WO2012021754A3 - Bismuth-thiols as antiseptics for agricultural, industrial and other uses - Google Patents

Bismuth-thiols as antiseptics for agricultural, industrial and other uses Download PDF

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Publication number
WO2012021754A3
WO2012021754A3 PCT/US2011/047490 US2011047490W WO2012021754A3 WO 2012021754 A3 WO2012021754 A3 WO 2012021754A3 US 2011047490 W US2011047490 W US 2011047490W WO 2012021754 A3 WO2012021754 A3 WO 2012021754A3
Authority
WO
WIPO (PCT)
Prior art keywords
certain
compositions
bismuth
treating
compounds
Prior art date
Application number
PCT/US2011/047490
Other languages
French (fr)
Other versions
WO2012021754A2 (en
Inventor
Brett Hugh James Baker
Original Assignee
Microbion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2011/023549 external-priority patent/WO2011097347A2/en
Priority to NZ606634A priority Critical patent/NZ606634A/en
Priority to JP2013524237A priority patent/JP2013535506A/en
Priority to KR1020187019857A priority patent/KR20180085042A/en
Priority to AU2011289338A priority patent/AU2011289338B2/en
Priority to CA2807993A priority patent/CA2807993C/en
Priority to UAA201303059A priority patent/UA113616C2/en
Priority to SG2013010053A priority patent/SG187801A1/en
Priority to MX2013001581A priority patent/MX362785B/en
Priority to CN201180042863.XA priority patent/CN103096720B/en
Priority to BR112013003127A priority patent/BR112013003127A2/en
Priority to RU2013110493/10A priority patent/RU2013110493A/en
Priority to KR1020137006121A priority patent/KR20130132410A/en
Priority to EP11817067.9A priority patent/EP2603083A4/en
Application filed by Microbion Corporation filed Critical Microbion Corporation
Publication of WO2012021754A2 publication Critical patent/WO2012021754A2/en
Publication of WO2012021754A3 publication Critical patent/WO2012021754A3/en
Priority to IL224684A priority patent/IL224684A/en
Priority to US13/765,514 priority patent/US9408393B2/en
Priority to US15/199,554 priority patent/US20170150724A1/en
Priority to IL248446A priority patent/IL248446B/en
Priority to PH12016502498A priority patent/PH12016502498A1/en
Priority to IL258908A priority patent/IL258908A/en
Priority to US16/433,660 priority patent/US20200138033A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/29—Antimony or bismuth compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural and artificial surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.
PCT/US2011/047490 2009-02-03 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses WO2012021754A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
JP2013524237A JP2013535506A (en) 2010-08-12 2011-08-11 Bismuth-thiol as a disinfectant for agricultural, industrial and other uses
KR1020137006121A KR20130132410A (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
RU2013110493/10A RU2013110493A (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other applications
AU2011289338A AU2011289338B2 (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
CA2807993A CA2807993C (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
UAA201303059A UA113616C2 (en) 2010-08-12 2011-08-11 METHOD OF TREATMENT PLANTS to protect against bacterial pathogens, pathogenic fungi or viral pathogens WITH bismuth-thiol AND METHOD FOR PROCESSING PLANTS to overcome antibiotic resistance in bacterial pathogens WITH bismuth-thiol (optional)
SG2013010053A SG187801A1 (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
MX2013001581A MX362785B (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses.
CN201180042863.XA CN103096720B (en) 2010-08-12 2011-08-11 Bismuth-mercaptan that is agriculture, industrial and other purposes is used for as preservative
EP11817067.9A EP2603083A4 (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
KR1020187019857A KR20180085042A (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
NZ606634A NZ606634A (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
BR112013003127A BR112013003127A2 (en) 2010-08-12 2011-08-11 bismuththiols as antiseptics for agricultural, industrial and other uses
US13/765,514 US9408393B2 (en) 2010-02-03 2013-02-12 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
IL224684A IL224684A (en) 2010-08-12 2013-02-12 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
US15/199,554 US20170150724A1 (en) 2010-02-03 2016-06-30 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
IL248446A IL248446B (en) 2010-08-12 2016-10-21 Bismuth thiols as antiseptics for agricultural, industrial and other uses
PH12016502498A PH12016502498A1 (en) 2010-08-12 2016-12-14 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
IL258908A IL258908A (en) 2010-08-12 2018-04-24 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
US16/433,660 US20200138033A1 (en) 2009-02-03 2019-06-06 Bismuth-thiols as antiseptics for agricultural, industrial and other uses

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37318810P 2010-08-12 2010-08-12
US61/373,188 2010-08-12
USPCT/US2011/023549 2011-02-03
PCT/US2011/023549 WO2011097347A2 (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2011/023549 Continuation-In-Part WO2011097347A2 (en) 2009-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
US13/566,816 Continuation-In-Part US9028878B2 (en) 2009-02-03 2012-08-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/765,514 Continuation US9408393B2 (en) 2009-02-03 2013-02-12 Bismuth-thiols as antiseptics for agricultural, industrial and other uses

Publications (2)

Publication Number Publication Date
WO2012021754A2 WO2012021754A2 (en) 2012-02-16
WO2012021754A3 true WO2012021754A3 (en) 2012-05-24

Family

ID=44356067

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/047490 WO2012021754A2 (en) 2009-02-03 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses

Country Status (16)

Country Link
EP (1) EP2603083A4 (en)
JP (7) JP2013535506A (en)
KR (6) KR20200015814A (en)
CN (2) CN105766990B (en)
AU (3) AU2011289338B2 (en)
BR (2) BR112012019286A2 (en)
CA (1) CA2807993C (en)
CL (2) CL2013000430A1 (en)
IL (3) IL224684A (en)
MX (4) MX371047B (en)
NZ (1) NZ606634A (en)
PH (1) PH12016502498A1 (en)
RU (2) RU2018108411A (en)
SG (3) SG10201506131RA (en)
UA (1) UA113616C2 (en)
WO (1) WO2012021754A2 (en)

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US9028878B2 (en) 2009-02-03 2015-05-12 Microbion Corporation Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
US8389021B2 (en) 2009-02-03 2013-03-05 Microbion Corporation Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
KR20200015814A (en) * 2010-02-03 2020-02-12 마이크로비온 코포레이션 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
CN105307633B (en) * 2013-03-18 2019-06-21 瑟拉诺维斯两合有限公司 Oral care composition
RU2525200C1 (en) * 2013-04-09 2014-08-10 Алексей Георгиевич Бородкин Agent for protection and repair of wound of trees
KR101703732B1 (en) * 2013-11-07 2017-02-07 (주)아모레퍼시픽 Anti-inflammatory composition containing enzymated camellia japonica seed oil
WO2017145142A1 (en) 2016-02-25 2017-08-31 Nobio Ltd. Micro and nanoparticulate compositions comprising anti-microbially active groups
EP3675802A4 (en) 2017-08-30 2021-03-03 Nobio Ltd. Compositions and medical devices comprising anti-microbial particles
CN107950536A (en) * 2017-12-04 2018-04-24 刘志伟 A kind of bactericidal composition containing Bravo
CN108839186B (en) * 2018-05-15 2021-02-26 阜南县金威工艺品有限公司 Mildew-proof treatment method for mulberry twig woven product
CN112788950A (en) 2018-07-31 2021-05-11 微生物公司 Bismuth-thiol compositions and methods for treating wounds
US11464749B2 (en) 2018-07-31 2022-10-11 Microbion Corporation Bismuth-thiol compositions and methods of use
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