MX366197B - Metodo de monitoreo terapeutico de farmacos depuradores de nitrogeno. - Google Patents

Metodo de monitoreo terapeutico de farmacos depuradores de nitrogeno.

Info

Publication number
MX366197B
MX366197B MX2014003854A MX2014003854A MX366197B MX 366197 B MX366197 B MX 366197B MX 2014003854 A MX2014003854 A MX 2014003854A MX 2014003854 A MX2014003854 A MX 2014003854A MX 366197 B MX366197 B MX 366197B
Authority
MX
Mexico
Prior art keywords
monitoring method
nitrogen
therapeutic monitoring
nitrogen cleaning
drugs
Prior art date
Application number
MX2014003854A
Other languages
English (en)
Other versions
MX2014003854A (es
Inventor
Scharschmidt Bruce
Mokhtarani Masoud
Original Assignee
Horizon Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47892277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX366197(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Horizon Therapeutics Llc filed Critical Horizon Therapeutics Llc
Publication of MX2014003854A publication Critical patent/MX2014003854A/es
Publication of MX366197B publication Critical patent/MX366197B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173845—Amine and quaternary ammonium
    • Y10T436/175383—Ammonia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)

Abstract

La presente invención se refiere a métodos para evaluar la exposición de amoníaco diario con base en una medición única del nivel en sangre de amoníaco en ayunas, así como también métodos que utilizan esta técnica para ajustar la dosificación de un fármaco depurador de nitrógeno, determinar ya sea administrar un fármaco depurador de nitrógeno, y tratar trastornos de retención de nitrógeno.
MX2014003854A 2011-09-30 2012-03-09 Metodo de monitoreo terapeutico de farmacos depuradores de nitrogeno. MX366197B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161542100P 2011-09-30 2011-09-30
US201161564668P 2011-11-29 2011-11-29
PCT/US2012/028620 WO2013048558A2 (en) 2011-09-30 2012-03-09 Methods of therapeutic monitoring of nitrogen scavenging drugs

Publications (2)

Publication Number Publication Date
MX2014003854A MX2014003854A (es) 2014-10-17
MX366197B true MX366197B (es) 2019-06-25

Family

ID=47892277

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014003854A MX366197B (es) 2011-09-30 2012-03-09 Metodo de monitoreo terapeutico de farmacos depuradores de nitrogeno.
MX2019006900A MX2019006900A (es) 2011-09-30 2014-03-28 Metodos de monitoreo terapeutico de farmacos depuradores de nitrogeno.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019006900A MX2019006900A (es) 2011-09-30 2014-03-28 Metodos de monitoreo terapeutico de farmacos depuradores de nitrogeno.

Country Status (25)

Country Link
US (21) US8404215B1 (es)
EP (2) EP3263102A1 (es)
JP (2) JP6073898B2 (es)
KR (2) KR102019000B1 (es)
CN (2) CN104039358A (es)
AU (2) AU2012316750B2 (es)
BR (1) BR112014007357B1 (es)
CA (1) CA2850391A1 (es)
CL (1) CL2014000783A1 (es)
CY (1) CY1119028T1 (es)
DK (1) DK2760479T3 (es)
ES (1) ES2629859T3 (es)
HR (1) HRP20171063T1 (es)
HU (1) HUE035220T2 (es)
IL (2) IL231732A (es)
LT (1) LT2760479T (es)
MX (2) MX366197B (es)
PL (1) PL2760479T3 (es)
PT (1) PT2760479T (es)
RS (1) RS56196B1 (es)
SG (1) SG11201400781TA (es)
SI (1) SI2760479T1 (es)
SM (1) SMT201700321T1 (es)
WO (1) WO2013048558A2 (es)
ZA (1) ZA201401851B (es)

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HUE036133T2 (hu) 2012-11-21 2018-06-28 Horizon Therapeutics Llc Eljárások hepatikus enkefalopátia kezelésére szolgáló nitrogénelvonó gyógyszerek beadására és értékelésére
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Also Published As

Publication number Publication date
MX2019006900A (es) 2019-09-04
US9962359B2 (en) 2018-05-08
US20180055807A1 (en) 2018-03-01
US20190125713A1 (en) 2019-05-02
EP2760479B1 (en) 2017-05-03
JP2014532179A (ja) 2014-12-04
US8404215B1 (en) 2013-03-26
CY1119028T1 (el) 2018-01-10
US20180021293A1 (en) 2018-01-25
EP2760479A4 (en) 2015-08-26
HUE035220T2 (hu) 2018-05-02
US9254278B2 (en) 2016-02-09
AU2012316750A1 (en) 2014-03-27
IL231732A0 (en) 2014-05-28
US20150335605A1 (en) 2015-11-26
ZA201401851B (en) 2018-05-30
IL231732A (en) 2017-09-28
CN107271696A (zh) 2017-10-20
US20180263949A1 (en) 2018-09-20
US10183006B2 (en) 2019-01-22
US20210000784A1 (en) 2021-01-07
US20180021291A1 (en) 2018-01-25
US20180263948A1 (en) 2018-09-20
US20160199333A1 (en) 2016-07-14
SMT201700321T1 (it) 2017-09-07
US20160199334A1 (en) 2016-07-14
US10183005B2 (en) 2019-01-22
US20180221325A1 (en) 2018-08-09
US10183002B2 (en) 2019-01-22
US9326966B2 (en) 2016-05-03
HRP20171063T1 (hr) 2017-10-06
US20160199332A1 (en) 2016-07-14
AU2012316750B2 (en) 2017-08-31
US10045958B1 (en) 2018-08-14
US20180221327A1 (en) 2018-08-09
EP3263102A1 (en) 2018-01-03
PT2760479T (pt) 2017-07-21
US9095559B2 (en) 2015-08-04
US20130210914A1 (en) 2013-08-15
ES2629859T3 (es) 2017-08-16
IL254134A0 (en) 2017-10-31
JP6425746B2 (ja) 2018-11-21
US10183004B2 (en) 2019-01-22
LT2760479T (lt) 2017-07-10
US20180235920A1 (en) 2018-08-23
SI2760479T1 (sl) 2017-07-31
US10045959B1 (en) 2018-08-14
US9962358B2 (en) 2018-05-08
BR112014007357A2 (pt) 2017-04-04
US20180221324A1 (en) 2018-08-09
WO2013048558A2 (en) 2013-04-04
CL2014000783A1 (es) 2015-01-16
US10617665B2 (en) 2020-04-14
US20160202240A1 (en) 2016-07-14
DK2760479T3 (en) 2017-07-17
JP2017067791A (ja) 2017-04-06
US20130085179A1 (en) 2013-04-04
KR20140094517A (ko) 2014-07-30
US20160081969A1 (en) 2016-03-24
MX2014003854A (es) 2014-10-17
KR20180085823A (ko) 2018-07-27
CA2850391A1 (en) 2013-04-04
AU2017251691A1 (en) 2017-11-09
KR102019000B1 (ko) 2019-09-05
US20180015064A1 (en) 2018-01-18
BR112014007357B1 (pt) 2022-12-06
PL2760479T3 (pl) 2017-09-29
JP6073898B2 (ja) 2017-02-01
WO2013048558A3 (en) 2014-04-03
CN104039358A (zh) 2014-09-10
RS56196B1 (sr) 2017-11-30
US20180221326A1 (en) 2018-08-09
EP2760479A2 (en) 2014-08-06
US9999608B2 (en) 2018-06-19
US10183003B2 (en) 2019-01-22
SG11201400781TA (en) 2014-04-28

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