MX367850B - Prevención y tratamiento de condiciones inflamatorias. - Google Patents

Prevención y tratamiento de condiciones inflamatorias.

Info

Publication number
MX367850B
MX367850B MX2013015441A MX2013015441A MX367850B MX 367850 B MX367850 B MX 367850B MX 2013015441 A MX2013015441 A MX 2013015441A MX 2013015441 A MX2013015441 A MX 2013015441A MX 367850 B MX367850 B MX 367850B
Authority
MX
Mexico
Prior art keywords
prevention
treatment
inflammatory conditions
embodiments relate
liver disease
Prior art date
Application number
MX2013015441A
Other languages
English (en)
Other versions
MX2013015441A (es
Inventor
Kumar Chaturvedi Vipin
Original Assignee
Gri Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gri Bio Inc filed Critical Gri Bio Inc
Publication of MX2013015441A publication Critical patent/MX2013015441A/es
Publication of MX367850B publication Critical patent/MX367850B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Las presentes realizaciones se refieren a métodos para la prevención y el tratamiento de afecciones inflamatorias como la enfermedad hepática inducida por el alcohol (ALD). Mas específicamente, las presentes realizaciones se refieren a la prevención y tratamiento de ALD mediante la administración de un agonista del receptor del acido retinoico (RAR). Algunas realizaciones se refieren al uso de tazaroteno en la prevención y tratamiento de la lesión hepática inducida por el alcohol, la enfermedad hepática relacionada con el alcohol, la enfermedad del hígado graso, la esteatosis hepática, la hepatitis inducida por el alcohol o la cirrosis inducida por el alcohol.
MX2013015441A 2011-06-24 2012-06-22 Prevención y tratamiento de condiciones inflamatorias. MX367850B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161501139P 2011-06-24 2011-06-24
PCT/US2012/043875 WO2012178108A1 (en) 2011-06-24 2012-06-22 Prevention and treatment of inflammatory conditions

Publications (2)

Publication Number Publication Date
MX2013015441A MX2013015441A (es) 2014-09-22
MX367850B true MX367850B (es) 2019-09-09

Family

ID=47422987

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013015441A MX367850B (es) 2011-06-24 2012-06-22 Prevención y tratamiento de condiciones inflamatorias.

Country Status (13)

Country Link
US (3) US9949996B2 (es)
EP (2) EP3616701A1 (es)
JP (2) JP6441073B2 (es)
KR (2) KR102055395B1 (es)
CN (2) CN111298120A (es)
AU (1) AU2012272642B2 (es)
BR (1) BR112013033309B1 (es)
CA (1) CA2840272C (es)
DK (1) DK2723347T3 (es)
ES (1) ES2759584T3 (es)
MX (1) MX367850B (es)
RU (1) RU2678561C9 (es)
WO (1) WO2012178108A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2678561C9 (ru) 2011-06-24 2019-03-05 ДжиАрАй Био, Инк. Предупреждение и лечение воспалительных состояний
EP2945701B1 (en) * 2013-01-18 2023-04-05 Cornell University Methods of treating diseases associated with high fat diet and vitamin a deficiency using retinoic acid receptor agonists
US11191755B2 (en) 2014-01-17 2021-12-07 Cornell University Compositions and methods for providing cardioprotective effects
EP3094380B1 (en) 2014-01-17 2021-04-28 Cornell University Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists
CN106132422A (zh) 2014-02-27 2016-11-16 莱斯拉公司 使用视黄酸受体相关孤儿受体γ的激动剂的过继细胞疗法＆相关治疗方法
EP3116318B1 (en) * 2014-03-10 2019-03-13 Cornell University Combination therapy for head and neck cancer
US9896441B2 (en) 2014-05-05 2018-02-20 Lycera Corporation Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
JP6523337B2 (ja) 2014-05-05 2019-05-29 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物
CN114712504A (zh) 2014-12-09 2022-07-08 Gri生物有限公司 炎性病况的预防和治疗
JP2018515491A (ja) 2015-05-05 2018-06-14 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγの作動薬及び疾患の療法として使用するジヒドロ−２Ｈ−ベンゾ［ｂ］［１，４］オキサジンスルホンアミド及び関連化合物
CN107980042B (zh) 2015-06-11 2021-10-08 莱斯拉公司 用作RORγ激动剂和用于治疗疾病的芳基二氢-2H-苯并[b][1,4]噁嗪磺酰胺和相关化合物
US11931327B2 (en) 2017-07-04 2024-03-19 Daiichi Sankyo Company, Limited Drug for retinal degenerative disease associated with photoreceptor degeneration
EP3806839A4 (en) * 2018-06-14 2022-03-30 Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") COMPOSITIONS AND METHODS TO DELIVER CARDIOPROTECTIVE EFFECTS
CN113207799B (zh) * 2021-03-19 2022-03-15 中山大学 一种二型糖尿病小鼠快速心衰模型的构建方法
WO2023044355A1 (en) * 2021-09-15 2023-03-23 Cornell University Compositions and methods for mitigating alcohol liver disease

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59777B1 (en) 1985-12-04 1994-04-06 Max Planck Gesellschaft Medicaments
JP3879938B2 (ja) * 1994-03-31 2007-02-14 日本ケミカルリサーチ株式会社 抗炎症剤
JPH08109134A (ja) * 1994-10-11 1996-04-30 Sanwa Kagaku Kenkyusho Co Ltd 細胞変成抑制並びに臓器毒性軽減剤
US6025388A (en) 1995-04-26 2000-02-15 Allergan Sales, Inc. Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids
US5624957A (en) * 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
FR2739557B1 (fr) * 1995-10-09 1997-11-14 Cird Galderma Utilisation d'un ligand agoniste specifique rar-gamma
US5965606A (en) 1995-12-29 1999-10-12 Allergan Sales, Inc. Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity
IL128723A0 (en) 1996-08-28 2000-01-31 Inst Nat Sante De De La Rech M Pharmaceutical compositions containing rar antagonists and rxr agonists
AU756805B2 (en) 1998-01-22 2003-01-23 Zentaris Gmbh Solid pharmaceutical compositions containing miltefosine for oral administration in the treatment of leishmaniasis
JO2178B1 (en) 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of invasive diseases, using selected anti-PAR materials
US7390795B2 (en) 2000-12-18 2008-06-24 Pentraxin Therapeutics Limited Treatment and prevention of tissue damage
US7419958B2 (en) * 2001-03-26 2008-09-02 Dana-Farber Cancer Institute, Inc. Method of attenuating reactions to skin irritants
EP1567172A2 (en) * 2002-11-29 2005-08-31 GPC Biotech AG Formulations useful against hepatitis c virus infections
US20050026950A1 (en) * 2003-07-30 2005-02-03 Allergan, Inc. Methods of therapeutic treatment using retinoids to achieve consistent bioavailability
CN1210041C (zh) * 2003-09-29 2005-07-13 中国医学科学院皮肤病研究所 治疗痤疮的复方外用药物
WO2005120479A1 (en) * 2004-06-09 2005-12-22 Gpc Biotech Ag Use of selenium or a selenium salt and a retinoid acid or a retinoid in the treatment of viral hepatitis c
US20110118197A1 (en) * 2005-09-29 2011-05-19 Vipin Kumar Chaturvedi Prevention of hepatic ischemic reperfusion injury by administration of sulfatides
JP2009510124A (ja) * 2005-09-29 2009-03-12 トーリー パインズ インスティチュート フォー モルキュラー スタディーズ 自己免疫障害の治療のためのスルファチド
WO2007071402A1 (en) 2005-12-23 2007-06-28 Jado Technologies Gmbh Means and methods for the treatment and prevention of allergic diseases
DE102006019906A1 (de) 2006-04-28 2007-10-31 Müller-Enoch, Dieter, Prof. Dr. Verwendung von Verbindungen der Formel A-R-X oder deren pharmazeutisch akzeptable Salze zur Herstellung einer pharmazeutischen Zubereitung
EP2097075A1 (fr) * 2006-11-20 2009-09-09 Galderma Research & Development, S.N.C. Utilisation d'adapalène pour moduler l'expression de cd1d ou il-10.
AU2010273261B2 (en) * 2009-07-16 2013-07-25 Stiefel Laboratories, Inc. Tazarotene derivatives
IT1403356B1 (it) 2010-12-27 2013-10-17 Sit La Precisa Spa Con Socio Unico Dispositivo per il controllo dell'erogazione di un gas combustibile verso un bruciatore, particolarmente per apparecchi riscaldatori di acqua
EP2809648B1 (en) 2011-05-26 2019-04-03 GRI Bio, Inc. Oxygenated amino- or ammonium-containing sulfonic acid derivatives and their medical use
RU2678561C9 (ru) 2011-06-24 2019-03-05 ДжиАрАй Био, Инк. Предупреждение и лечение воспалительных состояний
US9005490B2 (en) 2012-12-14 2015-04-14 Delphi Technologies, Inc. Material for solid state sintered material
EP2983709A1 (en) 2013-04-08 2016-02-17 Academisch Medisch Centrum Miltefosin or perifosin for use in the treatment of ibd
CN114712504A (zh) 2014-12-09 2022-07-08 Gri生物有限公司 炎性病况的预防和治疗

Also Published As

Publication number Publication date
US11660309B2 (en) 2023-05-30
BR112013033309B1 (pt) 2022-07-05
US10925886B2 (en) 2021-02-23
CA2840272A1 (en) 2012-12-27
RU2678561C2 (ru) 2019-01-30
AU2012272642B2 (en) 2017-09-07
MX2013015441A (es) 2014-09-22
EP2723347B1 (en) 2019-09-04
ES2759584T3 (es) 2020-05-11
US20210169909A1 (en) 2021-06-10
CN103732231A (zh) 2014-04-16
US20180193368A1 (en) 2018-07-12
US9949996B2 (en) 2018-04-24
EP3616701A1 (en) 2020-03-04
JP6441073B2 (ja) 2018-12-19
CN111298120A (zh) 2020-06-19
KR102055395B1 (ko) 2019-12-12
RU2014100056A (ru) 2015-07-27
JP2017206523A (ja) 2017-11-24
KR20140048939A (ko) 2014-04-24
EP2723347A4 (en) 2015-02-25
AU2012272642A2 (en) 2014-02-13
AU2012272642A1 (en) 2014-01-30
EP2723347A1 (en) 2014-04-30
CN103732231B (zh) 2020-04-10
KR20190140087A (ko) 2019-12-18
RU2678561C9 (ru) 2019-03-05
DK2723347T3 (da) 2019-11-18
BR112013033309A2 (pt) 2017-03-07
BR112013033309A8 (pt) 2018-03-06
JP2014517077A (ja) 2014-07-17
US20140187504A1 (en) 2014-07-03
WO2012178108A1 (en) 2012-12-27
CA2840272C (en) 2020-09-15
KR102164567B1 (ko) 2020-10-12

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