech Pharmaceutical Co Ltd
Publication of MX2016010058A publication Critical patent/MX2016010058A/es
Publication of MX391083B publication Critical patent/MX391083B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector

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Abstract

La presente invención se refiere al uso de alfavirus en preparaciones de fármacos antitumorales. El alfavirus es el virus M1 o el virus Getah. Además, los tipos de tumor específicos sensibles al tratamiento con alfavirus antes mencionado se determinan a profundidad, de manera que se proporciona una solución segura y efectiva para esquemas de administración de fármaco antitumoral.
MX2016010058A 2014-08-26 2015-08-24 Uso de alfavirus en preparaciones de fármacos antitumorales. MX391083B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410425510.3A CN104814984B (zh) 2014-08-26 2014-08-26 甲病毒在制备抗肿瘤药物方面的应用
PCT/CN2015/087945 WO2016029833A1 (zh) 2014-08-26 2015-08-24 甲病毒在制备抗肿瘤药物方面的应用

Publications (2)

Publication Number Publication Date
MX2016010058A MX2016010058A (es) 2017-04-27
MX391083B true MX391083B (es) 2025-03-21

Family

ID=53725628

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010058A MX391083B (es) 2014-08-26 2015-08-24 Uso de alfavirus en preparaciones de fármacos antitumorales.

Country Status (15)

Country Link
US (2) US10517909B2 (es)
EP (1) EP3187588B1 (es)
JP (2) JP6441372B2 (es)
KR (2) KR20180119706A (es)
CN (3) CN107349226B (es)
AU (1) AU2015309403B2 (es)
CA (1) CA2939535C (es)
IL (1) IL247082B2 (es)
MX (1) MX391083B (es)
MY (1) MY188734A (es)
NZ (2) NZ722768A (es)
RU (1) RU2693938C2 (es)
SG (1) SG11201606707RA (es)
TW (1) TWI609690B (es)
WO (1) WO2016029833A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107349226B (zh) 2014-08-26 2020-08-25 广州威溶特医药科技有限公司 甲病毒在制备抗肿瘤药物方面的应用
CN105233285B (zh) * 2015-09-06 2018-10-12 广州威溶特医药科技有限公司 Epac直接或间接激动剂与溶瘤病毒的联合应用
CN105456302B (zh) * 2015-12-23 2019-09-24 广州威溶特医药科技有限公司 大黄酚或其衍生物和溶瘤病毒在制备抗肿瘤药物的应用
CN106177955B (zh) * 2016-08-18 2018-03-16 广州威溶特医药科技有限公司 Bcl‑xL抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
CN106177961B (zh) 2016-08-18 2018-03-13 广州威溶特医药科技有限公司 Vcp抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
CN106265764B (zh) 2016-08-18 2018-03-16 广州威溶特医药科技有限公司 Iap抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
CN109207491A (zh) * 2017-07-05 2019-01-15 中国科学院武汉物理与数学研究所 一种m1病毒全长感染性克隆及制备方法及其在制备m1病毒中的应用
CN109985242B (zh) * 2017-12-29 2022-07-29 广州威溶特医药科技有限公司 甲羟戊酸代谢通路抑制剂和甲病毒在制备抗肿瘤药物的应用
CN109985244A (zh) * 2017-12-29 2019-07-09 广州威溶特医药科技有限公司 E3连接酶抑制剂和溶瘤病毒在制备抗肿瘤药物的应用
CN109985239B (zh) * 2017-12-29 2024-10-18 广州威溶特医药科技有限公司 极光激酶抑制剂和甲病毒在制备抗肿瘤药物的应用
CN109985241B (zh) * 2017-12-29 2024-10-18 广州威溶特医药科技有限公司 Cdk抑制剂和溶瘤病毒在制备抗肿瘤药物的应用
CN108635584B (zh) * 2018-05-22 2021-12-21 广州威溶特医药科技有限公司 蛋白酶体抑制剂和甲病毒在制备抗肿瘤药物中的应用
CN108686221B (zh) * 2018-07-25 2022-02-22 广州威溶特医药科技有限公司 增效的抗肿瘤药物
US12529037B2 (en) 2019-05-31 2026-01-20 Guangzhou Virotech Pharmaceutical Co., Ltd. M1 virus mutant and use thereof
CN111603562A (zh) * 2020-05-29 2020-09-01 中山大学 5-脂氧合酶抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
CN111544595B (zh) * 2020-05-29 2021-10-26 中山大学 泛素结合酶e2抑制剂和溶瘤病毒在制备抗肿瘤药物的应用
CN111632146B (zh) * 2020-05-29 2021-09-28 中山大学 Oat抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
TWI778375B (zh) * 2020-06-18 2022-09-21 大陸商廣州威溶特醫藥科技有限公司 M1病毒變異體及其應用
CN120189493A (zh) * 2023-12-22 2025-06-24 广州威溶特医药科技有限公司 Dr-18和m1病毒在制备抗肿瘤药物中的应用

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CN104138375A (zh) 2013-05-08 2014-11-12 南开大学 苯并吡啶类衍生物在制备抗hiv药物中的用途
CN107349226B (zh) 2014-08-26 2020-08-25 广州威溶特医药科技有限公司 甲病毒在制备抗肿瘤药物方面的应用

Also Published As

Publication number Publication date
JP2017526612A (ja) 2017-09-14
RU2016131756A (ru) 2018-02-07
NZ746338A (en) 2019-10-25
JP6441372B2 (ja) 2018-12-19
JP2019048863A (ja) 2019-03-28
WO2016029833A1 (zh) 2016-03-03
TW201615202A (zh) 2016-05-01
KR20160105523A (ko) 2016-09-06
MX2016010058A (es) 2017-04-27
CN104814984A (zh) 2015-08-05
CN107456463A (zh) 2017-12-12
KR102125602B1 (ko) 2020-06-23
KR20180119706A (ko) 2018-11-02
EP3187588A4 (en) 2018-01-10
CA2939535A1 (en) 2016-03-03
IL247082B2 (en) 2023-11-01
EP3187588A1 (en) 2017-07-05
US20170304380A1 (en) 2017-10-26
CN107456463B (zh) 2022-10-14
CA2939535C (en) 2020-07-21
HK1212925A1 (zh) 2016-06-24
RU2693938C2 (ru) 2019-07-08
US11235011B2 (en) 2022-02-01
CN104814984B (zh) 2017-09-15
EP3187588B1 (en) 2020-11-18
MY188734A (en) 2021-12-27
NZ722768A (en) 2018-09-28
CN107349226A (zh) 2017-11-17
CN107349226B (zh) 2020-08-25
US10517909B2 (en) 2019-12-31
IL247082A0 (en) 2016-09-29
TWI609690B (zh) 2018-01-01
AU2015309403A1 (en) 2016-08-18
US20200085892A1 (en) 2020-03-19
AU2015309403B2 (en) 2017-03-16
SG11201606707RA (en) 2016-09-29
IL247082B1 (en) 2023-07-01

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