HK1244285B - 5.beta -6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators - Google Patents

5.beta -6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators Download PDF

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Publication number
HK1244285B
HK1244285B HK18103791.5A HK18103791A HK1244285B HK 1244285 B HK1244285 B HK 1244285B HK 18103791 A HK18103791 A HK 18103791A HK 1244285 B HK1244285 B HK 1244285B
Authority
HK
Hong Kong
Prior art keywords
general formula
compound
alkyl
halo
optionally substituted
Prior art date
Application number
HK18103791.5A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1244285A1 (en
Inventor
Alexander Weymouth-Wilson
Zofia KOMSTA
James Boydell
Laura WALLIS
Nathan Bartlett
Montserrat SHELBOURNE
Original Assignee
NZP UK Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505674.0A external-priority patent/GB201505674D0/en
Application filed by NZP UK Limited filed Critical NZP UK Limited
Publication of HK1244285A1 publication Critical patent/HK1244285A1/en
Publication of HK1244285B publication Critical patent/HK1244285B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK18103791.5A 2014-11-19 2015-11-19 5.beta -6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators HK1244285B (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1420594.2 2014-11-19
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420593.4 2014-11-19
GBGB1505674.0A GB201505674D0 (en) 2015-04-01 2015-04-01 Compounds
GB1505674.0 2015-04-01
PCT/GB2015/053517 WO2016079518A1 (en) 2014-11-19 2015-11-19 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators

Publications (2)

Publication Number Publication Date
HK1244285A1 HK1244285A1 (en) 2018-08-03
HK1244285B true HK1244285B (en) 2020-06-05

Family

ID=54704020

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103791.5A HK1244285B (en) 2014-11-19 2015-11-19 5.beta -6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators

Country Status (14)

Country Link
US (1) US10131688B2 (enExample)
EP (1) EP3221332B1 (enExample)
JP (1) JP6724004B2 (enExample)
KR (1) KR102526632B1 (enExample)
CN (1) CN107108687B (enExample)
CA (1) CA2968301C (enExample)
DK (1) DK3221332T3 (enExample)
EA (1) EA033445B1 (enExample)
ES (1) ES2733643T3 (enExample)
HK (1) HK1244285B (enExample)
MX (1) MX375864B (enExample)
PL (1) PL3221332T3 (enExample)
TW (1) TWI686400B (enExample)
WO (1) WO2016079518A1 (enExample)

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Also Published As

Publication number Publication date
EA033445B1 (ru) 2019-10-31
MX2017006564A (es) 2018-01-26
CA2968301C (en) 2023-05-16
EP3221332B1 (en) 2019-04-24
JP6724004B2 (ja) 2020-07-15
PL3221332T3 (pl) 2019-10-31
CN107108687A (zh) 2017-08-29
EP3221332A1 (en) 2017-09-27
WO2016079518A1 (en) 2016-05-26
JP2017538691A (ja) 2017-12-28
MX375864B (es) 2025-03-07
KR20170099895A (ko) 2017-09-01
EA201790881A1 (ru) 2017-11-30
US20170320907A1 (en) 2017-11-09
TWI686400B (zh) 2020-03-01
EA201790881A8 (ru) 2019-07-31
US10131688B2 (en) 2018-11-20
CN107108687B (zh) 2019-10-29
KR102526632B1 (ko) 2023-04-27
CA2968301A1 (en) 2016-05-26
DK3221332T3 (da) 2019-07-29
ES2733643T3 (es) 2019-12-02
TW201629081A (zh) 2016-08-16

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