MX361470B - Métodos para la síntesis de etilfumaratos y su uso como intermediarios. - Google Patents
Métodos para la síntesis de etilfumaratos y su uso como intermediarios.Info
- Publication number
- MX361470B MX361470B MX2014013075A MX2014013075A MX361470B MX 361470 B MX361470 B MX 361470B MX 2014013075 A MX2014013075 A MX 2014013075A MX 2014013075 A MX2014013075 A MX 2014013075A MX 361470 B MX361470 B MX 361470B
- Authority
- MX
- Mexico
- Prior art keywords
- synthesis
- intermediates
- activated
- improved
- disclosed embodiments
- Prior art date
Links
- 238000003786 synthesis reaction Methods 0.000 title abstract 5
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 239000000543 intermediate Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- SASYHUDIOGGZCN-ONEGZZNKSA-N (e)-2-ethylbut-2-enedioic acid Chemical class CC\C(C(O)=O)=C/C(O)=O SASYHUDIOGGZCN-ONEGZZNKSA-N 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- JVSFQJZRHXAUGT-UHFFFAOYSA-N 2,2-dimethylpropanoyl chloride Chemical compound CC(C)(C)C(Cl)=O JVSFQJZRHXAUGT-UHFFFAOYSA-N 0.000 abstract 1
- BTJIUGUIPKRLHP-UHFFFAOYSA-N 4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1 BTJIUGUIPKRLHP-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- WRJWRGBVPUUDLA-UHFFFAOYSA-N chlorosulfonyl isocyanate Chemical compound ClS(=O)(=O)N=C=O WRJWRGBVPUUDLA-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- YYLWXDIGYFPUSK-ONEGZZNKSA-N ethyl (e)-4-chloro-4-oxobut-2-enoate Chemical compound CCOC(=O)\C=C\C(Cl)=O YYLWXDIGYFPUSK-ONEGZZNKSA-N 0.000 abstract 1
- -1 for example Chemical compound 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 abstract 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261639536P | 2012-04-27 | 2012-04-27 | |
| PCT/US2013/032162 WO2013162764A1 (en) | 2012-04-27 | 2013-03-15 | Methods for the synthesis of ethylfumarates and their use as intermediates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014013075A MX2014013075A (es) | 2015-08-14 |
| MX361470B true MX361470B (es) | 2018-12-06 |
Family
ID=49477848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014013075A MX361470B (es) | 2012-04-27 | 2013-03-15 | Métodos para la síntesis de etilfumaratos y su uso como intermediarios. |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US9193691B2 (forum.php) |
| EP (1) | EP2841422B1 (forum.php) |
| JP (1) | JP6241682B2 (forum.php) |
| KR (1) | KR20150023315A (forum.php) |
| CN (2) | CN104797563B (forum.php) |
| AU (2) | AU2013252901B2 (forum.php) |
| BR (1) | BR112014026809A2 (forum.php) |
| CA (1) | CA2871126C (forum.php) |
| HK (1) | HK1207382A1 (forum.php) |
| IL (1) | IL235247A0 (forum.php) |
| IN (1) | IN2014DN09774A (forum.php) |
| MX (1) | MX361470B (forum.php) |
| RU (1) | RU2014143116A (forum.php) |
| SG (1) | SG11201406970QA (forum.php) |
| WO (1) | WO2013162764A1 (forum.php) |
| ZA (1) | ZA201408429B (forum.php) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| MX2007001903A (es) | 2004-08-20 | 2007-08-02 | Mannkind Corp | Catalisis de sintesis de dicetopiperazina. |
| PL2322180T3 (pl) | 2004-08-23 | 2015-10-30 | Mannkind Corp | Sole diketopiperazyny do dostarczania leków |
| BRPI0615819B8 (pt) | 2005-09-14 | 2021-05-25 | Mannkind Corp | processo para preparar uma composição de distribuição de fármaco compreendendo um agente ativo e uma micropartícula fumaril dicetopiperazina cristalina. |
| MX360812B (es) | 2006-02-22 | 2018-11-16 | Mannkind Corp | Un método para mejorar las propiedades farmacéuticas de micropartículas que contienen dicetopiperazina y un agente activo. |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| CA3086027C (en) | 2008-06-13 | 2022-05-17 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
| JP5479465B2 (ja) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | 吸入努力をリアルタイムにプロファイルする対話式機器および方法 |
| TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| MX2011009512A (es) | 2009-03-11 | 2011-11-29 | Mannkind Corp | Aparato, sistema y metodo para medir la resistencia de un inhalador. |
| KR20210027546A (ko) | 2009-06-12 | 2021-03-10 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| JP6385673B2 (ja) | 2010-06-21 | 2018-09-05 | マンカインド コーポレイション | 乾燥粉末薬物送達システム |
| RU2569776C2 (ru) | 2011-04-01 | 2015-11-27 | Маннкайнд Корпорейшн | Блистерная упаковка для фармацевтических картриджей |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| US9233159B2 (en) | 2011-10-24 | 2016-01-12 | Mannkind Corporation | Methods and compositions for treating pain |
| JP6241682B2 (ja) * | 2012-04-27 | 2017-12-06 | マンカインド・コーポレイシヨン | 活性化したエチルフマレートの合成のための方法および中間体としてのその使用 |
| CN104619369B (zh) | 2012-07-12 | 2018-01-30 | 曼金德公司 | 干粉药物输送系统和方法 |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| MX369136B (es) | 2013-03-15 | 2019-10-30 | Mannkind Corp | Composiciones de dicetopiperazina microcristalina y metodos. |
| MX375448B (es) | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| CN115894270B (zh) * | 2022-10-10 | 2024-09-06 | 深圳市迪克曼生物科技有限公司 | 一种神经酰胺及其制备方法和应用 |
| CN117646042B (zh) * | 2023-11-13 | 2025-04-11 | 浙江工业大学 | 一种富马酸单酯的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3407203A (en) | 1965-03-22 | 1968-10-22 | Union Carbide Corp | Novel process for the preparation of diketopiperazines |
| US5352461A (en) * | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
| DE10019879A1 (de) | 2000-04-20 | 2001-10-25 | Degussa | Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung |
| MX2007001903A (es) | 2004-08-20 | 2007-08-02 | Mannkind Corp | Catalisis de sintesis de dicetopiperazina. |
| PL2322180T3 (pl) | 2004-08-23 | 2015-10-30 | Mannkind Corp | Sole diketopiperazyny do dostarczania leków |
| MX360812B (es) * | 2006-02-22 | 2018-11-16 | Mannkind Corp | Un método para mejorar las propiedades farmacéuticas de micropartículas que contienen dicetopiperazina y un agente activo. |
| US8314106B2 (en) * | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| CA2748490C (en) * | 2008-12-29 | 2016-10-04 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| US8809382B2 (en) * | 2009-05-04 | 2014-08-19 | The Royal Institution For The Advancement Of Learning/Mcgill University | 5-oxo-ETE receptor antagonist compounds |
| CN101851213A (zh) * | 2010-06-21 | 2010-10-06 | 于清 | 3，6-双(4-双反丁烯二酰基氨丁基)-2，5-二酮哌嗪及其盐取代物的合成方法 |
| MX346331B (es) | 2011-02-10 | 2017-03-15 | Mannkind Corp | Formación de bis-3, 6-(4-aminoalquil) - 2, 5-dicetopiperazina con n protegido. |
| JP6241682B2 (ja) * | 2012-04-27 | 2017-12-06 | マンカインド・コーポレイシヨン | 活性化したエチルフマレートの合成のための方法および中間体としてのその使用 |
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2013
- 2013-03-15 JP JP2015508969A patent/JP6241682B2/ja active Active
- 2013-03-15 EP EP13781305.1A patent/EP2841422B1/en active Active
- 2013-03-15 SG SG11201406970QA patent/SG11201406970QA/en unknown
- 2013-03-15 MX MX2014013075A patent/MX361470B/es active IP Right Grant
- 2013-03-15 US US13/834,106 patent/US9193691B2/en active Active
- 2013-03-15 IN IN9774DEN2014 patent/IN2014DN09774A/en unknown
- 2013-03-15 WO PCT/US2013/032162 patent/WO2013162764A1/en not_active Ceased
- 2013-03-15 BR BR112014026809A patent/BR112014026809A2/pt not_active Application Discontinuation
- 2013-03-15 RU RU2014143116A patent/RU2014143116A/ru not_active Application Discontinuation
- 2013-03-15 KR KR20147033484A patent/KR20150023315A/ko not_active Withdrawn
- 2013-03-15 CN CN201380033409.7A patent/CN104797563B/zh active Active
- 2013-03-15 HK HK15108108.5A patent/HK1207382A1/xx unknown
- 2013-03-15 CN CN201711143342.9A patent/CN107879938A/zh active Pending
- 2013-03-15 CA CA2871126A patent/CA2871126C/en active Active
- 2013-03-15 AU AU2013252901A patent/AU2013252901B2/en active Active
-
2014
- 2014-10-21 IL IL235247A patent/IL235247A0/en unknown
- 2014-11-17 ZA ZA2014/08429A patent/ZA201408429B/en unknown
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2015
- 2015-11-23 US US14/949,489 patent/US10071969B2/en active Active
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2018
- 2018-02-27 AU AU2018201397A patent/AU2018201397B2/en active Active
- 2018-09-10 US US16/126,323 patent/US10858325B2/en active Active
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2020
- 2020-12-07 US US17/113,540 patent/US11479535B2/en active Active
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2022
- 2022-10-24 US US17/972,220 patent/US12202807B2/en active Active
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2024
- 2024-12-12 US US18/978,238 patent/US20250109109A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |