HK1244285B - 作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇 - Google Patents

作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇

Info

Publication number
HK1244285B
HK1244285B HK18103791.5A HK18103791A HK1244285B HK 1244285 B HK1244285 B HK 1244285B HK 18103791 A HK18103791 A HK 18103791A HK 1244285 B HK1244285 B HK 1244285B
Authority
HK
Hong Kong
Prior art keywords
asintermediates
steroids
beta
hydroxy
alkyl
Prior art date
Application number
HK18103791.5A
Other languages
English (en)
Inventor
Alexander Weymouth-Wilson
Zofia Komsta
James Boydell
Laura Wallis
Nathan Bartlett
Montserrat Shelbourne
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505674.0A external-priority patent/GB201505674D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of HK1244285B publication Critical patent/HK1244285B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK18103791.5A 2014-11-19 2018-03-19 作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇 HK1244285B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505674.0A GB201505674D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053517 WO2016079518A1 (en) 2014-11-19 2015-11-19 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators

Publications (1)

Publication Number Publication Date
HK1244285B true HK1244285B (zh) 2020-06-05

Family

ID=54704020

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103791.5A HK1244285B (zh) 2014-11-19 2018-03-19 作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇

Country Status (14)

Country Link
US (1) US10131688B2 (zh)
EP (1) EP3221332B1 (zh)
JP (1) JP6724004B2 (zh)
KR (1) KR102526632B1 (zh)
CN (1) CN107108687B (zh)
CA (1) CA2968301C (zh)
DK (1) DK3221332T3 (zh)
EA (1) EA033445B1 (zh)
ES (1) ES2733643T3 (zh)
HK (1) HK1244285B (zh)
MX (1) MX2017006564A (zh)
PL (1) PL3221332T3 (zh)
TW (1) TWI686400B (zh)
WO (1) WO2016079518A1 (zh)

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TWI688571B (zh) 2014-11-19 2020-03-21 英商Ｎｚｐ英國有限公司 化合物（四）
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Also Published As

Publication number Publication date
WO2016079518A1 (en) 2016-05-26
EP3221332B1 (en) 2019-04-24
US20170320907A1 (en) 2017-11-09
KR20170099895A (ko) 2017-09-01
DK3221332T3 (da) 2019-07-29
MX2017006564A (es) 2018-01-26
TWI686400B (zh) 2020-03-01
JP6724004B2 (ja) 2020-07-15
CN107108687A (zh) 2017-08-29
JP2017538691A (ja) 2017-12-28
EA033445B1 (ru) 2019-10-31
EA201790881A8 (ru) 2019-07-31
TW201629081A (zh) 2016-08-16
ES2733643T3 (es) 2019-12-02
KR102526632B1 (ko) 2023-04-27
EA201790881A1 (ru) 2017-11-30
CA2968301C (en) 2023-05-16
CN107108687B (zh) 2019-10-29
CA2968301A1 (en) 2016-05-26
PL3221332T3 (pl) 2019-10-31
US10131688B2 (en) 2018-11-20
EP3221332A1 (en) 2017-09-27

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