MX361342B - Composiciones y metodos para formulaciones de alfavirus vivos atenuados. - Google Patents

Composiciones y metodos para formulaciones de alfavirus vivos atenuados.

Info

Publication number
MX361342B
MX361342B MX2015012894A MX2015012894A MX361342B MX 361342 B MX361342 B MX 361342B MX 2015012894 A MX2015012894 A MX 2015012894A MX 2015012894 A MX2015012894 A MX 2015012894A MX 361342 B MX361342 B MX 361342B
Authority
MX
Mexico
Prior art keywords
live
compositions
attenuated
methods
attenuated alphavirus
Prior art date
Application number
MX2015012894A
Other languages
English (en)
Other versions
MX2015012894A (es
Inventor
Dan T Stinchcomb
Jill A Livengood
Laszlo Varga
Original Assignee
Takeda Vaccines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50489420&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX361342(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Vaccines Inc filed Critical Takeda Vaccines Inc
Publication of MX2015012894A publication Critical patent/MX2015012894A/es
Publication of MX361342B publication Critical patent/MX361342B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a composiciones y métodos para alfavirus vivos atenuados. En ciertas modalidades, una composición de virus vivo atenuado incluye, pero no se limita a, uno o más alfavirus vivosatenuados y composiciones para reducir la inactivación y/o degradación del alfavirus vivo atenuado. En otras modalidades, la composición de virus vivo atenuado puede ser una composición de vacuna. En otras composiciones, una composición de alfavirus vivo atenuado puede incluir tampón de HEPES. En otras modalidades, el tampón de HEPES puede incluir además un carbohidrato y gelatina y/o una sal.
MX2015012894A 2013-03-14 2014-03-13 Composiciones y metodos para formulaciones de alfavirus vivos atenuados. MX361342B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361784122P 2013-03-14 2013-03-14
PCT/US2014/026570 WO2014151855A1 (en) 2013-03-14 2014-03-13 Compositions and methods for live, attenuated alphavirus formulations

Publications (2)

Publication Number Publication Date
MX2015012894A MX2015012894A (es) 2016-04-04
MX361342B true MX361342B (es) 2018-12-04

Family

ID=50489420

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015012894A MX361342B (es) 2013-03-14 2014-03-13 Composiciones y metodos para formulaciones de alfavirus vivos atenuados.
MX2018014977A MX2018014977A (es) 2013-03-14 2015-09-14 Composiciones y metodos para formulaciones de alfavirus vivos atenuados.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018014977A MX2018014977A (es) 2013-03-14 2015-09-14 Composiciones y metodos para formulaciones de alfavirus vivos atenuados.

Country Status (20)

Country Link
US (2) US10137186B2 (es)
EP (2) EP2968515B1 (es)
JP (3) JP6426695B2 (es)
KR (1) KR20160003662A (es)
CN (2) CN111729077A (es)
AP (1) AP2015008733A0 (es)
AU (2) AU2014236804B2 (es)
BR (1) BR112015023205A2 (es)
CA (1) CA2903711A1 (es)
CR (1) CR20150553A (es)
DO (1) DOP2015000226A (es)
EC (1) ECSP20007842A (es)
HK (1) HK1220358A1 (es)
MX (2) MX361342B (es)
MY (1) MY178476A (es)
NZ (1) NZ631012A (es)
PH (1) PH12015502115A1 (es)
SG (3) SG10201909051QA (es)
TW (2) TWI649087B (es)
WO (1) WO2014151855A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI649087B (zh) 2013-03-14 2019-02-01 武田疫苗股份有限公司 用於活減毒阿爾法病毒配方之組成物及方法
EP3087188A1 (en) 2013-12-23 2016-11-02 Theravectys Lyophilized lentiviral vector particles, compositions and methods
CA3019529A1 (en) * 2016-03-31 2017-10-05 Takeda Vaccines, Inc. Compositions and methods for stabilizing alphaviruses with improved formulations
NL2022538B1 (en) * 2019-02-08 2020-08-19 Academisch Ziekenhuis Groningen Methods for providing purified viral particles of Semliki Forest Virus (SFV), preparations obtainable thereby, and uses thereof.
JPWO2022158097A1 (es) * 2021-01-19 2022-07-28

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338335A (en) * 1980-02-05 1982-07-06 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
RU2035508C1 (ru) * 1991-08-16 1995-05-20 Институт органической химии СО РАН Питательная среда для стабилизации вируса венесуэльского энцефалита лошадей
US5545555A (en) * 1994-07-25 1996-08-13 Microtest, Inc. Microbial transport media
AU4594996A (en) * 1994-11-30 1996-06-19 Chiron Viagene, Inc. Recombinant alphavirus vectors
US6465634B1 (en) * 1996-04-05 2002-10-15 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
US6290967B1 (en) * 1996-12-20 2001-09-18 Merck & Co., Inc. Stabilizers for lyophilized vaccines
US6210683B1 (en) 1997-09-05 2001-04-03 Merck & Co., Inc. Stabilizers containing recombinant human serum albumin for live virus vaccines
DE19803453A1 (de) * 1998-01-30 1999-08-12 Boehringer Ingelheim Int Vakzine
EP1100944A1 (en) * 1998-07-30 2001-05-23 The Johns Hopkins University School Of Medicine Targeted alphavirus and alphaviral vectors
US6869907B2 (en) * 2000-05-02 2005-03-22 Pentax Corporation Color-image-forming medium
FR2814957B1 (fr) 2000-10-06 2002-12-20 Aventis Pasteur Composition vaccinale et procede de stabilisation
CA2469491A1 (en) * 2001-12-12 2003-06-19 Kerrie Setiawan Composition for viral preservation
EP2591771A1 (en) * 2002-04-11 2013-05-15 MedImmune, LLC Preservation of bioactive materials by freeze dried foam
CN1893973B (zh) 2003-12-17 2010-12-08 惠氏公司 产生储存稳定病毒及其免疫原性组合物的方法
BRPI0716145B1 (pt) * 2006-09-01 2021-06-22 Bharat Biotech International Limited Composição de vacina e método para preparar uma composição de vacina para o vírus chikungunya
WO2008058035A1 (en) * 2006-11-03 2008-05-15 Alphavax, Inc. Alphavirus and alphavirus replicon particle formulations and methods
AU2007317847B2 (en) 2006-11-07 2013-10-31 Sanofi Pasteur Biologics, Llc Stabilization of vaccines by lyophilization
MY180465A (en) 2007-04-06 2020-11-30 Takeda Vaccines Inc Methods and compositions for live attenuated viruses
CN101835488B (zh) 2007-09-04 2018-10-26 美国政府(由卫生和人类服务部、疾病控制和预防中心的部长所代表) 轮状病毒的热灭活
KR20160005378A (ko) 2007-09-14 2016-01-14 사노피 파스테르 바이오로직스, 엘엘씨 클로스트리듐 디피실리 톡소이드 ａ 및 ｂ를 포함하는 약학적 조성물
JP5758632B2 (ja) 2008-01-24 2015-08-05 ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システムＴｈｅ Ｂｏａｒｄ Ｏｆ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｔｅｘａｓ Ｓｙｓｔｅｍ 蚊において複製不可能な弱毒化組み換えアルファウイルス属及びそれらの使用
NZ593220A (en) 2008-12-09 2012-10-26 Coley Pharm Group Inc Immunostimulatory oligonucleotides
WO2011090712A2 (en) 2009-12-28 2011-07-28 Ligocyte Pharmaceuticals, Inc. Methods for stabilizing influenza antigen enveloped virus-based virus-like particle solutions
WO2011151726A2 (en) * 2010-06-01 2011-12-08 Novartis Ag Concentration of vaccine antigens with lyophilization
TWI649087B (zh) * 2013-03-14 2019-02-01 武田疫苗股份有限公司 用於活減毒阿爾法病毒配方之組成物及方法

Also Published As

Publication number Publication date
SG10201801459SA (en) 2018-03-28
JP6426695B2 (ja) 2018-11-21
MX2015012894A (es) 2016-04-04
AU2018236897A1 (en) 2018-10-18
HK1220358A1 (zh) 2017-05-05
DOP2015000226A (es) 2016-02-29
SG10201909051QA (en) 2019-11-28
MY178476A (en) 2020-10-14
US20140271715A1 (en) 2014-09-18
ECSP20007842A (es) 2020-09-30
AU2018236897B2 (en) 2020-09-10
PH12015502115B1 (en) 2016-01-25
EP3603667A1 (en) 2020-02-05
US10806781B2 (en) 2020-10-20
AU2014236804A1 (en) 2015-10-01
US20190134182A1 (en) 2019-05-09
AP2015008733A0 (en) 2015-09-30
SG11201507462QA (en) 2015-10-29
AU2014236804B2 (en) 2018-12-13
EP2968515B1 (en) 2019-05-08
JP2020193231A (ja) 2020-12-03
CA2903711A1 (en) 2014-09-25
CN105377293A (zh) 2016-03-02
NZ631012A (en) 2017-08-25
PH12015502115A1 (en) 2016-01-25
JP2016513658A (ja) 2016-05-16
TWI649087B (zh) 2019-02-01
US10137186B2 (en) 2018-11-27
TW201900192A (zh) 2019-01-01
KR20160003662A (ko) 2016-01-11
BR112015023205A2 (pt) 2017-07-18
CR20150553A (es) 2015-12-01
JP2019031543A (ja) 2019-02-28
CN111729077A (zh) 2020-10-02
TW201513875A (zh) 2015-04-16
EP2968515A1 (en) 2016-01-20
WO2014151855A1 (en) 2014-09-25
MX2018014977A (es) 2022-06-27
JP6761015B2 (ja) 2020-09-23
CN105377293B (zh) 2020-07-17

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