BR112013033309A2 - método para tratar ou prevenir pelo menos uma afecção inflamatória em um paciente, método para inibir lesões hepáticas em um paciente em risco de lesões hepáticas químicas provenientes de drogas prescritas ou drogas de abuso, método para inibir danos de tecido mediados por célula nkt tipo i em um paciente, método para inibir a ativação de células nkt tipo i, método para inibir a ativação de células nkt tipo i em um paciente com uma doença inflamatória e método para inibir a liberação de células mieloides no fígado de um paciente - Google Patents
método para tratar ou prevenir pelo menos uma afecção inflamatória em um paciente, método para inibir lesões hepáticas em um paciente em risco de lesões hepáticas químicas provenientes de drogas prescritas ou drogas de abuso, método para inibir danos de tecido mediados por célula nkt tipo i em um paciente, método para inibir a ativação de células nkt tipo i, método para inibir a ativação de células nkt tipo i em um paciente com uma doença inflamatória e método para inibir a liberação de células mieloides no fígado de um pacienteInfo
- Publication number
- BR112013033309A2 BR112013033309A2 BR112013033309A BR112013033309A BR112013033309A2 BR 112013033309 A2 BR112013033309 A2 BR 112013033309A2 BR 112013033309 A BR112013033309 A BR 112013033309A BR 112013033309 A BR112013033309 A BR 112013033309A BR 112013033309 A2 BR112013033309 A2 BR 112013033309A2
- Authority
- BR
- Brazil
- Prior art keywords
- patient
- inhibiting
- cell
- liver
- nkt type
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title 5
- 206010067125 Liver injury Diseases 0.000 title 2
- 230000020411 cell activation Effects 0.000 title 2
- 239000003814 drug Substances 0.000 title 2
- 229940079593 drug Drugs 0.000 title 2
- 231100000234 hepatic damage Toxicity 0.000 title 2
- 230000008818 liver damage Effects 0.000 title 2
- 210000004027 cell Anatomy 0.000 title 1
- 230000004968 inflammatory condition Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 210000004185 liver Anatomy 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 210000000066 myeloid cell Anatomy 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 230000000451 tissue damage Effects 0.000 title 1
- 231100000827 tissue damage Toxicity 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161501139P | 2011-06-24 | 2011-06-24 | |
| US61/501,139 | 2011-06-24 | ||
| PCT/US2012/043875 WO2012178108A1 (en) | 2011-06-24 | 2012-06-22 | Prevention and treatment of inflammatory conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112013033309A2 true BR112013033309A2 (pt) | 2017-03-07 |
| BR112013033309A8 BR112013033309A8 (pt) | 2018-03-06 |
| BR112013033309B1 BR112013033309B1 (pt) | 2022-07-05 |
Family
ID=47422987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013033309-0A BR112013033309B1 (pt) | 2011-06-24 | 2012-06-22 | Uso de tazaroteno e método in vitro para inibição de ativação de células nkt tipo i |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9949996B2 (pt) |
| EP (2) | EP3616701A1 (pt) |
| JP (2) | JP6441073B2 (pt) |
| KR (2) | KR102164567B1 (pt) |
| CN (2) | CN111298120A (pt) |
| AU (1) | AU2012272642B2 (pt) |
| BR (1) | BR112013033309B1 (pt) |
| CA (1) | CA2840272C (pt) |
| DK (1) | DK2723347T3 (pt) |
| ES (1) | ES2759584T3 (pt) |
| MX (1) | MX367850B (pt) |
| RU (1) | RU2678561C9 (pt) |
| WO (1) | WO2012178108A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2759584T3 (es) | 2011-06-24 | 2020-05-11 | Gri Bio Inc | Prevención y tratamiento de afecciones inflamatorias |
| CA3114497A1 (en) | 2013-01-18 | 2014-07-24 | Cornell University | Methods of treating diseases associated with high fat diet and vitamin a deficiency using retinoic acid receptor agonists |
| US11191755B2 (en) | 2014-01-17 | 2021-12-07 | Cornell University | Compositions and methods for providing cardioprotective effects |
| WO2015109231A1 (en) * | 2014-01-17 | 2015-07-23 | Cornell University | Methods of treating metabolic syndrome related conditions using retinoic acid receptor agonists |
| CN106132422A (zh) | 2014-02-27 | 2016-11-16 | 莱斯拉公司 | 使用视黄酸受体相关孤儿受体γ的激动剂的过继细胞疗法＆相关治疗方法 |
| WO2015138354A1 (en) * | 2014-03-10 | 2015-09-17 | Cornell University | Combination therapy for head and neck cancer |
| AU2015256190B2 (en) | 2014-05-05 | 2019-08-15 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| EP3209641A4 (en) | 2014-05-05 | 2018-06-06 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of ror and the treatement of disease |
| RU2749132C2 (ru) | 2014-12-09 | 2021-06-04 | Гри Био, Инк. | Предотвращение и лечение воспалительных состояний |
| EP3292119A4 (en) | 2015-05-05 | 2018-10-03 | Lycera Corporation | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE |
| MX2017016134A (es) | 2015-06-11 | 2018-08-15 | Lycera Corp | Aril dihidro-2h-benzo[b][1,4]oxazina sulfonamida y compuestos relacionados para uso como agonistas de rory y el tratamiento de enfermedad. |
| WO2019009265A1 (ja) * | 2017-07-04 | 2019-01-10 | 第一三共株式会社 | 視細胞変性を伴う網膜変性疾患用薬 |
| EP3806839A4 (en) * | 2018-06-14 | 2022-03-30 | Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") | COMPOSITIONS AND METHODS TO DELIVER CARDIOPROTECTIVE EFFECTS |
| CN113207799B (zh) * | 2021-03-19 | 2022-03-15 | 中山大学 | 一种二型糖尿病小鼠快速心衰模型的构建方法 |
| WO2023044355A1 (en) * | 2021-09-15 | 2023-03-23 | Cornell University | Compositions and methods for mitigating alcohol liver disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE59777B1 (en) | 1985-12-04 | 1994-04-06 | Max Planck Gesellschaft | Medicaments |
| JP3879938B2 (ja) * | 1994-03-31 | 2007-02-14 | 日本ケミカルリサーチ株式会社 | 抗炎症剤 |
| JPH08109134A (ja) * | 1994-10-11 | 1996-04-30 | Sanwa Kagaku Kenkyusho Co Ltd | 細胞変成抑制並びに臓器毒性軽減剤 |
| US6025388A (en) | 1995-04-26 | 2000-02-15 | Allergan Sales, Inc. | Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids |
| US5624957A (en) * | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
| FR2739557B1 (fr) * | 1995-10-09 | 1997-11-14 | Cird Galderma | Utilisation d'un ligand agoniste specifique rar-gamma |
| US5965606A (en) | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
| IL128723A0 (en) * | 1996-08-28 | 2000-01-31 | Inst Nat Sante De De La Rech M | Pharmaceutical compositions containing rar antagonists and rxr agonists |
| PT1051159E (pt) | 1998-01-22 | 2002-09-30 | Zentaris Ag | Composicoes farmaceuticas solidas contendo miltefosina para administracao oral no tratamento de leishmaniose |
| JO2178B1 (en) | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of invasive diseases, using selected anti-PAR materials |
| US7390795B2 (en) | 2000-12-18 | 2008-06-24 | Pentraxin Therapeutics Limited | Treatment and prevention of tissue damage |
| ATE536185T1 (de) * | 2001-03-26 | 2011-12-15 | Dana Farber Cancer Inst Inc | Verfahren zur abschwächung von reaktionen auf hautreizende mittel |
| EP1567172A2 (en) * | 2002-11-29 | 2005-08-31 | GPC Biotech AG | Formulations useful against hepatitis c virus infections |
| US20050026950A1 (en) * | 2003-07-30 | 2005-02-03 | Allergan, Inc. | Methods of therapeutic treatment using retinoids to achieve consistent bioavailability |
| CN1210041C (zh) * | 2003-09-29 | 2005-07-13 | 中国医学科学院皮肤病研究所 | 治疗痤疮的复方外用药物 |
| WO2005120479A1 (en) | 2004-06-09 | 2005-12-22 | Gpc Biotech Ag | Use of selenium or a selenium salt and a retinoid acid or a retinoid in the treatment of viral hepatitis c |
| US20110118197A1 (en) * | 2005-09-29 | 2011-05-19 | Vipin Kumar Chaturvedi | Prevention of hepatic ischemic reperfusion injury by administration of sulfatides |
| ES2360235T3 (es) * | 2005-09-29 | 2011-06-02 | Torrey Pines Institute For Molecular Studies | Sulfatidas para tratar trastornos autoinmunes. |
| EP1981488A1 (en) | 2005-12-23 | 2008-10-22 | Jado Technologies GmbH | Means and methods for the treatment and prevention of allergic diseases |
| DE102006019906A1 (de) | 2006-04-28 | 2007-10-31 | Müller-Enoch, Dieter, Prof. Dr. | Verwendung von Verbindungen der Formel A-R-X oder deren pharmazeutisch akzeptable Salze zur Herstellung einer pharmazeutischen Zubereitung |
| EP2097075A1 (fr) * | 2006-11-20 | 2009-09-09 | Galderma Research & Development, S.N.C. | Utilisation d'adapalène pour moduler l'expression de cd1d ou il-10. |
| SG177579A1 (en) * | 2009-07-16 | 2012-02-28 | Stiefel Laboratories | Tazarotene derivatives |
| IT1403356B1 (it) | 2010-12-27 | 2013-10-17 | Sit La Precisa Spa Con Socio Unico | Dispositivo per il controllo dell'erogazione di un gas combustibile verso un bruciatore, particolarmente per apparecchi riscaldatori di acqua |
| DK2809648T3 (da) | 2011-05-26 | 2019-06-17 | Gri Bio Inc | Oxygenberigede amino- eller ammonium-holdige sulfonsyrederivater og disses medicinske anvendelse |
| ES2759584T3 (es) | 2011-06-24 | 2020-05-11 | Gri Bio Inc | Prevención y tratamiento de afecciones inflamatorias |
| US9005490B2 (en) | 2012-12-14 | 2015-04-14 | Delphi Technologies, Inc. | Material for solid state sintered material |
| WO2014166941A1 (en) | 2013-04-08 | 2014-10-16 | Academisch Medisch Centrum | Miltefosin or perifosin for use in the treatment of ibd |
| RU2749132C2 (ru) | 2014-12-09 | 2021-06-04 | Гри Био, Инк. | Предотвращение и лечение воспалительных состояний |
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2012
- 2012-06-22 ES ES12803312T patent/ES2759584T3/es active Active
- 2012-06-22 CA CA2840272A patent/CA2840272C/en active Active
- 2012-06-22 WO PCT/US2012/043875 patent/WO2012178108A1/en active Application Filing
- 2012-06-22 CN CN202010113948.3A patent/CN111298120A/zh active Pending
- 2012-06-22 CN CN201280039650.6A patent/CN103732231B/zh active Active
- 2012-06-22 EP EP19195197.9A patent/EP3616701A1/en active Pending
- 2012-06-22 MX MX2013015441A patent/MX367850B/es active IP Right Grant
- 2012-06-22 RU RU2014100056A patent/RU2678561C9/ru active
- 2012-06-22 KR KR1020197036256A patent/KR102164567B1/ko active IP Right Grant
- 2012-06-22 BR BR112013033309-0A patent/BR112013033309B1/pt active IP Right Grant
- 2012-06-22 JP JP2014517228A patent/JP6441073B2/ja active Active
- 2012-06-22 AU AU2012272642A patent/AU2012272642B2/en active Active
- 2012-06-22 EP EP12803312.3A patent/EP2723347B1/en active Active
- 2012-06-22 DK DK12803312T patent/DK2723347T3/da active
- 2012-06-22 US US14/128,566 patent/US9949996B2/en active Active
- 2012-06-22 KR KR1020147001610A patent/KR102055395B1/ko active IP Right Grant
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2017
- 2017-06-07 JP JP2017112987A patent/JP2017206523A/ja active Pending
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2018
- 2018-03-06 US US15/913,541 patent/US10925886B2/en active Active
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2021
- 2021-02-22 US US17/182,098 patent/US11660309B2/en active Active
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