MX371047B - Tioles de bismuto como antisépticos para usos biomédicos, que incluyen tratamiento de biopelículas bacterianas y otros usos. - Google Patents
Tioles de bismuto como antisépticos para usos biomédicos, que incluyen tratamiento de biopelículas bacterianas y otros usos.Info
- Publication number
- MX371047B MX371047B MX2016010269A MX2016010269A MX371047B MX 371047 B MX371047 B MX 371047B MX 2016010269 A MX2016010269 A MX 2016010269A MX 2016010269 A MX2016010269 A MX 2016010269A MX 371047 B MX371047 B MX 371047B
- Authority
- MX
- Mexico
- Prior art keywords
- certain
- compositions
- bismuth
- treating
- antiseptics
- Prior art date
Links
- 230000002421 anti-septic effect Effects 0.000 title abstract 2
- 230000001580 bacterial effect Effects 0.000 title abstract 2
- 229940064004 antiseptic throat preparations Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 5
- BIGYLAKFCGVRAN-UHFFFAOYSA-N 1,3,4-thiadiazolidine-2,5-dithione Chemical compound S=C1NNC(=S)S1 BIGYLAKFCGVRAN-UHFFFAOYSA-N 0.000 abstract 4
- 238000009472 formulation Methods 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003214 anti-biofilm Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 abstract 1
- 208000027136 gram-positive bacterial infections Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Abstract
Se describen composiciones y métodos que incluyen suspensiones microparticuladas homogéneas novedosas para tratar superficies naturales que contienen biopelículas bacterianas, que incluyen efectos inesperados de sinergia o incremento entre los compuestos de tiol de bismuto (BT) y algunos antibióticos, para proporcionar formulaciones que incluyen formulaciones antisépticas. Las propiedades antibacterianas previamente no predichas y las propiedades antibiopelícula de los compuestos BT descritos y las combinaciones de compuesto BT más antibiótico también se describen, incluyendo eficacias preferentes de algunas de estas composiciones para tratar ciertas infecciones por bacterias grampositivas y eficacias preferentes distintas de algunas de las composiciones para tratar algunas infecciones por bacterias gramnegativas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2010/023108 WO2010091124A2 (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
| US37318810P | 2010-08-12 | 2010-08-12 | |
| PCT/US2011/023549 WO2011097347A2 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX371047B true MX371047B (es) | 2020-01-14 |
Family
ID=44356067
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016010269A MX371047B (es) | 2010-02-03 | 2011-02-03 | Tioles de bismuto como antisépticos para usos biomédicos, que incluyen tratamiento de biopelículas bacterianas y otros usos. |
| MX2013001581A MX362785B (es) | 2010-08-12 | 2011-08-11 | Composición tiol-bismuto en la preparación de un medicamento útil en el tratamiento de una herida abierta, incluyendo una herida crónica. |
| MX2019010863A MX2019010863A (es) | 2010-02-03 | 2012-08-03 | Tioles de bismuto como antisepticos para usos biomedicos, que incluyen tratamiento de biopeliculas bacterianas y otros usos. |
| MX2019001293A MX2019001293A (es) | 2010-08-12 | 2013-02-08 | Composicion tiol-bismuto en la preparacion de un medicamento util en el tratamiento de una herida abierta, incluyendo una herida cronica. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013001581A MX362785B (es) | 2010-08-12 | 2011-08-11 | Composición tiol-bismuto en la preparación de un medicamento útil en el tratamiento de una herida abierta, incluyendo una herida crónica. |
| MX2019010863A MX2019010863A (es) | 2010-02-03 | 2012-08-03 | Tioles de bismuto como antisepticos para usos biomedicos, que incluyen tratamiento de biopeliculas bacterianas y otros usos. |
| MX2019001293A MX2019001293A (es) | 2010-08-12 | 2013-02-08 | Composicion tiol-bismuto en la preparacion de un medicamento util en el tratamiento de una herida abierta, incluyendo una herida cronica. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP2603083A4 (es) |
| JP (7) | JP2013535506A (es) |
| KR (6) | KR101821833B1 (es) |
| CN (2) | CN103096720B (es) |
| AU (3) | AU2011289338B2 (es) |
| BR (2) | BR112012019286A2 (es) |
| CA (1) | CA2807993C (es) |
| CL (2) | CL2013000430A1 (es) |
| IL (3) | IL224684A (es) |
| MX (4) | MX371047B (es) |
| NZ (1) | NZ606634A (es) |
| PH (1) | PH12016502498A1 (es) |
| RU (2) | RU2013110493A (es) |
| SG (3) | SG10202001032RA (es) |
| UA (1) | UA113616C2 (es) |
| WO (1) | WO2012021754A2 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3695835A1 (en) | 2009-02-03 | 2020-08-19 | Microbion Corporation | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
| US9028878B2 (en) | 2009-02-03 | 2015-05-12 | Microbion Corporation | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
| KR101821833B1 (ko) * | 2010-02-03 | 2018-01-25 | 마이크로비온 코포레이션 | 세균 균막의 치료 및 다른 용도를 포함하는, 생의학적 용도를 위한 방부제로서 비스무트-티올 |
| WO2014146644A1 (de) * | 2013-03-18 | 2014-09-25 | Theranovis Gmbh & Co. Kg | Zusammensetzung für die mundpflege |
| RU2525200C1 (ru) * | 2013-04-09 | 2014-08-10 | Алексей Георгиевич Бородкин | Средство для защиты и заживления ран деревьев |
| KR101703732B1 (ko) * | 2013-11-07 | 2017-02-07 | (주)아모레퍼시픽 | 효소처리 동백나무 씨 오일을 포함하는 항염 조성물 |
| WO2017145142A1 (en) | 2016-02-25 | 2017-08-31 | Nobio Ltd. | Micro and nanoparticulate compositions comprising anti-microbially active groups |
| BR112020004156A2 (pt) | 2017-08-30 | 2020-09-08 | Nobio Ltd. | partículas antimicrobianas e métodos de aplicação das mesmas |
| CN107950536A (zh) * | 2017-12-04 | 2018-04-24 | 刘志伟 | 一种含百菌清的杀菌组合物 |
| CN108839186B (zh) * | 2018-05-15 | 2021-02-26 | 阜南县金威工艺品有限公司 | 一种桑枝编织品防霉处理方法 |
| SG11202100823RA (en) | 2018-07-31 | 2021-02-25 | Microbion Corp | Bismuth-thiol compositions and methods of use |
| IL280413B1 (en) | 2018-07-31 | 2024-10-01 | Microbion Corp | Bismuth-thiol preparations and wound treatment methods |
| KR101990253B1 (ko) * | 2018-11-22 | 2019-06-17 | 하봉호 | 컨테이너형 버섯재배장치 |
| CN109997856B (zh) * | 2019-04-15 | 2020-11-03 | 广西大学 | 一种小分子化合物的组合物及其应用 |
| KR102126721B1 (ko) * | 2019-07-16 | 2020-06-25 | (주)인트론바이오테크놀로지 | 신규한 엔테로박터 애로진스 박테리오파지 Ent-AEP-1 및 이의 엔테로박터 애로진스 균과 엔테로박터 클로아카 균 증식 억제 용도 |
| JP7458622B2 (ja) * | 2019-09-18 | 2024-04-01 | 学校法人東京農業大学 | 抗生物質耐性微生物の耐性を低下させる物質及び抗生物質耐性微生物の耐性を低下させる方法 |
| CN110663672B (zh) * | 2019-11-13 | 2024-04-26 | 南京林业大学 | 一种螺纹驱动的根部施药头 |
| US11479655B2 (en) * | 2020-01-15 | 2022-10-25 | The Boeing Company | Compositions for use with polysulfide sealants and related methods |
| KR102197719B1 (ko) | 2020-05-07 | 2021-01-04 | 곽태진 | 갑오징어 양식 시스템 |
| CN111856546B (zh) * | 2020-06-23 | 2022-07-29 | 中国辐射防护研究院 | 一种关于海洋生物灰中Cs-137放化分析的制样方法 |
| CN113969300B (zh) * | 2020-07-23 | 2024-08-23 | 禾美生物科技(浙江)有限公司 | 一种桉树叶复合活性提取物工艺及其抗菌应用 |
| CN112640907B (zh) * | 2021-01-19 | 2021-11-16 | 西南大学 | 硫辛酸抑制植物真菌致病菌的新用途及防治柑橘果实采后真菌病害的方法 |
| KR102431000B1 (ko) * | 2021-07-22 | 2022-08-11 | 농업회사법인 주식회사 아그로비즈 | 아스피린과 벤조치아졸이 포함된 식물의 자가면역 증강제 조성물 및 이를 이용한 이용방법 |
| EP4310192A1 (en) * | 2022-07-21 | 2024-01-24 | C4Diagnostics | Method of determining the existence and/or degree of resistance of microorganisms to antimicrobial agents |
| CN115323778B (zh) * | 2022-08-16 | 2023-07-18 | 汕头市润丰纺织科技实业有限公司 | 壳聚糖-i型胶原氨基酸复合抗菌整理液及其制备方法和抗菌面料 |
| TR2022012983A2 (tr) * | 2022-08-17 | 2022-09-21 | Marmara Ueniv Strateji Gelis Dai Bsk Muhasebe Birimi | Kemi̇k rahatsizliklari ve/veya kirilmalari i̇çi̇n onarici ve tedavi̇ edi̇ci̇ özelli̇kte bi̇youyumlu bi̇r ürün ve söz konusu ürünün eldesi̇ i̇çi̇n bi̇r yöntem |
| CN115532295B (zh) * | 2022-09-27 | 2023-07-25 | 苏州大学 | 含有Zn-N-C活性中心的纳米材料在去除细菌生物膜中的应用 |
| KR102644907B1 (ko) * | 2023-12-01 | 2024-03-07 | (주)신용이엔씨 | 지반 보강을 위한 친환경 그라우팅용 조성물 및 이의 제조 방법 |
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| AU2656799A (en) * | 1998-02-04 | 1999-08-23 | Winthrop-University Hospital | Metal-thiols as imminomodulating agents |
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