MX390187B - Compuesto heterociclico. - Google Patents

Compuesto heterociclico.

Info

Publication number
MX390187B
MX390187B MX2019012808A MX2019012808A MX390187B MX 390187 B MX390187 B MX 390187B MX 2019012808 A MX2019012808 A MX 2019012808A MX 2019012808 A MX2019012808 A MX 2019012808A MX 390187 B MX390187 B MX 390187B
Authority
MX
Mexico
Prior art keywords
compound
heterocyclic compound
prevention
calcium
expected
Prior art date
Application number
MX2019012808A
Other languages
English (en)
Other versions
MX2019012808A (es
Inventor
Hideki Hirose
Kenjiro Sato
Koji Watanabe
Minoru Ikoma
Sachie Morimoto
Shuji Kitamura
Takafumi Yukawa
Zenichi Ikeda
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of MX2019012808A publication Critical patent/MX2019012808A/es
Publication of MX390187B publication Critical patent/MX390187B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona un compuesto o una de sus sales que tiene una actividad antagonista del receptor sensible a calcio, y se espera que sea útil como agente para prevenir o tratar la insuficiencia cardíaca, la hipertensión pulmonar o similares. Los compuestos representados por la fórmula (I) o una de sus sales tiene una actividad antagonista del receptor sensible a calcio, y se espera que sea útil como agente para prevenir o tratar la insuficiencia cardíaca, la hipertensión pulmonar o similares, en donde cada símbolo se encuentra tal y como se describe en la memoria descriptiva.
MX2019012808A 2017-04-27 2018-04-26 Compuesto heterociclico. MX390187B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017087959 2017-04-27
PCT/JP2018/016995 WO2018199235A1 (ja) 2017-04-27 2018-04-26 複素環化合物

Publications (2)

Publication Number Publication Date
MX2019012808A MX2019012808A (es) 2022-02-21
MX390187B true MX390187B (es) 2025-03-20

Family

ID=63919858

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012808A MX390187B (es) 2017-04-27 2018-04-26 Compuesto heterociclico.

Country Status (14)

Country Link
US (1) US10919891B2 (es)
EP (1) EP3617209A4 (es)
JP (1) JP7177042B2 (es)
CN (1) CN110573512B (es)
AU (1) AU2018257331B2 (es)
BR (1) BR112019022465A2 (es)
CA (1) CA3061600A1 (es)
CO (1) CO2019012270A2 (es)
IL (1) IL270155B (es)
MX (1) MX390187B (es)
RU (1) RU2768473C2 (es)
SG (1) SG11201909812VA (es)
WO (1) WO2018199235A1 (es)
ZA (1) ZA201907792B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA129159C2 (uk) * 2019-05-01 2025-01-29 Бьорінгер Інгельхайм Інтернаціональ Гмбх ТВЕРДІ ФОРМИ ІНГІБІТОРА GlyT1

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1368355E (pt) * 2001-03-14 2006-09-29 Gruenenthal Gmbh Pirazolopirimidinas e tiazolopirimidinas substituidas, como analgesicos
CA2494700C (en) 2002-08-26 2011-06-28 Takeda Pharmaceutical Company Limited Calcium receptor modulating compound and use thereof
ZA200500782B (en) 2002-08-26 2007-10-31 Takeda Pharmaceutical Calcium receptor modulating compound and use thereof
US7205322B2 (en) 2003-02-12 2007-04-17 Bristol-Myers Squibb Company Thiazolidine compounds as calcium sensing receptor modulators
US7501405B2 (en) * 2003-04-11 2009-03-10 High Point Pharmaceuticals, Llc Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders
JP2005239611A (ja) 2004-02-25 2005-09-08 Takeda Chem Ind Ltd ピラゾロピリミジン誘導体およびその用途
WO2007102531A1 (ja) 2006-03-08 2007-09-13 Takeda Pharmaceutical Company Limited 併用薬
ES2623167T3 (es) 2012-02-03 2017-07-10 Sanofi Pirroldicarboxamidas condensadas y su uso como productos farmacéuticos
EP2927229B1 (en) * 2012-10-16 2018-09-05 Takeda Pharmaceutical Company Limited Benzene-fused 5-membered nitrogen-containing heteroaromatic compounds useful for prophylaxis or treatment of neurodegenerative diseases or epilepsy
CN104910118B (zh) 2014-03-13 2017-07-04 中国科学院上海药物研究所 一类双香豆素类化合物及其制备方法和用途
WO2017110881A1 (ja) 2015-12-25 2017-06-29 武田薬品工業株式会社 医薬
ES2882175T3 (es) 2016-03-28 2021-12-01 Takeda Pharmaceuticals Co Compuestos para su uso en el tratamiento de la hipertensión pulmonar

Also Published As

Publication number Publication date
IL270155B (en) 2022-07-01
RU2019138175A (ru) 2021-05-27
AU2018257331A1 (en) 2019-11-14
JPWO2018199235A1 (ja) 2020-03-12
RU2019138175A3 (es) 2021-06-10
CN110573512B (zh) 2022-09-06
BR112019022465A2 (pt) 2020-05-12
US10919891B2 (en) 2021-02-16
MX2019012808A (es) 2022-02-21
CA3061600A1 (en) 2019-10-25
IL270155A (es) 2019-12-31
RU2768473C2 (ru) 2022-03-24
US20200131174A1 (en) 2020-04-30
EP3617209A4 (en) 2020-08-26
CN110573512A (zh) 2019-12-13
AU2018257331B2 (en) 2022-04-07
JP7177042B2 (ja) 2022-11-22
CO2019012270A2 (es) 2020-02-28
ZA201907792B (en) 2022-03-30
SG11201909812VA (en) 2019-11-28
EP3617209A1 (en) 2020-03-04
WO2018199235A1 (ja) 2018-11-01

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