MX345768B - Procedimiento para la preparación de 2,2-dufluoroetilamina partiendo de un compuesto de bencilamina. - Google Patents

Procedimiento para la preparación de 2,2-dufluoroetilamina partiendo de un compuesto de bencilamina.

Info

Publication number
MX345768B
MX345768B MX2013004796A MX2013004796A MX345768B MX 345768 B MX345768 B MX 345768B MX 2013004796 A MX2013004796 A MX 2013004796A MX 2013004796 A MX2013004796 A MX 2013004796A MX 345768 B MX345768 B MX 345768B
Authority
MX
Mexico
Prior art keywords
sub
formula
compound
preparing
difluoroethylamine
Prior art date
Application number
MX2013004796A
Other languages
English (en)
Other versions
MX2013004796A (es
Inventor
Günter Schlegel
Norbert Lui
Christian Funke
Jens-Dietmar Heinrich
Thomas Norbert Müller
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MX2013004796A publication Critical patent/MX2013004796A/es
Publication of MX345768B publication Critical patent/MX345768B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un procedimiento para la preparación de 2,2-difluoroetilamina de fórmula (I) CHF2CH2NH2 (I) que comprende las etapas (i) y (ii): etapa (i): reacción de 2,2-difluoro-1-haloetano de fórmula general (II) CHF2-CH2HaI (II) con un compuesto de bencilamina de fórmula (III) (Ver Fórmula) en presencia de un neutralizador de ácido, en el que, en la fórmula (II), Hal es cloro, bromo o yodo, y, en la fórmula (III), R1 es hidrógeno o alquilo-C1-C12, y R2 es hidrógeno, halógeno, alquilo-C1-C12 o alcoxi-C1-C6 etapa (ii): hidrogenación catalítica del compuesto de N-bencil-2,2-difluoroeta namina de fórmula (IV) obtenido en la etapa (i), para dar 2,2-difluoroetilamina de fórmula (I) o una de sus sales.
MX2013004796A 2010-11-12 2011-11-07 Procedimiento para la preparación de 2,2-dufluoroetilamina partiendo de un compuesto de bencilamina. MX345768B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41304510P 2010-11-12 2010-11-12
EP10191061 2010-11-12
PCT/EP2011/069545 WO2012062702A1 (de) 2010-11-12 2011-11-07 Verfahren zur herstellung von 2,2-difluorethylamin ausgehend von einer benzylamin-verbindung

Publications (2)

Publication Number Publication Date
MX2013004796A MX2013004796A (es) 2013-06-28
MX345768B true MX345768B (es) 2017-02-14

Family

ID=43480430

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004796A MX345768B (es) 2010-11-12 2011-11-07 Procedimiento para la preparación de 2,2-dufluoroetilamina partiendo de un compuesto de bencilamina.

Country Status (12)

Country Link
US (1) US8450528B2 (es)
EP (1) EP2638002B1 (es)
JP (1) JP5893042B2 (es)
KR (1) KR101869994B1 (es)
CN (1) CN103201251B (es)
BR (1) BR112013011410B1 (es)
DK (1) DK2638002T3 (es)
ES (1) ES2636776T3 (es)
IL (1) IL226060A (es)
MX (1) MX345768B (es)
TW (1) TWI515176B (es)
WO (1) WO2012062702A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101837072B1 (ko) * 2010-11-12 2018-03-09 바이엘 인텔렉쳐 프로퍼티 게엠베하 Ｎ-(2,2-디플루오로에틸)프로프-2-엔-1-아민으로부터 2,2-디플루오로에틸아민 유도체의 제조방법
JP2024506203A (ja) 2021-02-17 2024-02-09 バイエル・アクチエンゲゼルシヤフト ポリフルオロアルキルアルコールからのポリフルオロアルキルアミンの調製方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL173388C (nl) * 1970-08-03 1984-01-16 Merck & Co Inc Werkwijze voor het fluoreren van organische verbindingen.
US4030994A (en) 1971-06-18 1977-06-21 Merck & Co., Inc. Substitutive fluorination of organic compounds
JPH06157430A (ja) * 1992-09-25 1994-06-03 Idemitsu Petrochem Co Ltd ペルフルオロアルキル基含有アミンの製造方法
JP2005263772A (ja) * 2003-07-23 2005-09-29 Chisso Corp ジアミン、それを用いた配向膜、および該配向膜を有する液晶表示素子
DE102006015467A1 (de) * 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
EP2039684A1 (de) 2007-09-18 2009-03-25 Bayer CropScience AG Verfahren zur Herstellung von 2,2-Difluorethylamin-Derivaten durch Imin-Hydrierung
CN101638370B (zh) * 2009-08-18 2013-04-10 浙江大学 一种n，n-二异丙基丁胺的合成方法

Also Published As

Publication number Publication date
BR112013011410A2 (pt) 2016-08-02
TWI515176B (zh) 2016-01-01
BR112013011410B1 (pt) 2018-12-11
MX2013004796A (es) 2013-06-28
JP2014500253A (ja) 2014-01-09
EP2638002A1 (de) 2013-09-18
US20120123163A1 (en) 2012-05-17
EP2638002B1 (de) 2017-05-10
WO2012062702A1 (de) 2012-05-18
DK2638002T3 (en) 2017-09-11
JP5893042B2 (ja) 2016-03-23
KR20130125366A (ko) 2013-11-18
CN103201251A (zh) 2013-07-10
IL226060A0 (en) 2013-06-27
US8450528B2 (en) 2013-05-28
ES2636776T3 (es) 2017-10-09
CN103201251B (zh) 2015-12-02
KR101869994B1 (ko) 2018-06-22
IL226060A (en) 2014-09-30
TW201228998A (en) 2012-07-16

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