PL3221332T3 - Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr - Google Patents

Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr

Info

Publication number
PL3221332T3
PL3221332T3 PL15800910T PL15800910T PL3221332T3 PL 3221332 T3 PL3221332 T3 PL 3221332T3 PL 15800910 T PL15800910 T PL 15800910T PL 15800910 T PL15800910 T PL 15800910T PL 3221332 T3 PL3221332 T3 PL 3221332T3
Authority
PL
Poland
Prior art keywords
steroids
intermediates
beta
hydroxy
alkyl
Prior art date
Application number
PL15800910T
Other languages
English (en)
Polish (pl)
Inventor
Alexander Weymouth-Wilson
Zofia Komsta
James Boydell
Laura Wallis
Nathan Bartlett
Montserrat Shelbourne
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505674.0A external-priority patent/GB201505674D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of PL3221332T3 publication Critical patent/PL3221332T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL15800910T 2014-11-19 2015-11-19 Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr PL3221332T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505674.0A GB201505674D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053517 WO2016079518A1 (en) 2014-11-19 2015-11-19 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators
EP15800910.0A EP3221332B1 (en) 2014-11-19 2015-11-19 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators

Publications (1)

Publication Number Publication Date
PL3221332T3 true PL3221332T3 (pl) 2019-10-31

Family

ID=54704020

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15800910T PL3221332T3 (pl) 2014-11-19 2015-11-19 Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr

Country Status (14)

Country Link
US (1) US10131688B2 (enExample)
EP (1) EP3221332B1 (enExample)
JP (1) JP6724004B2 (enExample)
KR (1) KR102526632B1 (enExample)
CN (1) CN107108687B (enExample)
CA (1) CA2968301C (enExample)
DK (1) DK3221332T3 (enExample)
EA (1) EA033445B1 (enExample)
ES (1) ES2733643T3 (enExample)
HK (1) HK1244285B (enExample)
MX (1) MX375864B (enExample)
PL (1) PL3221332T3 (enExample)
TW (1) TWI686400B (enExample)
WO (1) WO2016079518A1 (enExample)

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EP3431486A1 (en) * 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
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CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
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Also Published As

Publication number Publication date
EA033445B1 (ru) 2019-10-31
MX2017006564A (es) 2018-01-26
CA2968301C (en) 2023-05-16
EP3221332B1 (en) 2019-04-24
JP6724004B2 (ja) 2020-07-15
CN107108687A (zh) 2017-08-29
EP3221332A1 (en) 2017-09-27
WO2016079518A1 (en) 2016-05-26
JP2017538691A (ja) 2017-12-28
MX375864B (es) 2025-03-07
KR20170099895A (ko) 2017-09-01
EA201790881A1 (ru) 2017-11-30
US20170320907A1 (en) 2017-11-09
TWI686400B (zh) 2020-03-01
EA201790881A8 (ru) 2019-07-31
US10131688B2 (en) 2018-11-20
CN107108687B (zh) 2019-10-29
KR102526632B1 (ko) 2023-04-27
HK1244285B (en) 2020-06-05
CA2968301A1 (en) 2016-05-26
DK3221332T3 (da) 2019-07-29
ES2733643T3 (es) 2019-12-02
TW201629081A (zh) 2016-08-16

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