HK1244285B - 作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇 - Google Patents

作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇

Info

Publication number
HK1244285B
HK1244285B HK18103791.5A HK18103791A HK1244285B HK 1244285 B HK1244285 B HK 1244285B HK 18103791 A HK18103791 A HK 18103791A HK 1244285 B HK1244285 B HK 1244285B
Authority
HK
Hong Kong
Prior art keywords
asintermediates
steroids
beta
hydroxy
alkyl
Prior art date
Application number
HK18103791.5A
Other languages
English (en)
Inventor
Alexander Weymouth-Wilson
Zofia Komsta
James Boydell
Laura Wallis
Nathan Bartlett
Montserrat Shelbourne
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505674.0A external-priority patent/GB201505674D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of HK1244285B publication Critical patent/HK1244285B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK18103791.5A 2014-11-19 2018-03-19 作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇 HK1244285B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505674.0A GB201505674D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053517 WO2016079518A1 (en) 2014-11-19 2015-11-19 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators

Publications (1)

Publication Number Publication Date
HK1244285B true HK1244285B (zh) 2020-06-05

Family

ID=54704020

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18103791.5A HK1244285B (zh) 2014-11-19 2018-03-19 作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇

Country Status (14)

Country Link
US (1) US10131688B2 (zh)
EP (1) EP3221332B1 (zh)
JP (1) JP6724004B2 (zh)
KR (1) KR102526632B1 (zh)
CN (1) CN107108687B (zh)
CA (1) CA2968301C (zh)
DK (1) DK3221332T3 (zh)
EA (1) EA033445B1 (zh)
ES (1) ES2733643T3 (zh)
HK (1) HK1244285B (zh)
MX (1) MX2017006564A (zh)
PL (1) PL3221332T3 (zh)
TW (1) TWI686400B (zh)
WO (1) WO2016079518A1 (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3221333T3 (da) 2014-11-19 2019-09-30 Nzp Uk Ltd 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer
EA033427B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
KR102527821B1 (ko) 2014-11-19 2023-05-02 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드
EA201891491A1 (ru) * 2015-12-22 2018-11-30 Интерсепт Фармасьютикалз, Инк. Полиморфные кристаллические формы обетихолевой кислоты
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608779D0 (en) * 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
CN106279331B (zh) * 2016-07-27 2019-06-14 宋火良 胆酸类肝病治疗药物
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
CN113135970A (zh) * 2020-01-20 2021-07-20 成都贝诺科成生物科技有限公司 一种具有抗芽孢活性的化合物及其药用组合物

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2624748A (en) 1950-09-09 1953-01-06 Upjohn Co Bisnorchola-4, 6-dien-3-one-22-al
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
ATE156158T1 (de) 1992-04-14 1997-08-15 Cornell Res Foundation Inc Makromoleküle auf basis von dendritischen polymeren und verfahren zur herstellung
WO1994019366A1 (en) 1993-02-26 1994-09-01 Magainin Pharmaceuticals Inc. Chemical synthesis of squalamine
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
CA2440680C (en) 2001-03-12 2010-06-01 Roberto Pellicciari Steroids as agonists for fxr
US20090062256A1 (en) 2001-06-01 2009-03-05 Bristol-Myers Squibb Pharma Company LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
MXPA04004336A (es) 2001-11-07 2005-05-16 Nektar Therapeutics Al Corp Polimeros ramificados y sus conjugados.
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
JP2007210888A (ja) 2006-01-12 2007-08-23 Mitsubishi Chemicals Corp ステロイド化合物の製造方法
CA2642220A1 (en) 2006-02-14 2007-08-23 Intercept Pharmaceuticals, Inc. Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions
CA2656320C (en) 2006-06-27 2015-04-28 Intercept Pharmaceuticals, Inc. Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions
EA017714B1 (ru) 2007-01-19 2013-02-28 Интерсепт Фармасьютикалз, Инк. Модуляторы tgr5 и способы их применения
WO2010014836A2 (en) * 2008-07-30 2010-02-04 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
WO2010059853A1 (en) 2008-11-19 2010-05-27 Intercept Pharmaceuticals, Inc. Tgr5 modulators and method of use thereof
EP3150620B1 (en) * 2008-11-19 2020-01-08 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
CN102482315A (zh) 2009-07-29 2012-05-30 芝加哥大学 肝x受体激动剂
EP3336097B1 (en) 2012-06-19 2020-08-19 Intercept Pharmaceuticals, Inc. Preparation of the non-crystalline form of obeticholic acid
EP2912013B1 (en) 2012-10-26 2017-10-11 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives
US20140148428A1 (en) 2012-11-28 2014-05-29 Intercept Pharmaceuticals, Inc. Treatment of Pulmonary Disease
US20140206657A1 (en) * 2013-01-18 2014-07-24 City Of Hope Bile acid analog tgr5 agonists
EP3360882B1 (en) 2013-05-14 2020-12-09 Intercept Pharmaceuticals, Inc. 11-hydroxyl-6-substituted-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators
EP3004892B1 (en) 2013-05-24 2018-10-10 Nestec S.A. Method for diagnosing irritable bowel syndrome
WO2015183794A1 (en) 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
ES2768718T3 (es) 2014-05-29 2020-06-23 Bar Pharmaceuticals S R L Derivados de colano para su uso en el tratamiento y/o prevención de enfermedades mediadas por FXR y TGR5/GPBAR1
US10266560B2 (en) 2014-11-06 2019-04-23 Enanta Pharmaceuticals, Inc. Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
EA033427B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
KR102527821B1 (ko) 2014-11-19 2023-05-02 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드
DK3221333T3 (da) 2014-11-19 2019-09-30 Nzp Uk Ltd 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer
WO2016086115A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof
WO2016086134A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
CA2968404A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Bile acid analogs as fxr/tgr5 agonists and methods of use thereof
CN106279328A (zh) 2015-05-20 2017-01-04 重庆药友制药有限责任公司 一种制备6α-烷基鹅去氧胆酸的方法
EP3310801B1 (en) 2015-06-19 2021-04-07 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
CN106397522A (zh) 2015-07-31 2017-02-15 中国人民解放军军事医学科学院毒物药物研究所 3,7‑二（叔丁基二甲基硅基氧基）‑6‑烯‑5β‑胆烷‑24‑酸甲酯
CN106478759A (zh) 2015-08-31 2017-03-08 陕西合成药业股份有限公司 奥贝胆酸衍生物及其制备方法和用途
CN106478756A (zh) 2015-09-02 2017-03-08 中美华世通生物医药科技（武汉）有限公司 Oca-e单晶及其制备方法和用途
CN106518946A (zh) 2015-09-10 2017-03-22 上海迪诺医药科技有限公司 磺酰脲衍生物、其药物组合物及应用

Also Published As

Publication number Publication date
JP6724004B2 (ja) 2020-07-15
PL3221332T3 (pl) 2019-10-31
EA033445B1 (ru) 2019-10-31
ES2733643T3 (es) 2019-12-02
CN107108687B (zh) 2019-10-29
US20170320907A1 (en) 2017-11-09
WO2016079518A1 (en) 2016-05-26
EP3221332B1 (en) 2019-04-24
DK3221332T3 (da) 2019-07-29
EP3221332A1 (en) 2017-09-27
JP2017538691A (ja) 2017-12-28
KR102526632B1 (ko) 2023-04-27
US10131688B2 (en) 2018-11-20
EA201790881A1 (ru) 2017-11-30
KR20170099895A (ko) 2017-09-01
TW201629081A (zh) 2016-08-16
TWI686400B (zh) 2020-03-01
EA201790881A8 (ru) 2019-07-31
CN107108687A (zh) 2017-08-29
MX2017006564A (es) 2018-01-26
CA2968301A1 (en) 2016-05-26
CA2968301C (en) 2023-05-16

Similar Documents

Publication Publication Date Title
HK1244285B (zh) 作為製備類固醇FXR調節劑的中間體的5β-6-烷基-7-羥基-3-酮類固醇
HK1245326A1 (zh) 用於生產scaav的組合物和方法
HK1246801A1 (zh) 作為製備類固醇fxr調節劑的中間體的6-烷基-7-羥基-4-烯-3-酮類固醇
HK1244286A1 (zh) 作為製備類固醇FXR調節劑的中間體的6α-烷基-6，7-二酮類固醇
EP3125044A4 (en) Toner and process for producing toner
HK1244287A1 (zh) 作為製備類固醇FXR調節劑的中間體的6α-烷基-3，7-二酮類固醇
IL249988A0 (en) Process for preparing 3-(3-chloro-h1-pyrazol-1-yl)pyridine
EP3119401A4 (en) Cenicriviroc for the treatment of fibrosis
IL250628A0 (en) Process for preparing 3-(3-chloro-h1-pyrazol-1-yl)pyridine
ZA201700243B (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
IL250984A0 (en) Process for preparing 3-(3-chloro-1h-pyrazol-1-yl)pyridine
ZA201700168B (en) Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
EP3212315A4 (en) Compositions and methods for forming emulsions
GB201704946D0 (en) Method for obfuscating the display of text
ZA201608784B (en) Fused triterpene compounds and uses thereof
EP3227298A4 (en) Process for the preparation of baricitinib and an intermediate thereof
IL285700A (en) 21- Hydroxylation of steroids
EP3098821A4 (en) In-vehicle transformer
EP3200749A4 (en) Methods for the treatment of peri-implantitis
GB201420390D0 (en) Integrated panel
GB201402328D0 (en) Device for resisting the formation of wrinkles
SG11201610277SA (en) Process for producing benzene and lpg2
IL247443B (en) Process for the preparation of 5-fluorotryptophol
EP3116494B8 (en) Method of cleansing the colon
GB201404124D0 (en) The theory of european monetary