MX375059B - Compuestos para el tratamiento de cancer. - Google Patents
Compuestos para el tratamiento de cancer.Info
- Publication number
- MX375059B MX375059B MX2015011713A MX2015011713A MX375059B MX 375059 B MX375059 B MX 375059B MX 2015011713 A MX2015011713 A MX 2015011713A MX 2015011713 A MX2015011713 A MX 2015011713A MX 375059 B MX375059 B MX 375059B
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- compounds
- treatment
- inhibitors
- treating cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 abstract 1
- 229940124647 MEK inhibitor Drugs 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 abstract 1
- 229960004066 trametinib Drugs 0.000 abstract 1
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003744 tubulin modulator Substances 0.000 abstract 1
- 229960003862 vemurafenib Drugs 0.000 abstract 1
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361772885P | 2013-03-05 | 2013-03-05 | |
| PCT/US2014/020858 WO2014138279A1 (en) | 2013-03-05 | 2014-03-05 | Compounds for treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015011713A MX2015011713A (es) | 2016-05-09 |
| MX375059B true MX375059B (es) | 2025-03-06 |
Family
ID=51491914
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015011713A MX375059B (es) | 2013-03-05 | 2014-03-05 | Compuestos para el tratamiento de cancer. |
| MX2020009256A MX2020009256A (es) | 2013-03-05 | 2015-09-04 | Compuestos para el tratamiento de cancer. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009256A MX2020009256A (es) | 2013-03-05 | 2015-09-04 | Compuestos para el tratamiento de cancer. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10022356B2 (enExample) |
| EP (1) | EP2964028A4 (enExample) |
| JP (2) | JP6835472B2 (enExample) |
| KR (1) | KR102246652B1 (enExample) |
| CN (2) | CN105163584B (enExample) |
| AU (2) | AU2014225761B2 (enExample) |
| CA (1) | CA2904338C (enExample) |
| IL (1) | IL241232B (enExample) |
| MX (2) | MX375059B (enExample) |
| RU (1) | RU2708247C2 (enExample) |
| WO (1) | WO2014138279A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| US9029408B2 (en) * | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| DK2303021T3 (en) * | 2008-06-16 | 2019-04-08 | Univ Tennessee Res Found | RELATIONSHIPS FOR TREATING CANCER |
| US11084811B2 (en) | 2010-03-01 | 2021-08-10 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
| CN105163584B (zh) * | 2013-03-05 | 2019-06-04 | 田纳西大学研究基金会 | 用于治疗癌症的化合物 |
| RU2733393C9 (ru) | 2014-05-06 | 2021-09-09 | Джи Ти Икс, ИНК. | Соединения для лечения рака |
| CN104434924B (zh) * | 2014-11-10 | 2016-09-14 | 暨南大学 | 曲美替尼在制备逆转肿瘤多药耐药性药物中的应用 |
| WO2016106359A1 (en) * | 2014-12-23 | 2016-06-30 | Millennium Pharmaceuticals, Inc. | Combination of raf inhibitors and taxanes |
| EP3256473A4 (en) | 2015-02-12 | 2018-08-01 | Memorial Sloan Kettering Cancer Center | Synergistic cancer treatment |
| WO2016197129A1 (en) * | 2015-06-05 | 2016-12-08 | The Board Of Trustees Of The University Of Illinois | Pac-1 combination therapy |
| AR105483A1 (es) | 2015-06-30 | 2017-10-11 | Exelixis Inc | Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona |
| CA2991777A1 (en) * | 2015-07-09 | 2017-01-12 | The Jackson Laboratory | Methods of treating cancer by administering a mek inhibitor in combination with a proteasome inhibitor |
| US20180228740A1 (en) * | 2015-08-06 | 2018-08-16 | The Wistar Institute Of Anatomy And Biology | Combination therapies targeting mitochondrial biogenesis for cancer therapy |
| AU2017232496B2 (en) | 2016-03-16 | 2022-11-24 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for the treatment of a beta-catenin-associated disease or disorder |
| WO2017200826A1 (en) * | 2016-05-16 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Assays and compounds for treatment of cancer |
| CN110291089B (zh) | 2017-01-17 | 2022-05-27 | 海帕瑞吉尼克斯股份有限公司 | 用于促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂 |
| US12339285B2 (en) | 2017-03-10 | 2025-06-24 | Konica Minolta, Inc. | Method for estimating therapeutic efficacy |
| JP7291399B2 (ja) * | 2017-05-03 | 2023-06-15 | ティン セラピューティクス エルエルシー | 難聴の予防および治療のための組成物および方法 |
| IL274663B2 (en) | 2017-11-17 | 2024-01-01 | Univ Illinois | Cancer therapy by degrading dual mek signaling |
| CN108218855A (zh) * | 2018-03-12 | 2018-06-29 | 桑文军 | 一种新型微管蛋白抑制剂及其在抗肿瘤药物中的应用 |
| CN112437664A (zh) * | 2018-05-15 | 2021-03-02 | 田纳西大学研究基金会 | 用于治疗胰腺癌的化合物 |
| AU2019270089B2 (en) * | 2018-05-15 | 2022-11-10 | University Of Tennessee Research Foundation | Compounds for treatment of triple negative breast cancer and ovarian cancer |
| CA3114385A1 (en) | 2018-10-05 | 2020-04-09 | The Board Of Trustees Of The University Of Illinois | Combination therapy for the treatment of uveal melanoma |
| GB201913124D0 (en) | 2019-09-11 | 2019-10-23 | Seald As | Compositions and methods for treatment of cholangiocarcinoma |
| MX2022009347A (es) * | 2020-01-31 | 2022-12-15 | Verastem Inc | Terapia de combinacion para el tratamiento del crecimiento celular anormal. |
| CN113440616A (zh) * | 2020-03-25 | 2021-09-28 | 上海科州药物研发有限公司 | Ras或raf突变型癌症的联合疗法 |
| WO2022006512A1 (en) * | 2020-07-02 | 2022-01-06 | The Board Of Regents Of The University Of Texas System | Methods of treatment for melanoma |
| WO2022067185A1 (en) * | 2020-09-27 | 2022-03-31 | Veru Inc. | Methods of treating prostate cancer with minimal side effects |
| WO2022131667A1 (ko) * | 2020-12-18 | 2022-06-23 | 경희대학교 산학협력단 | Oligodendrocyte transcription factor 2 억제제를 유효성분으로 포함하는 흑색종 치료 효과 증진용 약학적 조성물 |
| CN115504964A (zh) * | 2022-04-12 | 2022-12-23 | 海创药业股份有限公司 | 氘代杂环酮类化合物及其用途 |
| CN117143081B (zh) * | 2022-05-24 | 2025-08-01 | 赣南医科大学 | 一种Sabizabulin的制备方法 |
| US20260115209A1 (en) * | 2022-08-08 | 2026-04-30 | The Regents Of The University Of California | Combination therapy including cox-2 inhibitor for the treatment of cancer |
| WO2024186641A1 (en) * | 2023-03-03 | 2024-09-12 | Onconova Therapeutics, Inc. | Methods and compositions for treating cancer |
| US20250032788A1 (en) * | 2023-06-30 | 2025-01-30 | Novocure Gmbh | Compositions and methods for treating with a combination of alternating electric fields and dna-dependent protein kinase inhibitors |
| CN119409641A (zh) * | 2024-11-05 | 2025-02-11 | 杭州电子科技大学 | 一种磺酰基衍生物和用途 |
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| ES2620644T3 (es) | 2011-04-01 | 2017-06-29 | Genentech, Inc. | Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso |
| EA024890B1 (ru) | 2011-04-07 | 2016-10-31 | Байер Интеллектчуал Проперти Гмбх | Имидазопиридазины в качестве ингибиторов akt киназы |
| CN105163584B (zh) | 2013-03-05 | 2019-06-04 | 田纳西大学研究基金会 | 用于治疗癌症的化合物 |
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2014
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| CN109568312A (zh) | 2019-04-05 |
| RU2015142102A (ru) | 2017-04-07 |
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| RU2708247C2 (ru) | 2019-12-05 |
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| JP2019077727A (ja) | 2019-05-23 |
| AU2014225761A1 (en) | 2015-10-08 |
| KR102246652B1 (ko) | 2021-04-29 |
| CN105163584B (zh) | 2019-06-04 |
| KR20150123328A (ko) | 2015-11-03 |
| EP2964028A4 (en) | 2017-06-07 |
| MX2020009256A (es) | 2020-10-28 |
| WO2014138279A1 (en) | 2014-09-12 |
| US10022356B2 (en) | 2018-07-17 |
| CA2904338A1 (en) | 2014-09-12 |
| JP6835472B2 (ja) | 2021-02-24 |
| CA2904338C (en) | 2022-07-05 |
| IL241232A0 (en) | 2015-11-30 |
| MX2015011713A (es) | 2016-05-09 |
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| US20180325872A1 (en) | 2018-11-15 |
| AU2018226470B2 (en) | 2019-11-28 |
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| US20160015688A1 (en) | 2016-01-21 |
| CN105163584A (zh) | 2015-12-16 |
| AU2018226470A1 (en) | 2018-09-27 |
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