MX355134B - Metodo para producir cepas atenuadas de salmonella con alto rendimiento. - Google Patents
Metodo para producir cepas atenuadas de salmonella con alto rendimiento.Info
- Publication number
- MX355134B MX355134B MX2014007575A MX2014007575A MX355134B MX 355134 B MX355134 B MX 355134B MX 2014007575 A MX2014007575 A MX 2014007575A MX 2014007575 A MX2014007575 A MX 2014007575A MX 355134 B MX355134 B MX 355134B
- Authority
- MX
- Mexico
- Prior art keywords
- salmonella typhi
- attenuated mutant
- high yield
- producing high
- attenuated salmonella
- Prior art date
Links
- 230000002238 attenuated effect Effects 0.000 title abstract 4
- 241000607142 Salmonella Species 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 102000053602 DNA Human genes 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 230000005526 G1 to G0 transition Effects 0.000 abstract 1
- 108091008605 VEGF receptors Proteins 0.000 abstract 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 108010010662 galactose epimerase Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001109—Vascular endothelial growth factor receptors [VEGFR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q3/00—Condition responsive control processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se relaciona con un método novedoso para desarrollar cepas mutantes atenuadas de Salmonella typhi que carecen de actividad de galactosa epimerasa y que contienen una molécula recombinante de ADN. El método comprende la etapa de cultivar la cepa de Salmonella typhi sin agregar glucosa al medio durante la fermentación con una cantidad de partida de glucosa que se reduce antes de alcanzar la fase estacionaria. La invención se relaciona adicionalmente con cepas mutantes atenuadas de Salmonella typhi asequibles por el método y con una cepa mutante atenuada que contiene una molécula recombinante de ADN que codifica una proteína del receptor de VEGF para usarse como una vacuna. Figura 1. El método se caracteriza además porque dicha cepa mutante atenuada de Salmonella.typhi es Salmonella typhi Ty21a.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11400061 | 2011-12-22 | ||
| PCT/EP2012/005364 WO2013091898A1 (en) | 2011-12-22 | 2012-12-21 | Method for producing high yield attenuated salmonella strains |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014007575A MX2014007575A (es) | 2015-02-05 |
| MX355134B true MX355134B (es) | 2018-04-06 |
Family
ID=47458857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014007575A MX355134B (es) | 2011-12-22 | 2012-12-21 | Metodo para producir cepas atenuadas de salmonella con alto rendimiento. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9493738B2 (es) |
| EP (1) | EP2794849B1 (es) |
| JP (1) | JP6251179B2 (es) |
| KR (1) | KR102015932B1 (es) |
| CN (1) | CN104066834B (es) |
| AU (1) | AU2012359166B2 (es) |
| BR (1) | BR112014015706A2 (es) |
| CA (1) | CA2853656C (es) |
| DK (1) | DK2794849T3 (es) |
| ES (1) | ES2650269T3 (es) |
| HU (1) | HUE035438T2 (es) |
| IL (1) | IL233167A (es) |
| LT (1) | LT2794849T (es) |
| MX (1) | MX355134B (es) |
| PL (1) | PL2794849T3 (es) |
| RU (1) | RU2631924C2 (es) |
| SG (1) | SG11201403525PA (es) |
| SI (1) | SI2794849T1 (es) |
| WO (1) | WO2013091898A1 (es) |
| ZA (1) | ZA201404501B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013286335B2 (en) | 2012-07-05 | 2017-08-10 | Vaximm Ag | DNA vaccine for use in pancreatic cancer patients |
| RU2016129044A (ru) * | 2013-12-18 | 2018-01-23 | Факсимм Гмбх | Новая вакцина днк, нацеленная на мезотелин, для иммунотерапии рака |
| ES2760699T3 (es) * | 2015-06-18 | 2020-05-14 | Vaximm Ag | Vacuna de ADN dirigida al VEGFR-2 para terapia de combinación |
| US20180153976A1 (en) | 2015-06-18 | 2018-06-07 | Vaximm Ag | Novel cmv pp65 targeting dna vaccine for cancer immunotherapy |
| JP7098599B2 (ja) | 2016-07-13 | 2022-07-11 | エンエーセー オンコイミュニティ アクスイェ セルスカプ | 癌免疫療法用のｄｎａワクチンの製造方法 |
| CA3050833A1 (en) * | 2017-02-17 | 2018-08-23 | Vaximm Ag | Novel vegfr-2 targeting immunotherapy approach |
| WO2020205528A1 (en) * | 2019-04-01 | 2020-10-08 | North Carolina State University | Probiotic bacteria capable of adaptive response to pomegranate extract and methods of production and use thereof |
| CN115715198A (zh) | 2020-03-31 | 2023-02-24 | Nec奥克尔姆内特公司 | 新型的基于沙门氏菌的冠状病毒疫苗 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH542928A (de) * | 1971-04-29 | 1973-10-15 | Schweiz Serum & Impfinst | Verfahren zur Herstellung einer neuen Typhus-Vakzine |
| KR930001382B1 (ko) | 1990-09-05 | 1993-02-27 | 보령신약 주식회사 | 경구용 장티프스 생균백신 및 그의 제조방법 |
| ATE322288T1 (de) * | 2001-01-03 | 2006-04-15 | Epitopix Llc | Zusammensetzungen zur immunisierung sowie deren verwendung |
| US7094410B2 (en) | 2002-03-02 | 2006-08-22 | The Scripps Research Institute | DNA vaccine against proliferating endothelial cells and methods of use thereof |
| EP1670505B1 (en) * | 2003-09-18 | 2012-11-14 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Dna promoters and anthrax vaccines |
| WO2010045620A1 (en) | 2008-10-17 | 2010-04-22 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae |
| CN101985610A (zh) * | 2010-10-26 | 2011-03-16 | 中国人民解放军军事医学科学院微生物流行病研究所 | 一种伤寒沙门氏菌菌蜕、制备方法及作为递送系统的应用 |
-
2012
- 2012-12-21 US US14/366,186 patent/US9493738B2/en active Active
- 2012-12-21 SI SI201231125T patent/SI2794849T1/en unknown
- 2012-12-21 EP EP12808264.1A patent/EP2794849B1/en active Active
- 2012-12-21 SG SG11201403525PA patent/SG11201403525PA/en unknown
- 2012-12-21 PL PL12808264T patent/PL2794849T3/pl unknown
- 2012-12-21 KR KR1020147020387A patent/KR102015932B1/ko active IP Right Grant
- 2012-12-21 RU RU2014130045A patent/RU2631924C2/ru not_active IP Right Cessation
- 2012-12-21 MX MX2014007575A patent/MX355134B/es active IP Right Grant
- 2012-12-21 DK DK12808264.1T patent/DK2794849T3/da active
- 2012-12-21 HU HUE12808264A patent/HUE035438T2/en unknown
- 2012-12-21 CA CA2853656A patent/CA2853656C/en active Active
- 2012-12-21 AU AU2012359166A patent/AU2012359166B2/en active Active
- 2012-12-21 LT LTEP12808264.1T patent/LT2794849T/lt unknown
- 2012-12-21 BR BR112014015706-5A patent/BR112014015706A2/pt not_active Application Discontinuation
- 2012-12-21 CN CN201280064144.2A patent/CN104066834B/zh active Active
- 2012-12-21 JP JP2014547768A patent/JP6251179B2/ja active Active
- 2012-12-21 WO PCT/EP2012/005364 patent/WO2013091898A1/en active Application Filing
- 2012-12-21 ES ES12808264.1T patent/ES2650269T3/es active Active
-
2014
- 2014-06-16 IL IL233167A patent/IL233167A/en active IP Right Grant
- 2014-06-19 ZA ZA2014/04501A patent/ZA201404501B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014007575A (es) | 2015-02-05 |
| CN104066834A (zh) | 2014-09-24 |
| BR112014015706A2 (pt) | 2020-10-27 |
| KR102015932B1 (ko) | 2019-08-29 |
| AU2012359166A1 (en) | 2014-06-19 |
| AU2012359166B2 (en) | 2017-08-10 |
| JP6251179B2 (ja) | 2017-12-20 |
| PL2794849T3 (pl) | 2018-02-28 |
| SI2794849T1 (en) | 2018-01-31 |
| HUE035438T2 (en) | 2018-05-02 |
| US20140349274A1 (en) | 2014-11-27 |
| RU2014130045A (ru) | 2016-02-10 |
| SG11201403525PA (en) | 2014-10-30 |
| CN104066834B (zh) | 2017-04-19 |
| ZA201404501B (en) | 2016-02-24 |
| EP2794849A1 (en) | 2014-10-29 |
| LT2794849T (lt) | 2017-12-11 |
| ES2650269T3 (es) | 2018-01-17 |
| IL233167A0 (en) | 2014-07-31 |
| US9493738B2 (en) | 2016-11-15 |
| CA2853656A1 (en) | 2013-06-27 |
| WO2013091898A8 (en) | 2015-03-12 |
| EP2794849B1 (en) | 2017-08-30 |
| RU2631924C2 (ru) | 2017-09-28 |
| IL233167A (en) | 2017-08-31 |
| DK2794849T3 (da) | 2017-11-06 |
| KR20140105028A (ko) | 2014-08-29 |
| JP2015502162A (ja) | 2015-01-22 |
| CA2853656C (en) | 2020-12-29 |
| WO2013091898A1 (en) | 2013-06-27 |
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Legal Events
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| FG | Grant or registration |