MX375864B - Esteroides de 5.beta-6-alquil-7-hidroxi-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr) - Google Patents

Esteroides de 5.beta-6-alquil-7-hidroxi-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr)

Info

Publication number
MX375864B
MX375864B MX2017006564A MX2017006564A MX375864B MX 375864 B MX375864 B MX 375864B MX 2017006564 A MX2017006564 A MX 2017006564A MX 2017006564 A MX2017006564 A MX 2017006564A MX 375864 B MX375864 B MX 375864B
Authority
MX
Mexico
Prior art keywords
farnesoid
fxr
steroids
receptor
beta
Prior art date
Application number
MX2017006564A
Other languages
English (en)
Spanish (es)
Other versions
MX2017006564A (es
Inventor
Alexander Weymouth-Wilson
James Boydell
Laura Wallis
Montserrat Shelbourne
Nathan Bartlett
Zofia Komsta
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505674.0A external-priority patent/GB201505674D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of MX2017006564A publication Critical patent/MX2017006564A/es
Publication of MX375864B publication Critical patent/MX375864B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MX2017006564A 2014-11-19 2015-11-19 Esteroides de 5.beta-6-alquil-7-hidroxi-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr) MX375864B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505674.0A GB201505674D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053517 WO2016079518A1 (en) 2014-11-19 2015-11-19 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators

Publications (2)

Publication Number Publication Date
MX2017006564A MX2017006564A (es) 2018-01-26
MX375864B true MX375864B (es) 2025-03-07

Family

ID=54704020

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017006564A MX375864B (es) 2014-11-19 2015-11-19 Esteroides de 5.beta-6-alquil-7-hidroxi-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr)

Country Status (14)

Country Link
US (1) US10131688B2 (enExample)
EP (1) EP3221332B1 (enExample)
JP (1) JP6724004B2 (enExample)
KR (1) KR102526632B1 (enExample)
CN (1) CN107108687B (enExample)
CA (1) CA2968301C (enExample)
DK (1) DK3221332T3 (enExample)
EA (1) EA033445B1 (enExample)
ES (1) ES2733643T3 (enExample)
HK (1) HK1244285B (enExample)
MX (1) MX375864B (enExample)
PL (1) PL3221332T3 (enExample)
TW (1) TWI686400B (enExample)
WO (1) WO2016079518A1 (enExample)

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EP3221333B1 (en) 2014-11-19 2019-07-24 NZP UK Limited 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators
EP3221331B1 (en) 2014-11-19 2019-09-18 Nzp Uk Limited 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators
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GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
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CN106279331B (zh) * 2016-07-27 2019-06-14 宋火良 胆酸类肝病治疗药物
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GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
CN113135970B (zh) * 2020-01-20 2024-11-22 成都贝诺科成生物科技有限公司 一种具有抗芽孢活性的化合物及其药用组合物
GB202416085D0 (en) 2024-10-31 2024-12-18 Nzp Uk Ltd Reduction process

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Also Published As

Publication number Publication date
ES2733643T3 (es) 2019-12-02
JP2017538691A (ja) 2017-12-28
CA2968301C (en) 2023-05-16
US20170320907A1 (en) 2017-11-09
KR102526632B1 (ko) 2023-04-27
DK3221332T3 (da) 2019-07-29
EA033445B1 (ru) 2019-10-31
PL3221332T3 (pl) 2019-10-31
TWI686400B (zh) 2020-03-01
MX2017006564A (es) 2018-01-26
WO2016079518A1 (en) 2016-05-26
KR20170099895A (ko) 2017-09-01
HK1244285B (en) 2020-06-05
CN107108687A (zh) 2017-08-29
CN107108687B (zh) 2019-10-29
EA201790881A1 (ru) 2017-11-30
EP3221332B1 (en) 2019-04-24
CA2968301A1 (en) 2016-05-26
TW201629081A (zh) 2016-08-16
JP6724004B2 (ja) 2020-07-15
EA201790881A8 (ru) 2019-07-31
EP3221332A1 (en) 2017-09-27
US10131688B2 (en) 2018-11-20

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