WO2011097347A3 - Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses - Google Patents

Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses Download PDF

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Publication number
WO2011097347A3
WO2011097347A3 PCT/US2011/023549 US2011023549W WO2011097347A3 WO 2011097347 A3 WO2011097347 A3 WO 2011097347A3 US 2011023549 W US2011023549 W US 2011023549W WO 2011097347 A3 WO2011097347 A3 WO 2011097347A3
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WO
WIPO (PCT)
Prior art keywords
certain
compositions
bismuth
treating
antiseptics
Prior art date
Application number
PCT/US2011/023549
Other languages
French (fr)
Other versions
WO2011097347A2 (en
Inventor
Brett Hugh James Baker
Original Assignee
Microbion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2010/023108 external-priority patent/WO2010091124A2/en
Application filed by Microbion Corporation filed Critical Microbion Corporation
Priority to CN2011800153054A priority Critical patent/CN103079557A/en
Priority to KR1020197009488A priority patent/KR102074444B1/en
Priority to JP2012552075A priority patent/JP2013518895A/en
Priority to AU2011212941A priority patent/AU2011212941B2/en
Priority to KR1020207003093A priority patent/KR20200015814A/en
Priority to CA2788669A priority patent/CA2788669C/en
Priority to BR112012019286A priority patent/BR112012019286A2/en
Priority to KR1020177034637A priority patent/KR101966867B1/en
Priority to MX2016010269A priority patent/MX371047B/en
Priority to KR1020127022562A priority patent/KR101821833B1/en
Priority to EP11740333.7A priority patent/EP2536406A4/en
Priority to MX2012009054A priority patent/MX346409B/en
Priority to SG10202001032RA priority patent/SG10202001032RA/en
Priority to MX2013001581A priority patent/MX362785B/en
Priority to JP2013524237A priority patent/JP2013535506A/en
Priority to EP11817067.9A priority patent/EP2603083A4/en
Priority to KR1020187019857A priority patent/KR20180085042A/en
Priority to SG2013010053A priority patent/SG187801A1/en
Priority to BR112013003127A priority patent/BR112013003127A2/en
Priority to NZ606634A priority patent/NZ606634A/en
Priority to CN201610127111.8A priority patent/CN105766990B/en
Priority to SG10201506131RA priority patent/SG10201506131RA/en
Priority to RU2018108411A priority patent/RU2018108411A/en
Priority to NZ720220A priority patent/NZ720220A/en
Priority to AU2011289338A priority patent/AU2011289338B2/en
Priority to PCT/US2011/047490 priority patent/WO2012021754A2/en
Priority to KR1020137006121A priority patent/KR20130132410A/en
Priority to RU2013110493/10A priority patent/RU2013110493A/en
Priority to CA2807993A priority patent/CA2807993C/en
Priority to CN201180042863.XA priority patent/CN103096720B/en
Publication of WO2011097347A2 publication Critical patent/WO2011097347A2/en
Publication of WO2011097347A3 publication Critical patent/WO2011097347A3/en
Priority to US13/566,816 priority patent/US9028878B2/en
Priority to MX2019001293A priority patent/MX2019001293A/en
Priority to IL224684A priority patent/IL224684A/en
Priority to CL2013000430A priority patent/CL2013000430A1/en
Priority to US14/676,698 priority patent/US20160058772A1/en
Priority to US15/151,130 priority patent/US20160375034A1/en
Priority to IL248446A priority patent/IL248446B/en
Priority to PH12016502498A priority patent/PH12016502498A1/en
Priority to JP2017141774A priority patent/JP2018008971A/en
Priority to CL2017002549A priority patent/CL2017002549A1/en
Priority to IL258908A priority patent/IL258908A/en
Priority to US15/980,622 priority patent/US20180303846A1/en
Priority to US16/284,723 priority patent/US10960012B2/en
Priority to US16/433,660 priority patent/US20200138033A1/en
Priority to JP2019219070A priority patent/JP7097344B2/en
Priority to US17/181,781 priority patent/US20220016132A1/en
Priority to JP2021166416A priority patent/JP2022003090A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/02—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing metal atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/29—Antimony or bismuth compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/65—Tetracyclines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.
PCT/US2011/023549 2009-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses WO2011097347A2 (en)

Priority Applications (47)

Application Number Priority Date Filing Date Title
CN2011800153054A CN103079557A (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
KR1020197009488A KR102074444B1 (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
JP2012552075A JP2013518895A (en) 2010-02-03 2011-02-03 Bismuth-thiol as a disinfectant for biomedical use, including treatment of bacterial biofilms and other uses
AU2011212941A AU2011212941B2 (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
KR1020207003093A KR20200015814A (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
CA2788669A CA2788669C (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
BR112012019286A BR112012019286A2 (en) 2010-02-03 2011-02-03 bismuththiols as an antiseptic for biomedical uses, including treatment of bacterial biofilms and other uses
KR1020177034637A KR101966867B1 (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
MX2016010269A MX371047B (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses.
KR1020127022562A KR101821833B1 (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
EP11740333.7A EP2536406A4 (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
MX2012009054A MX346409B (en) 2010-02-03 2011-02-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses.
SG10202001032RA SG10202001032RA (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
MX2013001581A MX362785B (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses.
JP2013524237A JP2013535506A (en) 2010-08-12 2011-08-11 Bismuth-thiol as a disinfectant for agricultural, industrial and other uses
EP11817067.9A EP2603083A4 (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
KR1020187019857A KR20180085042A (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
SG2013010053A SG187801A1 (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
BR112013003127A BR112013003127A2 (en) 2010-08-12 2011-08-11 bismuththiols as antiseptics for agricultural, industrial and other uses
NZ606634A NZ606634A (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
CN201610127111.8A CN105766990B (en) 2010-08-12 2011-08-11 As preservative for agricultural, bismuth-mercaptan of industry and other purposes
SG10201506131RA SG10201506131RA (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
RU2018108411A RU2018108411A (en) 2010-08-12 2011-08-11 METHOD FOR PROTECTING THE PRODUCT, SURFACE OF THE PRODUCT OR NATURAL OR ARTIFICIAL SURFACE FROM A BACTERIAL, FUNGAL OR VIRUS PATHOGEN
NZ720220A NZ720220A (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
AU2011289338A AU2011289338B2 (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
PCT/US2011/047490 WO2012021754A2 (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
KR1020137006121A KR20130132410A (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
RU2013110493/10A RU2013110493A (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other applications
CA2807993A CA2807993C (en) 2010-08-12 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
CN201180042863.XA CN103096720B (en) 2010-08-12 2011-08-11 Bismuth-mercaptan that is agriculture, industrial and other purposes is used for as preservative
US13/566,816 US9028878B2 (en) 2009-02-03 2012-08-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
MX2019001293A MX2019001293A (en) 2010-08-12 2013-02-08 Bismuth-thiols as antiseptics for agricultural, industrial and other uses.
IL224684A IL224684A (en) 2010-08-12 2013-02-12 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
CL2013000430A CL2013000430A1 (en) 2010-08-12 2013-02-12 Method to protect a plant against a bacterial, fungal or viral pathogen because it comprises contacting the plant with bismuth thiol (bt); method for overcoming antibiotic resistance in a plant, in or on which a bacterial plant pathogen resistant to antibiotics is present.
US14/676,698 US20160058772A1 (en) 2009-02-03 2015-04-01 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
US15/151,130 US20160375034A1 (en) 2009-02-03 2016-05-10 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
IL248446A IL248446B (en) 2010-08-12 2016-10-21 Bismuth thiols as antiseptics for agricultural, industrial and other uses
PH12016502498A PH12016502498A1 (en) 2010-08-12 2016-12-14 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
JP2017141774A JP2018008971A (en) 2010-08-12 2017-07-21 Bismuth-thiol as disinfectant for used in agricultural, industrial and other use
CL2017002549A CL2017002549A1 (en) 2010-08-12 2017-10-10 Use of a bismuth-thiol (bt) composition, which is used to prepare a medication useful for the treatment of an open wound that has or is at risk of having a bacterial biofilm infection.
IL258908A IL258908A (en) 2010-08-12 2018-04-24 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
US15/980,622 US20180303846A1 (en) 2009-02-03 2018-05-15 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
US16/284,723 US10960012B2 (en) 2009-02-03 2019-02-25 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
US16/433,660 US20200138033A1 (en) 2009-02-03 2019-06-06 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
JP2019219070A JP7097344B2 (en) 2010-08-12 2019-12-03 Bismuth-thiol as a disinfectant for agricultural, industrial and other uses
US17/181,781 US20220016132A1 (en) 2009-02-03 2021-02-22 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
JP2021166416A JP2022003090A (en) 2010-08-12 2021-10-08 Bismuth-thiols as antiseptics for agricultural, industrial and other uses

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USPCT/US2010/023108 2010-02-03
PCT/US2010/023108 WO2010091124A2 (en) 2009-02-03 2010-02-03 Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
US37318810P 2010-08-12 2010-08-12
US61/373,188 2010-08-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/023108 Continuation-In-Part WO2010091124A2 (en) 2009-02-03 2010-02-03 Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2011/047490 Continuation-In-Part WO2012021754A2 (en) 2009-02-03 2011-08-11 Bismuth-thiols as antiseptics for agricultural, industrial and other uses
US13/566,816 Continuation US9028878B2 (en) 2009-02-03 2012-08-03 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses

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WO2011097347A2 WO2011097347A2 (en) 2011-08-11
WO2011097347A3 true WO2011097347A3 (en) 2011-12-22

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