MX353142B - Compuestos, composiciones, kits y metodos de uso para tratar oral y topicamente el acne y otras condiciones de la piel mediante administracion de un analogo de vitamina d que contiene 19-nor, con o sin un retinoide. - Google Patents

Compuestos, composiciones, kits y metodos de uso para tratar oral y topicamente el acne y otras condiciones de la piel mediante administracion de un analogo de vitamina d que contiene 19-nor, con o sin un retinoide.

Info

Publication number
MX353142B
MX353142B MX2011000850A MX2011000850A MX353142B MX 353142 B MX353142 B MX 353142B MX 2011000850 A MX2011000850 A MX 2011000850A MX 2011000850 A MX2011000850 A MX 2011000850A MX 353142 B MX353142 B MX 353142B
Authority
MX
Mexico
Prior art keywords
methylene
hydroxy
acid
dihydroxyvitamin
retinoyl
Prior art date
Application number
MX2011000850A
Other languages
English (en)
Inventor
F Deluca Hector
Clagett-Dame Margaret
A Plum Lori
Barycki Rafal
J Nieves Nirca
E Kaiser Mary
Original Assignee
Wisconsin Alumni Res Foundation Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Foundation Star filed Critical Wisconsin Alumni Res Foundation Star
Publication of MX353142B publication Critical patent/MX353142B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Birds (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen las composiciones farmacéuticas orales y tópicas, los kits y métodos de tratamiento de los mismos para tratar diversos trastornos de la piel que incluyen acné, psoriasis, ictiosis, fotoenvejecimiento, piel fotodañada y cáncer de piel. Los análogos de vitamina D ejemplares como ingredientes farmacéuticos activos incluyen 2-metilen-19-nor-20(S)-1a-hidroxi-b ishomopregnacalciferol, 19-nor-26,27-dimetilen-20(S)-2-metilen-1a, 25-dihidroxivitamina D3, 2-metilen-1a,25-dihidroxi-(17E)-17(20)-de shidro-19-nor-vitamina D3, 2-metilen-19-nor-(24R)-1a,25-dihidroxiv itamina D2, 2-metilen-(20R,25S)-19,26-dinor-1a,25-dihidroxivitamin a D3, 2-metilen-19-nor-1a-hidroxi-pregnacalciferol, 1a-hidroxi-2-metilen-19-nor-homopregnacalciferol, (20R)-1a-hidroxi-2-metilen-19-nor-bishomopregnacalciferol, 2-metilen-19-nor-(20S)-1a-hidroxi-trishomopregnacalciferol, 2-metilen-23,23-difluoro-1a-hidroxi-19-nor-bishomopregnacalcifero l, 2-metilen-(20S)-23,23-difluoro-1a-hidroxi-19-nor-bishomopregnac alciferol. (2-(3'hidroxipropil-1',2'-iden)-19,23,24-trinor-(20S)-1 a-hidroxivitamina D3, 2-metilen-18-19-dinor-(20S)-1a, 25-dihidroxivitamina D3 un estereoisómero de los mismos, un profármaco de los mismos en composiciones orales, una sal de los mismos, y/o un soluto de los mismos. Los compuestos que activan los receptores del ácido retinoico, tales como los retinoilos y los ésteres de retinoilo, incluyen el ácido 13-cis-retinoico, ácido todo-trans-retinoico, ácido (2E,4E,6Z,8E)-3,7-dimetil-9-(2,6 ,6-trimetil-1-ciclohexenil)nona-2,4,6,8-tetranoico, ácido 9-(4-metoxi-2,3,6-trimetil-fenil)-3,7-dimetil-nona-2,4,6,8-tetrae noico, ácido 6-[3-(1-adamantil)-4-metoxifenil]-2-naftoico, ácido 4-[1-(3,5,5,8,8-pentametil-tetralin-2-il)etenil]benzoico, ácido retinobenzoico, 6-[2-(4,4-dimetiltiocroman-6-il)etinil]piridin-3-c arboxilato, t-butirato de retinoilo, retinoil-pinacol, retinoil-colesterol, un isómero de los mismos, un profármaco de los mismos para composiciones orales, un éster de los mismos, una sal de los mismos, y/o, un soluto de los mismos. Las combinaciones de tales ingredientes activos demuestran eficacia sinérgica.
MX2011000850A 2006-12-29 2007-12-31 Compuestos, composiciones, kits y metodos de uso para tratar oral y topicamente el acne y otras condiciones de la piel mediante administracion de un analogo de vitamina d que contiene 19-nor, con o sin un retinoide. MX353142B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88270506P 2006-12-29 2006-12-29
US1721907P 2007-12-28 2007-12-28
US1721707P 2007-12-28 2007-12-28
US11/966,504 US8404667B2 (en) 2006-12-29 2007-12-28 Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
PCT/US2007/089193 WO2008083370A2 (en) 2006-12-29 2007-12-31 Compounds, compostions, kits and methods of use to orally and topically treat acne and other skin conditions by adminstering a 19-nor containing vitamin d analog with or without a reyinoid

Publications (1)

Publication Number Publication Date
MX353142B true MX353142B (es) 2017-12-20

Family

ID=39446431

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2011000850A MX353142B (es) 2006-12-29 2007-12-31 Compuestos, composiciones, kits y metodos de uso para tratar oral y topicamente el acne y otras condiciones de la piel mediante administracion de un analogo de vitamina d que contiene 19-nor, con o sin un retinoide.
MX2009007015A MX2009007015A (es) 2006-12-29 2007-12-31 Compuestos, composiciones, kits y metodos de uso para tratar oral y topicamente el acne y otras condiciones de la piel mediante administracion de un analogo de vitamina d que contiene 19-nor, con o sin un retinoide.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2009007015A MX2009007015A (es) 2006-12-29 2007-12-31 Compuestos, composiciones, kits y metodos de uso para tratar oral y topicamente el acne y otras condiciones de la piel mediante administracion de un analogo de vitamina d que contiene 19-nor, con o sin un retinoide.

Country Status (7)

Country Link
US (5) US8404667B2 (es)
EP (2) EP2101727B1 (es)
JP (1) JP5840348B2 (es)
CA (1) CA2674063C (es)
MX (2) MX353142B (es)
NZ (1) NZ577962A (es)
WO (1) WO2008083370A2 (es)

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WO2008083370A2 (en) 2008-07-10
EP2591769A2 (en) 2013-05-15
AU2007341940A1 (en) 2008-07-10
CA2674063C (en) 2016-01-19
CA2674063A1 (en) 2008-07-10
US20140018332A1 (en) 2014-01-16
EP2101727A2 (en) 2009-09-23
JP2010514812A (ja) 2010-05-06
WO2008083370A3 (en) 2009-06-18
NZ577962A (en) 2012-07-27
EP2101727B1 (en) 2017-11-08
US8404667B2 (en) 2013-03-26
EP2591769B1 (en) 2017-11-08
JP5840348B2 (ja) 2016-01-06
US20160235770A1 (en) 2016-08-18
US9339509B2 (en) 2016-05-17
EP2591769A3 (en) 2013-09-11
US20080261925A1 (en) 2008-10-23
US20110195941A1 (en) 2011-08-11
MX2009007015A (es) 2009-07-09

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