MX391074B - Composiciones para el tratamiento de condiciones patológicas de calcificación y sus métodos de uso. - Google Patents

Composiciones para el tratamiento de condiciones patológicas de calcificación y sus métodos de uso.

Info

Publication number
MX391074B
MX391074B MX2017014805A MX2017014805A MX391074B MX 391074 B MX391074 B MX 391074B MX 2017014805 A MX2017014805 A MX 2017014805A MX 2017014805 A MX2017014805 A MX 2017014805A MX 391074 B MX391074 B MX 391074B
Authority
MX
Mexico
Prior art keywords
calcification
methods
pathological
compositions
osteoarthritis
Prior art date
Application number
MX2017014805A
Other languages
English (en)
Spanish (es)
Other versions
MX2017014805A (es
Inventor
Demetrios Braddock
Ronald Albright
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Publication of MX2017014805A publication Critical patent/MX2017014805A/es
Publication of MX391074B publication Critical patent/MX391074B/es

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1741—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals alpha-Glycoproteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04001—Phosphodiesterase I (3.1.4.1)
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    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01009—Nucleotide diphosphatase (3.6.1.9), i.e. nucleotide-pyrophosphatase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/00—Modified animals
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    • A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
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    • A01K2227/00—Animals characterised by species
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    • A—HUMAN NECESSITIES
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    • A01K2267/03—Animal model, e.g. for test or diseases
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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    • C12N2840/00—Vectors comprising a special translation-regulating system
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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
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  • Biotechnology (AREA)
  • Immunology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Urology & Nephrology (AREA)
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  • Environmental Sciences (AREA)
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MX2017014805A 2015-05-19 2016-05-19 Composiciones para el tratamiento de condiciones patológicas de calcificación y sus métodos de uso. MX391074B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562163500P 2015-05-19 2015-05-19
PCT/US2016/033236 WO2016187408A1 (en) 2015-05-19 2016-05-19 Compositions for treating pathological calcification conditions, and methods using same

Publications (2)

Publication Number Publication Date
MX2017014805A MX2017014805A (es) 2018-02-15
MX391074B true MX391074B (es) 2025-03-21

Family

ID=57320640

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017014805A MX391074B (es) 2015-05-19 2016-05-19 Composiciones para el tratamiento de condiciones patológicas de calcificación y sus métodos de uso.
MX2022003467A MX2022003467A (es) 2015-05-19 2017-11-17 Composiciones para el tratamiento de condiciones patologicas de calcificacion y sus metodos de uso.

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Application Number Title Priority Date Filing Date
MX2022003467A MX2022003467A (es) 2015-05-19 2017-11-17 Composiciones para el tratamiento de condiciones patologicas de calcificacion y sus metodos de uso.

Country Status (11)

Country Link
US (10) US10064917B2 (enExample)
EP (2) EP3298140B1 (enExample)
JP (4) JP6995627B2 (enExample)
KR (2) KR20250078598A (enExample)
AU (3) AU2016264364B2 (enExample)
CA (2) CA2984947A1 (enExample)
ES (1) ES2983910T3 (enExample)
MX (2) MX391074B (enExample)
PL (1) PL3298140T3 (enExample)
RU (2) RU2757417C2 (enExample)
WO (1) WO2016187408A1 (enExample)

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EP3298140B1 (en) * 2015-05-19 2024-04-24 Yale University Compositions for treating pathological calcification conditions, and methods using same
EP3377105A4 (en) 2015-11-20 2019-04-24 Yale University COMPOSITIONS FOR THE TREATMENT OF ECTOPIC CALIBRATION DISORDERS AND METHODS THEREWITH
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US11390859B2 (en) 2016-08-05 2022-07-19 Yale University Compositions and methods for stroke prevention in pediatric sickle cell anemia patients
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JP2021523139A (ja) 2018-05-08 2021-09-02 イエール ユニバーシティ 腎石症の進行を遅らせるための組成物および方法
EP3844280A4 (en) * 2018-08-31 2022-09-14 Yale University ENPP1 POLYPEPTIDES AND METHODS OF USE
CN113631033B (zh) * 2019-01-18 2024-10-15 依诺兹梅制药公司 与enpp1或enpp3缺乏有关的疾病的治疗
CA3127256A1 (en) 2019-01-24 2020-07-30 Northwestern University High density lipoprotein mimetic nanoparticles using lipid conjugated core scaffolds
US20220195402A1 (en) * 2019-04-05 2022-06-23 Yale University Enpp1 polypeptides and methods of using same
KR20230048480A (ko) * 2020-05-27 2023-04-11 이노자임 파마, 인코포레이티드 말초 동맥 질환을 치료하기 위한 조성물 및 방법
EP4162036A1 (en) 2020-06-09 2023-04-12 Inozyme Pharma, Inc. Soluble enpp1 or enpp3 proteins and uses thereof
WO2022076848A1 (en) * 2020-10-08 2022-04-14 Inozyme Pharma, Inc. Liver specific production of enpp1 or enpp3
KR20230123932A (ko) * 2020-11-19 2023-08-24 이노자임 파마, 인코포레이티드 Enpp1 결핍증 및 abcc6 결핍증의 치료
MX2024003506A (es) * 2021-09-24 2024-04-23 Inozyme Pharma Inc Formulaciones de polipéptidos enpp1 liofilizados y usos de estas.
EP4766376A1 (en) * 2023-08-22 2026-07-01 BioMarin Pharmaceutical Inc. TREATMENT OF ENPP1 AND ABCC6 DEFICIENCY IN CHILDREN
WO2025255052A1 (en) * 2024-06-03 2025-12-11 Inozyme Pharma, Inc. Treatment of enpp1 deficiency and abcc6 deficiency in infants
WO2026102337A1 (en) 2024-11-08 2026-05-15 Biomarin Pharmaceutical Inc. Enpp1 for use in the treatment of calciphylaxis

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