MX387420B - Producción de virus en cultivos celulares. - Google Patents
Producción de virus en cultivos celulares.Info
- Publication number
- MX387420B MX387420B MX2018006373A MX2018006373A MX387420B MX 387420 B MX387420 B MX 387420B MX 2018006373 A MX2018006373 A MX 2018006373A MX 2018006373 A MX2018006373 A MX 2018006373A MX 387420 B MX387420 B MX 387420B
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- relates
- cell cultures
- virus production
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/17—Newcastle disease virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16051—Methods of production or purification of viral material
- C12N2760/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
- C12N2760/16152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16311—Influenzavirus C, i.e. influenza C virus
- C12N2760/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18211—Henipavirus, e.g. hendra virus
- C12N2760/18251—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015904851A AU2015904851A0 (en) | 2015-11-24 | Production of viruses in cell culture | |
| PCT/AU2016/051147 WO2017088018A1 (en) | 2015-11-24 | 2016-11-23 | Production of viruses in cell culture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018006373A MX2018006373A (es) | 2018-11-09 |
| MX387420B true MX387420B (es) | 2025-03-18 |
Family
ID=58762866
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018006373A MX387420B (es) | 2015-11-24 | 2016-11-23 | Producción de virus en cultivos celulares. |
| MX2021009554A MX2021009554A (es) | 2015-11-24 | 2018-05-23 | Produccion de virus en cultivos celulares. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021009554A MX2021009554A (es) | 2015-11-24 | 2018-05-23 | Produccion de virus en cultivos celulares. |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US11174466B2 (https=) |
| EP (1) | EP3380611A4 (https=) |
| JP (2) | JP7189017B2 (https=) |
| KR (1) | KR20180081615A (https=) |
| CN (1) | CN108603188A (https=) |
| AU (2) | AU2016361455A1 (https=) |
| BR (1) | BR112018010499A8 (https=) |
| CA (2) | CA3247290A1 (https=) |
| MX (2) | MX387420B (https=) |
| WO (1) | WO2017088018A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX387420B (es) * | 2015-11-24 | 2025-03-18 | Commw Scient Ind Res Org | Producción de virus en cultivos celulares. |
| EP3380616A4 (en) | 2015-11-24 | 2019-11-06 | Commonwealth Scientific and Industrial Research Organisation | MANUFACTURE OF VIRUSES IN BIRDS |
| US11845989B2 (en) | 2019-01-23 | 2023-12-19 | Regeneron Pharmaceuticals, Inc. | Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors |
| MX2021008797A (es) | 2019-01-23 | 2022-01-31 | Regeneron Pharma | Tratamiento de afecciones oftalmicas con inhibidores de proteinas relacionadas a angiopoyetina 7 (angptl7). |
| CN110129281A (zh) * | 2019-05-15 | 2019-08-16 | 成都天邦生物制品有限公司 | 一种使用悬浮细胞培养新城疫病毒的方法及应用 |
| US11865134B2 (en) | 2021-02-26 | 2024-01-09 | Regeneron Pharmaceuticals, Inc. | Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (ANGPTL7) inhibitors |
| KR102898506B1 (ko) * | 2021-04-30 | 2025-12-10 | 서울대학교산학협력단 | 바이러스 백신 생산용 조류 세포 제조용 조성물 및 바이러스 저항성 조류 세포 제조용 조성물 |
| CN114774418B (zh) * | 2022-04-19 | 2023-11-14 | 深圳市人民医院 | shRNA分子及其在敲低TM9SF2基因表达中的应用 |
| CN116656628A (zh) * | 2023-07-31 | 2023-08-29 | 深圳市卫光生物制品股份有限公司 | 一种痘病毒载体疫苗的制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162215A (en) | 1988-09-22 | 1992-11-10 | Amgen Inc. | Method of gene transfer into chickens and other avian species |
| DE69937999T2 (de) | 1998-06-12 | 2009-01-29 | Avir Green Hills Biotechnology Research Development Trade Ag | Interferon induzierende genetisch veränderte attenuierte viren |
| JP4837827B2 (ja) * | 1998-06-12 | 2011-12-14 | マウント シナイ スクール オブ メディシン | 新規なウイルス増殖方法およびそのためのインターフェロン欠損培養基 |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US20030104526A1 (en) | 1999-03-24 | 2003-06-05 | Qiang Liu | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
| US8202979B2 (en) | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| AU2002228841C1 (en) | 2000-12-07 | 2006-11-23 | Sangamo Biosciences, Inc | Regulation of angiogenesis with zinc finger proteins |
| WO2002057293A2 (en) | 2001-01-22 | 2002-07-25 | Sangamo Biosciences, Inc. | Modified zinc finger binding proteins |
| AU2002225187A1 (en) | 2001-01-22 | 2002-07-30 | Sangamo Biosciences, Inc. | Zinc finger polypeptides and their use |
| US7145057B2 (en) | 2002-02-01 | 2006-12-05 | Origen Therapeutics, Inc. | Chimeric bird from embryonic stem cells |
| WO2005113756A1 (en) | 2004-05-14 | 2005-12-01 | Glaxosmithkline Biologicals S.A. | Method |
| CA2595576A1 (en) | 2005-02-01 | 2006-08-10 | Origen Therapeutics, Inc. | Transgenic chickens |
| PL2251034T3 (pl) | 2005-12-02 | 2018-07-31 | Icahn School Of Medicine At Mount Sinai | Chimeryczne wirusy prezentujące nienatywne białka powierzchniowe i zastosowania tych wirusów |
| ES2586210T3 (es) | 2006-12-14 | 2016-10-13 | Sangamo Biosciences, Inc. | Proteínas de dedo de zinc no canónicas optimizadas |
| AU2008301229B2 (en) | 2007-09-20 | 2013-10-10 | Australian Poultry Crc Pty Ltd | Novel avian cytokines and genetic sequences encoding same |
| EP2408921B1 (en) | 2009-03-20 | 2017-04-19 | Sangamo BioSciences, Inc. | Modification of cxcr4 using engineered zinc finger proteins |
| US20140154783A1 (en) | 2009-07-06 | 2014-06-05 | Alnylam Pharmaceuticals, Inc. | Bioprocessing |
| WO2011017293A2 (en) | 2009-08-03 | 2011-02-10 | The General Hospital Corporation | Engineering of zinc finger arrays by context-dependent assembly |
| EP2295543A1 (en) | 2009-09-11 | 2011-03-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the preparation of an influenza virus |
| WO2011072247A2 (en) | 2009-12-11 | 2011-06-16 | The Brigham And Women's Hospital, Inc. | Pathogen restriction factors |
| WO2012164130A1 (es) * | 2011-05-27 | 2012-12-06 | Consejo Superior De Investigaciones Científicas (Csic) | Construcción de células deficitarias en un modulador negativo del virus de la gripe para incrementar la producción de virus vacunales |
| WO2013059299A1 (en) * | 2011-10-17 | 2013-04-25 | The Uab Research Foundation | Antibodies for interferon subtypes and interferon/interferon receptor ternary complex and uses thereof |
| AU2013204327B2 (en) | 2012-04-20 | 2016-09-01 | Aviagen | Cell transfection method |
| WO2013166264A2 (en) | 2012-05-02 | 2013-11-07 | University Of Georgia Research Foundation, Inc. | Methods for altering virus replication |
| JP2016502526A (ja) | 2012-11-16 | 2016-01-28 | ノバルティス アーゲー | 末梢動脈疾患を処置するためのＩＬ−１β結合抗体の使用 |
| BR112015018493A2 (pt) | 2013-02-05 | 2017-08-22 | Univ Georgia | Linhagens celulares para produção de vírus e métodos de uso |
| WO2014142433A1 (ko) | 2013-03-13 | 2014-09-18 | 고려대학교산학협력단 | 바이러스 생산능이 증가된 세포주 및 그 제조방법 |
| US9902973B2 (en) | 2013-04-11 | 2018-02-27 | Caribou Biosciences, Inc. | Methods of modifying a target nucleic acid with an argonaute |
| GB201310031D0 (en) | 2013-06-05 | 2013-07-17 | Pirbright Inst The | Cell |
| GB201310432D0 (en) | 2013-06-12 | 2013-07-24 | Univ St Andrews | Virus Production |
| CN104560864B (zh) * | 2014-12-22 | 2017-08-11 | 中国科学院微生物研究所 | 利用CRISPR‑Cas9系统构建的敲除IFN‑β基因的293T细胞系 |
| CN104694576B (zh) * | 2015-03-30 | 2018-04-17 | 山东省农业科学院家禽研究所 | 一种沉默df‑1细胞系中ifnar1基因的方法 |
| EP3380616A4 (en) | 2015-11-24 | 2019-11-06 | Commonwealth Scientific and Industrial Research Organisation | MANUFACTURE OF VIRUSES IN BIRDS |
| MX387420B (es) | 2015-11-24 | 2025-03-18 | Commw Scient Ind Res Org | Producción de virus en cultivos celulares. |
-
2016
- 2016-11-23 MX MX2018006373A patent/MX387420B/es unknown
- 2016-11-23 CN CN201680079158.XA patent/CN108603188A/zh active Pending
- 2016-11-23 US US15/777,890 patent/US11174466B2/en not_active Expired - Fee Related
- 2016-11-23 JP JP2018526926A patent/JP7189017B2/ja active Active
- 2016-11-23 CA CA3247290A patent/CA3247290A1/en active Pending
- 2016-11-23 AU AU2016361455A patent/AU2016361455A1/en not_active Abandoned
- 2016-11-23 WO PCT/AU2016/051147 patent/WO2017088018A1/en not_active Ceased
- 2016-11-23 EP EP16867451.3A patent/EP3380611A4/en not_active Withdrawn
- 2016-11-23 CA CA3005989A patent/CA3005989C/en active Active
- 2016-11-23 KR KR1020187017660A patent/KR20180081615A/ko active Pending
- 2016-11-23 BR BR112018010499A patent/BR112018010499A8/pt not_active Application Discontinuation
-
2018
- 2018-05-23 MX MX2021009554A patent/MX2021009554A/es unknown
-
2019
- 2019-01-25 US US16/258,229 patent/US10626379B2/en active Active
-
2021
- 2021-10-12 US US17/499,509 patent/US12054750B2/en active Active
-
2022
- 2022-12-01 JP JP2022193050A patent/JP2023014322A/ja active Pending
-
2023
- 2023-02-03 AU AU2023200556A patent/AU2023200556A1/en active Pending
-
2024
- 2024-06-26 US US18/755,417 patent/US20250011731A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US11174466B2 (en) | 2021-11-16 |
| US20190322989A1 (en) | 2019-10-24 |
| AU2016361455A1 (en) | 2018-06-21 |
| BR112018010499A2 (en) | 2018-11-13 |
| CA3247290A1 (en) | 2025-07-09 |
| CN108603188A (zh) | 2018-09-28 |
| CA3005989C (en) | 2025-11-18 |
| EP3380611A4 (en) | 2020-02-12 |
| US20250011731A1 (en) | 2025-01-09 |
| JP2019500860A (ja) | 2019-01-17 |
| CA3005989A1 (en) | 2017-06-01 |
| BR112018010499A8 (pt) | 2019-02-26 |
| KR20180081615A (ko) | 2018-07-16 |
| MX2021009554A (es) | 2021-09-08 |
| US10626379B2 (en) | 2020-04-21 |
| US20180340153A1 (en) | 2018-11-29 |
| US20220106574A1 (en) | 2022-04-07 |
| JP7189017B2 (ja) | 2022-12-13 |
| US12054750B2 (en) | 2024-08-06 |
| JP2023014322A (ja) | 2023-01-26 |
| EP3380611A1 (en) | 2018-10-03 |
| MX2018006373A (es) | 2018-11-09 |
| WO2017088018A1 (en) | 2017-06-01 |
| AU2023200556A1 (en) | 2023-03-02 |
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