UA113616C2 - METHOD OF TREATMENT PLANTS to protect against bacterial pathogens, pathogenic fungi or viral pathogens WITH bismuth-thiol AND METHOD FOR PROCESSING PLANTS to overcome antibiotic resistance in bacterial pathogens WITH bismuth-thiol (optional) - Google Patents
METHOD OF TREATMENT PLANTS to protect against bacterial pathogens, pathogenic fungi or viral pathogens WITH bismuth-thiol AND METHOD FOR PROCESSING PLANTS to overcome antibiotic resistance in bacterial pathogens WITH bismuth-thiol (optional)Info
- Publication number
- UA113616C2 UA113616C2 UAA201303059A UAA201303059A UA113616C2 UA 113616 C2 UA113616 C2 UA 113616C2 UA A201303059 A UAA201303059 A UA A201303059A UA A201303059 A UAA201303059 A UA A201303059A UA 113616 C2 UA113616 C2 UA 113616C2
- Authority
- UA
- Ukraine
- Prior art keywords
- bismuth
- pathogen
- thiol
- viral
- pathogens
- Prior art date
Links
- 244000052616 bacterial pathogen Species 0.000 title abstract 7
- 244000052613 viral pathogen Species 0.000 title abstract 6
- 244000053095 fungal pathogen Species 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- BIGYLAKFCGVRAN-UHFFFAOYSA-N 1,3,4-thiadiazolidine-2,5-dithione Chemical compound S=C1NNC(=S)S1 BIGYLAKFCGVRAN-UHFFFAOYSA-N 0.000 title abstract 4
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 239000011859 microparticle Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000035899 viability Effects 0.000 abstract 2
- 230000032770 biofilm formation Effects 0.000 abstract 1
- 230000000035 biogenic effect Effects 0.000 abstract 1
- 229910052797 bismuth Inorganic materials 0.000 abstract 1
- -1 bismuth thiols Chemical class 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Abstract
Винахід належить до способів лікування мікробних інфекцій у сільськогосподарській, промисловій, виробничій та клінічній галузях. Заявлено спосіб обробки рослини для захисту від бактеріального патогену, патогенного гриба або вірусного патогену із використанням вісмут-тіолів та спосіб обробки рослини для подолання стійкості до антибіотика у бактеріального патогену, що включає етапи, на яких: приводять у контакт рослину з ефективною кількістю вісмут-тіольної (ВТ) композиції при умовах і протягом часу, достатніх для одного або декількох з: і) попередження інфікування рослини бактеріальним патогеном, патогенним грибом або вірусним патогеном, іі) інгібування життєздатності клітин або клітинного росту практично всіх планктонних клітин бактеріального патогену, патогенного гриба або вірусного патогену, ііі) інгібування формування біоплівки бактеріальним патогеном, патогенним грибом або вірусним патогеном та iv) інгібування життєздатності біоплівки або росту біоплівки практично всіх формуючих біоплівку клітин бактеріального патогену, патогенного гриба або вірусного патогену, де ВТ композиція містить монодисперсну суспензію мікрочастинок, що містять ВТ сполуку, причому зазначені мікрочастинки мають середній об'ємний діаметр від 0,4 мкм до 10 мкм.The invention relates to methods for the treatment of microbial infections in agricultural, industrial, industrial and clinical fields. A method of treating a plant for protection against a bacterial pathogen, a pathogenic fungus or a viral pathogen using bismuth thiols and a method of treating a plant for overcoming antibiotic resistance in a bacterial pathogen, comprising the steps of: contacting a plant with an effective amount of bismuth thiol (VT) compositions under conditions and for a time sufficient for one or more of: (i) prevention of infection by a bacterial pathogen, pathogenic fungus or viral pathogen, (ii) inhibition of viability the presence of cells or cell growth of virtually all planktonic cells of a bacterial pathogen, pathogenic fungus or viral pathogen, iii) inhibition of biofilm formation by a bacterial pathogen, pathogenic fungus or viral pathogen, and iv) inhibition of biofilm viability, or biogenic pathogen growth, or viral pathogen, where the BT composition contains a monodisperse suspension of microparticles containing BT compound, and these microparticles have average volume diameter from 0.4 μm to 10 μm.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37318810P | 2010-08-12 | 2010-08-12 | |
| PCT/US2011/047490 WO2012021754A2 (en) | 2010-08-12 | 2011-08-11 | Bismuth-thiols as antiseptics for agricultural, industrial and other uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA113616C2 true UA113616C2 (en) | 2017-02-27 |
Family
ID=44356067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201303059A UA113616C2 (en) | 2010-08-12 | 2011-08-11 | METHOD OF TREATMENT PLANTS to protect against bacterial pathogens, pathogenic fungi or viral pathogens WITH bismuth-thiol AND METHOD FOR PROCESSING PLANTS to overcome antibiotic resistance in bacterial pathogens WITH bismuth-thiol (optional) |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP2603083A4 (en) |
| JP (7) | JP2013535506A (en) |
| KR (6) | KR20200015814A (en) |
| CN (2) | CN105766990B (en) |
| AU (3) | AU2011289338B2 (en) |
| BR (2) | BR112012019286A2 (en) |
| CA (1) | CA2807993C (en) |
| CL (2) | CL2013000430A1 (en) |
| IL (3) | IL224684A (en) |
| MX (4) | MX371047B (en) |
| NZ (1) | NZ606634A (en) |
| PH (1) | PH12016502498A1 (en) |
| RU (2) | RU2018108411A (en) |
| SG (3) | SG187801A1 (en) |
| UA (1) | UA113616C2 (en) |
| WO (1) | WO2012021754A2 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9028878B2 (en) | 2009-02-03 | 2015-05-12 | Microbion Corporation | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
| US8389021B2 (en) | 2009-02-03 | 2013-03-05 | Microbion Corporation | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
| KR20200015814A (en) * | 2010-02-03 | 2020-02-12 | 마이크로비온 코포레이션 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
| US20160022568A1 (en) * | 2013-03-18 | 2016-01-28 | Theranovis Gmbh & Co. Kg | Composition for oral care |
| RU2525200C1 (en) * | 2013-04-09 | 2014-08-10 | Алексей Георгиевич Бородкин | Agent for protection and repair of wound of trees |
| KR101703732B1 (en) * | 2013-11-07 | 2017-02-07 | (주)아모레퍼시픽 | Anti-inflammatory composition containing enzymated camellia japonica seed oil |
| WO2017145142A1 (en) | 2016-02-25 | 2017-08-31 | Nobio Ltd. | Micro and nanoparticulate compositions comprising anti-microbially active groups |
| US11134676B2 (en) | 2017-08-30 | 2021-10-05 | Nobio Ltd. | Anti-microbial particles and methods of use thereof |
| CN107950536A (en) * | 2017-12-04 | 2018-04-24 | 刘志伟 | A kind of bactericidal composition containing Bravo |
| CN108839186B (en) * | 2018-05-15 | 2021-02-26 | 阜南县金威工艺品有限公司 | Mildew-proof treatment method for mulberry twig woven product |
| CN112788950A (en) | 2018-07-31 | 2021-05-11 | 微生物公司 | Bismuth-thiol compositions and methods for treating wounds |
| WO2020028558A1 (en) | 2018-07-31 | 2020-02-06 | Microbion Corporation | Bismuth-thiol compositions and methods of use |
| KR101990253B1 (en) * | 2018-11-22 | 2019-06-17 | 하봉호 | Container type mushroom growing apparatus |
| CN109997856B (en) * | 2019-04-15 | 2020-11-03 | 广西大学 | Composition of small molecular compound and application thereof |
| KR102126721B1 (en) * | 2019-07-16 | 2020-06-25 | (주)인트론바이오테크놀로지 | Novel Enterobacter aerogenes bacteriophage Ent-AEP-1 and its use for preventing proliferation of Enterobacter aerogenes and Enterobacter cloacae |
| JP7458622B2 (en) * | 2019-09-18 | 2024-04-01 | 学校法人東京農業大学 | Substances that reduce the resistance of antibiotic-resistant microorganisms and methods for reducing the resistance of antibiotic-resistant microorganisms |
| CN110663672B (en) * | 2019-11-13 | 2024-04-26 | 南京林业大学 | Thread-driven root pesticide application head |
| US11479655B2 (en) * | 2020-01-15 | 2022-10-25 | The Boeing Company | Compositions for use with polysulfide sealants and related methods |
| KR102197719B1 (en) | 2020-05-07 | 2021-01-04 | 곽태진 | Cuttlefish breeding system |
| CN111856546B (en) * | 2020-06-23 | 2022-07-29 | 中国辐射防护研究院 | Sample preparation method for radiochemical analysis of Cs-137 in marine organism ash |
| CN113969300B (en) * | 2020-07-23 | 2024-08-23 | 禾美生物科技(浙江)有限公司 | Eucalyptus leaf composite active extract process and antibacterial application thereof |
| CN112640907B (en) * | 2021-01-19 | 2021-11-16 | 西南大学 | Novel application of lipoic acid in inhibiting plant fungal pathogenic bacteria and method for preventing and treating citrus fruit postharvest fungal diseases |
| KR102431000B1 (en) * | 2021-07-22 | 2022-08-11 | 농업회사법인 주식회사 아그로비즈 | Composition for an autoimmune builder of plants containing aspirin and benzothiazole, and method of using the same |
| EP4310192A1 (en) * | 2022-07-21 | 2024-01-24 | C4Diagnostics | Method of determining the existence and/or degree of resistance of microorganisms to antimicrobial agents |
| CN115323778B (en) * | 2022-08-16 | 2023-07-18 | 汕头市润丰纺织科技实业有限公司 | Chitosan-I type collagen amino acid composite antibacterial finishing liquid, preparation method thereof and antibacterial fabric |
| TR2022012983A2 (en) * | 2022-08-17 | 2022-09-21 | Marmara Ueniv Strateji Gelis Dai Bsk Muhasebe Birimi | A BIOCOMPATIBLE PRODUCT WITH REPRESENTATIVE AND THERAPEUTIC PROPERTIES FOR BONE DISORDERS AND/OR FRACTURES AND A METHOD FOR OBTAINING THE SUBJECT PRODUCT |
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