MX374576B - Derivado de 5h-pirrolo[2,3-d]pirimidin-6(7h)-ona novedoso. - Google Patents
Derivado de 5h-pirrolo[2,3-d]pirimidin-6(7h)-ona novedoso.Info
- Publication number
- MX374576B MX374576B MX2018014022A MX2018014022A MX374576B MX 374576 B MX374576 B MX 374576B MX 2018014022 A MX2018014022 A MX 2018014022A MX 2018014022 A MX2018014022 A MX 2018014022A MX 374576 B MX374576 B MX 374576B
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- hydrogen atom
- kinase
- independently represent
- different
- Prior art date
Links
- NCIZQRMMYUHTDP-UHFFFAOYSA-N 5,7-dihydropyrrolo[2,3-d]pyrimidin-6-one Chemical class N1=CN=C2NC(=O)CC2=C1 NCIZQRMMYUHTDP-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención de la presente solicitud proporciona un compuesto representado por la fórmula (I) o una sal del mismo, que exhibe una actividad inhibidora contra al menos una cinasa seleccionada del grupo que consiste de la cinasa Akt, cinasa Rsk y cinasa S6K y/o un efecto inhibidor de la proliferación de células es útil como agente profiláctico y/o terapéutico para enfermedades asociadas con las cinasas mencionadas anteriormente, particularmente el cáncer. [En la fórmula, R1 representa un grupo heterocíclico insaturado monocíclico de 4 a 6 elementos que tiene 1 a 3 heteroátomos seleccionados independientemente de N, S y O y puede tener un sustituyente; R2 representa un átomo de hidrógeno o similar; R3, R4 y R5 pueden ser iguales o diferentes entre sí y representan independientemente un átomo de hidrógeno o similar; R6 representa un átomo de hidrógeno o similar; R7 y R8 pueden ser iguales o diferentes entre sí y representan independientemente un átomo de hidrógeno o similar; X1 y X2 pueden ser iguales o diferentes entre sí y representan independientemente N o CR9; R9 representa un átomo de hidrógeno o similar; y X3 representa N o CH cuando la línea discontinua (---) representa un enlace sencillo, y representa C cuando una línea discontinua indica un enlace doble; en donde al menos uno de X1 y X2 representa N].
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016101599 | 2016-05-20 | ||
| PCT/JP2017/018825 WO2017200087A1 (ja) | 2016-05-20 | 2017-05-19 | 新規５Ｈ－ピロロ［２，３－ｄ］ピリミジン－６（７Ｈ）－オン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018014022A MX2018014022A (es) | 2019-04-04 |
| MX374576B true MX374576B (es) | 2025-03-06 |
Family
ID=60325930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014022A MX374576B (es) | 2016-05-20 | 2017-05-19 | Derivado de 5h-pirrolo[2,3-d]pirimidin-6(7h)-ona novedoso. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10538528B2 (es) |
| EP (1) | EP3459953B1 (es) |
| JP (1) | JP6576553B2 (es) |
| KR (1) | KR102149734B1 (es) |
| CN (1) | CN109153681B (es) |
| AU (1) | AU2017265769B9 (es) |
| BR (1) | BR112018073721B1 (es) |
| CA (1) | CA3024831C (es) |
| DK (1) | DK3459953T3 (es) |
| ES (1) | ES2882018T3 (es) |
| HU (1) | HUE055846T2 (es) |
| MA (1) | MA45048A (es) |
| MX (1) | MX374576B (es) |
| MY (1) | MY185962A (es) |
| PH (1) | PH12018502411A1 (es) |
| PL (1) | PL3459953T3 (es) |
| PT (1) | PT3459953T (es) |
| RU (1) | RU2713181C1 (es) |
| SG (1) | SG11201810360YA (es) |
| TW (2) | TWI732187B (es) |
| WO (1) | WO2017200087A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240408100A1 (en) * | 2021-10-13 | 2024-12-12 | Taiho Pharmaceutical Co., Ltd. | Treatment methods for subjects having cancer with a dysregulated mapk and/or pi3k pathway |
| CN118525022A (zh) * | 2022-01-27 | 2024-08-20 | 西藏海思科制药有限公司 | 一种氮杂并环衍生物及其在医药上的应用 |
| TW202421127A (zh) | 2022-07-05 | 2024-06-01 | 日商大鵬藥品工業股份有限公司 | ５Ｈ－吡咯并〔２，３－ｄ〕嘧啶－６（７Ｈ）－酮及其鹽體之結晶 |
| CN115850244B (zh) * | 2023-02-24 | 2023-05-16 | 成都大学 | 一种托吡司他的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5213229B2 (ja) | 2004-04-23 | 2013-06-19 | エグゼリクシス， インコーポレイテッド | キナーゼ調節因子および使用方法 |
| GB0608184D0 (en) * | 2006-04-25 | 2006-06-07 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| US8915177B2 (en) * | 2008-08-08 | 2014-12-23 | Nestec S.A. | Beverage machine with carrying handle and configurable appearance and side functions |
| AR074072A1 (es) * | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| WO2011050016A1 (en) * | 2009-10-23 | 2011-04-28 | Eli Lilly And Company | Akt inhibitors |
| SG10201900954SA (en) * | 2013-03-11 | 2019-02-27 | Merck Patent Gmbh | Heterocycles as Modulators of Kinase Activity |
| JP6398659B2 (ja) | 2014-11-28 | 2018-10-03 | アイシン・エィ・ダブリュ株式会社 | 歯形部品の製造方法および歯形部品製造装置 |
-
2017
- 2017-05-19 DK DK17799511.5T patent/DK3459953T3/da active
- 2017-05-19 WO PCT/JP2017/018825 patent/WO2017200087A1/ja not_active Ceased
- 2017-05-19 MX MX2018014022A patent/MX374576B/es active IP Right Grant
- 2017-05-19 US US16/302,829 patent/US10538528B2/en active Active
- 2017-05-19 KR KR1020187030344A patent/KR102149734B1/ko active Active
- 2017-05-19 TW TW108107835A patent/TWI732187B/zh active
- 2017-05-19 SG SG11201810360YA patent/SG11201810360YA/en unknown
- 2017-05-19 AU AU2017265769A patent/AU2017265769B9/en active Active
- 2017-05-19 MA MA045048A patent/MA45048A/fr unknown
- 2017-05-19 HU HUE17799511A patent/HUE055846T2/hu unknown
- 2017-05-19 RU RU2018144542A patent/RU2713181C1/ru active
- 2017-05-19 CN CN201780030144.3A patent/CN109153681B/zh active Active
- 2017-05-19 EP EP17799511.5A patent/EP3459953B1/en active Active
- 2017-05-19 MY MYPI2018704229A patent/MY185962A/en unknown
- 2017-05-19 PT PT177995115T patent/PT3459953T/pt unknown
- 2017-05-19 JP JP2018518384A patent/JP6576553B2/ja active Active
- 2017-05-19 BR BR112018073721-6A patent/BR112018073721B1/pt active IP Right Grant
- 2017-05-19 CA CA3024831A patent/CA3024831C/en active Active
- 2017-05-19 PL PL17799511T patent/PL3459953T3/pl unknown
- 2017-05-19 ES ES17799511T patent/ES2882018T3/es active Active
- 2017-05-19 TW TW106116606A patent/TWI679202B/zh active
-
2018
- 2018-11-15 PH PH12018502411A patent/PH12018502411A1/en unknown
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |