MX345885B - Dispositivo de mezclado de alimentacion y su uso. - Google Patents

Dispositivo de mezclado de alimentacion y su uso.

Info

Publication number
MX345885B
MX345885B MX2013005389A MX2013005389A MX345885B MX 345885 B MX345885 B MX 345885B MX 2013005389 A MX2013005389 A MX 2013005389A MX 2013005389 A MX2013005389 A MX 2013005389A MX 345885 B MX345885 B MX 345885B
Authority
MX
Mexico
Prior art keywords
value
feed
cultivation
mixing device
feed mixing
Prior art date
Application number
MX2013005389A
Other languages
English (en)
Other versions
MX2013005389A (es
Inventor
Hoffmann Jens
Baumann Sylvia
Jockwer Alexander
Klinger Christian
Troebs Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013005389A publication Critical patent/MX2013005389A/es
Publication of MX345885B publication Critical patent/MX345885B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/16—Apparatus for enzymology or microbiology containing, or adapted to contain, solid media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/02—Tissue, human, animal or plant cell, or virus culture apparatus with means providing suspensions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/044—Numerical composition values of components or mixtures, e.g. percentage of components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/88—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise
    • B01F35/883—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise using flow rate controls for feeding the substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un dispositivo de mezclado de alimentación para agregar las soluciones de la alimentación con un valor del pH no fisiológico al recipiente de cultivo de las células, que comprende una cámara para el mezclado de las soluciones de la alimentación previo a su adición al recipiente de cultivo de las células, así como a su uso. Con el dispositivo del mezclado de alimentación como se describe aquí, los componentes de la alimentación pueden ser provistos en solución a un valor del pH en el cual los mismos tienen buena solubilidad y/o una buena estabilidad por lo cual el valor de pH puede ser claramente diferente del valor del pH del medio de cultivo, es decir diferente del valor de pH fisiológico. Esto permite efectuar el cultivo con mayor flexibilidad comparado con un cultivo en el cual el valor del pH de la solución de alimentación está limitado a un intervalo pequeño alrededor del valor del pH del cultivo.
MX2013005389A 2010-12-07 2011-12-05 Dispositivo de mezclado de alimentacion y su uso. MX345885B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10194025 2010-12-07
PCT/EP2011/071696 WO2012076441A1 (en) 2010-12-07 2011-12-05 Feed mixing device and its use

Publications (2)

Publication Number Publication Date
MX2013005389A MX2013005389A (es) 2013-07-29
MX345885B true MX345885B (es) 2017-02-22

Family

ID=44026647

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005389A MX345885B (es) 2010-12-07 2011-12-05 Dispositivo de mezclado de alimentacion y su uso.

Country Status (11)

Country Link
US (3) US20140051121A1 (es)
EP (1) EP2649176B1 (es)
JP (2) JP5824527B2 (es)
KR (1) KR101507254B1 (es)
CN (1) CN103221534B (es)
BR (1) BR112013009934A2 (es)
CA (1) CA2817874A1 (es)
HK (1) HK1187647A1 (es)
MX (1) MX345885B (es)
RU (1) RU2595407C2 (es)
WO (1) WO2012076441A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018113907A (ja) * 2017-01-18 2018-07-26 株式会社Ｒｅｇｅｎｅ Ｐｈａｒｍ 動物細胞の培養方法

Family Cites Families (24)

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US5081036A (en) 1987-01-23 1992-01-14 Hoffmann-La Roche Inc. Method and apparatus for cell culture
JP2509630B2 (ja) 1987-07-29 1996-06-26 三井石油化学工業株式会社 培養方法及び培養装置
CA2089653A1 (en) 1991-06-17 1992-12-18 Dennis M. Disorbo Media concentrate technology
US5856179A (en) * 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
RU2102472C1 (ru) * 1994-07-19 1998-01-20 Научно-исследовательский институт микробиологии МО РФ Способ получения биомассы чумного микроба
JPH10201467A (ja) * 1997-01-20 1998-08-04 Ishikawajima Harima Heavy Ind Co Ltd 被培養体の生長判定方法および培養装置
US20060003448A1 (en) 2003-12-30 2006-01-05 Richard Fike Dry powder cells and cell culture reagents and methods of production thereof
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US20030092652A1 (en) * 1998-08-14 2003-05-15 Maria Bruno Protected one-vial formulation for nucleic acid molecules, methods of making the same by in-line mixing, and related products and methods
KR100283499B1 (ko) * 1998-12-23 2001-03-02 이금용 폐기물 매립지의 매립가스 발생량 조절방법 및 그 장치
AU3240602A (en) 2000-11-06 2002-05-15 Invitrogen Corp Dry powder cells and cell culture reagents and methods of production thereof
FR2836910B1 (fr) * 2002-03-08 2005-02-11 Amenagement Urbain & Rural Procede de degradation de la matiere organique par voie mycelienne
US6924124B1 (en) 2002-08-23 2005-08-02 Immunex Corporation Feeding strategies for cell culture
AU2003295584A1 (en) * 2002-11-18 2004-06-15 Taurus Hsa Llc Method for continuous, automated blending of solutions from acids and bases
US9410175B2 (en) 2005-03-24 2016-08-09 Dsm Ip Assets B.V. Process for microbial production of a valuable compound
WO2008013809A1 (en) * 2006-07-24 2008-01-31 Amgen Inc. Cell culture methods
DK2115126T3 (en) 2007-03-02 2015-05-04 Wyeth Llc Use of copper and glutamate in cell culture for the preparation of polypeptides
KR101761289B1 (ko) * 2007-09-28 2017-08-04 엔진 인코포레이티드 고농도 키토산-핵산 폴리플렉스 조성물
DE102008021483A1 (de) * 2008-04-29 2009-12-03 Forschungszentrum Jülich GmbH Zuleitungssystem
WO2010034443A1 (en) 2008-09-29 2010-04-01 F. Hoffmann-La Roche Ag Antibodies against human il 17 and uses thereof
WO2010045168A1 (en) * 2008-10-16 2010-04-22 Andrew Desbarats Method and apparatus for producing alcohol or sugar using a commercial-scale bioreactor
PT2563906T (pt) * 2010-04-26 2018-02-16 Novartis Ag Processo para cultivo de células cho
RU2644651C2 (ru) * 2010-04-26 2018-02-13 Новартис Аг Среда для культивирования клеток
WO2012030838A1 (en) * 2010-08-30 2012-03-08 Honda Motor Co., Ltd. Belief tracking and action selection in spoken dialog systems

Also Published As

Publication number Publication date
JP5824527B2 (ja) 2015-11-25
HK1187647A1 (zh) 2014-04-11
JP2016028596A (ja) 2016-03-03
BR112013009934A2 (pt) 2016-07-05
CA2817874A1 (en) 2012-06-14
CN103221534B (zh) 2016-05-18
WO2012076441A1 (en) 2012-06-14
KR101507254B1 (ko) 2015-03-30
EP2649176A1 (en) 2013-10-16
JP6117885B2 (ja) 2017-04-19
US20210040528A1 (en) 2021-02-11
KR20130095789A (ko) 2013-08-28
US20180010162A1 (en) 2018-01-11
RU2595407C2 (ru) 2016-08-27
MX2013005389A (es) 2013-07-29
EP2649176B1 (en) 2018-01-17
US10837042B2 (en) 2020-11-17
RU2013129008A (ru) 2015-01-20
CN103221534A (zh) 2013-07-24
US20140051121A1 (en) 2014-02-20
JP2014500025A (ja) 2014-01-09

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