MX371298B - Métodos y reactivos para la evaluación de diabetes gestacional. - Google Patents
Métodos y reactivos para la evaluación de diabetes gestacional.Info
- Publication number
- MX371298B MX371298B MX2016007123A MX2016007123A MX371298B MX 371298 B MX371298 B MX 371298B MX 2016007123 A MX2016007123 A MX 2016007123A MX 2016007123 A MX2016007123 A MX 2016007123A MX 371298 B MX371298 B MX 371298B
- Authority
- MX
- Mexico
- Prior art keywords
- assessment
- kits
- gestational diabetes
- epitope
- detection
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
- G01N2440/38—Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención implica ensayos, diagnósticos, kits y componentes de ensayo para determinar niveles de CD59 glicada en la evaluación de diabetes mellitus gestacional y/o trastornos y/o afecciones relacionados. Algunos kits comprenden un anticuerpo de captura capaz de asociarse con un epítopo de captura en CD59, en donde dicho epítopo de captura puede carecer del residuo lisina numero 41 (K41). Los kits pueden también comprender un anticuerpo de detección capaz de asociarse con un epítopo de detección en CD59. Estos epítopos de detección pueden comprender K41 glicado.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361911306P | 2013-12-03 | 2013-12-03 | |
US201461946373P | 2014-02-28 | 2014-02-28 | |
US201461945860P | 2014-02-28 | 2014-02-28 | |
PCT/US2014/068426 WO2015084994A1 (en) | 2013-12-03 | 2014-12-03 | Methods and reagents for the assessment of gestational diabetes |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016007123A MX2016007123A (es) | 2017-02-15 |
MX371298B true MX371298B (es) | 2020-01-23 |
Family
ID=53274086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016007123A MX371298B (es) | 2013-12-03 | 2014-12-03 | Métodos y reactivos para la evaluación de diabetes gestacional. |
Country Status (11)
Country | Link |
---|---|
US (1) | US10732186B2 (es) |
EP (2) | EP3077815B1 (es) |
JP (2) | JP6542219B2 (es) |
KR (1) | KR20160092006A (es) |
CN (2) | CN109917125A (es) |
AU (1) | AU2014360539A1 (es) |
CA (1) | CA2932607A1 (es) |
IL (2) | IL245925B (es) |
MX (1) | MX371298B (es) |
SG (1) | SG10201906981TA (es) |
WO (1) | WO2015084994A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012214259B2 (en) * | 2011-02-10 | 2017-02-23 | President And Fellows Of Harvard College | Surrogates of post-translationally modified proteins and uses thereof |
CN105181869B (zh) * | 2015-09-21 | 2016-05-18 | 南京医科大学 | 一种巨大儿辅助诊断标志物的应用 |
WO2017123666A2 (en) * | 2016-01-11 | 2017-07-20 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | In vivo positron emission tomography-based perfusion/blood pool imaging using labeled erythrocytes |
AU2018255244A1 (en) * | 2017-04-21 | 2019-10-31 | Mellitus, Llc | Methods and antibodies for diabetes-related applications |
RU2703342C1 (ru) * | 2018-11-19 | 2019-10-16 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Амурская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Прогнозирование развития гестационного сахарного диабета у первородящих юного возраста |
RU2710498C1 (ru) * | 2019-03-04 | 2019-12-26 | федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ прогнозирования высокого риска развития пролиферативной диабетической ретинопатии у беременных с сахарным диабетом 1 типа |
CN112924682B (zh) * | 2019-12-05 | 2023-02-10 | 张曼 | 尿液纤维蛋白原α链蛋白及其多肽片段在正常妊娠中的应用 |
KR102525374B1 (ko) | 2020-12-16 | 2023-04-24 | 가톨릭대학교 산학협력단 | 고위험 임신성 당뇨병 예측모델 설계 방법 및 장치 |
CN113009152B (zh) * | 2021-02-19 | 2022-05-10 | 山东省大健康精准医疗产业技术研究院 | 一种糖基化cd59酶联免疫检测试剂盒及其制备方法与应用 |
CN112904009B (zh) * | 2021-02-19 | 2022-03-18 | 山东莱博生物科技有限公司 | 一种检测糖基化cd59的磁性微球检测试剂盒及其应用 |
WO2022241236A2 (en) * | 2021-05-13 | 2022-11-17 | Mellitus, Llc | Methods and reagents for protein analysis |
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
FR2619568B1 (fr) * | 1987-08-21 | 1989-07-07 | Centre Nat Rech Scient | Polymeres derives du polystyrene, leurs procedes de preparation et leurs applications pour l'analyse et la purification de molecules d'origine biologique |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
GB9110962D0 (en) | 1991-05-21 | 1991-07-10 | Ici Plc | Process |
ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
AU670108B2 (en) * | 1992-09-11 | 1996-07-04 | Becton Dickinson & Company | Improved antibodies to plasmodium falciparum |
US5407912A (en) | 1993-04-19 | 1995-04-18 | Akzo, N.V. | Method of treating bladder cancer with a keyhole limpet hemocyanin composition with enhanced anti-tumor activity |
US5675063A (en) | 1995-02-28 | 1997-10-07 | Loyola University Of Chicago | Immortalized rabbit hybridoma fusion partner |
US5670377A (en) | 1996-03-14 | 1997-09-23 | Sansum Medical Research Foundation | Method of diagnosing gestational diabetes |
US6348584B1 (en) | 1996-10-17 | 2002-02-19 | John Edward Hodgson | Fibronectin binding protein compounds |
US6323361B1 (en) * | 1997-04-17 | 2001-11-27 | Corning Inc. | Photocurable halofluorinated acrylates |
DK0985039T3 (da) | 1997-06-12 | 2008-06-09 | Novartis Int Pharm Ltd | Kunstige antistof-polypeptider |
JP2002513911A (ja) * | 1998-05-06 | 2002-05-14 | アイソテクニカ、インコーポレーテッド | 糖尿病症状の診断及び血糖コントロール監視用13cグルコース呼気試験 |
US7439330B2 (en) * | 2000-05-08 | 2008-10-21 | President And Fellows Of Harvard College | Anti-glycated CD59 antibodies and uses thereof |
US6835545B2 (en) | 2000-05-08 | 2004-12-28 | President And Fellows Of Harvard College | Methods, products and treatments for diabetes |
JP2003055366A (ja) * | 2001-08-20 | 2003-02-26 | Shiseido Co Ltd | ラクトン誘導体、並びに、これを有効成分とする植物成長調整剤および発根誘導剤 |
CA2492524A1 (en) | 2002-08-15 | 2004-02-26 | Epitomics, Inc. | Humanized rabbit antibodies |
US20040067496A1 (en) | 2002-10-07 | 2004-04-08 | Robert Pytela | System for production and screening of monoclonal antibodies |
AU2003259718A1 (en) | 2003-08-07 | 2005-03-07 | Epitomics, Inc. | Methods for humanizing rabbit monoclonal antibodies |
CA2612303C (en) | 2004-06-17 | 2018-03-13 | Jose Halperin | Anti-glycated cd59 antibodies and uses thereof |
US7462697B2 (en) | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
US7833725B2 (en) | 2005-01-06 | 2010-11-16 | President And Fellows Of Harvard College | Mass spectrometric methods and products |
US7429487B2 (en) | 2005-07-05 | 2008-09-30 | Epitomics, Inc. | Fusion partner for production of monoclonal rabbit antibodies |
WO2008137165A1 (en) | 2007-05-07 | 2008-11-13 | President And Fellows Of Harvard College | Anti-glycated cd59 antibodies and uses thereof |
EP2331561A4 (en) | 2008-09-03 | 2013-02-27 | Xenome Ltd | PEPTIDE CONJUGATE LIBRARIES AND METHODS OF MAKING SAME |
US20120027658A1 (en) * | 2010-07-30 | 2012-02-02 | Karwacki Christopher J | Oxidation Catalysts Useful for Ambient Temperature Operation |
WO2012027555A2 (en) | 2010-08-25 | 2012-03-01 | President And Fellows Of Harvard College | Glycated cd59 peptides, their preparation, and uses thereof |
AU2012214259B2 (en) | 2011-02-10 | 2017-02-23 | President And Fellows Of Harvard College | Surrogates of post-translationally modified proteins and uses thereof |
WO2013078122A1 (en) | 2011-11-22 | 2013-05-30 | President And Fellows Of Harvard College | Diabetes diagnosis through the detection of glycated proteins in urine |
CN102590491B (zh) * | 2012-02-06 | 2014-12-10 | 中国人民解放军第三军医大学第一附属医院 | 一种用于早期筛查或辅助诊断泌尿系统疾病的检测试剂盒、检测方法及其用途 |
WO2014004586A1 (en) | 2012-06-25 | 2014-01-03 | Zymeworks Inc. | Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells |
-
2014
- 2014-12-03 US US15/100,563 patent/US10732186B2/en active Active
- 2014-12-03 CN CN201910250407.2A patent/CN109917125A/zh active Pending
- 2014-12-03 WO PCT/US2014/068426 patent/WO2015084994A1/en active Application Filing
- 2014-12-03 MX MX2016007123A patent/MX371298B/es active IP Right Grant
- 2014-12-03 SG SG10201906981TA patent/SG10201906981TA/en unknown
- 2014-12-03 CA CA2932607A patent/CA2932607A1/en not_active Abandoned
- 2014-12-03 JP JP2016535634A patent/JP6542219B2/ja active Active
- 2014-12-03 KR KR1020167017465A patent/KR20160092006A/ko not_active Application Discontinuation
- 2014-12-03 CN CN201480074004.2A patent/CN105934671B/zh active Active
- 2014-12-03 EP EP14867264.5A patent/EP3077815B1/en active Active
- 2014-12-03 AU AU2014360539A patent/AU2014360539A1/en not_active Abandoned
- 2014-12-03 EP EP19186103.8A patent/EP3620793A1/en not_active Withdrawn
-
2016
- 2016-05-30 IL IL245925A patent/IL245925B/en active IP Right Grant
-
2019
- 2019-01-30 IL IL264559A patent/IL264559A/en unknown
- 2019-06-12 JP JP2019109338A patent/JP2019191186A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2017502267A (ja) | 2017-01-19 |
EP3620793A1 (en) | 2020-03-11 |
CN109917125A (zh) | 2019-06-21 |
KR20160092006A (ko) | 2016-08-03 |
SG10201906981TA (en) | 2019-09-27 |
EP3077815A4 (en) | 2017-06-21 |
CN105934671A (zh) | 2016-09-07 |
US10732186B2 (en) | 2020-08-04 |
JP2019191186A (ja) | 2019-10-31 |
EP3077815A1 (en) | 2016-10-12 |
WO2015084994A1 (en) | 2015-06-11 |
MX2016007123A (es) | 2017-02-15 |
US20170108505A2 (en) | 2017-04-20 |
IL245925B (en) | 2019-02-28 |
EP3077815B1 (en) | 2019-07-17 |
CN105934671B (zh) | 2019-04-19 |
AU2014360539A1 (en) | 2016-06-23 |
US20160299150A1 (en) | 2016-10-13 |
IL245925A0 (en) | 2016-07-31 |
JP6542219B2 (ja) | 2019-07-10 |
CA2932607A1 (en) | 2015-06-11 |
IL264559A (en) | 2019-02-28 |
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Legal Events
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