MX348337B - Peptido derivado de lactoferrina humana para usarse como agente de enmascaramiento de antigenos. - Google Patents

Peptido derivado de lactoferrina humana para usarse como agente de enmascaramiento de antigenos.

Info

Publication number
MX348337B
MX348337B MX2013005820A MX2013005820A MX348337B MX 348337 B MX348337 B MX 348337B MX 2013005820 A MX2013005820 A MX 2013005820A MX 2013005820 A MX2013005820 A MX 2013005820A MX 348337 B MX348337 B MX 348337B
Authority
MX
Mexico
Prior art keywords
derived peptide
human lactoferrin
masking agent
active substance
lactoferrin derived
Prior art date
Application number
MX2013005820A
Other languages
English (en)
Other versions
MX2013005820A (es
Inventor
Windhab Norbert
Hartwig Benedikt
Tome Alcalde Juan
Del Pilar Ansuategui Panzano Maria
Javier Vara Carrera Matías
Original Assignee
Evonik Roehm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm Gmbh filed Critical Evonik Roehm Gmbh
Publication of MX2013005820A publication Critical patent/MX2013005820A/es
Publication of MX348337B publication Critical patent/MX348337B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere a un péptido derivado de lactoferrina humana para usarse como un agente de enmascaramiento de antígenos en la producción de una composición farmacéutica para el suministro de una sustancia biológicamente activa en un organismo mamífero, en donde la sustancia biológicamente activa es capaz de inducir una respuesta inmune no deseada por el organismo mamífero, en donde la composición farmacéutica comprende un agregado supramolecular de la sustancia biológicamente activa y el péptido derivado de lactoferrina humana, con el efecto de que después del suministro de la composición farmacéutica al organismo mamífero, no hay o sólo hay una inducción reducida de la respuesta inmune no deseada contra la sustancia biológicamente activa.
MX2013005820A 2010-11-26 2010-11-26 Peptido derivado de lactoferrina humana para usarse como agente de enmascaramiento de antigenos. MX348337B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2010/068302 WO2012069089A1 (en) 2010-11-26 2010-11-26 Human lactoferrin derived peptide for use as an antigen masking agent

Publications (2)

Publication Number Publication Date
MX2013005820A MX2013005820A (es) 2013-07-12
MX348337B true MX348337B (es) 2017-06-07

Family

ID=43837881

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005820A MX348337B (es) 2010-11-26 2010-11-26 Peptido derivado de lactoferrina humana para usarse como agente de enmascaramiento de antigenos.

Country Status (16)

Country Link
US (1) US9724422B2 (es)
EP (1) EP2643344B1 (es)
JP (1) JP6073239B2 (es)
KR (1) KR101765364B1 (es)
CN (1) CN103906760B (es)
AU (1) AU2010364538B2 (es)
BR (1) BR112013012811B8 (es)
CA (1) CA2818951C (es)
ES (1) ES2627960T3 (es)
HU (1) HUE033501T2 (es)
IL (1) IL226198B (es)
MX (1) MX348337B (es)
PL (1) PL2643344T3 (es)
RU (1) RU2573422C2 (es)
SI (1) SI2643344T1 (es)
WO (1) WO2012069089A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3148515B1 (en) 2014-05-28 2019-12-04 Evonik Degussa GmbH Nanoparticle
CN108697798A (zh) * 2016-02-16 2018-10-23 达纳-法伯癌症研究所有限公司 免疫疗法组合物及方法
DE102016008601B4 (de) 2016-07-14 2019-05-23 Giesecke+Devrient Currency Technology Gmbh Sicherheitselement mit reversibel veränderbarem Farbbereich
US11021529B2 (en) 2017-03-03 2021-06-01 Massachusetts Institute Of Technology Antimicrobial constructs and uses thereof
CN107226860B (zh) * 2017-07-06 2020-04-10 浙江辉肽生命健康科技有限公司 一种生物活性多肽skhssldcvl及其制备方法和应用
HUE063939T2 (hu) 2018-05-08 2024-02-28 Evonik Operations Gmbh Bio-reszorbeálható poliésztert, hidrofil polimert és acilált humán laktoferrin-eredetû peptidet tartalmazó nanorészecske

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066469A (en) * 1990-03-08 2000-05-23 Ferro Dynamics, Inc. Cloning, expression, and uses of human lactoferrin
US5977337A (en) 1997-06-03 1999-11-02 Connaught Laboratories Limited Lactoferrin receptor genes of Moraxella
US6423509B1 (en) 1998-07-15 2002-07-23 Samyang Genex Corporation Pichia pastoris strain for producing lactoferrin and methods of use
JP2000045182A (ja) 1998-07-23 2000-02-15 Peptide Science:Kk 抗菌性繊維および繊維・皮革用抗菌加工剤
US20070259007A1 (en) * 1999-10-19 2007-11-08 Kruzel Marian L Lactoferrin: an adjuvant for vaccines
RU2165769C1 (ru) 2000-07-13 2001-04-27 Якубовская Раиса Ивановна Антибактериальный, антиоксидантный, иммуномодулирующий и антиканцерогенный препарат и способ его применения
DE60321027D1 (de) 2002-10-25 2008-06-26 Techlab Inc Diagnostisches panel ibd-first chek fur entzundliche darmerkrankung (ibd) und reizkolon
US7592306B2 (en) 2002-12-10 2009-09-22 Agennix, Inc. Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
DE102005051366A1 (de) 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
DE602006020617D1 (de) 2005-12-30 2011-04-21 Evonik Roehm Gmbh Lactoferrin-peptide, geeignet als in die zelle eindringende peptide

Also Published As

Publication number Publication date
KR101765364B1 (ko) 2017-08-08
WO2012069089A1 (en) 2012-05-31
HUE033501T2 (en) 2017-12-28
US9724422B2 (en) 2017-08-08
MX2013005820A (es) 2013-07-12
KR20130119955A (ko) 2013-11-01
PL2643344T3 (pl) 2017-09-29
JP6073239B2 (ja) 2017-02-01
US20130302342A1 (en) 2013-11-14
HK1196379A1 (zh) 2014-12-12
BR112013012811B8 (pt) 2022-07-05
CA2818951A1 (en) 2012-05-31
IL226198A0 (en) 2013-07-31
CA2818951C (en) 2018-03-13
JP2014501723A (ja) 2014-01-23
CN103906760A (zh) 2014-07-02
SI2643344T1 (sl) 2017-07-31
EP2643344B1 (en) 2017-03-22
IL226198B (en) 2019-01-31
RU2013128884A (ru) 2015-01-10
RU2573422C2 (ru) 2016-01-20
BR112013012811B1 (pt) 2021-07-06
AU2010364538B2 (en) 2016-04-14
ES2627960T3 (es) 2017-08-01
CN103906760B (zh) 2017-02-22
BR112013012811A2 (pt) 2016-09-13
EP2643344A1 (en) 2013-10-02
AU2010364538A1 (en) 2013-07-11

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