RU2018108411A - METHOD FOR PROTECTING THE PRODUCT, SURFACE OF THE PRODUCT OR NATURAL OR ARTIFICIAL SURFACE FROM A BACTERIAL, FUNGAL OR VIRUS PATHOGEN - Google Patents

METHOD FOR PROTECTING THE PRODUCT, SURFACE OF THE PRODUCT OR NATURAL OR ARTIFICIAL SURFACE FROM A BACTERIAL, FUNGAL OR VIRUS PATHOGEN Download PDF

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RU2018108411A
RU2018108411A RU2018108411A RU2018108411A RU2018108411A RU 2018108411 A RU2018108411 A RU 2018108411A RU 2018108411 A RU2018108411 A RU 2018108411A RU 2018108411 A RU2018108411 A RU 2018108411A RU 2018108411 A RU2018108411 A RU 2018108411A
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bacterial
fungal
viral pathogen
product
bismuth
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RU2018108411A
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Бретт Хью Джеймс БЕЙКЕР
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Микробион Корпорейшн
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Priority claimed from PCT/US2011/023549 external-priority patent/WO2011097347A2/en
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/04—Antibacterial agents
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    • A61P31/10—Antimycotics
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    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
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Claims (30)

1. Способ защиты поверхности изделия от бактериального, грибкового или вирусного патогена, включающий:1. The method of protecting the surface of the product from a bacterial, fungal or viral pathogen, including: приведение в контакт поверхности изделия с эффективным количеством дезинфектанта, содержащего висмут-тиольную (BT) композицию, при условиях и в течение времени, достаточного для одного или более из:bringing into contact the surface of the product with an effective amount of a disinfectant containing a bismuth-thiol (BT) composition, under conditions and for a time sufficient for one or more of: (i) предотвращения заражения поверхности изделия бактериальным, грибковым или вирусным патогеном,(i) preventing infection of the surface of the product with a bacterial, fungal or viral pathogen, (ii) ингибирования жизнеспособности клеток или клеточного роста практически всех планктонных клеток бактериального, грибкового или вирусного патогена,(ii) inhibiting cell viability or cell growth of virtually all planktonic cells of a bacterial, fungal or viral pathogen, (iii) ингибирования образования биопленки бактериальным, грибковым или вирусным патогеном, и(iii) inhibiting biofilm formation by a bacterial, fungal or viral pathogen, and (iv) ингибирования жизнеспособности биопленки или роста биопленки практически всех образующих биопленки клеток бактериального, грибкового или вирусного патогена,(iv) inhibiting biofilm viability or biofilm growth of virtually all bacterial, fungal, or viral pathogen-forming biofilm cells, где BT-композиция содержит практически монодисперсную суспензию твердых микрочастиц, которые содержат BT-соединение, при этом указанные микрочастицы характеризуются волюметрическим средним диаметром, составляющим от приблизительно 0,4 до приблизительно 10 мкм, и где висмут-тиольное соединение не было микронизировано, измельчено или не подвергалось обработке сверхкритической жидкостью.where the BT composition contains a substantially monodisperse suspension of solid microparticles that contain a BT compound, said microparticles having a volumetric average diameter of from about 0.4 to about 10 μm, and where the bismuth thiol compound has not been micronized, ground or not was treated with supercritical fluid. 2. Способ защиты природной или искусственной поверхности от бактериального, грибкового или вирусного патогена, включающий:2. A method of protecting a natural or artificial surface from a bacterial, fungal or viral pathogen, including: приведение в контакт природной или искусственной поверхности с эффективным количеством дезинфектанта, содержащего висмут-тиольную (BT) композицию, при условиях и в течение времени, достаточного для одного или более из:bringing into contact a natural or artificial surface with an effective amount of a disinfectant containing a bismuth-thiol (BT) composition, under conditions and for a time sufficient for one or more of: (i) предотвращения заражения природной или искусственной поверхности бактериальным, грибковым или вирусным патогеном,(i) preventing infection of the natural or artificial surface with a bacterial, fungal or viral pathogen, (ii) ингибирования жизнеспособности клеток или клеточного роста практически всех планктонных клеток бактериального, грибкового или вирусного патогена,(ii) inhibiting cell viability or cell growth of virtually all planktonic cells of a bacterial, fungal or viral pathogen, (iii) ингибирования образования биопленки бактериальным, грибковым или вирусным патогеном, и(iii) inhibiting biofilm formation by a bacterial, fungal or viral pathogen, and (iv) ингибирования жизнеспособности биопленки или роста биопленки практически всех образующих биопленки клеток бактериального, грибкового или вирусного патогена,(iv) inhibiting biofilm viability or biofilm growth of virtually all bacterial, fungal, or viral pathogen-forming biofilm cells, где BT-композиция содержит практически монодисперсную суспензию твердых микрочастиц, которые содержат BT-соединение, при этом указанные микрочастицы характеризуются волюметрическим средним диаметром, составляющим от приблизительно 0,4 до приблизительно 10 мкм, причем висмут-тиольное соединение не было микронизировано, измельчено или не подвергалось обработке сверхкритической жидкостью.where the BT composition contains an almost monodisperse suspension of solid microparticles that contain a BT compound, wherein said microparticles have a volumetric average diameter of from about 0.4 to about 10 μm, and the bismuth-thiol compound was not micronized, ground or not subjected supercritical fluid treatment. 3. Способ по п. 1 или 2, где поверхность присутствует (i) на участке хирургического вмешательства, (ii) на медицинском устройстве или медицинском имплантате, (iii) на стоматологическом устройстве или зубном имплантате или (iv) на кости, суставе, сухожилии, связке или зубе.3. The method according to claim 1 or 2, where the surface is present (i) on the surgical site, (ii) on the medical device or medical implant, (iii) on the dental device or dental implant, or (iv) on the bone, joint, tendon ligament or tooth. 4. Способ по п. 3, где медицинское устройство или медицинский имплантат представляет собой протез кости или сустава, катетер, стент, питательную трубку или гастростомическую трубку.4. The method of claim 3, wherein the medical device or medical implant is a prosthesis of a bone or joint, a catheter, a stent, a feeding tube or a gastrostomy tube. 5. Способ защиты изделия от бактериального, грибкового или вирусного патогена, включающий:5. A method of protecting the product from a bacterial, fungal or viral pathogen, including: приведение в контакт изделия с эффективным количеством дезинфектанта, содержащего висмут-тиольную (BT) композицию, при условиях и в течение времени, достаточного для одного или более из:bringing the product into contact with an effective amount of a disinfectant containing a bismuth thiol (BT) composition, under conditions and for a time sufficient for one or more of: (i) предотвращения заражения изделия бактериальным, грибковым или вирусным патогеном,(i) preventing infection of the product with a bacterial, fungal or viral pathogen, (ii) ингибирования жизнеспособности клеток или клеточного роста практически всех планктонных клеток бактериального, грибкового или вирусного патогена,(ii) inhibiting cell viability or cell growth of virtually all planktonic cells of a bacterial, fungal or viral pathogen, (iii) ингибирования образования биопленки бактериальным, грибковым или вирусным патогеном, и(iii) inhibiting biofilm formation by a bacterial, fungal or viral pathogen, and (iv) ингибирования жизнеспособности биопленки или роста биопленки практически всех образующих биопленки клеток бактериального, грибкового или вирусного патогена,(iv) inhibiting biofilm viability or biofilm growth of virtually all bacterial, fungal, or viral pathogen-forming biofilm cells, где BT-композиция содержит практически монодисперсную суспензию твердых микрочастиц, которые содержат BT-соединение, при этом указанные микрочастицы характеризуются волюметрическим средним диаметром, составляющим от приблизительно 0,4 до приблизительно 10 мкм, причем висмут-тиольное соединение не было микронизировано, измельчено или не подвергалось обработке сверхкритической жидкостью.where the BT composition contains an almost monodisperse suspension of solid microparticles that contain a BT compound, wherein said microparticles have a volumetric average diameter of from about 0.4 to about 10 μm, and the bismuth-thiol compound was not micronized, ground or not subjected supercritical fluid treatment. 6. Способ по любому из пп. 1, 2 или 5, где поверхность изделия, природная или искусственная поверхность или изделие содержат одну или более из цементной поверхности, бетонной поверхности, резиновой поверхности, силиконовой поверхности, пластиковой поверхности, окрашенной поверхности или поверхности с нанесенным покрытием.6. The method according to any one of paragraphs. 1, 2 or 5, where the surface of the product, natural or artificial surface or product contains one or more of a cement surface, concrete surface, rubber surface, silicone surface, plastic surface, painted surface or coated surface. 7. Способ по п. 2, где природную или искусственную поверхность защищают от бактериального патогена,7. The method according to p. 2, where the natural or artificial surface is protected from a bacterial pathogen, где природная или искусственная поверхность содержит одно или более из (i) протеза кости или сустава и (ii) тканевой или скелетной структуры, смежной с протезом кости или сустава, иwhere the natural or artificial surface contains one or more of (i) a bone or joint prosthesis and (ii) a tissue or skeletal structure adjacent to the bone or joint prosthesis, and где дезинфектант содержит BT-композицию, предусматривающую BT-соединение в виде микрочастиц в костном цементе.where the disinfectant contains a BT composition comprising a BT compound in the form of microparticles in bone cement. 8. Способ по п. 7, где костный цемент содержит гидрогель.8. The method according to p. 7, where the bone cement contains a hydrogel. 9. Способ по п. 8, где гидрогель содержит полиметилметакрилат.9. The method of claim 8, wherein the hydrogel comprises polymethyl methacrylate. 10. Способ по п. 7, где BT-соединение в виде микрочастиц выбрано из висмут-1,2-этандитиола (EDT), висмут-пиритион/-1,2-этандитиола и висмут-пиритион/2,3-бутандитиола.10. The method of claim 7, wherein the microparticle BT compound is selected from bismuth-1,2-ethanedithiol (EDT), bismuth-pyrithione / -1,2-ethanedithiol, and bismuth-pyrithione / 2,3-butanedithiol.
RU2018108411A 2010-08-12 2011-08-11 METHOD FOR PROTECTING THE PRODUCT, SURFACE OF THE PRODUCT OR NATURAL OR ARTIFICIAL SURFACE FROM A BACTERIAL, FUNGAL OR VIRUS PATHOGEN RU2018108411A (en)

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PCT/US2011/023549 WO2011097347A2 (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses

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