MX371093B - Compuestos de microarn y metodos para modular al mir-122. - Google Patents
Compuestos de microarn y metodos para modular al mir-122.Info
- Publication number
- MX371093B MX371093B MX2015014816A MX2015014816A MX371093B MX 371093 B MX371093 B MX 371093B MX 2015014816 A MX2015014816 A MX 2015014816A MX 2015014816 A MX2015014816 A MX 2015014816A MX 371093 B MX371093 B MX 371093B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- mir
- compositions
- compounds
- modulating mir
- Prior art date
Links
- 108091007780 MiR-122 Proteins 0.000 title abstract 3
- 108091051828 miR-122 stem-loop Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 108091070501 miRNA Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 241000711549 Hepacivirus C Species 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
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| US201461927897P | 2014-01-15 | 2014-01-15 | |
| PCT/US2014/036137 WO2014179446A2 (en) | 2013-05-01 | 2014-04-30 | Microrna compounds and methods for modulating mir-122 |
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Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| EP2992096B1 (en) * | 2013-05-01 | 2021-03-03 | Regulus Therapeutics Inc. | Compounds and methods for enhanced cellular uptake |
| DK3047160T3 (en) * | 2013-09-16 | 2019-04-08 | Vaelinge Innovation Ab | TOTAL FURNITURE PRODUCT |
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| US10308937B2 (en) * | 2014-11-10 | 2019-06-04 | Glaxosmithkline Intellectual Property (No. 2) Limited | Combination long acting compositions and methods for Hepatitis C |
| MA40844A (fr) * | 2014-11-10 | 2017-09-20 | Glaxosmithkline Ip No 2 Ltd | Compositions pharmaceutiques à action prolongée pour l'hépatite c |
| AU2016349625B2 (en) | 2015-11-06 | 2022-07-07 | Ionis Pharmaceuticals, Inc. | Modulating apolipoprotein (a) expression |
| LT4119569T (lt) * | 2015-11-06 | 2024-09-25 | Ionis Pharmaceuticals, Inc. | Konjuguoti priešprasmiai junginiai, skirti panaudoti terapijoje |
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| JP7179721B2 (ja) | 2016-06-21 | 2022-11-29 | オリオン・オフサルモロジー・エルエルシー | 複素環式プロリンアミド誘導体 |
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| US20180193270A1 (en) | 2016-11-29 | 2018-07-12 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| TWI854980B (zh) * | 2018-05-08 | 2024-09-11 | 美商雷格勒斯治療公司 | 用於調節mir-122之微小rna化合物及方法 |
| TW202019441A (zh) * | 2018-07-20 | 2020-06-01 | 美商雷格勒斯治療公司 | 用於經口遞送寡核苷酸之方法 |
| CN112843084A (zh) * | 2019-11-27 | 2021-05-28 | 中国人民解放军第四军医大学 | MiR-122-5p在制备促进创伤愈合药物中的应用 |
| CN114057816B (zh) * | 2020-07-30 | 2025-02-11 | 浙江柏拉阿图医药科技有限公司 | 富含腺嘌呤硫代磷酸酯化寡核苷酸及其抗肝炎病毒的应用 |
| WO2023060237A1 (en) * | 2021-10-08 | 2023-04-13 | Regulus Therapeutics Inc. | Methods and compositions for treatment of polycystic kidney disease |
| JP2024535445A (ja) * | 2021-10-08 | 2024-09-30 | レグルス セラピューティクス インコーポレイテッド | オフターゲット効果を回避するための方法及び組成物 |
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Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10503364A (ja) | 1994-05-10 | 1998-03-31 | ザ ジェネラル ホスピタル コーポレーション | C型肝炎ウイルスのアンチセンス阻害 |
| TW520293B (en) | 1995-11-22 | 2003-02-11 | Univ Johns Hopkins Med | Delivery system to enhance cellular uptake of biomolecules |
| US6300319B1 (en) | 1998-06-16 | 2001-10-09 | Isis Pharmaceuticals, Inc. | Targeted oligonucleotide conjugates |
| US6656730B1 (en) | 1999-06-15 | 2003-12-02 | Isis Pharmaceuticals, Inc. | Oligonucleotides conjugated to protein-binding drugs |
| AU7406700A (en) | 1999-10-04 | 2001-05-10 | Exiqon A/S | Design of high affinity rnase h recruiting oligonucleotide |
| WO2001048190A2 (en) * | 1999-12-23 | 2001-07-05 | Exiqon A/S | Therapeutic uses of lna-modified oligonucleotides |
| US7491805B2 (en) | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| CN100406065C (zh) | 2000-12-01 | 2008-07-30 | 细胞工厂治疗公司 | 糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法 |
| CN1344803A (zh) | 2001-09-27 | 2002-04-17 | 吴昌 | 核酸靶分子选择及扩增方法 |
| CA2504694C (en) | 2002-11-05 | 2013-10-01 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| EP2669377A3 (en) | 2003-04-17 | 2015-10-14 | Alnylam Pharmaceuticals Inc. | Modified iRNA agents |
| WO2005013901A2 (en) | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| DK1661905T3 (da) | 2003-08-28 | 2012-07-23 | Takeshi Imanishi | Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype |
| JP4989225B2 (ja) | 2003-09-25 | 2012-08-01 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 核酸親油性接合体 |
| ES2344566T3 (es) | 2003-12-23 | 2010-08-31 | Santaris Pharma A/S | Compuestos oligomericos para la modulacion de bcl-2. |
| AU2005325262B2 (en) | 2004-04-27 | 2011-08-11 | Alnylam Pharmaceuticals, Inc. | Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety |
| PT1747023E (pt) | 2004-05-04 | 2011-04-11 | Univ Leland Stanford Junior | Métodos e composições para reduzir quantidades de genoma viral numa célula alvo |
| EP1913011B1 (en) | 2004-08-04 | 2016-11-02 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase |
| WO2006031461A2 (en) | 2004-09-09 | 2006-03-23 | Isis Pharmaceuticals, Inc. | Pyrrolidinyl groups for attaching conjugates to oligomeric compounds |
| US20070099196A1 (en) | 2004-12-29 | 2007-05-03 | Sakari Kauppinen | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs |
| US20060148740A1 (en) | 2005-01-05 | 2006-07-06 | Prosensa B.V. | Mannose-6-phosphate receptor mediated gene transfer into muscle cells |
| US20120122801A1 (en) | 2005-01-05 | 2012-05-17 | Prosensa B.V. | Mannose-6-phosphate receptor mediated gene transfer into muscle cells |
| EP1841867A1 (en) | 2005-01-24 | 2007-10-10 | Avaris AB | COMPLEX CONTAINING SiRNA, ShRNA OR ANTISENSE MOLECULE AND FUNCTIONAL ENTITY, FOR IMPROVED SPECIFICITY AND DELIVERY |
| US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| AU2006279906B2 (en) | 2005-08-10 | 2012-05-10 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| ATE494372T1 (de) | 2005-08-29 | 2011-01-15 | Regulus Therapeutics Inc | Verfahren für mir-122a-modulation |
| WO2007027894A2 (en) | 2005-08-29 | 2007-03-08 | Isis Pharmaceuticals, Inc. | Antisense compounds having enhanced anti-microrna activity |
| EP2388328A1 (en) | 2006-01-27 | 2011-11-23 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of micrornas |
| DE602007009487D1 (de) | 2006-01-27 | 2010-11-11 | Isis Pharmaceutical Inc | 6-modifizierte bicyclische nukleinsäureanaloga |
| CA3042781C (en) | 2006-04-03 | 2021-10-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| EA201100811A1 (ru) | 2006-04-03 | 2012-06-29 | Сантарис Фарма А/С | Фармацевтическая композиция |
| CA3144493A1 (en) | 2006-10-03 | 2008-04-10 | Arbutus Biopharma Corporation | Lipid containing formulations |
| DK2152879T3 (da) | 2007-05-01 | 2013-02-18 | Santaris Pharma As | RNA antagonistforbindelser til modulering af beta-catenin |
| DK2170917T3 (da) | 2007-05-30 | 2012-10-08 | Isis Pharmaceuticals Inc | N-Substituerede bicycliske nukleinsyreanaloge med aminomethylenbro |
| WO2008154401A2 (en) | 2007-06-08 | 2008-12-18 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| AU2008272918B2 (en) | 2007-07-05 | 2012-09-13 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
| DK2205737T3 (da) | 2007-10-04 | 2013-05-21 | Santaris Pharma As | Mikromirer |
| NZ585327A (en) | 2007-11-26 | 2012-10-26 | Santaris Pharma As | Lna antagonists targeting the androgen receptor |
| EP2229186A2 (en) | 2007-12-04 | 2010-09-22 | Alnylam Pharmaceuticals Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| WO2009091972A2 (en) | 2008-01-18 | 2009-07-23 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides and small molecules for use in reducing micro rna activity levels and uses thereof |
| EP2268811A1 (en) | 2008-03-07 | 2011-01-05 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| WO2010076248A1 (en) | 2008-12-31 | 2010-07-08 | Santaris Pharma A/S | Use of lna apob antisense oligomers for the treatment of acute coronary syndromes |
| US9034837B2 (en) | 2009-04-24 | 2015-05-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical compositions for treatment of HCV patients that are poor-responders to interferon |
| MA33488B1 (fr) | 2009-06-08 | 2012-08-01 | Miragen Therapeutics | Motifs de modification chimique pour des inhibiteurs et mimétiques de miarn |
| ES2651308T3 (es) | 2009-10-16 | 2018-01-25 | Glaxo Group Limited | Inhibidores antisentido de HBV |
| PH12012501596A1 (en) | 2010-02-24 | 2017-02-03 | Arrowhead Res Corporation | Compositions for targeted delivery of sirna |
| US8349308B2 (en) | 2010-03-26 | 2013-01-08 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| WO2011130458A2 (en) | 2010-04-13 | 2011-10-20 | John Rossi | Rna aptamers against baff-r as cell-type specific delivery agents and methods for their use |
| WO2012007477A1 (en) | 2010-07-12 | 2012-01-19 | Santaris Pharma A/S | Anti hcv oligomers |
| US9290760B2 (en) * | 2010-09-15 | 2016-03-22 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
| RU2013117288A (ru) | 2010-12-17 | 2015-01-27 | Эрроухэд Рисерч Корпорейшн | СОДЕРЖАЩАЯ ГАЛАКТОЗНЫЙ КЛАСТЕР НАЦЕЛИВАЮЩАЯ ГРУППА ДЛЯ миРНК, МОДУЛИРУЮЩАЯ ФОРМАКОКИНЕТИЧЕСКИЕ СВОЙСТВА |
| RU2582235C2 (ru) | 2010-12-29 | 2016-04-20 | Ф.Хоффманн-Ля Рош Аг | Низкомолекулярные конъюгаты для внутриклеточной доставки нуклеиновых кислот |
| MX393138B (es) | 2011-04-25 | 2025-03-24 | Sanofi Sa | Compuestos de microarn y metodos para modular la actividad de mir-21. |
| US20140248611A1 (en) * | 2011-06-16 | 2014-09-04 | Nippon Steel & Sumikin Eco-Tech Corporation | Nucleic acid probe for assaying nucleic acids |
| WO2012175733A1 (en) | 2011-06-23 | 2012-12-27 | Santaris Pharma A/S | Hcv combination therapy |
| KR20140058536A (ko) | 2011-06-30 | 2014-05-14 | 스텔라 에이피에스 | Hcv 조합 치료 |
| EP2726610A1 (en) | 2011-06-30 | 2014-05-07 | Stella ApS | Hcv combination therapy |
| US10023861B2 (en) * | 2011-08-29 | 2018-07-17 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| WO2013068348A1 (en) | 2011-11-07 | 2013-05-16 | Santaris Pharma A/S | Lna oligomers for improvement in hepatic function |
| EP2776590B1 (en) | 2011-11-07 | 2016-10-26 | Roche Innovation Center Copenhagen A/S | Prognostic method for checking efficacy of micro rna-122 inhibitors in hcv+ patients |
| EP2864482A4 (en) | 2012-06-21 | 2016-02-10 | Miragen Therapeutics Inc | OLIGONUCLEOTIDE INHIBITORS COMPRISING A BLOCKED NUCLEIC ACID PATTERN |
| CN104955950B (zh) | 2012-09-26 | 2019-04-26 | 米尔克斯治疗学公司 | 具有改善的脱靶特征谱的寡核苷酸 |
| CA2889044A1 (en) | 2012-11-15 | 2014-05-22 | Roche Innovation Center Copenhagen A/S | Anti apob antisense conjugate compounds |
| WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
| CA2893801A1 (en) | 2013-01-30 | 2014-08-07 | F. Hoffmann-La Roche Ag | Lna oligonucleotide carbohydrate conjugates |
| EP2992096B1 (en) | 2013-05-01 | 2021-03-03 | Regulus Therapeutics Inc. | Compounds and methods for enhanced cellular uptake |
| PL2992098T3 (pl) | 2013-05-01 | 2019-09-30 | Ionis Pharmaceuticals, Inc. | Kompozycje i sposoby modulowania ekspresji hbv i ttr |
| JP2016518842A (ja) | 2013-05-01 | 2016-06-30 | レグルス セラピューティクス インコーポレイテッド | マイクロRNA化合物およびmiR−122をモジュレートする方法 |
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| EA034731B1 (ru) | 2020-03-13 |
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| KR20160002862A (ko) | 2016-01-08 |
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| US10150967B2 (en) | 2018-12-11 |
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| US20160251657A1 (en) | 2016-09-01 |
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| HK1221256A1 (zh) | 2017-05-26 |
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| EP2992095B1 (en) | 2019-01-09 |
| KR102214740B1 (ko) | 2021-02-10 |
| IL241957B (en) | 2019-07-31 |
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