MX357613B - Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas. - Google Patents

Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas.

Info

Publication number
MX357613B
MX357613B MX2014010358A MX2014010358A MX357613B MX 357613 B MX357613 B MX 357613B MX 2014010358 A MX2014010358 A MX 2014010358A MX 2014010358 A MX2014010358 A MX 2014010358A MX 357613 B MX357613 B MX 357613B
Authority
MX
Mexico
Prior art keywords
methods
viloxazine
novel
polymorphs
novel polymorphs
Prior art date
Application number
MX2014010358A
Other languages
English (en)
Inventor
Liang Likan
P Bhatt Padmanabh
Dain David
Taquet Jean-Philippe
Pechenov Aleksandr
Tchesnokov Alexei
Mariaux Reynold
Original Assignee
Supernus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supernus Pharmaceuticals Inc filed Critical Supernus Pharmaceuticals Inc
Publication of MX357613B publication Critical patent/MX357613B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms

Abstract

Se proporcionan en la presente métodos de fabricación de viloxazina y sus diversas sales, así como también compuestos relacionados con viloxazina, tales como productos de reacción intermedia novedosos y polimorfos de los mismos. En particular, los métodos proporcionan un API sustancialmente puro de HCl de viloxazina mientras que evita las impurezas indeseables. Los métodos además se proporcionan para separar, identificar y caracterizar polimorfos novedosos de viloxazina. Se proporcionan además métodos para síntesis e identificación y caracterización de intermedios novedosos de viloxazina, así como también algunos metabolitos importantes y precursores de metabolitos de viloxazina.
MX2014010358A 2010-04-12 2011-04-12 Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas. MX357613B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32315110P 2010-04-12 2010-04-12
PCT/US2011/032013 WO2011130194A2 (en) 2010-04-12 2011-04-12 Methods for producing viloxazine salts and novel polymorphs thereof

Publications (1)

Publication Number Publication Date
MX357613B true MX357613B (es) 2018-07-17

Family

ID=44065289

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2012011821A MX2012011821A (es) 2010-04-12 2011-04-12 Metodos para producir sales de viloxazina y polimorfos novedosos de las mismas.
MX2014010356A MX347218B (es) 2010-04-12 2011-04-12 Metodos para producir sales de viloxazina y polimorfos novedosos de las mismas.
MX2014010369A MX357614B (es) 2010-04-12 2011-04-12 Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas.
MX2014010358A MX357613B (es) 2010-04-12 2011-04-12 Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas.
MX2014010368A MX355697B (es) 2010-04-12 2011-04-12 Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
MX2012011821A MX2012011821A (es) 2010-04-12 2011-04-12 Metodos para producir sales de viloxazina y polimorfos novedosos de las mismas.
MX2014010356A MX347218B (es) 2010-04-12 2011-04-12 Metodos para producir sales de viloxazina y polimorfos novedosos de las mismas.
MX2014010369A MX357614B (es) 2010-04-12 2011-04-12 Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014010368A MX355697B (es) 2010-04-12 2011-04-12 Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas.

Country Status (8)

Country Link
US (6) US9403783B2 (es)
EP (1) EP2558437B1 (es)
JP (5) JP6196551B2 (es)
AU (1) AU2011240773C1 (es)
CA (4) CA2795408C (es)
ES (1) ES2552166T3 (es)
MX (5) MX2012011821A (es)
WO (1) WO2011130194A2 (es)

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JP6196551B2 (ja) 2010-04-12 2017-09-13 スパーナス ファーマシューティカルズ インコーポレイテッド ビロキサジン塩を製造する方法及びその新規な多形
CA3067044A1 (en) 2017-06-16 2018-12-20 Beta Pharma, Inc. Pharmaceutical formulations of n-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide and salts thereof
CN108760719A (zh) * 2018-08-17 2018-11-06 北京理工大学 一种利用拉曼光谱分析cl-20的晶型纯度的方法
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US20230295100A1 (en) * 2022-03-18 2023-09-21 Supernus Pharmaceuticals, Inc. Process of making derivatives of substituted morpholines
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EP4317141A1 (en) 2022-08-04 2024-02-07 Curia Spain S.A.U. Process and intermediates for the preparation of viloxazine and other 2-substituted morpholine derivatives

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Also Published As

Publication number Publication date
US9403783B2 (en) 2016-08-02
CA2795408A1 (en) 2011-10-20
CA3126096A1 (en) 2011-10-20
JP2018076325A (ja) 2018-05-17
JP6196551B2 (ja) 2017-09-13
EP2558437A2 (en) 2013-02-20
CA2795408C (en) 2018-03-13
AU2011240773B2 (en) 2015-04-02
CA3215310A1 (en) 2011-10-20
US20150126735A1 (en) 2015-05-07
US10160733B2 (en) 2018-12-25
AU2011240773A1 (en) 2012-11-01
ES2552166T3 (es) 2015-11-26
JP2013530129A (ja) 2013-07-25
JP2016006062A (ja) 2016-01-14
JP2017039754A (ja) 2017-02-23
US10005743B2 (en) 2018-06-26
US20180265482A1 (en) 2018-09-20
US20190300492A1 (en) 2019-10-03
US20160304475A1 (en) 2016-10-20
CA2992219A1 (en) 2011-10-20
JP6663413B2 (ja) 2020-03-11
CA3126096C (en) 2023-11-21
WO2011130194A3 (en) 2012-01-05
US20220024885A1 (en) 2022-01-27
MX2012011821A (es) 2012-11-30
EP2558437B1 (en) 2015-08-05
MX347218B (es) 2017-04-20
US20110251198A1 (en) 2011-10-13
AU2011240773C1 (en) 2015-08-27
MX357614B (es) 2018-07-17
US9434703B2 (en) 2016-09-06
MX355697B (es) 2018-04-27
WO2011130194A2 (en) 2011-10-20
JP2019194191A (ja) 2019-11-07

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