MX362315B - Imidazolcarboxamidas y su uso como inhibidores de amida de acidos grasos hidrolasa (faah). - Google Patents

Imidazolcarboxamidas y su uso como inhibidores de amida de acidos grasos hidrolasa (faah).

Info

Publication number
MX362315B
MX362315B MX2016000797A MX2016000797A MX362315B MX 362315 B MX362315 B MX 362315B MX 2016000797 A MX2016000797 A MX 2016000797A MX 2016000797 A MX2016000797 A MX 2016000797A MX 362315 B MX362315 B MX 362315B
Authority
MX
Mexico
Prior art keywords
imidazolecarboxamides
faah inhibitors
compound
faah
inhibitors
Prior art date
Application number
MX2016000797A
Other languages
English (en)
Other versions
MX2016000797A (es
Inventor
Erno Kiss Laszlo
Patrícia Da Costa Pereira Rosa Carla
Gusmão De Noronha Rita
Original Assignee
BIAL PORTELA & Cª S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201313204A external-priority patent/GB201313204D0/en
Priority claimed from GB201313202A external-priority patent/GB201313202D0/en
Priority claimed from GB201313203A external-priority patent/GB201313203D0/en
Application filed by BIAL PORTELA & Cª S A filed Critical BIAL PORTELA & Cª S A
Publication of MX2016000797A publication Critical patent/MX2016000797A/es
Publication of MX362315B publication Critical patent/MX362315B/es

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un compuesto que tiene una estructura seleccionada de las siguientes, o una sal farmacéuticamente aceptable del mismo. El compuesto puede ser usado como un inhibidor de la amida de ácidos grasos hidrolasa.
MX2016000797A 2013-07-24 2014-07-24 Imidazolcarboxamidas y su uso como inhibidores de amida de acidos grasos hidrolasa (faah). MX362315B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB201313204A GB201313204D0 (en) 2013-07-24 2013-07-24 Urea compound and its use as an enzyme inhibitor
GB201313202A GB201313202D0 (en) 2013-07-24 2013-07-24 Urea Compound And Its Use As An Enzyme Inhibitor
GB201313203A GB201313203D0 (en) 2013-07-24 2013-07-24 Urea compound and its use as an enzyme inhibitor
PCT/PT2014/000049 WO2015012708A1 (en) 2013-07-24 2014-07-24 Imidazolecarboxamides and their use as faah inhibitors

Publications (2)

Publication Number Publication Date
MX2016000797A MX2016000797A (es) 2016-09-08
MX362315B true MX362315B (es) 2019-01-11

Family

ID=51358056

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000797A MX362315B (es) 2013-07-24 2014-07-24 Imidazolcarboxamidas y su uso como inhibidores de amida de acidos grasos hidrolasa (faah).

Country Status (20)

Country Link
US (2) US10501447B2 (es)
EP (1) EP3024825B1 (es)
JP (1) JP6449277B2 (es)
KR (1) KR20160034359A (es)
CN (1) CN105793247B (es)
AU (1) AU2014293731B2 (es)
CA (1) CA2918993C (es)
CY (1) CY1119482T1 (es)
DK (1) DK3024825T3 (es)
ES (1) ES2640800T3 (es)
HR (1) HRP20171378T1 (es)
HU (1) HUE033615T2 (es)
LT (1) LT3024825T (es)
MX (1) MX362315B (es)
PL (1) PL3024825T3 (es)
PT (1) PT3024825T (es)
RS (1) RS56297B1 (es)
RU (1) RU2671404C2 (es)
SI (1) SI3024825T1 (es)
WO (1) WO2015012708A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702487B2 (en) 2017-08-19 2020-07-07 Frimline Private Limited Pharmaceutical composition for prevention of diet induced obesity
SG10201807034XA (en) 2017-09-05 2019-04-29 Frimline Private Ltd A pharmaceutical composition for improving or preventing progression of Chronic Kidney Disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2458965C3 (de) 1974-12-13 1979-10-11 Bayer Ag, 5090 Leverkusen 3-Amino-indazol-N-carbonsäure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel
EP0014810A3 (en) 1979-01-18 1980-11-26 Fbc Limited Pesticidal pyrazoles, their production, compositions and uses, as well as intermediates and their preparation
JPH01203366A (ja) 1988-02-10 1989-08-16 Mitsui Petrochem Ind Ltd Ｎ−置換イミダゾール誘導体
JP3457669B2 (ja) 1992-10-28 2003-10-20 富山化学工業株式会社 新規な１，２−ベンゾイソオキサゾール誘導体またはその塩，それらからなる脳保護剤
DE102004005172A1 (de) 2004-02-02 2005-08-18 Aventis Pharma Deutschland Gmbh Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
LT2937341T (lt) * 2004-12-30 2017-09-11 Janssen Pharmaceutica N.V. 4-(benzil)-piperazin-1-karboksilinės rūgšties fenilamido dariniai ir giminingi junginiai kaip riebalų rūgščių amido hidrolazės (rrah) moduliatoriai, skirti nerimo, skausmo ir kitų būklių gydymui
FI20075264A0 (fi) 2007-04-18 2007-04-18 Kuopion Yliopisto Heterosykliset fenyylikarbamaatit uusina FAAH-inhibiittoreina
WO2009126624A1 (en) 2008-04-11 2009-10-15 Bristol-Myers Squibb Company Triazolo compounds useful as dgat1 inhibitors
MX342128B (es) * 2008-12-24 2016-09-14 Bial - Portela & C A S A Compuestos farmaceuticos.
CA2806701A1 (en) 2010-07-29 2012-02-02 Bial - Portela & Ca, S.A. Process for the synthesis of substituted urea compounds
FR2965262A1 (fr) 2010-09-24 2012-03-30 Sanofi Aventis Derives de nicotinamide, leur preparation et leur application en therapeutique
TWI624460B (zh) 2012-07-24 2018-05-21 巴爾 波特拉及康邦亞公司 尿素化合物及其作爲酵素抑制劑之用途

Also Published As

Publication number Publication date
AU2014293731A1 (en) 2016-02-11
US20200255412A1 (en) 2020-08-13
RS56297B1 (sr) 2017-12-29
HUE033615T2 (hu) 2017-12-28
ES2640800T3 (es) 2017-11-06
EP3024825A1 (en) 2016-06-01
RU2016104221A (ru) 2017-08-29
SI3024825T1 (sl) 2017-11-30
CA2918993C (en) 2021-08-24
HRP20171378T1 (hr) 2017-12-15
AU2014293731B2 (en) 2018-03-08
CN105793247B (zh) 2018-03-16
WO2015012708A1 (en) 2015-01-29
MX2016000797A (es) 2016-09-08
PT3024825T (pt) 2017-09-28
JP2016525543A (ja) 2016-08-25
CY1119482T1 (el) 2018-03-07
DK3024825T3 (en) 2017-10-02
JP6449277B2 (ja) 2019-01-09
KR20160034359A (ko) 2016-03-29
CA2918993A1 (en) 2015-01-29
LT3024825T (lt) 2017-12-11
EP3024825B1 (en) 2017-06-21
US20160176854A1 (en) 2016-06-23
PL3024825T3 (pl) 2017-12-29
CN105793247A (zh) 2016-07-20
US10501447B2 (en) 2019-12-10
RU2671404C2 (ru) 2018-10-31

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